AU2002352797A1 - Methods for identifying and validating potential drug targets - Google Patents

Info

Publication number

AU2002352797A1

AU2002352797A1 AU2002352797A AU2002352797A AU2002352797A1 AU 2002352797 A1 AU2002352797 A1 AU 2002352797A1 AU 2002352797 A AU2002352797 A AU 2002352797A AU 2002352797 A AU2002352797 A AU 2002352797A AU 2002352797 A1 AU2002352797 A1 AU 2002352797A1

Authority

AU

Australia

Prior art keywords

protein

disease

expression

nucleic acid

sequences

Prior art date

2001-11-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims description 194
• 239000003596 drug target Substances 0.000 title claims description 76
• 108090000623 proteins and genes Proteins 0.000 claims description 853
• 102000004169 proteins and genes Human genes 0.000 claims description 591
• 210000004027 cell Anatomy 0.000 claims description 255
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 206
• 201000010099 disease Diseases 0.000 claims description 190
• 230000014509 gene expression Effects 0.000 claims description 178
• 150000007523 nucleic acids Chemical group 0.000 claims description 103
• 108020004414 DNA Proteins 0.000 claims description 91
• 102000039446 nucleic acids Human genes 0.000 claims description 71
• 108020004707 nucleic acids Proteins 0.000 claims description 71
• 230000000694 effects Effects 0.000 claims description 58
• 101710201734 E3 protein Proteins 0.000 claims description 56
• 230000009368 gene silencing by RNA Effects 0.000 claims description 50
• 108091034117 Oligonucleotide Proteins 0.000 claims description 49
• 230000003247 decreasing effect Effects 0.000 claims description 46
• 238000003556 assay Methods 0.000 claims description 37
• 108090000848 Ubiquitin Proteins 0.000 claims description 35
• 102000044159 Ubiquitin Human genes 0.000 claims description 35
• 102000053642 Catalytic RNA Human genes 0.000 claims description 32
• 108090000994 Catalytic RNA Proteins 0.000 claims description 32
• 108091092562 ribozyme Proteins 0.000 claims description 32
• 102000004190 Enzymes Human genes 0.000 claims description 30
• 108090000790 Enzymes Proteins 0.000 claims description 30
• 108091005461 Nucleic proteins Chemical group 0.000 claims description 29
• 101000908058 Homo sapiens Dihydrolipoyl dehydrogenase, mitochondrial Proteins 0.000 claims description 21
• 241000700605 Viruses Species 0.000 claims description 20
• 230000007423 decrease Effects 0.000 claims description 20
• 230000001965 increasing effect Effects 0.000 claims description 19
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 18
• 230000001404 mediated effect Effects 0.000 claims description 18
• 206010028980 Neoplasm Diseases 0.000 claims description 17
• 230000008859 change Effects 0.000 claims description 17
• 239000000074 antisense oligonucleotide Substances 0.000 claims description 16
• 238000012230 antisense oligonucleotides Methods 0.000 claims description 16
• 230000004071 biological effect Effects 0.000 claims description 16
• 230000015556 catabolic process Effects 0.000 claims description 16
• 238000006731 degradation reaction Methods 0.000 claims description 16
• 239000002245 particle Substances 0.000 claims description 16
• 208000036142 Viral infection Diseases 0.000 claims description 15
• 230000009385 viral infection Effects 0.000 claims description 15
• 239000000758 substrate Substances 0.000 claims description 14
• 238000004166 bioassay Methods 0.000 claims description 13
• 238000012360 testing method Methods 0.000 claims description 13
• 238000004458 analytical method Methods 0.000 claims description 12
• 230000002159 abnormal effect Effects 0.000 claims description 11
• 230000035755 proliferation Effects 0.000 claims description 11
• 230000001225 therapeutic effect Effects 0.000 claims description 10
• 230000003612 virological effect Effects 0.000 claims description 10
• 239000002253 acid Substances 0.000 claims description 9
• 102000003960 Ligases Human genes 0.000 claims description 8
• 108090000364 Ligases Proteins 0.000 claims description 8
• 102000000395 SH3 domains Human genes 0.000 claims description 8
• 108050008861 SH3 domains Proteins 0.000 claims description 8
• 201000011510 cancer Diseases 0.000 claims description 8
• 230000001747 exhibiting effect Effects 0.000 claims description 8
• 210000004881 tumor cell Anatomy 0.000 claims description 8
• 230000002062 proliferating effect Effects 0.000 claims description 7
• 230000030570 cellular localization Effects 0.000 claims description 6
• 206010038997 Retroviral infections Diseases 0.000 claims description 5
• 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims description 5
• 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims description 5
• 230000026447 protein localization Effects 0.000 claims description 4
• 238000012216 screening Methods 0.000 claims description 4
• 108010076504 Protein Sorting Signals Proteins 0.000 claims description 3
• 150000003384 small molecules Chemical class 0.000 claims description 3
• 208000005623 Carcinogenesis Diseases 0.000 claims description 2
• 230000036952 cancer formation Effects 0.000 claims description 2
• 231100000504 carcinogenesis Toxicity 0.000 claims description 2
• 108091030071 RNAI Proteins 0.000 claims 9
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000037357 HIV infectious disease Diseases 0.000 claims 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 description 533
• 241000282414 Homo sapiens Species 0.000 description 397
• 102000053602 DNA Human genes 0.000 description 88
• 108020004999 messenger RNA Proteins 0.000 description 55
• 102000034354 Gi proteins Human genes 0.000 description 52
• 108091006101 Gi proteins Proteins 0.000 description 52
• 239000000047 product Substances 0.000 description 50
• 229920002477 rna polymer Polymers 0.000 description 43
• 101000591312 Homo sapiens Putative MORF4 family-associated protein 1-like protein UPP Proteins 0.000 description 41
• 102100034096 Putative MORF4 family-associated protein 1-like protein UPP Human genes 0.000 description 41
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 41
• 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 description 40
• 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 description 40
• 102000018700 F-Box Proteins Human genes 0.000 description 36
• 108010066805 F-Box Proteins Proteins 0.000 description 36
• 108090000765 processed proteins & peptides Proteins 0.000 description 35
• 230000000692 anti-sense effect Effects 0.000 description 33
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 31
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 31
• 108010029485 Protein Isoforms Proteins 0.000 description 31
• 102000001708 Protein Isoforms Human genes 0.000 description 31
• 230000008569 process Effects 0.000 description 31
• 102000011408 Tripartite Motif Proteins Human genes 0.000 description 30
• 108010023649 Tripartite Motif Proteins Proteins 0.000 description 30
• 230000027455 binding Effects 0.000 description 30
• 108020004459 Small interfering RNA Proteins 0.000 description 29
• 235000001014 amino acid Nutrition 0.000 description 29
• 150000001413 amino acids Chemical group 0.000 description 29
• 229940024606 amino acid Drugs 0.000 description 28
• 238000001890 transfection Methods 0.000 description 28
• 102000004196 processed proteins & peptides Human genes 0.000 description 24
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 22
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 22
• 239000002773 nucleotide Substances 0.000 description 22
• 125000003729 nucleotide group Chemical group 0.000 description 22
• 230000037361 pathway Effects 0.000 description 22
• 229920001184 polypeptide Polymers 0.000 description 22
• 230000000295 complement effect Effects 0.000 description 21
• 230000000875 corresponding effect Effects 0.000 description 21
• 239000012634 fragment Substances 0.000 description 20
• 239000000203 mixture Substances 0.000 description 20
• 239000000523 sample Substances 0.000 description 19
• 238000010798 ubiquitination Methods 0.000 description 19
• 101000837060 Homo sapiens E3 ubiquitin-protein ligase SH3RF1 Proteins 0.000 description 18
• 230000034512 ubiquitination Effects 0.000 description 18
• 102100028660 E3 ubiquitin-protein ligase SH3RF1 Human genes 0.000 description 17
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 17
• 230000003993 interaction Effects 0.000 description 17
• 239000006228 supernatant Substances 0.000 description 17
• 238000012546 transfer Methods 0.000 description 17
• 230000006870 function Effects 0.000 description 16
• 229910052725 zinc Inorganic materials 0.000 description 16
• 239000011701 zinc Substances 0.000 description 16
• 101710185494 Zinc finger protein Proteins 0.000 description 14
• 102100023597 Zinc finger protein 816 Human genes 0.000 description 14
• 210000000170 cell membrane Anatomy 0.000 description 14
• 210000002472 endoplasmic reticulum Anatomy 0.000 description 14
• 239000002609 medium Substances 0.000 description 14
• 239000008188 pellet Substances 0.000 description 14
• 230000014616 translation Effects 0.000 description 14
• 239000012528 membrane Substances 0.000 description 13
• 230000001105 regulatory effect Effects 0.000 description 13
• 102000040430 polynucleotide Human genes 0.000 description 12
• 108091033319 polynucleotide Proteins 0.000 description 12
• 239000002157 polynucleotide Substances 0.000 description 12
• 238000013518 transcription Methods 0.000 description 12
• 230000035897 transcription Effects 0.000 description 12
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 11
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 11
• 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 description 11
• 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 description 11
• 239000000427 antigen Substances 0.000 description 11
• 108091007433 antigens Proteins 0.000 description 11
• 102000036639 antigens Human genes 0.000 description 11
• 230000034994 death Effects 0.000 description 11
• 208000035475 disorder Diseases 0.000 description 11
• 238000005516 engineering process Methods 0.000 description 11
• 238000003197 gene knockdown Methods 0.000 description 11
• 238000009396 hybridization Methods 0.000 description 11
• 230000001575 pathological effect Effects 0.000 description 11
• 210000001519 tissue Anatomy 0.000 description 11
• 238000013519 translation Methods 0.000 description 11
• -1 HIV-VLP Proteins 0.000 description 10
• 241000725303 Human immunodeficiency virus Species 0.000 description 10
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 10
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 10
• 230000001413 cellular effect Effects 0.000 description 10
• 238000006243 chemical reaction Methods 0.000 description 10
• 238000004519 manufacturing process Methods 0.000 description 10
• 238000012545 processing Methods 0.000 description 10
• 239000000243 solution Substances 0.000 description 10
• 102100036465 Autoimmune regulator Human genes 0.000 description 9
• 102000014914 Carrier Proteins Human genes 0.000 description 9
• 201000003883 Cystic fibrosis Diseases 0.000 description 9
• 101000928549 Homo sapiens Autoimmune regulator Proteins 0.000 description 9
• 238000013459 approach Methods 0.000 description 9
• 108091008324 binding proteins Proteins 0.000 description 9
• 230000015572 biosynthetic process Effects 0.000 description 9
• 230000005764 inhibitory process Effects 0.000 description 9
• 230000003834 intracellular effect Effects 0.000 description 9
• 102000051819 Baculoviral IAP Repeat-Containing 3 Human genes 0.000 description 8
• 108091023040 Transcription factor Proteins 0.000 description 8
• 102000040945 Transcription factor Human genes 0.000 description 8
• 230000006907 apoptotic process Effects 0.000 description 8
• 238000004422 calculation algorithm Methods 0.000 description 8
• 230000004807 localization Effects 0.000 description 8
• 108090000668 Annexin A2 Proteins 0.000 description 7
• 108020005544 Antisense RNA Proteins 0.000 description 7
• 101710177291 Gag polyprotein Proteins 0.000 description 7
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
• 101000772888 Homo sapiens Ubiquitin-protein ligase E3A Proteins 0.000 description 7
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 7
• 239000012124 Opti-MEM Substances 0.000 description 7
• 125000003275 alpha amino acid group Chemical group 0.000 description 7
• 239000003184 complementary RNA Substances 0.000 description 7
• 239000003814 drug Substances 0.000 description 7
• 239000003112 inhibitor Substances 0.000 description 7
• 239000013612 plasmid Substances 0.000 description 7
• 102100034613 Annexin A2 Human genes 0.000 description 6
• 108700003785 Baculoviral IAP Repeat-Containing 3 Proteins 0.000 description 6
• 102000002110 C2 domains Human genes 0.000 description 6
• 108050009459 C2 domains Proteins 0.000 description 6
• 102100023431 E3 ubiquitin-protein ligase TRIM21 Human genes 0.000 description 6
• 102100037024 E3 ubiquitin-protein ligase XIAP Human genes 0.000 description 6
• 101000573199 Homo sapiens Protein PML Proteins 0.000 description 6
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 6
• 102100031014 Phosphatidylinositol-binding clathrin assembly protein Human genes 0.000 description 6
• 108020004511 Recombinant DNA Proteins 0.000 description 6
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 6
• 102000003431 Ubiquitin-Conjugating Enzyme Human genes 0.000 description 6
• 108060008747 Ubiquitin-Conjugating Enzyme Proteins 0.000 description 6
• 230000031018 biological processes and functions Effects 0.000 description 6
• 239000003795 chemical substances by application Substances 0.000 description 6
• 210000000349 chromosome Anatomy 0.000 description 6
• 238000004590 computer program Methods 0.000 description 6
• 230000001419 dependent effect Effects 0.000 description 6
• 238000013461 design Methods 0.000 description 6
• 238000011161 development Methods 0.000 description 6
• 230000018109 developmental process Effects 0.000 description 6
• 239000000284 extract Substances 0.000 description 6
• 239000000499 gel Substances 0.000 description 6
• 210000004962 mammalian cell Anatomy 0.000 description 6
• 239000000463 material Substances 0.000 description 6
• 230000017854 proteolysis Effects 0.000 description 6
