TWI330183B
(en)
|
2001-10-22 |
2010-09-11 |
Eisai R&D Man Co Ltd |
|
AU2002950853A0
(en)
*
|
2002-08-19 |
2002-09-12 |
Fujisawa Pharmaceutical Co., Ltd. |
Aminopyrimidine compound and pharmaceutical use thereof
|
ES2229928B1
(en)
*
|
2003-10-02 |
2006-07-01 |
Almirall Prodesfarma, S.A. |
NEW DERIVATIVES OF PIRIMIDIN-2-AMINA.
|
GB0323137D0
(en)
|
2003-10-03 |
2003-11-05 |
Chang Lisa C W |
2,4,6- Trisubstituted pyrimidines and their different uses
|
GB0323138D0
(en)
*
|
2003-10-03 |
2003-11-05 |
Chang Lisa C W |
Pyrimidines substituted in the 2,4,6 positions and their different uses
|
US20070099938A1
(en)
*
|
2003-10-24 |
2007-05-03 |
Ono Pharmaceutical Co., Ltd. |
Antistress drug and medical use thereof
|
EP1678160A1
(en)
*
|
2003-10-27 |
2006-07-12 |
Astellas Pharma Inc. |
Pyrazine derivatives and pharmaceutical use thereof
|
UA83101C2
(en)
*
|
2003-12-15 |
2008-06-10 |
Алмирал Аг |
2,6-bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists
|
PT1700856E
(en)
|
2003-12-26 |
2016-02-19 |
Kyowa Hakko Kirin Co Ltd |
Thiazole derivative
|
US20080125403A1
(en)
|
2004-04-02 |
2008-05-29 |
Merck & Co., Inc. |
Method of Treating Men with Metabolic and Anthropometric Disorders
|
EP1732541A4
(en)
*
|
2004-04-07 |
2008-03-05 |
Takeda Pharmaceutical |
Cyclic compounds
|
GB2416125A
(en)
*
|
2004-07-15 |
2006-01-18 |
Michael James Hill |
Device for supplying fluid to an ear
|
EP1831225A2
(en)
*
|
2004-11-19 |
2007-09-12 |
The Regents of the University of California |
Anti-inflammatory pyrazolopyrimidines
|
GB0428514D0
(en)
*
|
2004-12-31 |
2005-02-09 |
Prosidion Ltd |
Compounds
|
US7538117B2
(en)
|
2005-03-21 |
2009-05-26 |
Eisai R&D Management Co., Ltd. |
Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds
|
US7396928B2
(en)
|
2005-03-21 |
2008-07-08 |
Eisai R&D Management Co., Ltd. |
Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same
|
KR20070112368A
(en)
|
2005-03-21 |
2007-11-23 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
Pyrimidine compound crystal or amorphous form and process for producing the same
|
EP1888565B1
(en)
*
|
2005-04-11 |
2011-03-23 |
Almirall, S.A. |
2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists
|
AU2006244072B2
(en)
|
2005-05-10 |
2012-09-20 |
Intermune, Inc. |
Pyridone derivatives for modulating stress-activated protein kinase system
|
JPWO2006137527A1
(en)
|
2005-06-23 |
2009-01-22 |
協和発酵キリン株式会社 |
Thiazole derivative
|
ES2270715B1
(en)
*
|
2005-07-29 |
2008-04-01 |
Laboratorios Almirall S.A. |
NEW DERIVATIVES OF PIRAZINA.
|
WO2007015528A1
(en)
|
2005-08-02 |
2007-02-08 |
Kyowa Hakko Kogyo Co., Ltd. |
Agent for treating and/or preventing sleep disorder
|
ES2274712B1
(en)
*
|
2005-10-06 |
2008-03-01 |
Laboratorios Almirall S.A. |
NEW IMIDAZOPIRIDINE DERIVATIVES.