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 6
• 239000013598 vector Substances 0.000 description 6
• QAPSNMNOIOSXSQ-YNEHKIRRSA-N 1-[(2r,4s,5r)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O[Si](C)(C)C(C)(C)C)C1 QAPSNMNOIOSXSQ-YNEHKIRRSA-N 0.000 description 5
• 102100030933 CDK-activating kinase assembly factor MAT1 Human genes 0.000 description 5
• 108091026890 Coding region Proteins 0.000 description 5
• 108091035707 Consensus sequence Proteins 0.000 description 5
• 101150005585 E3 gene Proteins 0.000 description 5
• 102100031918 E3 ubiquitin-protein ligase NEDD4 Human genes 0.000 description 5
• 102100029520 E3 ubiquitin-protein ligase TRIM31 Human genes 0.000 description 5
• 102100029671 E3 ubiquitin-protein ligase TRIM8 Human genes 0.000 description 5
• 101710160621 Fusion glycoprotein F0 Proteins 0.000 description 5
• 102000030782 GTP binding Human genes 0.000 description 5
• 108091000058 GTP-Binding Proteins 0.000 description 5
• 101000737269 Homo sapiens E3 ubiquitin-protein ligase CBL-C Proteins 0.000 description 5
• 101000634974 Homo sapiens E3 ubiquitin-protein ligase TRIM31 Proteins 0.000 description 5
• 101001026853 Homo sapiens F-box/LRR-repeat protein 5 Proteins 0.000 description 5
• 101001088879 Homo sapiens Lysine-specific demethylase 5D Proteins 0.000 description 5
• 101001003584 Homo sapiens Prelamin-A/C Proteins 0.000 description 5
• 101000596277 Homo sapiens TSC22 domain family protein 3 Proteins 0.000 description 5
• 108010002616 Interleukin-5 Proteins 0.000 description 5
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 5
• 102100033246 Lysine-specific demethylase 5A Human genes 0.000 description 5
• 102100033143 Lysine-specific demethylase 5D Human genes 0.000 description 5
• 101710125418 Major capsid protein Proteins 0.000 description 5
• 102100021698 Peregrin Human genes 0.000 description 5
• 102100025516 Peroxisome biogenesis factor 2 Human genes 0.000 description 5
• 101710169596 Phosphatidylinositol-binding clathrin assembly protein Proteins 0.000 description 5
• 108091000080 Phosphotransferase Proteins 0.000 description 5
• 102100026531 Prelamin-A/C Human genes 0.000 description 5
• 102100026310 Probable E3 ubiquitin-protein ligase MID2 Human genes 0.000 description 5
• 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 5
• 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 5
• 102100026375 Protein PML Human genes 0.000 description 5
• 102000036366 SCF complex Human genes 0.000 description 5
• 108091007047 SCF complex Proteins 0.000 description 5
• 102000051614 SET domains Human genes 0.000 description 5
• 108700039010 SET domains Proteins 0.000 description 5
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 5
• 102100035260 TSC22 domain family protein 3 Human genes 0.000 description 5
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 5
• 102100030434 Ubiquitin-protein ligase E3A Human genes 0.000 description 5
• 108010067390 Viral Proteins Proteins 0.000 description 5
• 150000007513 acids Chemical class 0.000 description 5
• 125000000539 amino acid group Chemical group 0.000 description 5
• 239000000872 buffer Substances 0.000 description 5
• 229940079593 drug Drugs 0.000 description 5
• 238000002474 experimental method Methods 0.000 description 5
• 239000001963 growth medium Substances 0.000 description 5
• 238000000338 in vitro Methods 0.000 description 5
• 230000004048 modification Effects 0.000 description 5
• 238000012986 modification Methods 0.000 description 5
• 230000035772 mutation Effects 0.000 description 5
• 102000020233 phosphotransferase Human genes 0.000 description 5
• 108020001580 protein domains Proteins 0.000 description 5
• 102000005962 receptors Human genes 0.000 description 5
• 108020003175 receptors Proteins 0.000 description 5
• 230000002829 reductive effect Effects 0.000 description 5
• 230000004044 response Effects 0.000 description 5
• 238000003757 reverse transcription PCR Methods 0.000 description 5
• 241000894007 species Species 0.000 description 5
• 238000003860 storage Methods 0.000 description 5
• 230000008685 targeting Effects 0.000 description 5
• 238000011282 treatment Methods 0.000 description 5
• 108700006471 APECED Proteins 0.000 description 4
• 108020000948 Antisense Oligonucleotides Proteins 0.000 description 4
• 229940088872 Apoptosis inhibitor Drugs 0.000 description 4
• 108091007065 BIRCs Proteins 0.000 description 4
• 102000001805 Bromodomains Human genes 0.000 description 4
• 101150013553 CD40 gene Proteins 0.000 description 4
• 102000016736 Cyclin Human genes 0.000 description 4
• 108050006400 Cyclin Proteins 0.000 description 4
• 102100035813 E3 ubiquitin-protein ligase CBL Human genes 0.000 description 4
• 102100035275 E3 ubiquitin-protein ligase CBL-C Human genes 0.000 description 4
• 102100031438 E3 ubiquitin-protein ligase RING1 Human genes 0.000 description 4
• 102100028152 E3 ubiquitin-protein ligase RNF113A Human genes 0.000 description 4
• 102100040278 E3 ubiquitin-protein ligase RNF19A Human genes 0.000 description 4
• 101710157279 E3 ubiquitin-protein ligase RNF19A Proteins 0.000 description 4
• 101710164941 E3 ubiquitin-protein ligase TRIM21 Proteins 0.000 description 4
• 102100034596 E3 ubiquitin-protein ligase TRIM23 Human genes 0.000 description 4
• 102100040085 E3 ubiquitin-protein ligase TRIM38 Human genes 0.000 description 4
• 102100029211 E3 ubiquitin-protein ligase TTC3 Human genes 0.000 description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
• 102100022116 F-box only protein 2 Human genes 0.000 description 4
• 102100029186 F-box only protein 9 Human genes 0.000 description 4
• 102100029234 Histone-lysine N-methyltransferase NSD2 Human genes 0.000 description 4
• 101000848625 Homo sapiens E3 ubiquitin-protein ligase TRIM23 Proteins 0.000 description 4
• 101000610492 Homo sapiens E3 ubiquitin-protein ligase TRIM38 Proteins 0.000 description 4
• 101000633723 Homo sapiens E3 ubiquitin-protein ligase TTC3 Proteins 0.000 description 4
• 101000917834 Homo sapiens F-box only protein 9 Proteins 0.000 description 4
• 101001026867 Homo sapiens F-box/LRR-repeat protein 4 Proteins 0.000 description 4
• 101000896765 Homo sapiens Peregrin Proteins 0.000 description 4
• 101001125496 Homo sapiens Pre-mRNA-processing factor 19 Proteins 0.000 description 4
• 101000766246 Homo sapiens Probable E3 ubiquitin-protein ligase MID2 Proteins 0.000 description 4
• 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 4
• 102000043129 MHC class I family Human genes 0.000 description 4
• 108091054437 MHC class I family Proteins 0.000 description 4
• 108010052285 Membrane Proteins Proteins 0.000 description 4
• 241001465754 Metazoa Species 0.000 description 4
• 102100033115 Mitogen-activated protein kinase kinase kinase 1 Human genes 0.000 description 4
• 102000008297 Nuclear Matrix-Associated Proteins Human genes 0.000 description 4
• 108010035916 Nuclear Matrix-Associated Proteins Proteins 0.000 description 4
• 102000001253 Protein Kinase Human genes 0.000 description 4
• 201000000582 Retinoblastoma Diseases 0.000 description 4
• 108010071010 Retinoblastoma-Binding Protein 2 Proteins 0.000 description 4
• 102000014400 SH2 domains Human genes 0.000 description 4
• 108050003452 SH2 domains Proteins 0.000 description 4
• 108091081021 Sense strand Proteins 0.000 description 4
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 4
• 108700019146 Transgenes Proteins 0.000 description 4
• 102100034593 Tripartite motif-containing protein 26 Human genes 0.000 description 4
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 4
• 102100029504 Zinc finger protein RFP Human genes 0.000 description 4
• 101710110903 Zinc finger protein RFP Proteins 0.000 description 4
• 239000000158 apoptosis inhibitor Substances 0.000 description 4
• 210000000481 breast Anatomy 0.000 description 4
• 230000003197 catalytic effect Effects 0.000 description 4
• 150000001875 compounds Chemical class 0.000 description 4
• 238000010790 dilution Methods 0.000 description 4
• 239000012895 dilution Substances 0.000 description 4
• 229940011871 estrogen Drugs 0.000 description 4
• 239000000262 estrogen Substances 0.000 description 4
• 230000002209 hydrophobic effect Effects 0.000 description 4
• 238000001114 immunoprecipitation Methods 0.000 description 4
• 238000001727 in vivo Methods 0.000 description 4
• 238000002372 labelling Methods 0.000 description 4
• 230000035800 maturation Effects 0.000 description 4
• NRZWYNLTFLDQQX-UHFFFAOYSA-N p-tert-Amylphenol Chemical compound CCC(C)(C)C1=CC=C(O)C=C1 NRZWYNLTFLDQQX-UHFFFAOYSA-N 0.000 description 4
• 108060006633 protein kinase Proteins 0.000 description 4
• 230000002797 proteolythic effect Effects 0.000 description 4
• 230000019491 signal transduction Effects 0.000 description 4
• 230000011664 signaling Effects 0.000 description 4
• 150000007970 thio esters Chemical class 0.000 description 4
• 230000001131 transforming effect Effects 0.000 description 4
• 230000032258 transport Effects 0.000 description 4
• 230000001960 triggered effect Effects 0.000 description 4
• 101000650779 Boana raniceps Raniseptin-5 Proteins 0.000 description 3
• 102100033640 Bromodomain-containing protein 1 Human genes 0.000 description 3
• 108050009021 Bromodomains Proteins 0.000 description 3
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
• 102100031266 Chromodomain-helicase-DNA-binding protein 3 Human genes 0.000 description 3
• 102100038214 Chromodomain-helicase-DNA-binding protein 4 Human genes 0.000 description 3
• 102100026810 Cyclin-dependent kinase 7 Human genes 0.000 description 3
• 101100439546 Drosophila melanogaster Mi-2 gene Proteins 0.000 description 3
• 102100032045 E3 ubiquitin-protein ligase AMFR Human genes 0.000 description 3
• 101710111890 E3 ubiquitin-protein ligase NEDD4 Proteins 0.000 description 3
• 102100022166 E3 ubiquitin-protein ligase NEURL1 Human genes 0.000 description 3
• 102100037964 E3 ubiquitin-protein ligase RING2 Human genes 0.000 description 3
• 102100034185 E3 ubiquitin-protein ligase RLIM Human genes 0.000 description 3
• 101710162457 E3 ubiquitin-protein ligase RNF103 Proteins 0.000 description 3
• 102100029501 E3 ubiquitin-protein ligase TRIM35 Human genes 0.000 description 3
• 102100040068 E3 ubiquitin-protein ligase TRIM37 Human genes 0.000 description 3
• 101710197966 E3 ubiquitin-protein ligase TRIM8 Proteins 0.000 description 3
• 102100024739 E3 ubiquitin-protein ligase UHRF1 Human genes 0.000 description 3
• 102100026078 F-box only protein 3 Human genes 0.000 description 3
• 102100029525 F-box only protein 7 Human genes 0.000 description 3
• 102100029203 F-box only protein 8 Human genes 0.000 description 3
• 102100037317 F-box/LRR-repeat protein 7 Human genes 0.000 description 3
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 3
• 108091006027 G proteins Proteins 0.000 description 3
• 101000871846 Homo sapiens Bromodomain-containing protein 1 Proteins 0.000 description 3
• 101000777071 Homo sapiens Chromodomain-helicase-DNA-binding protein 3 Proteins 0.000 description 3
• 101000973232 Homo sapiens E3 ubiquitin-protein ligase NEURL1 Proteins 0.000 description 3
• 101000634987 Homo sapiens E3 ubiquitin-protein ligase TRIM35 Proteins 0.000 description 3
• 101000610400 Homo sapiens E3 ubiquitin-protein ligase TRIM37 Proteins 0.000 description 3
• 101000760417 Homo sapiens E3 ubiquitin-protein ligase UHRF1 Proteins 0.000 description 3
• 101000804865 Homo sapiens E3 ubiquitin-protein ligase XIAP Proteins 0.000 description 3
• 101000913305 Homo sapiens F-box only protein 3 Proteins 0.000 description 3
• 101000917536 Homo sapiens F-box only protein 7 Proteins 0.000 description 3
• 101000634048 Homo sapiens Histone-lysine N-methyltransferase NSD2 Proteins 0.000 description 3
• 101000613625 Homo sapiens Lysine-specific demethylase 4A Proteins 0.000 description 3
• 101000597272 Homo sapiens PHD finger protein 10 Proteins 0.000 description 3
• 101000872514 Homo sapiens Probable E3 ubiquitin-protein ligase HERC1 Proteins 0.000 description 3
• 101001035260 Homo sapiens Probable E3 ubiquitin-protein ligase HERC3 Proteins 0.000 description 3
• 101000808654 Homo sapiens Ubiquitin conjugation factor E4 A Proteins 0.000 description 3
• 101000855256 Homo sapiens Uncharacterized protein C16orf74 Proteins 0.000 description 3
• 101000915470 Homo sapiens Zinc finger MYND domain-containing protein 11 Proteins 0.000 description 3
• 102000003839 Human Proteins Human genes 0.000 description 3
• 108090000144 Human Proteins Proteins 0.000 description 3
• 241000701024 Human betaherpesvirus 5 Species 0.000 description 3
• 102000055031 Inhibitor of Apoptosis Proteins Human genes 0.000 description 3
• 102000014150 Interferons Human genes 0.000 description 3
• 108010050904 Interferons Proteins 0.000 description 3
• 239000012097 Lipofectamine 2000 Substances 0.000 description 3
• 108010075654 MAP Kinase Kinase Kinase 1 Proteins 0.000 description 3
• 102000018697 Membrane Proteins Human genes 0.000 description 3
• 208000034578 Multiple myelomas Diseases 0.000 description 3
• 101100058550 Mus musculus Bmi1 gene Proteins 0.000 description 3
• 102000043276 Oncogene Human genes 0.000 description 3
• 102100036879 PHD finger protein 1 Human genes 0.000 description 3
• 102100035125 PHD finger protein 10 Human genes 0.000 description 3
• 108091093037 Peptide nucleic acid Proteins 0.000 description 3
• 206010035226 Plasma cell myeloma Diseases 0.000 description 3
• 102100029522 Pre-mRNA-processing factor 19 Human genes 0.000 description 3
• 102100034747 Probable E3 ubiquitin-protein ligase HERC1 Human genes 0.000 description 3
• 102100039910 Probable E3 ubiquitin-protein ligase HERC3 Human genes 0.000 description 3
• 102000003923 Protein Kinase C Human genes 0.000 description 3
• 108090000315 Protein Kinase C Proteins 0.000 description 3
• 102100023874 RING-box protein 2 Human genes 0.000 description 3
• 102000015097 RNA Splicing Factors Human genes 0.000 description 3
• 108010039259 RNA Splicing Factors Proteins 0.000 description 3
• 102100035544 Ret finger protein-like 2 Human genes 0.000 description 3
• 241000251131 Sphyrna Species 0.000 description 3
• 102100033082 TNF receptor-associated factor 3 Human genes 0.000 description 3
• 102100033159 Transcription factor 19 Human genes 0.000 description 3
• 102100023931 Transcriptional regulator ATRX Human genes 0.000 description 3