|
EP1991531A1
(en)
*
|
2006-02-28 |
2008-11-19 |
Amgen Inc. |
Cinnoline and quinoxaline derivates as phosphodiesterase 10 inhibitors
|
TWI417095B
(en)
|
2006-03-15 |
2013-12-01 |
Janssen Pharmaceuticals Inc |
1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors
|
EA200870409A1
(en)
*
|
2006-04-04 |
2009-04-28 |
Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния |
ANTAGONISTS OF KINASE PI3
|
US20080009623A1
(en)
*
|
2006-07-06 |
2008-01-10 |
Eisai R&D Management Co., Ltd. |
Pyrimidine compounds
|
JP2009286694A
(en)
*
|
2006-09-07 |
2009-12-10 |
Eisai R & D Management Co Ltd |
Salt of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1h)-one and crystal thereof
|
ES2303776B1
(en)
*
|
2006-12-29 |
2009-08-07 |
Laboratorios Almirall S.A. |
DERIVATIVES OF 5-PHENYL-6-PIRIDIN-4-IL-1,3-DIHIDRO-2H-IMIDAZO (4,5-B) PIRIDIN-2-ONA USEFUL AS ANTAGONISTS OF ADENOSINE A2B RECEIVER.
|
TW200845978A
(en)
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
TW200900065A
(en)
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
AU2008278966B2
(en)
*
|
2007-07-26 |
2012-02-23 |
Novartis Ag |
Pyrimidine derivatives useful for the treatment of inflammatory or allergic conditions
|
CN101801951B
(en)
|
2007-09-14 |
2013-11-13 |
杨森制药有限公司 |
1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones
|
WO2009046448A1
(en)
*
|
2007-10-04 |
2009-04-09 |
Intellikine, Inc. |
Chemical entities and therapeutic uses thereof
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
MX2010007418A
(en)
*
|
2008-01-04 |
2010-11-12 |
Intellikine Inc |
Certain chemical entities, compositions and methods.
|
US8993580B2
(en)
|
2008-03-14 |
2015-03-31 |
Intellikine Llc |
Benzothiazole kinase inhibitors and methods of use
|
US8637542B2
(en)
*
|
2008-03-14 |
2014-01-28 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
EP2268641B1
(en)
|
2008-03-26 |
2014-09-03 |
Advinus Therapeutics Pvt. Ltd. |
Heterocyclic compounds as adenosine receptor antagonist
|
US8304413B2
(en)
*
|
2008-06-03 |
2012-11-06 |
Intermune, Inc. |
Compounds and methods for treating inflammatory and fibrotic disorders
|
CN101343253B
(en)
*
|
2008-06-24 |
2011-03-16 |
陕西师范大学 |
2-amido-4, 5-diaryl miazines compound, preparation and pharmaceutical use thereof
|
BRPI0915231A2
(en)
|
2008-07-08 |
2018-06-12 |
Intellikine Inc |
kinase inhibitor compounds and methods of use
|
US20110224223A1
(en)
*
|
2008-07-08 |
2011-09-15 |
The Regents Of The University Of California, A California Corporation |
MTOR Modulators and Uses Thereof
|
ES2439291T3
(en)
|
2008-09-02 |
2014-01-22 |
Janssen Pharmaceuticals, Inc. |
3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors
|
WO2010036380A1
(en)
|
2008-09-26 |
2010-04-01 |
Intellikine, Inc. |
Heterocyclic kinase inhibitors
|
DK2358720T3
(en)
|
2008-10-16 |
2016-06-06 |
Univ California |
Heteroarylkinaseinhibitorer fused-ring
|
US8476282B2
(en)
*
|
2008-11-03 |
2013-07-02 |
Intellikine Llc |
Benzoxazole kinase inhibitors and methods of use
|
US8691813B2
(en)
|
2008-11-28 |
2014-04-08 |
Janssen Pharmaceuticals, Inc. |
Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
|
AU2010222289B2
(en)
|
2009-03-13 |
2013-07-11 |
Advinus Therapeutics Private Limited |
Substituted fused pyrimidine compounds
|
CA2760791C
(en)
|
2009-05-07 |
2017-06-20 |
Intellikine, Inc. |
Heterocyclic compounds and uses thereof
|
MX2011011962A
(en)
|
2009-05-12 |
2012-02-28 |
Janssen Pharmaceuticals Inc |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors.