• 101710113296 Transcriptional regulator ATRX Proteins 0.000 description 3
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 3
• 102100038532 Ubiquitin conjugation factor E4 A Human genes 0.000 description 3
• 102100026591 Uncharacterized protein C16orf74 Human genes 0.000 description 3
• 208000006254 Wolf-Hirschhorn Syndrome Diseases 0.000 description 3
• 108700031544 X-Linked Inhibitor of Apoptosis Proteins 0.000 description 3
• 102100028551 Zinc finger MYND domain-containing protein 11 Human genes 0.000 description 3
• 102100032701 Zinc finger protein ubi-d4 Human genes 0.000 description 3
• 125000001931 aliphatic group Chemical group 0.000 description 3
• 239000003242 anti bacterial agent Substances 0.000 description 3
• 229940088710 antibiotic agent Drugs 0.000 description 3
• 239000002246 antineoplastic agent Substances 0.000 description 3
• 238000003491 array Methods 0.000 description 3
• 125000003118 aryl group Chemical group 0.000 description 3
• 230000001363 autoimmune Effects 0.000 description 3
• 239000011324 bead Substances 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 3
• 230000008436 biogenesis Effects 0.000 description 3
• 239000012472 biological sample Substances 0.000 description 3
• 210000004899 c-terminal region Anatomy 0.000 description 3
• 229910052791 calcium Inorganic materials 0.000 description 3
• 239000011575 calcium Substances 0.000 description 3
• 230000022131 cell cycle Effects 0.000 description 3
• 238000003776 cleavage reaction Methods 0.000 description 3
• 239000002299 complementary DNA Substances 0.000 description 3
• 230000006378 damage Effects 0.000 description 3
• 238000001514 detection method Methods 0.000 description 3
• 102000038037 druggable proteins Human genes 0.000 description 3
• 108091007999 druggable proteins Proteins 0.000 description 3
• 239000013604 expression vector Substances 0.000 description 3
• 230000005714 functional activity Effects 0.000 description 3
• 230000012010 growth Effects 0.000 description 3
• 235000003642 hunger Nutrition 0.000 description 3
• 239000000411 inducer Substances 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 229940079322 interferon Drugs 0.000 description 3
• 239000003446 ligand Substances 0.000 description 3
• 239000012139 lysis buffer Substances 0.000 description 3
• 239000011159 matrix material Substances 0.000 description 3
• YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical class CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 3
• 238000002493 microarray Methods 0.000 description 3
• 210000000299 nuclear matrix Anatomy 0.000 description 3
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 3
• 150000003904 phospholipids Chemical class 0.000 description 3
• DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 description 3
• 238000001243 protein synthesis Methods 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 230000007017 scission Effects 0.000 description 3
• 238000013515 script Methods 0.000 description 3
• 102000030938 small GTPase Human genes 0.000 description 3
• 108060007624 small GTPase Proteins 0.000 description 3
• 230000037351 starvation Effects 0.000 description 3
• 239000000126 substance Substances 0.000 description 3
• 208000024891 symptom Diseases 0.000 description 3
• 238000003786 synthesis reaction Methods 0.000 description 3
• 230000009897 systematic effect Effects 0.000 description 3
• 102000004217 thyroid hormone receptors Human genes 0.000 description 3
• 108090000721 thyroid hormone receptors Proteins 0.000 description 3
• 230000009261 transgenic effect Effects 0.000 description 3
• 230000014848 ubiquitin-dependent protein catabolic process Effects 0.000 description 3
• 238000001262 western blot Methods 0.000 description 3
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
• RFLVMTUMFYRZCB-UHFFFAOYSA-N 1-methylguanine Chemical compound O=C1N(C)C(N)=NC2=C1N=CN2 RFLVMTUMFYRZCB-UHFFFAOYSA-N 0.000 description 2
• RHCSKNNOAZULRK-APZFVMQVSA-N 2,2-dideuterio-2-(3,4,5-trimethoxyphenyl)ethanamine Chemical compound NCC([2H])([2H])C1=CC(OC)=C(OC)C(OC)=C1 RHCSKNNOAZULRK-APZFVMQVSA-N 0.000 description 2
• YSAJFXWTVFGPAX-UHFFFAOYSA-N 2-[(2,4-dioxo-1h-pyrimidin-5-yl)oxy]acetic acid Chemical compound OC(=O)COC1=CNC(=O)NC1=O YSAJFXWTVFGPAX-UHFFFAOYSA-N 0.000 description 2
• FZWGECJQACGGTI-UHFFFAOYSA-N 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one Chemical compound NC1=NC(O)=C2N(C)C=NC2=N1 FZWGECJQACGGTI-UHFFFAOYSA-N 0.000 description 2
• OVONXEQGWXGFJD-UHFFFAOYSA-N 4-sulfanylidene-1h-pyrimidin-2-one Chemical compound SC=1C=CNC(=O)N=1 OVONXEQGWXGFJD-UHFFFAOYSA-N 0.000 description 2
• OIVLITBTBDPEFK-UHFFFAOYSA-N 5,6-dihydrouracil Chemical compound O=C1CCNC(=O)N1 OIVLITBTBDPEFK-UHFFFAOYSA-N 0.000 description 2
• ZLAQATDNGLKIEV-UHFFFAOYSA-N 5-methyl-2-sulfanylidene-1h-pyrimidin-4-one Chemical compound CC1=CNC(=S)NC1=O ZLAQATDNGLKIEV-UHFFFAOYSA-N 0.000 description 2
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
• 108010053971 ADP-Ribosylation Factors Proteins 0.000 description 2
• 102000016954 ADP-Ribosylation Factors Human genes 0.000 description 2
• 108091006112 ATPases Proteins 0.000 description 2
• 102000057290 Adenosine Triphosphatases Human genes 0.000 description 2
• HIIJOGIBQXHFKE-HHKYUTTNSA-N Ala-Thr-Ala-Pro Chemical compound C[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O HIIJOGIBQXHFKE-HHKYUTTNSA-N 0.000 description 2
• 108700028369 Alleles Proteins 0.000 description 2
• 102100039722 Ankyrin repeat and IBR domain-containing protein 1 Human genes 0.000 description 2
• 101100322085 Arabidopsis thaliana CAC3 gene Proteins 0.000 description 2
• 101000956243 Arabidopsis thaliana CSC1-like protein HYP1 Proteins 0.000 description 2
• 101100165819 Arabidopsis thaliana LHCA1 gene Proteins 0.000 description 2
• 102100021677 Baculoviral IAP repeat-containing protein 2 Human genes 0.000 description 2
• 101710177962 Baculoviral IAP repeat-containing protein 3 Proteins 0.000 description 2
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
• 101150104237 Birc3 gene Proteins 0.000 description 2
• 102100036168 CXXC-type zinc finger protein 1 Human genes 0.000 description 2
• 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 2
• 108010077544 Chromatin Proteins 0.000 description 2
• 108091033380 Coding strand Proteins 0.000 description 2
• 108020004635 Complementary DNA Proteins 0.000 description 2
• 102100038254 Cyclin-F Human genes 0.000 description 2
• 101710177611 DNA polymerase II large subunit Proteins 0.000 description 2
• 101710184669 DNA polymerase II small subunit Proteins 0.000 description 2
• 230000004568 DNA-binding Effects 0.000 description 2
• 102100032501 Death-inducer obliterator 1 Human genes 0.000 description 2
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 2
• 101000928788 Drosophila melanogaster Death-associated inhibitor of apoptosis 2 Proteins 0.000 description 2
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
• 108010069091 Dystrophin Proteins 0.000 description 2
• 102000001039 Dystrophin Human genes 0.000 description 2
• 101710094160 E3 ubiquitin-protein ligase AMFR Proteins 0.000 description 2
• 102100035493 E3 ubiquitin-protein ligase NEDD4-like Human genes 0.000 description 2
• 101710093740 E3 ubiquitin-protein ligase RING1 Proteins 0.000 description 2
• 101710196516 E3 ubiquitin-protein ligase RLIM Proteins 0.000 description 2
• 102100027416 E3 ubiquitin-protein ligase RNF103 Human genes 0.000 description 2
• 101710173223 E3 ubiquitin-protein ligase RNF113A Proteins 0.000 description 2
• 102100021766 E3 ubiquitin-protein ligase RNF138 Human genes 0.000 description 2
• 102100021820 E3 ubiquitin-protein ligase RNF4 Human genes 0.000 description 2
• 102100038631 E3 ubiquitin-protein ligase SMURF1 Human genes 0.000 description 2
• 102100022403 E3 ubiquitin-protein ligase TRIM17 Human genes 0.000 description 2
• 102100038795 E3 ubiquitin-protein ligase TRIM4 Human genes 0.000 description 2
• 102100025020 E3 ubiquitin-protein ligase TRIM62 Human genes 0.000 description 2
• 102100034582 E3 ubiquitin/ISG15 ligase TRIM25 Human genes 0.000 description 2
• 101710183057 E3 ubiquitin/ISG15 ligase TRIM25 Proteins 0.000 description 2
• 230000008341 ER-associated protein catabolic process Effects 0.000 description 2
• 102000003951 Erythropoietin Human genes 0.000 description 2
• 108090000394 Erythropoietin Proteins 0.000 description 2
• 108010075944 Erythropoietin Receptors Proteins 0.000 description 2
• 102100036509 Erythropoietin receptor Human genes 0.000 description 2
• 101710199775 F-box only protein 2 Proteins 0.000 description 2
• 102100024524 F-box only protein 4 Human genes 0.000 description 2
• 101710199743 F-box only protein 7 Proteins 0.000 description 2
• 101710199745 F-box only protein 9 Proteins 0.000 description 2
• 101710161546 F-box protein FBW2 Proteins 0.000 description 2
• 102100037309 F-box/LRR-repeat protein 2 Human genes 0.000 description 2
• 102100037338 F-box/LRR-repeat protein 5 Human genes 0.000 description 2
• 102100028147 F-box/WD repeat-containing protein 4 Human genes 0.000 description 2
• 102100035577 G2/M phase-specific E3 ubiquitin-protein ligase Human genes 0.000 description 2
• 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 101000959548 Homo sapiens Ankyrin repeat and IBR domain-containing protein 1 Proteins 0.000 description 2
• 101000896157 Homo sapiens Baculoviral IAP repeat-containing protein 2 Proteins 0.000 description 2
• 101000583935 Homo sapiens CDK-activating kinase assembly factor MAT1 Proteins 0.000 description 2
• 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 2
• 101000883749 Homo sapiens Chromodomain-helicase-DNA-binding protein 4 Proteins 0.000 description 2
• 101000869896 Homo sapiens Death-inducer obliterator 1 Proteins 0.000 description 2
• 101000610505 Homo sapiens E3 ubiquitin ligase TRIM40 Proteins 0.000 description 2
• 101000636713 Homo sapiens E3 ubiquitin-protein ligase NEDD4 Proteins 0.000 description 2
• 101001023703 Homo sapiens E3 ubiquitin-protein ligase NEDD4-like Proteins 0.000 description 2
• 101000707962 Homo sapiens E3 ubiquitin-protein ligase RING1 Proteins 0.000 description 2
• 101001079154 Homo sapiens E3 ubiquitin-protein ligase RNF113A Proteins 0.000 description 2
• 101001106980 Homo sapiens E3 ubiquitin-protein ligase RNF138 Proteins 0.000 description 2
• 101001107086 Homo sapiens E3 ubiquitin-protein ligase RNF4 Proteins 0.000 description 2
• 101000664993 Homo sapiens E3 ubiquitin-protein ligase SMURF1 Proteins 0.000 description 2
• 101000664589 Homo sapiens E3 ubiquitin-protein ligase TRIM13 Proteins 0.000 description 2
• 101000680664 Homo sapiens E3 ubiquitin-protein ligase TRIM17 Proteins 0.000 description 2
• 101000685877 Homo sapiens E3 ubiquitin-protein ligase TRIM21 Proteins 0.000 description 2
• 101000664604 Homo sapiens E3 ubiquitin-protein ligase TRIM4 Proteins 0.000 description 2
• 101000830236 Homo sapiens E3 ubiquitin-protein ligase TRIM62 Proteins 0.000 description 2
• 101000795300 Homo sapiens E3 ubiquitin-protein ligase TRIM8 Proteins 0.000 description 2
• 101000824158 Homo sapiens F-box only protein 2 Proteins 0.000 description 2
• 101001052775 Homo sapiens F-box only protein 4 Proteins 0.000 description 2
• 101000917828 Homo sapiens F-box only protein 8 Proteins 0.000 description 2
• 101001026881 Homo sapiens F-box/LRR-repeat protein 2 Proteins 0.000 description 2
• 101000862163 Homo sapiens F-box/LRR-repeat protein 20 Proteins 0.000 description 2
• 101001060244 Homo sapiens F-box/WD repeat-containing protein 4 Proteins 0.000 description 2
• 101100502521 Homo sapiens FBXL7 gene Proteins 0.000 description 2
• 101100334493 Homo sapiens FBXO8 gene Proteins 0.000 description 2
• 101001000828 Homo sapiens G2/M phase-specific E3 ubiquitin-protein ligase Proteins 0.000 description 2
• 101001045848 Homo sapiens Histone-lysine N-methyltransferase 2B Proteins 0.000 description 2
• 101001088887 Homo sapiens Lysine-specific demethylase 5C Proteins 0.000 description 2
• 101001059535 Homo sapiens Megakaryocyte-associated tyrosine-protein kinase Proteins 0.000 description 2
• 101000836112 Homo sapiens Nuclear body protein SP140 Proteins 0.000 description 2
• 101001129712 Homo sapiens PHD and RING finger domain-containing protein 1 Proteins 0.000 description 2
• 101001071238 Homo sapiens PHD finger protein 14 Proteins 0.000 description 2
• 101000579354 Homo sapiens PHD finger protein 21A Proteins 0.000 description 2
• 101000693847 Homo sapiens Peroxisome biogenesis factor 2 Proteins 0.000 description 2
• 101000872170 Homo sapiens Polycomb complex protein BMI-1 Proteins 0.000 description 2
• 101000892360 Homo sapiens Protein AF-17 Proteins 0.000 description 2
• 101001074295 Homo sapiens Protein kinase C-binding protein 1 Proteins 0.000 description 2
• 101000830237 Homo sapiens Putative tripartite motif-containing protein 61 Proteins 0.000 description 2
• 101000734222 Homo sapiens RING finger protein 10 Proteins 0.000 description 2
• 101000711577 Homo sapiens RING finger protein 122 Proteins 0.000 description 2
• 101001092194 Homo sapiens Ret finger protein-like 2 Proteins 0.000 description 2
• 101000701625 Homo sapiens Sp110 nuclear body protein Proteins 0.000 description 2
• 101000800580 Homo sapiens Transcription factor 19 Proteins 0.000 description 2
• 101000848653 Homo sapiens Tripartite motif-containing protein 26 Proteins 0.000 description 2
• 101000634986 Homo sapiens Tripartite motif-containing protein 34 Proteins 0.000 description 2
• 101000613251 Homo sapiens Tumor susceptibility gene 101 protein Proteins 0.000 description 2
• 101000864118 Homo sapiens Zinc finger protein neuro-d4 Proteins 0.000 description 2
• 101000708874 Homo sapiens Zinc finger protein ubi-d4 Proteins 0.000 description 2
• 108090000191 Inhibitor of growth protein 1 Proteins 0.000 description 2
• 102000003781 Inhibitor of growth protein 1 Human genes 0.000 description 2
• 102100024070 Inhibitor of growth protein 3 Human genes 0.000 description 2
• 101710197061 Interferon-induced protein 75 Proteins 0.000 description 2
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
• 102100033249 Lysine-specific demethylase 5C Human genes 0.000 description 2
• 102100040632 Metal-response element-binding transcription factor 2 Human genes 0.000 description 2
• HYVABZIGRDEKCD-UHFFFAOYSA-N N(6)-dimethylallyladenine Chemical compound CC(C)=CCNC1=NC=NC2=C1N=CN2 HYVABZIGRDEKCD-UHFFFAOYSA-N 0.000 description 2
• 239000000020 Nitrocellulose Substances 0.000 description 2
• 102100025638 Nuclear body protein SP140 Human genes 0.000 description 2
• 102100024057 Nuclear pore glycoprotein p62 Human genes 0.000 description 2
• 101710163270 Nuclease Proteins 0.000 description 2
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 2
• 108700020796 Oncogene Proteins 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 102100031567 PHD and RING finger domain-containing protein 1 Human genes 0.000 description 2
• 101710151874 PHD finger protein 1 Proteins 0.000 description 2
• 102100036866 PHD finger protein 14 Human genes 0.000 description 2
• 102100028222 PHD finger protein 21A Human genes 0.000 description 2
• 102100026391 PHD finger protein 3 Human genes 0.000 description 2
• 108010055088 Peroxisomal Biogenesis Factor 2 Proteins 0.000 description 2
• 102000015439 Phospholipases Human genes 0.000 description 2
• 108010064785 Phospholipases Proteins 0.000 description 2
• 108010089430 Phosphoproteins Proteins 0.000 description 2
• 102000007982 Phosphoproteins Human genes 0.000 description 2
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
• 102100040638 Protein AF-17 Human genes 0.000 description 2
• 229940096437 Protein S Drugs 0.000 description 2
• 102000029301 Protein S Human genes 0.000 description 2
• 108010066124 Protein S Proteins 0.000 description 2
• 102100035697 Protein kinase C-binding protein 1 Human genes 0.000 description 2
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 2
• 102000052575 Proto-Oncogene Human genes 0.000 description 2
• 108700020978 Proto-Oncogene Proteins 0.000 description 2
• 208000003251 Pruritus Diseases 0.000 description 2
• 102100025021 Putative tripartite motif-containing protein 61 Human genes 0.000 description 2
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 2
• 102000001183 RAG-1 Human genes 0.000 description 2
• 108060006897 RAG1 Proteins 0.000 description 2
• 102100033605 RING finger protein 10 Human genes 0.000 description 2
• 102100028089 RING finger protein 112 Human genes 0.000 description 2
• 102100034117 RING finger protein 122 Human genes 0.000 description 2
• 101710178917 RING-box protein 2 Proteins 0.000 description 2
• 102100025781 RING-type E3 ubiquitin-protein ligase PPIL2 Human genes 0.000 description 2
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
• 208000006265 Renal cell carcinoma Diseases 0.000 description 2
• 108091027981 Response element Proteins 0.000 description 2
• 101710183524 Ret finger protein-like 2 Proteins 0.000 description 2
• 102100035528 Ret finger protein-like 3 Human genes 0.000 description 2
• 108010023377 Retinoblastoma Binding Proteins Proteins 0.000 description 2
• 108091006629 SLC13A2 Proteins 0.000 description 2
• 101100379220 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) API2 gene Proteins 0.000 description 2
• 101100514477 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) MSI1 gene Proteins 0.000 description 2
• 208000021386 Sjogren Syndrome Diseases 0.000 description 2
• 102100030435 Sp110 nuclear body protein Human genes 0.000 description 2
• 108091081024 Start codon Proteins 0.000 description 2
• 208000033781 Thyroid carcinoma Diseases 0.000 description 2
• 208000024770 Thyroid neoplasm Diseases 0.000 description 2
• 102100029502 Tripartite motif-containing protein 34 Human genes 0.000 description 2
• 102100028020 Tripartite motif-containing protein 49 Human genes 0.000 description 2
• 101710154670 Tripartite motif-containing protein 49 Proteins 0.000 description 2
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
• 102100040879 Tumor susceptibility gene 101 protein Human genes 0.000 description 2
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
• 210000002593 Y chromosome Anatomy 0.000 description 2
• PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 2
• 102100029859 Zinc finger protein neuro-d4 Human genes 0.000 description 2
• 101150039629 aah1 gene Proteins 0.000 description 2
• 230000001594 aberrant effect Effects 0.000 description 2
• 125000000217 alkyl group Chemical group 0.000 description 2
• 229910052782 aluminium Inorganic materials 0.000 description 2
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
• 229940034982 antineoplastic agent Drugs 0.000 description 2
• 239000003443 antiviral agent Substances 0.000 description 2
• 230000008827 biological function Effects 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 239000000090 biomarker Substances 0.000 description 2
• 210000004556 brain Anatomy 0.000 description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 238000007385 chemical modification Methods 0.000 description 2
• 210000003483 chromatin Anatomy 0.000 description 2
• 239000000470 constituent Substances 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• 230000002596 correlated effect Effects 0.000 description 2
• 235000018417 cysteine Nutrition 0.000 description 2
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
• VKVBSQRURLRCHO-UHFFFAOYSA-N dactylin Chemical compound COC1=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)OC2C(C(O)C(O)C(CO)O2)O)=CC=C1OC1OC(CO)C(O)C(O)C1O VKVBSQRURLRCHO-UHFFFAOYSA-N 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• 239000005547 deoxyribonucleotide Substances 0.000 description 2
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 2
• 238000010586 diagram Methods 0.000 description 2
• 230000009274 differential gene expression Effects 0.000 description 2
• 238000007876 drug discovery Methods 0.000 description 2
• 238000001962 electrophoresis Methods 0.000 description 2
• 229940105423 erythropoietin Drugs 0.000 description 2
• 238000007667 floating Methods 0.000 description 2
• 239000011888 foil Substances 0.000 description 2
• 230000004927 fusion Effects 0.000 description 2
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• HSKHNTITGMOIAJ-UHFFFAOYSA-N hortein Chemical compound O=C1CCC(=O)C2=C1[C]1C([C]34)=CC=C(O)C4=C(O)C=CC3=C1C(O)=C2O HSKHNTITGMOIAJ-UHFFFAOYSA-N 0.000 description 2
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
• 230000036737 immune function Effects 0.000 description 2
• 238000010348 incorporation Methods 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 208000015181 infectious disease Diseases 0.000 description 2
• 230000001524 infective effect Effects 0.000 description 2
• CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
• 238000003780 insertion Methods 0.000 description 2
• 230000037431 insertion Effects 0.000 description 2
• 230000002452 interceptive effect Effects 0.000 description 2
• 239000000543 intermediate Substances 0.000 description 2
• 210000004020 intracellular membrane Anatomy 0.000 description 2
• 210000004185 liver Anatomy 0.000 description 2
• 238000011068 loading method Methods 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• 230000014759 maintenance of location Effects 0.000 description 2
• 229910052751 metal Inorganic materials 0.000 description 2
• 239000002184 metal Substances 0.000 description 2
• 239000007758 minimum essential medium Substances 0.000 description 2
• 238000010369 molecular cloning Methods 0.000 description 2
• 230000004899 motility Effects 0.000 description 2
• 238000002887 multiple sequence alignment Methods 0.000 description 2
• 230000007935 neutral effect Effects 0.000 description 2
• 229920001220 nitrocellulos Polymers 0.000 description 2
• 238000010606 normalization Methods 0.000 description 2
• 239000002777 nucleoside Substances 0.000 description 2
• 229940124276 oligodeoxyribonucleotide Drugs 0.000 description 2
• 239000002751 oligonucleotide probe Substances 0.000 description 2
• 231100000590 oncogenic Toxicity 0.000 description 2
• 230000002246 oncogenic effect Effects 0.000 description 2
• 230000002611 ovarian Effects 0.000 description 2
• 230000000858 peroxisomal effect Effects 0.000 description 2
• 210000002824 peroxisome Anatomy 0.000 description 2
• PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 description 2
• 235000002949 phytic acid Nutrition 0.000 description 2
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 2
• 102000038041 potential drug target proteins Human genes 0.000 description 2
• 108091008002 potential drug target proteins Proteins 0.000 description 2
• 238000002360 preparation method Methods 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• 102000021127 protein binding proteins Human genes 0.000 description 2
• 108091011138 protein binding proteins Proteins 0.000 description 2
• 230000012846 protein folding Effects 0.000 description 2
• 150000003212 purines Chemical class 0.000 description 2
• 150000003230 pyrimidines Chemical class 0.000 description 2
• 230000017610 release of virus from host Effects 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 125000002652 ribonucleotide group Chemical group 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• 239000012723 sample buffer Substances 0.000 description 2
• CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 2
• 230000003248 secreting effect Effects 0.000 description 2
• 108091006024 signal transducing proteins Proteins 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 229920006132 styrene block copolymer Polymers 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 108060008004 synaptotagmin Proteins 0.000 description 2
• 102000003137 synaptotagmin Human genes 0.000 description 2
• 208000011580 syndromic disease Diseases 0.000 description 2
• 230000002194 synthesizing effect Effects 0.000 description 2
• 210000001550 testis Anatomy 0.000 description 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 2
• 229940104230 thymidine Drugs 0.000 description 2
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
• 201000002510 thyroid cancer Diseases 0.000 description 2
• 208000013077 thyroid gland carcinoma Diseases 0.000 description 2
• 230000002103 transcriptional effect Effects 0.000 description 2
• 238000010361 transduction Methods 0.000 description 2
• 230000026683 transduction Effects 0.000 description 2
• 230000014621 translational initiation Effects 0.000 description 2
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
• 230000007306 turnover Effects 0.000 description 2
• 230000004906 unfolded protein response Effects 0.000 description 2
• 229940035893 uracil Drugs 0.000 description 2
• 238000010200 validation analysis Methods 0.000 description 2
• 230000029302 virus maturation Effects 0.000 description 2
• AWNBSWDIOCXWJW-WTOYTKOKSA-N (2r)-n-[(2s)-1-[[(2s)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n'-hydroxy-2-(2-methylpropyl)butanediamide Chemical compound C1=CC=CC2=CC(C[C@H](NC(=O)[C@@H](CC(=O)NO)CC(C)C)C(=O)N[C@@H](C)C(=O)NCCN)=CC=C21 AWNBSWDIOCXWJW-WTOYTKOKSA-N 0.000 description 1
• RFFPAVPLLZAQTB-JJYYJPOSSA-N (2s,3r,4r)-2,3,4,5-tetrahydroxypentanoyl fluoride Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(F)=O RFFPAVPLLZAQTB-JJYYJPOSSA-N 0.000 description 1
• XUHRVZXFBWDCFB-QRTDKPMLSA-N (3R)-4-[[(3S,6S,9S,12R,15S,18R,21R,24R,27R,28R)-12-(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-3-(2-carboxyethyl)-18-(hydroxymethyl)-28-methyl-9,15,21,24-tetrakis(2-methylpropyl)-2,5,8,11,14,17,20,23,26-nonaoxo-1-oxa-4,7,10,13,16,19,22,25-octazacyclooctacos-27-yl]amino]-3-[[(2R)-2-[[(3S)-3-hydroxydecanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid Chemical compound CCCCCCC[C@H](O)CC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H]1[C@@H](C)OC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC1=O)[C@@H](C)CC XUHRVZXFBWDCFB-QRTDKPMLSA-N 0.000 description 1
• 101710163045 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 Proteins 0.000 description 1
• WEYNBWVKOYCCQT-UHFFFAOYSA-N 1-(3-chloro-4-methylphenyl)-3-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}urea Chemical compound O1C(CN(C)C)=CC=C1CSCCNC(=O)NC1=CC=C(C)C(Cl)=C1 WEYNBWVKOYCCQT-UHFFFAOYSA-N 0.000 description 1
• WJNGQIYEQLPJMN-IOSLPCCCSA-N 1-methylinosine Chemical compound C1=NC=2C(=O)N(C)C=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WJNGQIYEQLPJMN-IOSLPCCCSA-N 0.000 description 1
• 101150029062 15 gene Proteins 0.000 description 1
• NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
• 102000007445 2',5'-Oligoadenylate Synthetase Human genes 0.000 description 1
• 108010086241 2',5'-Oligoadenylate Synthetase Proteins 0.000 description 1
• VGONTNSXDCQUGY-RRKCRQDMSA-N 2'-deoxyinosine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC2=O)=C2N=C1 VGONTNSXDCQUGY-RRKCRQDMSA-N 0.000 description 1
• IQFYYKKMVGJFEH-BIIVOSGPSA-N 2'-deoxythymidine Natural products O=C1NC(=O)C(C)=CN1[C@@H]1O[C@@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-BIIVOSGPSA-N 0.000 description 1
• ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
• SGAKLDIYNFXTCK-UHFFFAOYSA-N 2-[(2,4-dioxo-1h-pyrimidin-5-yl)methylamino]acetic acid Chemical compound OC(=O)CNCC1=CNC(=O)NC1=O SGAKLDIYNFXTCK-UHFFFAOYSA-N 0.000 description 1
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
• AXAVXPMQTGXXJZ-UHFFFAOYSA-N 2-aminoacetic acid;2-amino-2-(hydroxymethyl)propane-1,3-diol Chemical compound NCC(O)=O.OCC(N)(CO)CO AXAVXPMQTGXXJZ-UHFFFAOYSA-N 0.000 description 1
• MWBWWFOAEOYUST-UHFFFAOYSA-N 2-aminopurine Chemical compound NC1=NC=C2N=CNC2=N1 MWBWWFOAEOYUST-UHFFFAOYSA-N 0.000 description 1
• XMSMHKMPBNTBOD-UHFFFAOYSA-N 2-dimethylamino-6-hydroxypurine Chemical compound N1C(N(C)C)=NC(=O)C2=C1N=CN2 XMSMHKMPBNTBOD-UHFFFAOYSA-N 0.000 description 1
• SMADWRYCYBUIKH-UHFFFAOYSA-N 2-methyl-7h-purin-6-amine Chemical compound CC1=NC(N)=C2NC=NC2=N1 SMADWRYCYBUIKH-UHFFFAOYSA-N 0.000 description 1
• 102100022644 26S proteasome regulatory subunit 4 Human genes 0.000 description 1
• GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 description 1
• UTSXERRKRAEDOV-UHFFFAOYSA-N 3-[dimethyl-[3-(tetradecanoylamino)propyl]azaniumyl]propane-1-sulfonate Chemical compound CCCCCCCCCCCCCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O UTSXERRKRAEDOV-UHFFFAOYSA-N 0.000 description 1
• KOLPWZCZXAMXKS-UHFFFAOYSA-N 3-methylcytosine Chemical compound CN1C(N)=CC=NC1=O KOLPWZCZXAMXKS-UHFFFAOYSA-N 0.000 description 1