|
ME01573B
(en)
|
2009-05-12 |
2014-09-20 |
Addex Pharma Sa |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
US8980899B2
(en)
|
2009-10-16 |
2015-03-17 |
The Regents Of The University Of California |
Methods of inhibiting Ire1
|
JP5843778B2
(en)
|
2009-11-09 |
2016-01-13 |
アドヴィナス・セラピューティックス・リミテッド |
Substituted fused pyrimidine compounds, their preparation and their use
|
KR20130044381A
(en)
*
|
2010-03-04 |
2013-05-02 |
머크 샤프 앤드 돔 코포레이션 |
Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders
|
ES2365960B1
(en)
*
|
2010-03-31 |
2012-06-04 |
Palobiofarma, S.L |
NEW ANTAGONISTS OF ADENOSINE RECEPTORS.
|
EP2571357B1
(en)
|
2010-05-21 |
2016-07-06 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
WO2012027331A1
(en)
|
2010-08-27 |
2012-03-01 |
Ironwood Pharmaceuticals, Inc. |
Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
|
AU2011303420B2
(en)
|
2010-09-13 |
2014-03-20 |
Impetis Biosciences Ltd. |
Purine compounds as prodrugs of A2B adenosine receptor antagonists, their process and medicinal applications
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
WO2012039718A1
(en)
|
2010-09-24 |
2012-03-29 |
N30 Pharmaceuticals, Llc |
Novel dihydropyrimidin-2(1h)-one compounds as neurokinin-3 receptor antagonists
|
AU2011328195B2
(en)
|
2010-11-08 |
2015-04-02 |
Janssen Pharmaceuticals, Inc. |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
|
US9271967B2
(en)
|
2010-11-08 |
2016-03-01 |
Janssen Pharmaceuticals, Inc. |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
|
JP5852666B2
(en)
|
2010-11-08 |
2016-02-03 |
ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド |
1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor
|
WO2012064973A2
(en)
|
2010-11-10 |
2012-05-18 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
AR084824A1
(en)
|
2011-01-10 |
2013-06-26 |
Intellikine Inc |
PROCESSES TO PREPARE ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONAS
|
AR085397A1
(en)
|
2011-02-23 |
2013-09-25 |
Intellikine Inc |
COMBINATION OF QUINASA INHIBITORS AND THEIR USES
|
CZ305457B6
(en)
*
|
2011-02-28 |
2015-09-30 |
Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. |
Pyrimidine compounds inhibiting formation of nitrogen monoxide and prostaglandin E2, process for their preparation and use
|
CN103946226A
(en)
|
2011-07-19 |
2014-07-23 |
无限药品股份有限公司 |
Heterocyclic compounds and uses thereof
|
AU2012284088B2
(en)
|
2011-07-19 |
2015-10-08 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
WO2013032591A1
(en)
|
2011-08-29 |
2013-03-07 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
AU2012341028C1
(en)
|
2011-09-02 |
2017-10-19 |
Mount Sinai School Of Medicine |
Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
|
SI3321262T1
(en)
*
|
2012-03-01 |
2021-04-30 |
Array Biopharma, Inc. |
Serine/threonine kinase inhibitors
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
WO2014052669A1
(en)
|
2012-09-26 |
2014-04-03 |
The Regents Of The University Of California |
Modulation of ire1
|
AR092742A1
(en)
|
2012-10-02 |
2015-04-29 |
Intermune Inc |
ANTIFIBROTIC PYRIDINONES
|
WO2014081617A1
(en)
*
|
2012-11-20 |
2014-05-30 |
Merck Sharp & Dohme Corp. |
Substituted pyridone derivatives as pde10 inhibitors
|
KR101529496B1
(en)
*
|
2012-12-27 |
2015-06-22 |
한국과학기술원 |
poly(amide imide) having low thermal expansion coefficient
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
JO3368B1
(en)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
US10011637B2
(en)
|
2013-06-05 |
2018-07-03 |
Synergy Pharmaceuticals, Inc. |
Ultra-pure agonists of guanylate cyclase C, method of making and using same
|
JO3367B1
(en)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