• GJAKJCICANKRFD-UHFFFAOYSA-N 4-acetyl-4-amino-1,3-dihydropyrimidin-2-one Chemical compound CC(=O)C1(N)NC(=O)NC=C1 GJAKJCICANKRFD-UHFFFAOYSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• SPBWHPXCWJLQRU-FITJORAGSA-N 4-amino-8-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide Chemical compound C12=NC=NC(N)=C2C(=O)C(C(=O)N)=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O SPBWHPXCWJLQRU-FITJORAGSA-N 0.000 description 1
• ZLOIGESWDJYCTF-XVFCMESISA-N 4-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=S)C=C1 ZLOIGESWDJYCTF-XVFCMESISA-N 0.000 description 1
• 101150096316 5 gene Proteins 0.000 description 1
• MQJSSLBGAQJNER-UHFFFAOYSA-N 5-(methylaminomethyl)-1h-pyrimidine-2,4-dione Chemical compound CNCC1=CNC(=O)NC1=O MQJSSLBGAQJNER-UHFFFAOYSA-N 0.000 description 1
• WPYRHVXCOQLYLY-UHFFFAOYSA-N 5-[(methoxyamino)methyl]-2-sulfanylidene-1h-pyrimidin-4-one Chemical compound CONCC1=CNC(=S)NC1=O WPYRHVXCOQLYLY-UHFFFAOYSA-N 0.000 description 1
• LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical compound BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 description 1
• ZFTBZKVVGZNMJR-UHFFFAOYSA-N 5-chlorouracil Chemical compound ClC1=CNC(=O)NC1=O ZFTBZKVVGZNMJR-UHFFFAOYSA-N 0.000 description 1
• KSNXJLQDQOIRIP-UHFFFAOYSA-N 5-iodouracil Chemical compound IC1=CNC(=O)NC1=O KSNXJLQDQOIRIP-UHFFFAOYSA-N 0.000 description 1
• KELXHQACBIUYSE-UHFFFAOYSA-N 5-methoxy-1h-pyrimidine-2,4-dione Chemical compound COC1=CNC(=O)NC1=O KELXHQACBIUYSE-UHFFFAOYSA-N 0.000 description 1
• LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 description 1
• DCPSTSVLRXOYGS-UHFFFAOYSA-N 6-amino-1h-pyrimidine-2-thione Chemical compound NC1=CC=NC(S)=N1 DCPSTSVLRXOYGS-UHFFFAOYSA-N 0.000 description 1
• CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 1
• VKKXEIQIGGPMHT-UHFFFAOYSA-N 7h-purine-2,8-diamine Chemical compound NC1=NC=C2NC(N)=NC2=N1 VKKXEIQIGGPMHT-UHFFFAOYSA-N 0.000 description 1
• 108010016281 ADP-Ribosylation Factor 1 Proteins 0.000 description 1
• 102100034341 ADP-ribosylation factor 1 Human genes 0.000 description 1
• 102100023818 ADP-ribosylation factor 3 Human genes 0.000 description 1
• 101150046097 ANAPC11 gene Proteins 0.000 description 1
• 101710154713 Acireductone dioxygenase 1 Proteins 0.000 description 1
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
• 102100038740 Activator of RNA decay Human genes 0.000 description 1
• 101710137115 Adenylyl cyclase-associated protein 1 Proteins 0.000 description 1
• 108010074725 Alpha,alpha-trehalose phosphorylase Proteins 0.000 description 1
• 102000052593 Anaphase-Promoting Complex-Cyclosome Apc11 Subunit Human genes 0.000 description 1
• 102100033899 Ankyrin repeat and SOCS box protein 14 Human genes 0.000 description 1
• 108090000669 Annexin A4 Proteins 0.000 description 1
• 102100034612 Annexin A4 Human genes 0.000 description 1
• 244000303258 Annona diversifolia Species 0.000 description 1
• 235000002198 Annona diversifolia Nutrition 0.000 description 1
• 108020004491 Antisense DNA Proteins 0.000 description 1
• 101710106364 Apoptosis inhibitor 1 Proteins 0.000 description 1
• 101100457315 Arabidopsis thaliana MIP3 gene Proteins 0.000 description 1
• 208000023275 Autoimmune disease Diseases 0.000 description 1
• 102000036365 BRCA1 Human genes 0.000 description 1
• 108700020463 BRCA1 Proteins 0.000 description 1
• 101150072950 BRCA1 gene Proteins 0.000 description 1
• 102100027106 BRCA1-associated protein Human genes 0.000 description 1
• 102100021662 Baculoviral IAP repeat-containing protein 3 Human genes 0.000 description 1
• 102100027522 Baculoviral IAP repeat-containing protein 7 Human genes 0.000 description 1
• 101710177963 Baculoviral IAP repeat-containing protein 7 Proteins 0.000 description 1
• 102100027311 Beta,beta-carotene 15,15'-dioxygenase Human genes 0.000 description 1
• 102100026189 Beta-galactosidase Human genes 0.000 description 1
• 244000212312 Blighia sapida Species 0.000 description 1
• 101000803681 Bombyx mori Vacuolar protein sorting-associated protein 4 Proteins 0.000 description 1
• 101001016210 Bos taurus Dynein axonemal heavy chain 12 Proteins 0.000 description 1
• 238000009010 Bradford assay Methods 0.000 description 1
• 102100026008 Breakpoint cluster region protein Human genes 0.000 description 1
• 206010006187 Breast cancer Diseases 0.000 description 1
• 208000026310 Breast neoplasm Diseases 0.000 description 1
• 108091005575 Bromodomain-containing proteins Proteins 0.000 description 1
• 101710117545 C protein Proteins 0.000 description 1
• 102100036850 C-C motif chemokine 23 Human genes 0.000 description 1
• 108091007381 CBL proteins Proteins 0.000 description 1
• 101710175583 CDK-activating kinase assembly factor MAT1 Proteins 0.000 description 1
• 101710103504 CXXC-type zinc finger protein 1 Proteins 0.000 description 1
• 101100268671 Caenorhabditis elegans acc-4 gene Proteins 0.000 description 1
• 101100409468 Caenorhabditis elegans prp-19 gene Proteins 0.000 description 1
• 101100427201 Caenorhabditis elegans ufd-2 gene Proteins 0.000 description 1
• 102000004082 Calreticulin Human genes 0.000 description 1
• 108090000549 Calreticulin Proteins 0.000 description 1
• 201000009030 Carcinoma Diseases 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 1
• 102100032765 Chordin-like protein 1 Human genes 0.000 description 1
• 101710170308 Chromodomain-helicase-DNA-binding protein 4 Proteins 0.000 description 1
• 108010019874 Clathrin Proteins 0.000 description 1
• 102000005853 Clathrin Human genes 0.000 description 1
• 108010060434 Co-Repressor Proteins Proteins 0.000 description 1
• 102000008169 Co-Repressor Proteins Human genes 0.000 description 1
• 101100339481 Cochliobolus miyabeanus HOG1 gene Proteins 0.000 description 1
• 108020004394 Complementary RNA Proteins 0.000 description 1
• 102100041023 Coronin-2A Human genes 0.000 description 1
• 101001017206 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) Histone-like protein Hq1 Proteins 0.000 description 1
• 102000052581 Cullin Human genes 0.000 description 1
• 108700020475 Cullin Proteins 0.000 description 1
• 102100026398 Cyclic AMP-responsive element-binding protein 3 Human genes 0.000 description 1
• 108010068192 Cyclin A Proteins 0.000 description 1
• 102000002427 Cyclin B Human genes 0.000 description 1
• 108010068150 Cyclin B Proteins 0.000 description 1
• 102000002431 Cyclin G Human genes 0.000 description 1
• 108090000404 Cyclin G1 Proteins 0.000 description 1
• 102100025191 Cyclin-A2 Human genes 0.000 description 1
• 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 description 1
• 101710183447 Cyclin-F Proteins 0.000 description 1
• 102100036239 Cyclin-dependent kinase 2 Human genes 0.000 description 1
• 108010068682 Cyclophilins Proteins 0.000 description 1
• 102000001493 Cyclophilins Human genes 0.000 description 1
• 101150097493 D gene Proteins 0.000 description 1
• 102100026908 D-amino-acid oxidase Human genes 0.000 description 1
• 108010003989 D-amino-acid oxidase Proteins 0.000 description 1
• ZAQJHHRNXZUBTE-WUJLRWPWSA-N D-xylulose Chemical compound OC[C@@H](O)[C@H](O)C(=O)CO ZAQJHHRNXZUBTE-WUJLRWPWSA-N 0.000 description 1
• 108020001738 DNA Glycosylase Proteins 0.000 description 1
• 102000028381 DNA glycosylase Human genes 0.000 description 1
• 238000000018 DNA microarray Methods 0.000 description 1
• 230000033616 DNA repair Effects 0.000 description 1
• 102000052510 DNA-Binding Proteins Human genes 0.000 description 1
• 101710096438 DNA-binding protein Proteins 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• NZHWXNQBZKBACG-UHFFFAOYSA-N Dactylin Natural products CCC(Br)=CCC1OC(CC=CC#C)C(Cl)CC1Br NZHWXNQBZKBACG-UHFFFAOYSA-N 0.000 description 1
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 1
• 241001649081 Dina Species 0.000 description 1
• 102000015554 Dopamine receptor Human genes 0.000 description 1
• 108050004812 Dopamine receptor Proteins 0.000 description 1
• 108010035533 Drosophila Proteins Proteins 0.000 description 1
• 101100004158 Drosophila melanogaster bab2 gene Proteins 0.000 description 1
• 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 1
• 102100021242 Dymeclin Human genes 0.000 description 1
• 102100021238 Dynamin-2 Human genes 0.000 description 1
• 102100039922 E3 ISG15-protein ligase HERC5 Human genes 0.000 description 1
• 102100021740 E3 ubiquitin-protein ligase BRE1A Human genes 0.000 description 1
• 102100021739 E3 ubiquitin-protein ligase BRE1B Human genes 0.000 description 1
• 101710090887 E3 ubiquitin-protein ligase CBL Proteins 0.000 description 1
• 102100035273 E3 ubiquitin-protein ligase CBL-B Human genes 0.000 description 1
• 101710141336 E3 ubiquitin-protein ligase CBL-B Proteins 0.000 description 1
• 102100029641 E3 ubiquitin-protein ligase DTX4 Human genes 0.000 description 1
• 102100033360 E3 ubiquitin-protein ligase DZIP3 Human genes 0.000 description 1
• 102100027325 E3 ubiquitin-protein ligase HACE1 Human genes 0.000 description 1
• 102100034675 E3 ubiquitin-protein ligase HECW2 Human genes 0.000 description 1
• 102100034745 E3 ubiquitin-protein ligase HERC2 Human genes 0.000 description 1
• 102100035102 E3 ubiquitin-protein ligase MYCBP2 Human genes 0.000 description 1
• 102100034568 E3 ubiquitin-protein ligase PDZRN3 Human genes 0.000 description 1
• 102100036333 E3 ubiquitin-protein ligase Praja-2 Human genes 0.000 description 1
• 108091012458 E3 ubiquitin-protein ligase RING2 Proteins 0.000 description 1
• 102100028107 E3 ubiquitin-protein ligase RNF115 Human genes 0.000 description 1
• 102100034116 E3 ubiquitin-protein ligase RNF123 Human genes 0.000 description 1
• 102100034165 E3 ubiquitin-protein ligase RNF13 Human genes 0.000 description 1
• 102100039815 E3 ubiquitin-protein ligase RNF181 Human genes 0.000 description 1
• 102100040324 E3 ubiquitin-protein ligase RNF186 Human genes 0.000 description 1
• 102100027418 E3 ubiquitin-protein ligase RNF213 Human genes 0.000 description 1
• 102100039495 E3 ubiquitin-protein ligase RNF25 Human genes 0.000 description 1
• 101710109187 E3 ubiquitin-protein ligase RNF25 Proteins 0.000 description 1
• 102100021811 E3 ubiquitin-protein ligase RNF5 Human genes 0.000 description 1
• 101710202025 E3 ubiquitin-protein ligase RNF5 Proteins 0.000 description 1
• 102100021810 E3 ubiquitin-protein ligase RNF6 Human genes 0.000 description 1
• 102100021819 E3 ubiquitin-protein ligase RNF8 Human genes 0.000 description 1
• 102100038662 E3 ubiquitin-protein ligase SMURF2 Human genes 0.000 description 1
• 102100038796 E3 ubiquitin-protein ligase TRIM13 Human genes 0.000 description 1
• 101710165009 E3 ubiquitin-protein ligase TRIM13 Proteins 0.000 description 1
• 102100034597 E3 ubiquitin-protein ligase TRIM22 Human genes 0.000 description 1
• 102100029505 E3 ubiquitin-protein ligase TRIM33 Human genes 0.000 description 1
• 102100040067 E3 ubiquitin-protein ligase TRIM36 Human genes 0.000 description 1
• 102100025026 E3 ubiquitin-protein ligase TRIM68 Human genes 0.000 description 1
• 102100029672 E3 ubiquitin-protein ligase TRIM7 Human genes 0.000 description 1
• 102100029674 E3 ubiquitin-protein ligase TRIM9 Human genes 0.000 description 1
• 102100028093 E3 ubiquitin-protein ligase TRIP12 Human genes 0.000 description 1
• 101710148712 E3 ubiquitin-protein ligase TTC3 Proteins 0.000 description 1
• 102100037460 E3 ubiquitin-protein ligase Topors Human genes 0.000 description 1
• 101710136259 E3 ubiquitin-protein ligase XIAP Proteins 0.000 description 1
• 102100033594 E3 ubiquitin-protein ligase makorin-1 Human genes 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 238000002965 ELISA Methods 0.000 description 1
• 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 102000004533 Endonucleases Human genes 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 102000002494 Endoribonucleases Human genes 0.000 description 1
• 108010093099 Endoribonucleases Proteins 0.000 description 1
• 101000953091 Enterobacteria phage P4 Uncharacterized protein ORF88 Proteins 0.000 description 1
• 102000003837 Epithelial Sodium Channels Human genes 0.000 description 1
• 108090000140 Epithelial Sodium Channels Proteins 0.000 description 1
• 102100035177 Ergosterol biosynthetic protein 28 homolog Human genes 0.000 description 1
• 101000829922 Escherichia phage Mu Putative capsid assembly protein F Proteins 0.000 description 1
• 108091029865 Exogenous DNA Proteins 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 108060002716 Exonuclease Proteins 0.000 description 1
• 108050001049 Extracellular proteins Proteins 0.000 description 1
• 102100022113 F-box only protein 28 Human genes 0.000 description 1
• 101710199777 F-box only protein 3 Proteins 0.000 description 1
• 102100040641 F-box only protein 34 Human genes 0.000 description 1
• 101710199772 F-box only protein 4 Proteins 0.000 description 1
• 102100039836 F-box/LRR-repeat protein 12 Human genes 0.000 description 1
• 102100039834 F-box/LRR-repeat protein 15 Human genes 0.000 description 1
• 102100037315 F-box/LRR-repeat protein 3 Human genes 0.000 description 1
• 102100037316 F-box/LRR-repeat protein 4 Human genes 0.000 description 1
• 102100028146 F-box/WD repeat-containing protein 2 Human genes 0.000 description 1
• 102100028143 F-box/WD repeat-containing protein 5 Human genes 0.000 description 1
• 102000013340 FBXL7 Human genes 0.000 description 1
• 108091007024 FBXOs Proteins 0.000 description 1
• 102000036355 FBXOs Human genes 0.000 description 1
• 101150049384 Fbxl7 gene Proteins 0.000 description 1
• 101100058548 Felis catus BMI1 gene Proteins 0.000 description 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
• HILUWRPVFKJTAD-ZGHMGGRHSA-N GA21 Chemical compound O=C(O)[C@H]1[C@@H]2[C@]3(C(=O)O)C(=O)O[C@@]2([C@H]2[C@]41CC(=C)[C@@](O)(C4)CC2)CCC3 HILUWRPVFKJTAD-ZGHMGGRHSA-N 0.000 description 1
• 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
• 101100494437 Glycine max IFS2 gene Proteins 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 101100494439 Glycyrrhiza uralensis CYP93C2 gene Proteins 0.000 description 1
• 101150009243 HAP1 gene Proteins 0.000 description 1
• 108090001102 Hammerhead ribozyme Proteins 0.000 description 1
• 102100027489 Helicase-like transcription factor Human genes 0.000 description 1
• 101710180472 Helicase-like transcription factor Proteins 0.000 description 1
• 102100033071 Histone acetyltransferase KAT6A Human genes 0.000 description 1
• 102100022103 Histone-lysine N-methyltransferase 2A Human genes 0.000 description 1
• 108050002855 Histone-lysine N-methyltransferase 2A Proteins 0.000 description 1
• 102100022102 Histone-lysine N-methyltransferase 2B Human genes 0.000 description 1
• 101710196680 Histone-lysine N-methyltransferase NSD2 Proteins 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000619137 Homo sapiens 26S proteasome regulatory subunit 4 Proteins 0.000 description 1
• 101000684275 Homo sapiens ADP-ribosylation factor 3 Proteins 0.000 description 1
• 101000925508 Homo sapiens Ankyrin repeat and SOCS box protein 14 Proteins 0.000 description 1
• 101000984746 Homo sapiens BRCA1-associated protein Proteins 0.000 description 1
• 101000937772 Homo sapiens Beta,beta-carotene 15,15'-dioxygenase Proteins 0.000 description 1
• 101000944524 Homo sapiens Bombesin receptor-activated protein C6orf89 Proteins 0.000 description 1
• 101000933320 Homo sapiens Breakpoint cluster region protein Proteins 0.000 description 1
• 101100005560 Homo sapiens CCL23 gene Proteins 0.000 description 1
• 101000947157 Homo sapiens CXXC-type zinc finger protein 1 Proteins 0.000 description 1
• 101000941971 Homo sapiens Chordin-like protein 1 Proteins 0.000 description 1
• 101000748858 Homo sapiens Coronin-2A Proteins 0.000 description 1
• 101000855520 Homo sapiens Cyclic AMP-responsive element-binding protein 3 Proteins 0.000 description 1
• 101000884183 Homo sapiens Cyclin-F Proteins 0.000 description 1
• 101000911952 Homo sapiens Cyclin-dependent kinase 7 Proteins 0.000 description 1
• 101100171539 Homo sapiens DZIP3 gene Proteins 0.000 description 1
• 101000817629 Homo sapiens Dymeclin Proteins 0.000 description 1
• 101000817607 Homo sapiens Dynamin-2 Proteins 0.000 description 1
• 101001035145 Homo sapiens E3 ISG15-protein ligase HERC5 Proteins 0.000 description 1
• 101000776154 Homo sapiens E3 ubiquitin-protein ligase AMFR Proteins 0.000 description 1
• 101000896083 Homo sapiens E3 ubiquitin-protein ligase BRE1A Proteins 0.000 description 1
• 101000896080 Homo sapiens E3 ubiquitin-protein ligase BRE1B Proteins 0.000 description 1
• 101000715390 Homo sapiens E3 ubiquitin-protein ligase CBL Proteins 0.000 description 1
• 101000865806 Homo sapiens E3 ubiquitin-protein ligase DTX4 Proteins 0.000 description 1
• 101001009246 Homo sapiens E3 ubiquitin-protein ligase HACE1 Proteins 0.000 description 1
• 101000872871 Homo sapiens E3 ubiquitin-protein ligase HECW2 Proteins 0.000 description 1
• 101000872516 Homo sapiens E3 ubiquitin-protein ligase HERC2 Proteins 0.000 description 1
• 101001131834 Homo sapiens E3 ubiquitin-protein ligase PDZRN3 Proteins 0.000 description 1
• 101001001821 Homo sapiens E3 ubiquitin-protein ligase Praja-2 Proteins 0.000 description 1
• 101001095815 Homo sapiens E3 ubiquitin-protein ligase RING2 Proteins 0.000 description 1
• 101000711924 Homo sapiens E3 ubiquitin-protein ligase RLIM Proteins 0.000 description 1
• 101000650319 Homo sapiens E3 ubiquitin-protein ligase RNF103 Proteins 0.000 description 1
• 101001079862 Homo sapiens E3 ubiquitin-protein ligase RNF115 Proteins 0.000 description 1
• 101000711573 Homo sapiens E3 ubiquitin-protein ligase RNF123 Proteins 0.000 description 1
• 101000712021 Homo sapiens E3 ubiquitin-protein ligase RNF13 Proteins 0.000 description 1
• 101000667685 Homo sapiens E3 ubiquitin-protein ligase RNF181 Proteins 0.000 description 1
• 101001104289 Homo sapiens E3 ubiquitin-protein ligase RNF186 Proteins 0.000 description 1
• 101000650316 Homo sapiens E3 ubiquitin-protein ligase RNF213 Proteins 0.000 description 1
• 101001107079 Homo sapiens E3 ubiquitin-protein ligase RNF6 Proteins 0.000 description 1
• 101001107071 Homo sapiens E3 ubiquitin-protein ligase RNF8 Proteins 0.000 description 1
• 101000664952 Homo sapiens E3 ubiquitin-protein ligase SMURF2 Proteins 0.000 description 1
• 101000848629 Homo sapiens E3 ubiquitin-protein ligase TRIM22 Proteins 0.000 description 1
• 101000634991 Homo sapiens E3 ubiquitin-protein ligase TRIM33 Proteins 0.000 description 1
• 101000610402 Homo sapiens E3 ubiquitin-protein ligase TRIM36 Proteins 0.000 description 1
• 101000830201 Homo sapiens E3 ubiquitin-protein ligase TRIM68 Proteins 0.000 description 1
• 101000795296 Homo sapiens E3 ubiquitin-protein ligase TRIM7 Proteins 0.000 description 1
• 101000795280 Homo sapiens E3 ubiquitin-protein ligase TRIM9 Proteins 0.000 description 1
• 101000649025 Homo sapiens E3 ubiquitin-protein ligase TRIP12 Proteins 0.000 description 1
• 101000662670 Homo sapiens E3 ubiquitin-protein ligase Topors Proteins 0.000 description 1
• 101001038784 Homo sapiens E3 ubiquitin-protein ligase listerin Proteins 0.000 description 1
• 101001018965 Homo sapiens E3 ubiquitin-protein ligase makorin-1 Proteins 0.000 description 1
• 101001018973 Homo sapiens E3 ubiquitin-protein ligase makorin-2 Proteins 0.000 description 1
• 101000848655 Homo sapiens E3 ubiquitin/ISG15 ligase TRIM25 Proteins 0.000 description 1
• 101000876557 Homo sapiens Ergosterol biosynthetic protein 28 homolog Proteins 0.000 description 1
• 101001030684 Homo sapiens F-box only protein 10 Proteins 0.000 description 1
• 101000878591 Homo sapiens F-box only protein 24 Proteins 0.000 description 1
• 101000824152 Homo sapiens F-box only protein 28 Proteins 0.000 description 1
• 101000892349 Homo sapiens F-box only protein 34 Proteins 0.000 description 1
• 101000913298 Homo sapiens F-box only protein 44 Proteins 0.000 description 1
• 101000885591 Homo sapiens F-box/LRR-repeat protein 12 Proteins 0.000 description 1
• 101000885597 Homo sapiens F-box/LRR-repeat protein 15 Proteins 0.000 description 1
• 101001026868 Homo sapiens F-box/LRR-repeat protein 3 Proteins 0.000 description 1
• 101001026845 Homo sapiens F-box/LRR-repeat protein 6 Proteins 0.000 description 1
• 101001060245 Homo sapiens F-box/WD repeat-containing protein 2 Proteins 0.000 description 1
• 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 description 1
• 101000944179 Homo sapiens Histone acetyltransferase KAT6A Proteins 0.000 description 1
• 101001045846 Homo sapiens Histone-lysine N-methyltransferase 2A Proteins 0.000 description 1
• 101001008894 Homo sapiens Histone-lysine N-methyltransferase 2D Proteins 0.000 description 1
• 101001008896 Homo sapiens Inactive histone-lysine N-methyltransferase 2E Proteins 0.000 description 1
• 101001053716 Homo sapiens Inhibitor of growth protein 3 Proteins 0.000 description 1
• 101001001416 Homo sapiens Inhibitor of growth protein 5 Proteins 0.000 description 1
• 101000599647 Homo sapiens Integrator complex subunit 12 Proteins 0.000 description 1
• 101001077842 Homo sapiens Interferon regulatory factor 2-binding protein 1 Proteins 0.000 description 1
• 101001139136 Homo sapiens Krueppel-like factor 3 Proteins 0.000 description 1
• 101001037993 Homo sapiens LON peptidase N-terminal domain and RING finger protein 3 Proteins 0.000 description 1
• 101000613958 Homo sapiens Lysine-specific demethylase 2A Proteins 0.000 description 1
• 101001088893 Homo sapiens Lysine-specific demethylase 4C Proteins 0.000 description 1
• 101000624643 Homo sapiens M-phase inducer phosphatase 3 Proteins 0.000 description 1
• 101001030591 Homo sapiens Mitochondrial ubiquitin ligase activator of NFKB 1 Proteins 0.000 description 1
• 101000650158 Homo sapiens NEDD4-like E3 ubiquitin-protein ligase WWP1 Proteins 0.000 description 1
• 101000650160 Homo sapiens NEDD4-like E3 ubiquitin-protein ligase WWP2 Proteins 0.000 description 1
• 101000934489 Homo sapiens Nucleosome-remodeling factor subunit BPTF Proteins 0.000 description 1
• 101001071233 Homo sapiens PHD finger protein 1 Proteins 0.000 description 1
• 101000692946 Homo sapiens PHD finger protein 3 Proteins 0.000 description 1
• 101001095089 Homo sapiens PML-RARA-regulated adapter molecule 1 Proteins 0.000 description 1
• 101000583474 Homo sapiens Phosphatidylinositol-binding clathrin assembly protein Proteins 0.000 description 1
• 101000838314 Homo sapiens Probable E3 ubiquitin-protein ligase DTX2 Proteins 0.000 description 1
• 101000872867 Homo sapiens Probable E3 ubiquitin-protein ligase HECTD4 Proteins 0.000 description 1
• 101001035259 Homo sapiens Probable E3 ubiquitin-protein ligase HERC4 Proteins 0.000 description 1
• 101001035144 Homo sapiens Probable E3 ubiquitin-protein ligase HERC6 Proteins 0.000 description 1
• 101000599816 Homo sapiens Probable E3 ubiquitin-protein ligase IRF2BPL Proteins 0.000 description 1
• 101000718497 Homo sapiens Protein AF-10 Proteins 0.000 description 1
• 101001120874 Homo sapiens Putative E3 ubiquitin-protein ligase makorin-4 Proteins 0.000 description 1
• 101000700496 Homo sapiens Pygopus homolog 2 Proteins 0.000 description 1
• 101000858600 Homo sapiens RING finger and SPRY domain-containing protein 1 Proteins 0.000 description 1
• 101001079865 Homo sapiens RING finger protein 121 Proteins 0.000 description 1
• 101001106969 Homo sapiens RING finger protein 141 Proteins 0.000 description 1
• 101000854320 Homo sapiens RING finger protein 150 Proteins 0.000 description 1
• 101001103588 Homo sapiens RING finger protein 32 Proteins 0.000 description 1
• 101000692721 Homo sapiens RING finger protein 44 Proteins 0.000 description 1
• 101001111714 Homo sapiens RING-box protein 2 Proteins 0.000 description 1
• 101000574242 Homo sapiens RING-type E3 ubiquitin-protein ligase PPIL2 Proteins 0.000 description 1
• 101001095987 Homo sapiens RalBP1-associated Eps domain-containing protein 2 Proteins 0.000 description 1
• 101001130437 Homo sapiens Ras-related protein Rap-2b Proteins 0.000 description 1
• 101000580039 Homo sapiens Ras-specific guanine nucleotide-releasing factor 1 Proteins 0.000 description 1
• 101001092203 Homo sapiens Ret finger protein-like 1 Proteins 0.000 description 1
• 101001092196 Homo sapiens Ret finger protein-like 3 Proteins 0.000 description 1
• 101000650528 Homo sapiens Ribosome production factor 2 homolog Proteins 0.000 description 1
• 101000674728 Homo sapiens TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Proteins 0.000 description 1
• 101000850762 Homo sapiens TNF receptor-associated factor 3 Proteins 0.000 description 1
• 101000830933 Homo sapiens TNF receptor-associated factor 4 Proteins 0.000 description 1
• 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 1
• 101000753282 Homo sapiens Transcription intermediary factor 1-alpha Proteins 0.000 description 1
• 101000664599 Homo sapiens Tripartite motif-containing protein 2 Proteins 0.000 description 1
• 101000795292 Homo sapiens Tripartite motif-containing protein 6 Proteins 0.000 description 1
• 101000772955 Homo sapiens Ubiquitin-protein ligase E3B Proteins 0.000 description 1
• 101000772964 Homo sapiens Ubiquitin-protein ligase E3C Proteins 0.000 description 1
• 101000771974 Homo sapiens Vacuolar protein sorting-associated protein 41 homolog Proteins 0.000 description 1
• 101100264173 Homo sapiens XIAP gene Proteins 0.000 description 1
• 101000759453 Homo sapiens YY1-associated protein 1 Proteins 0.000 description 1
• 101000760174 Homo sapiens Zinc finger protein 3 Proteins 0.000 description 1
• 101000964746 Homo sapiens Zinc finger protein 69 Proteins 0.000 description 1
• 101000634977 Homo sapiens Zinc finger protein RFP Proteins 0.000 description 1
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
• 241001135569 Human adenovirus 5 Species 0.000 description 1
• 241000701806 Human papillomavirus Species 0.000 description 1
• 241000722343 Human papillomavirus types Species 0.000 description 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
• 102100027767 Inactive histone-lysine N-methyltransferase 2E Human genes 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 108700038214 Inhibitor of growth protein 3 Proteins 0.000 description 1
• 102100035677 Inhibitor of growth protein 4 Human genes 0.000 description 1
• 101710141736 Inhibitor of growth protein 4 Proteins 0.000 description 1
• 102100035676 Inhibitor of growth protein 5 Human genes 0.000 description 1
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
• 229930010555 Inosine Natural products 0.000 description 1
• CIPFCGZLFXVXBG-FTSGZOCFSA-N Inositol 1,3,4,5-tetraphosphate Chemical compound O[C@H]1C(OP(O)(O)=O)[C@H](O)[C@@H](OP(O)(O)=O)C(OP(O)(O)=O)[C@H]1OP(O)(O)=O CIPFCGZLFXVXBG-FTSGZOCFSA-N 0.000 description 1
• 102100037944 Integrator complex subunit 12 Human genes 0.000 description 1
• 102100025355 Interferon regulatory factor 2-binding protein 1 Human genes 0.000 description 1
• 102000000589 Interleukin-1 Human genes 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 108010063738 Interleukins Proteins 0.000 description 1
• 102000015696 Interleukins Human genes 0.000 description 1
• 108091092195 Intron Proteins 0.000 description 1
• 108010044467 Isoenzymes Proteins 0.000 description 1
• 102100020678 Krueppel-like factor 3 Human genes 0.000 description 1
• 125000000998 L-alanino group Chemical group [H]N([*])[C@](C([H])([H])[H])([H])C(=O)O[H] 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 description 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
• 102000023878 LIM domain binding proteins Human genes 0.000 description 1
• 108091008416 LIM domain binding proteins Proteins 0.000 description 1
• 101150113776 LMP1 gene Proteins 0.000 description 1
• 102100040389 LON peptidase N-terminal domain and RING finger protein 3 Human genes 0.000 description 1
• 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
• VTJUNIYRYIAIHF-IUCAKERBSA-N Leu-Pro Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O VTJUNIYRYIAIHF-IUCAKERBSA-N 0.000 description 1
• 101710097665 Leucine aminopeptidase 1 Proteins 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• 102100040598 Lysine-specific demethylase 2A Human genes 0.000 description 1
• 102100040863 Lysine-specific demethylase 4A Human genes 0.000 description 1
• 102100033230 Lysine-specific demethylase 4C Human genes 0.000 description 1
• 102100033247 Lysine-specific demethylase 5B Human genes 0.000 description 1
• 101710105712 Lysine-specific demethylase 5B Proteins 0.000 description 1
• 101710105720 Lysine-specific demethylase 5D Proteins 0.000 description 1
• 102100023330 M-phase inducer phosphatase 3 Human genes 0.000 description 1
• 101710159527 Maturation protein A Proteins 0.000 description 1
• 101710091157 Maturation protein A2 Proteins 0.000 description 1
• 108091027974 Mature messenger RNA Proteins 0.000 description 1
• 102000011202 Member 2 Subfamily B ATP Binding Cassette Transporter Human genes 0.000 description 1
• 101710137278 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Proteins 0.000 description 1
• 108090000157 Metallothionein Proteins 0.000 description 1
• 108060004795 Methyltransferase Proteins 0.000 description 1
• 102100038531 Mitochondrial ubiquitin ligase activator of NFKB 1 Human genes 0.000 description 1
• 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 description 1
• 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 description 1
• 101710164423 Mitogen-activated protein kinase kinase kinase 1 Proteins 0.000 description 1
• 241000353097 Molva molva Species 0.000 description 1
• 201000006054 Mulibrey nanism Diseases 0.000 description 1
• 101000973497 Mus musculus E3 ubiquitin-protein ligase MIB2 Proteins 0.000 description 1
• 101000636757 Mus musculus E3 ubiquitin-protein ligase NEDD4 Proteins 0.000 description 1
• 101100519086 Mus musculus Pcgf2 gene Proteins 0.000 description 1
• 101000734221 Mus musculus RING finger protein 10 Proteins 0.000 description 1
• 101100433195 Mus musculus Zfp26 gene Proteins 0.000 description 1
• 101100433196 Mus musculus Zfp27 gene Proteins 0.000 description 1
• SGSSKEDGVONRGC-UHFFFAOYSA-N N(2)-methylguanine Chemical compound O=C1NC(NC)=NC2=C1N=CN2 SGSSKEDGVONRGC-UHFFFAOYSA-N 0.000 description 1
• 102100023648 N-chimaerin Human genes 0.000 description 1
• 101710140152 N-chimaerin Proteins 0.000 description 1
• 102100027550 NEDD4-like E3 ubiquitin-protein ligase WWP1 Human genes 0.000 description 1
• 102100027549 NEDD4-like E3 ubiquitin-protein ligase WWP2 Human genes 0.000 description 1
• 108091008758 NR0A5 Proteins 0.000 description 1
• 101150097297 Nedd4 gene Proteins 0.000 description 1
• 241000244206 Nematoda Species 0.000 description 1
• 208000009869 Neu-Laxova syndrome Diseases 0.000 description 1
• 244000061176 Nicotiana tabacum Species 0.000 description 1
• 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
• 101100179449 Nicotiana tabacum A622 gene Proteins 0.000 description 1
• 238000000636 Northern blotting Methods 0.000 description 1
• 108010077850 Nuclear Localization Signals Proteins 0.000 description 1
• 102000007999 Nuclear Proteins Human genes 0.000 description 1
• 108010089610 Nuclear Proteins Proteins 0.000 description 1
• 101710190752 Nuclear pore glycoprotein p62 Proteins 0.000 description 1
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
• 102100025062 Nucleosome-remodeling factor subunit BPTF Human genes 0.000 description 1
• 102100027069 Odontogenic ameloblast-associated protein Human genes 0.000 description 1
• 101710091533 Odontogenic ameloblast-associated protein Proteins 0.000 description 1
• 101001027323 Oryctolagus cuniculus Permeability factor 2 Proteins 0.000 description 1
• 101150006573 PAN1 gene Proteins 0.000 description 1
• 238000012408 PCR amplification Methods 0.000 description 1
• 101710151868 PHD finger protein 3 Proteins 0.000 description 1
• 102100037019 PML-RARA-regulated adapter molecule 1 Human genes 0.000 description 1
• 241001631646 Papillomaviridae Species 0.000 description 1
• 208000027089 Parkinsonian disease Diseases 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 102000005877 Peptide Initiation Factors Human genes 0.000 description 1
• 108010044843 Peptide Initiation Factors Proteins 0.000 description 1
• 101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 description 1
• 101710139635 Peregrin Proteins 0.000 description 1
• KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 description 1
• 101710124390 Peroxisome biogenesis factor 2 Proteins 0.000 description 1
• 108010058514 Phosphate-Binding Proteins Proteins 0.000 description 1
• 102000006335 Phosphate-Binding Proteins Human genes 0.000 description 1
• 108010001441 Phosphopeptides Proteins 0.000 description 1
• 241001674048 Phthiraptera Species 0.000 description 1
• 102100033566 Polycomb complex protein BMI-1 Human genes 0.000 description 1
• 102100040919 Polycomb group RING finger protein 2 Human genes 0.000 description 1
• 101710092205 Polycomb group RING finger protein 2 Proteins 0.000 description 1
• 229920001213 Polysorbate 20 Polymers 0.000 description 1
• KQHKSGRIBYJYFX-UHFFFAOYSA-J Ponceau S Chemical compound [Na+].[Na+].[Na+].[Na+].Oc1c(cc2cc(ccc2c1N=Nc1ccc(cc1S([O-])(=O)=O)N=Nc1ccc(cc1)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O KQHKSGRIBYJYFX-UHFFFAOYSA-J 0.000 description 1
• 102100028977 Probable E3 ubiquitin-protein ligase DTX2 Human genes 0.000 description 1
• 102100034679 Probable E3 ubiquitin-protein ligase HECTD4 Human genes 0.000 description 1
• 102100039913 Probable E3 ubiquitin-protein ligase HERC4 Human genes 0.000 description 1
• 102100039921 Probable E3 ubiquitin-protein ligase HERC6 Human genes 0.000 description 1
• 102100037864 Probable E3 ubiquitin-protein ligase IRF2BPL Human genes 0.000 description 1
• 101710119937 Probable E3 ubiquitin-protein ligase MID2 Proteins 0.000 description 1
• 102100026051 Probable E3 ubiquitin-protein ligase makorin-3 Human genes 0.000 description 1
• 108700038895 Probable E3 ubiquitin-protein ligase makorin-3 Proteins 0.000 description 1
• 101710082688 Probable leucine aminopeptidase 1 Proteins 0.000 description 1
• 206010036790 Productive cough Diseases 0.000 description 1
• 101710151715 Protein 7 Proteins 0.000 description 1
• 102100026286 Protein AF-10 Human genes 0.000 description 1
• 101710188053 Protein D Proteins 0.000 description 1
• 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 description 1
• 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 description 1
• 101710188315 Protein X Proteins 0.000 description 1
• 108010026552 Proteome Proteins 0.000 description 1
• 241001430696 Protis Species 0.000 description 1
• 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 1
• 102000007568 Proto-Oncogene Proteins c-fos Human genes 0.000 description 1
• 102100026052 Putative E3 ubiquitin-protein ligase makorin-4 Human genes 0.000 description 1
• 102100029490 Pygopus homolog 2 Human genes 0.000 description 1
• 102100028855 RING finger and SPRY domain-containing protein 1 Human genes 0.000 description 1
• 102100028106 RING finger protein 121 Human genes 0.000 description 1
• 102100021764 RING finger protein 141 Human genes 0.000 description 1
• 102100036276 RING finger protein 150 Human genes 0.000 description 1
• 102100039500 RING finger protein 32 Human genes 0.000 description 1
• 102100026352 RING finger protein 44 Human genes 0.000 description 1
• 230000006819 RNA synthesis Effects 0.000 description 1
• 108010065108 RNA-cleaving DNA 10-23 Proteins 0.000 description 1
• 101100269971 Rattus norvegicus Apbb1 gene Proteins 0.000 description 1
• 108700005075 Regulator Genes Proteins 0.000 description 1
• 102100039977 Regulator of chromosome condensation Human genes 0.000 description 1
• 101710150974 Regulator of chromosome condensation Proteins 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 101710132893 Resolvase Proteins 0.000 description 1
• 102100035524 Ret finger protein-like 1 Human genes 0.000 description 1
• 101710183525 Ret finger protein-like 3 Proteins 0.000 description 1
• 102000011260 Retinoblastoma Binding Proteins Human genes 0.000 description 1
• 108050002653 Retinoblastoma protein Proteins 0.000 description 1
• 102000003661 Ribonuclease III Human genes 0.000 description 1
• 108010057163 Ribonuclease III Proteins 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 102100027486 Ribosome production factor 2 homolog Human genes 0.000 description 1
• 208000035217 Ring chromosome 1 syndrome Diseases 0.000 description 1
• 241000714474 Rous sarcoma virus Species 0.000 description 1
• 102000000341 S-Phase Kinase-Associated Proteins Human genes 0.000 description 1
• 108010055623 S-Phase Kinase-Associated Proteins Proteins 0.000 description 1
• 102100034374 S-phase kinase-associated protein 2 Human genes 0.000 description 1
• 239000012722 SDS sample buffer Substances 0.000 description 1
• 101150009928 SRM1 gene Proteins 0.000 description 1
• 108010076622 SS-A antigen Proteins 0.000 description 1
• 101100444912 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GCD1 gene Proteins 0.000 description 1
• 101100140586 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) NAM7 gene Proteins 0.000 description 1
• 101100365194 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SEC7 gene Proteins 0.000 description 1
• 101100086724 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SRM1 gene Proteins 0.000 description 1
• 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
• 101100491101 Schizosaccharomyces pombe (strain 972 / ATCC 24843) aah3 gene Proteins 0.000 description 1
• 238000012300 Sequence Analysis Methods 0.000 description 1
• 101710172711 Structural protein Proteins 0.000 description 1
• 101710137500 T7 RNA polymerase Proteins 0.000 description 1
• 101710199392 TATA-box-binding protein 1 Proteins 0.000 description 1
• 102100021227 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Human genes 0.000 description 1
• 102000004399 TNF receptor-associated factor 3 Human genes 0.000 description 1
• 108090000922 TNF receptor-associated factor 3 Proteins 0.000 description 1
• 102000003715 TNF receptor-associated factor 4 Human genes 0.000 description 1
• 108090000008 TNF receptor-associated factor 4 Proteins 0.000 description 1
• 102100024809 TNF receptor-associated factor 4 Human genes 0.000 description 1
• 102000008889 TNF receptor-associated factor TRAF Human genes 0.000 description 1
• 108050000808 TNF receptor-associated factor TRAF Proteins 0.000 description 1
• 108091007076 TRIP12 Proteins 0.000 description 1
• 102100024547 Tensin-1 Human genes 0.000 description 1
• 108010088950 Tensins Proteins 0.000 description 1
• 241000248384 Tetrahymena thermophila Species 0.000 description 1
• CUTPSEKWUPZFLV-WISUUJSJSA-N Thr-Cys Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CS)C(O)=O CUTPSEKWUPZFLV-WISUUJSJSA-N 0.000 description 1
• 102000006601 Thymidine Kinase Human genes 0.000 description 1
• 108020004440 Thymidine kinase Proteins 0.000 description 1
• AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
• 102100040396 Transcobalamin-1 Human genes 0.000 description 1
• 102100026428 Transcription elongation factor A protein 2 Human genes 0.000 description 1
• 101710119700 Transcription factor 19 Proteins 0.000 description 1
• 102100023132 Transcription factor Jun Human genes 0.000 description 1
• 102100038799 Tripartite motif-containing protein 2 Human genes 0.000 description 1
• 101710154892 Tripartite motif-containing protein 26 Proteins 0.000 description 1
• 102100029673 Tripartite motif-containing protein 6 Human genes 0.000 description 1
• 239000007983 Tris buffer Substances 0.000 description 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
• 102000015098 Tumor Suppressor Protein p53 Human genes 0.000 description 1
• 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 1
• 102000019229 U-box domains Human genes 0.000 description 1
• 108050006631 U-box domains Proteins 0.000 description 1
• 102100038487 Ubiquitin conjugation factor E4 B Human genes 0.000 description 1
• 101710189288 Ubiquitin conjugation factor E4 B Proteins 0.000 description 1
• 102000018478 Ubiquitin-Activating Enzymes Human genes 0.000 description 1
• 108010091546 Ubiquitin-Activating Enzymes Proteins 0.000 description 1
• 101710132695 Ubiquitin-conjugating enzyme E2 Proteins 0.000 description 1
• 102100030429 Ubiquitin-protein ligase E3B Human genes 0.000 description 1
• 102100030427 Ubiquitin-protein ligase E3C Human genes 0.000 description 1
• 101710135389 Unconventional myosin-Ia Proteins 0.000 description 1
• 108010075653 Utrophin Proteins 0.000 description 1
• 102000011856 Utrophin Human genes 0.000 description 1
• 101150036892 VP40 gene Proteins 0.000 description 1
• 102100029496 Vacuolar protein sorting-associated protein 41 homolog Human genes 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 108010031770 Vesicular Transport Adaptor Proteins Proteins 0.000 description 1
• 102000005456 Vesicular Transport Adaptor Proteins Human genes 0.000 description 1
• 108020005202 Viral DNA Proteins 0.000 description 1
• 102000050257 X-Linked Inhibitor of Apoptosis Human genes 0.000 description 1
• 101000740452 Xenopus laevis Baculoviral IAP repeat-containing protein 7-A Proteins 0.000 description 1
• 102100023267 YY1-associated protein 1 Human genes 0.000 description 1
• 102100040032 Zinc finger protein 185 Human genes 0.000 description 1
• 101710145550 Zinc finger protein 185 Proteins 0.000 description 1
• 102100024687 Zinc finger protein 2 Human genes 0.000 description 1
• 101710180929 Zinc finger protein 2 Proteins 0.000 description 1
• 102100024671 Zinc finger protein 3 Human genes 0.000 description 1
• 101710156852 Zinc finger protein ubi-d4 Proteins 0.000 description 1
• LUTSRLYCMSCGCS-BWOMAWGNSA-N [(3s,8r,9s,10r,13s)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,16-decahydrocyclopenta[a]phenanthren-3-yl] acetate Chemical compound C([C@@H]12)C[C@]3(C)C(=O)CC=C3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)C)C1 LUTSRLYCMSCGCS-BWOMAWGNSA-N 0.000 description 1
• XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
• 230000005856 abnormality Effects 0.000 description 1
• UELITFHSCLAHKR-UHFFFAOYSA-N acibenzolar-S-methyl Chemical compound CSC(=O)C1=CC=CC2=C1SN=N2 UELITFHSCLAHKR-UHFFFAOYSA-N 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 239000008186 active pharmaceutical agent Substances 0.000 description 1
• 125000002252 acyl group Chemical group 0.000 description 1
• 239000012082 adaptor molecule Substances 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• 230000001464 adherent effect Effects 0.000 description 1
• 230000002776 aggregation Effects 0.000 description 1
• 238000004220 aggregation Methods 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 229940041181 antineoplastic drug Drugs 0.000 description 1
• 239000003816 antisense DNA Substances 0.000 description 1
• PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
• 210000003567 ascitic fluid Anatomy 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 238000002869 basic local alignment search tool Methods 0.000 description 1
• VEVJTUNLALKRNO-TYHXJLICSA-N benzoyl-CoA Chemical compound O=C([C@H](O)C(C)(COP(O)(=O)OP(O)(=O)OC[C@@H]1[C@H]([C@@H](O)[C@@H](O1)N1C2=NC=NC(N)=C2N=C1)OP(O)(O)=O)C)NCCC(=O)NCCSC(=O)C1=CC=CC=C1 VEVJTUNLALKRNO-TYHXJLICSA-N 0.000 description 1
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
• 108010005774 beta-Galactosidase Proteins 0.000 description 1
• 230000000975 bioactive effect Effects 0.000 description 1
• 238000007622 bioinformatic analysis Methods 0.000 description 1
• 229960002685 biotin Drugs 0.000 description 1
• 235000020958 biotin Nutrition 0.000 description 1
• 239000011616 biotin Substances 0.000 description 1
• 238000007413 biotinylation Methods 0.000 description 1
• 230000006287 biotinylation Effects 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 230000008499 blood brain barrier function Effects 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 210000001218 blood-brain barrier Anatomy 0.000 description 1
• 238000009835 boiling Methods 0.000 description 1
• UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
• 238000010804 cDNA synthesis Methods 0.000 description 1
• 108020001778 catalytic domains Proteins 0.000 description 1
• 230000034303 cell budding Effects 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 239000006143 cell culture medium Substances 0.000 description 1
• 230000006369 cell cycle progression Effects 0.000 description 1
• 238000001516 cell proliferation assay Methods 0.000 description 1
• 230000033077 cellular process Effects 0.000 description 1
• 230000004700 cellular uptake Effects 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 210000001638 cerebellum Anatomy 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• 239000012707 chemical precursor Substances 0.000 description 1
• 239000003153 chemical reaction reagent Substances 0.000 description 1
• 108091006090 chromatin-associated proteins Proteins 0.000 description 1
• 229930193282 clathrin Natural products 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 238000012761 co-transfection Methods 0.000 description 1
• 230000003081 coactivator Effects 0.000 description 1
• 210000001072 colon Anatomy 0.000 description 1
• 238000004891 communication Methods 0.000 description 1
• 238000009833 condensation Methods 0.000 description 1
• 230000005494 condensation Effects 0.000 description 1
• 230000001268 conjugating effect Effects 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 108091036078 conserved sequence Proteins 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 239000005289 controlled pore glass Substances 0.000 description 1
• 239000003431 cross linking reagent Substances 0.000 description 1
• 230000001351 cycling effect Effects 0.000 description 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 210000000805 cytoplasm Anatomy 0.000 description 1
• 210000000172 cytosol Anatomy 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 description 1
• 238000007405 data analysis Methods 0.000 description 1
• 239000007857 degradation product Substances 0.000 description 1
• 238000000432 density-gradient centrifugation Methods 0.000 description 1
• VGONTNSXDCQUGY-UHFFFAOYSA-N desoxyinosine Natural products C1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 VGONTNSXDCQUGY-UHFFFAOYSA-N 0.000 description 1
• 230000010460 detection of virus Effects 0.000 description 1
• 239000003599 detergent Substances 0.000 description 1
• 150000001982 diacylglycerols Chemical class 0.000 description 1
• ANCLJVISBRWUTR-UHFFFAOYSA-N diaminophosphinic acid Chemical compound NP(N)(O)=O ANCLJVISBRWUTR-UHFFFAOYSA-N 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• RJBIAAZJODIFHR-UHFFFAOYSA-N dihydroxy-imino-sulfanyl-$l^{5}-phosphane Chemical compound NP(O)(O)=S RJBIAAZJODIFHR-UHFFFAOYSA-N 0.000 description 1
• CLBIEZBAENPDFY-HNXGFDTJSA-N dinophysistoxin 1 Chemical group C([C@H](O1)[C@H](C)/C=C/[C@H]2CC[C@@]3(CC[C@H]4O[C@@H](C([C@@H](O)[C@@H]4O3)=C)[C@@H](O)C[C@H](C)[C@@H]3[C@@H](CC[C@@]4(O3)[C@@H](CCCO4)C)C)O2)C(C)=C[C@]21O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]2O CLBIEZBAENPDFY-HNXGFDTJSA-N 0.000 description 1
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 238000009509 drug development Methods 0.000 description 1
• 238000012912 drug discovery process Methods 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 230000013020 embryo development Effects 0.000 description 1
• 210000002257 embryonic structure Anatomy 0.000 description 1
• 230000012202 endocytosis Effects 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 239000002532 enzyme inhibitor Substances 0.000 description 1
• DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 102000013165 exonuclease Human genes 0.000 description 1
• 239000013613 expression plasmid Substances 0.000 description 1
• 108010072251 fetal Alzheimer antigen Proteins 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
• 238000000799 fluorescence microscopy Methods 0.000 description 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
• 239000007850 fluorescent dye Substances 0.000 description 1
• 102000034287 fluorescent proteins Human genes 0.000 description 1
• 108091006047 fluorescent proteins Proteins 0.000 description 1
• 229960002949 fluorouracil Drugs 0.000 description 1
• 108010006620 fodrin Proteins 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 108020001507 fusion proteins Proteins 0.000 description 1
• 102000037865 fusion proteins Human genes 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 230000030279 gene silencing Effects 0.000 description 1
• 230000008571 general function Effects 0.000 description 1
• 208000005017 glioblastoma Diseases 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• 108010072285 growth inhibitory proteins Proteins 0.000 description 1
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 1
• 238000003306 harvesting Methods 0.000 description 1
• 230000011132 hemopoiesis Effects 0.000 description 1
• 239000000833 heterodimer Substances 0.000 description 1
• 150000002402 hexoses Chemical class 0.000 description 1
• 239000012145 high-salt buffer Substances 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
• 230000001744 histochemical effect Effects 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 102000050297 human MKRN2 Human genes 0.000 description 1
• 102000047457 human RFPL2 Human genes 0.000 description 1
• 102000052665 human SH3RF1 Human genes 0.000 description 1
• 102000051825 human TRIM13 Human genes 0.000 description 1
• 102000050448 human UBE3A Human genes 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 210000003026 hypopharynx Anatomy 0.000 description 1
• 238000003384 imaging method Methods 0.000 description 1
• 210000001822 immobilized cell Anatomy 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000000984 immunochemical effect Effects 0.000 description 1
• 238000010166 immunofluorescence Methods 0.000 description 1
• 238000010820 immunofluorescence microscopy Methods 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 229960003786 inosine Drugs 0.000 description 1
• 239000000138 intercalating agent Substances 0.000 description 1
• 210000005061 intracellular organelle Anatomy 0.000 description 1
• 230000004068 intracellular signaling Effects 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 108010057821 leucylproline Proteins 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 108020001756 ligand binding domains Proteins 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 235000020121 low-fat milk Nutrition 0.000 description 1
• HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
• 230000001320 lysogenic effect Effects 0.000 description 1
• 210000003712 lysosome Anatomy 0.000 description 1
• 230000001868 lysosomic effect Effects 0.000 description 1
• 230000002101 lytic effect Effects 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 230000007257 malfunction Effects 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 230000034217 membrane fusion Effects 0.000 description 1
• 230000008172 membrane trafficking Effects 0.000 description 1
• 229910021645 metal ion Inorganic materials 0.000 description 1
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
• 229960004452 methionine Drugs 0.000 description 1
• IZAGSTRIDUNNOY-UHFFFAOYSA-N methyl 2-[(2,4-dioxo-1h-pyrimidin-5-yl)oxy]acetate Chemical compound COC(=O)COC1=CNC(=O)NC1=O IZAGSTRIDUNNOY-UHFFFAOYSA-N 0.000 description 1
• 238000010208 microarray analysis Methods 0.000 description 1
• 238000012775 microarray technology Methods 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 238000000329 molecular dynamics simulation Methods 0.000 description 1
• 108700009710 mouse grey-lethal Proteins 0.000 description 1
• 206010051747 multiple endocrine neoplasia Diseases 0.000 description 1
• 208000025113 myeloid leukemia Diseases 0.000 description 1
• XJVXMWNLQRTRGH-UHFFFAOYSA-N n-(3-methylbut-3-enyl)-2-methylsulfanyl-7h-purin-6-amine Chemical compound CSC1=NC(NCCC(C)=C)=C2NC=NC2=N1 XJVXMWNLQRTRGH-UHFFFAOYSA-N 0.000 description 1
• 238000013188 needle biopsy Methods 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 230000009826 neoplastic cell growth Effects 0.000 description 1
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
• 108091027963 non-coding RNA Proteins 0.000 description 1
• 102000042567 non-coding RNA Human genes 0.000 description 1
• 108010054109 nuclear pore protein p62 Proteins 0.000 description 1
• 238000003499 nucleic acid array Methods 0.000 description 1
• 239000002853 nucleic acid probe Substances 0.000 description 1
• 150000003833 nucleoside derivatives Chemical class 0.000 description 1
• 125000003835 nucleoside group Chemical group 0.000 description 1
• 210000004940 nucleus Anatomy 0.000 description 1
• 238000002966 oligonucleotide array Methods 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 108091008819 oncoproteins Proteins 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 230000006320 pegylation Effects 0.000 description 1
• 229930192851 perforin Natural products 0.000 description 1
• 230000002085 persistent effect Effects 0.000 description 1
• 150000004633 phorbol derivatives Chemical class 0.000 description 1
• 239000002644 phorbol ester Substances 0.000 description 1
• 150000008300 phosphoramidites Chemical class 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 125000005642 phosphothioate group Chemical group 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 210000004910 pleural fluid Anatomy 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 102000054765 polymorphisms of proteins Human genes 0.000 description 1
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
• 239000011148 porous material Substances 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 230000001124 posttranscriptional effect Effects 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 238000007639 printing Methods 0.000 description 1
• 210000002307 prostate Anatomy 0.000 description 1
• 230000004952 protein activity Effects 0.000 description 1
• 230000004845 protein aggregation Effects 0.000 description 1
• 230000004853 protein function Effects 0.000 description 1
• 102000033506 protein kinase C binding proteins Human genes 0.000 description 1
• 108091009576 protein kinase C binding proteins Proteins 0.000 description 1
• 230000025220 protein targeting to vacuole Effects 0.000 description 1
• 108010006230 protelin Proteins 0.000 description 1
• 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
• 230000002285 radioactive effect Effects 0.000 description 1
• 102000005912 ran GTP Binding Protein Human genes 0.000 description 1
• 108010005597 ran GTP Binding Protein Proteins 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000014493 regulation of gene expression Effects 0.000 description 1
• 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
• 201000010174 renal carcinoma Diseases 0.000 description 1
• 230000010076 replication Effects 0.000 description 1
• 230000003938 response to stress Effects 0.000 description 1
• 230000007441 retrograde transport Effects 0.000 description 1
• 230000001177 retroviral effect Effects 0.000 description 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 210000003705 ribosome Anatomy 0.000 description 1
• 230000009962 secretion pathway Effects 0.000 description 1
• 238000005204 segregation Methods 0.000 description 1
• 230000008684 selective degradation Effects 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 238000002864 sequence alignment Methods 0.000 description 1
• 102000034285 signal transducing proteins Human genes 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 239000007790 solid phase Substances 0.000 description 1
• 238000000638 solvent extraction Methods 0.000 description 1
• 238000000527 sonication Methods 0.000 description 1
• 230000009870 specific binding Effects 0.000 description 1
• 210000003802 sputum Anatomy 0.000 description 1
• 208000024794 sputum Diseases 0.000 description 1
• 108700026239 src Genes Proteins 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 230000004960 subcellular localization Effects 0.000 description 1
• 238000010998 test method Methods 0.000 description 1
• MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
• 229940126585 therapeutic drug Drugs 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 239000005495 thyroid hormone Substances 0.000 description 1
• 229940036555 thyroid hormone Drugs 0.000 description 1
• 101150062121 tollip gene Proteins 0.000 description 1
• 108010069411 transcription factor S-II Proteins 0.000 description 1
• 230000009466 transformation Effects 0.000 description 1
• 102000035160 transmembrane proteins Human genes 0.000 description 1
• 108091005703 transmembrane proteins Proteins 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
• 238000010396 two-hybrid screening Methods 0.000 description 1
• ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
• HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
• 241001430294 unidentified retrovirus Species 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 210000004291 uterus Anatomy 0.000 description 1
• 230000007486 viral budding Effects 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 210000002845 virion Anatomy 0.000 description 1
• WCNMEQDMUYVWMJ-JPZHCBQBSA-N wybutoxosine Chemical compound C1=NC=2C(=O)N3C(CC([C@H](NC(=O)OC)C(=O)OC)OO)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WCNMEQDMUYVWMJ-JPZHCBQBSA-N 0.000 description 1
• 101150000251 xiap gene Proteins 0.000 description 1
• 230000004572 zinc-binding Effects 0.000 description 1