JP6466924B2
(en)
|
2013-10-04 |
2019-02-06 |
インフィニティー ファーマシューティカルズ, インコーポレイテッド |
Heterocyclic compounds and uses thereof
|
WO2015051241A1
(en)
|
2013-10-04 |
2015-04-09 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
PL3096790T3
(en)
|
2014-01-21 |
2020-01-31 |
Janssen Pharmaceutica, N.V. |
Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
|
KR20200036063A
(en)
|
2014-01-21 |
2020-04-06 |
얀센 파마슈티카 엔.브이. |
Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
|
EP3138839B1
(en)
*
|
2014-02-14 |
2020-10-28 |
Sichuan Haisco Pharmaceutical Co., Ltd. |
Pyridone or pyrimidone derivative, preparation method therefor and application thereof
|
US9775844B2
(en)
|
2014-03-19 |
2017-10-03 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
EP3126362B1
(en)
|
2014-04-02 |
2022-01-12 |
Intermune, Inc. |
Anti-fibrotic pyridinones
|
US20150320755A1
(en)
|
2014-04-16 |
2015-11-12 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
US9708348B2
(en)
|
2014-10-03 |
2017-07-18 |
Infinity Pharmaceuticals, Inc. |
Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
|
CA2998469A1
(en)
|
2015-09-14 |
2017-03-23 |
Infinity Pharmaceuticals, Inc. |
Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
|
JP2017149663A
(en)
*
|
2016-02-24 |
2017-08-31 |
株式会社Lttバイオファーマ |
Irritable bowel syndrome therapeutic agent
|
WO2017161116A1
(en)
|
2016-03-17 |
2017-09-21 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
|
US10919914B2
(en)
|
2016-06-08 |
2021-02-16 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
SG11201811237WA
(en)
|
2016-06-24 |
2019-01-30 |
Infinity Pharmaceuticals Inc |
Combination therapies
|
EP3570844B1
(en)
|
2017-01-20 |
2023-09-06 |
Arcus Biosciences, Inc. |
Azolopyrimidine for the treatment of cancer-related disorders
|
PL3611174T3
(en)
*
|
2017-04-07 |
2022-08-08 |
Medshine Discovery Inc. |
[1,2,4]triazolo[1,5-c]pyrimidine derivative as a2a receptor inhibitor
|
US11045472B2
(en)
*
|
2017-05-05 |
2021-06-29 |
Arcus Biosciences, Inc. |
Quinazoline-pyridine derivatives for the treatment of cancer-related disorders
|
KR20200121337A
(en)
|
2018-02-16 |
2020-10-23 |
아르커스 바이오사이언시즈 인코포레이티드 |
Administration of azolopyrimidine compounds
|
CN110240593A
(en)
*
|
2018-03-09 |
2019-09-17 |
四川科伦博泰生物医药股份有限公司 |
Substituted aromatic amines compound and its preparation method and application
|
CN108314631A
(en)
*
|
2018-04-19 |
2018-07-24 |
中国科学院昆明植物研究所 |
Diaryl ethylene compounds and its pharmaceutical composition and its application
|
CN110655509B
(en)
*
|
2018-06-29 |
2023-01-24 |
江苏恒瑞医药股份有限公司 |
2-aminopyrimidine derivatives, preparation method and medical application thereof
|
CN110684020B
(en)
*
|
2018-07-05 |
2023-01-20 |
江苏恒瑞医药股份有限公司 |
2-aminopyrimidine derivatives, preparation method and medical application thereof
|
US20210355104A1
(en)
*
|
2018-07-10 |
2021-11-18 |
Nikang Therapeutics, Inc. |
Adenosine receptor binding compounds
|
CN111094254B
(en)
*
|
2018-07-12 |
2022-07-26 |
江苏恒瑞医药股份有限公司 |
Heteroaryl derivative, preparation method and application thereof in medicine
|
US20210395226A1
(en)
*
|
2018-12-28 |
2021-12-23 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Substituted aryl compound and preparation method therefor and use thereof
|
CN111377873B
(en)
*
|
2018-12-28 |
2023-03-28 |
四川科伦博泰生物医药股份有限公司 |
Aminopyrimidine compounds, their preparation and use
|
CN113166109B
(en)
|
2018-12-28 |
2024-01-02 |
四川科伦博泰生物医药股份有限公司 |
Aminopyridine compound and preparation method and application thereof
|
US10689374B1
(en)
|
2019-07-12 |
2020-06-23 |
United Arab Emirates University |
Pyrimidine-thiazolidinone derivatives
|
US10702525B1
(en)
|
2019-09-04 |
2020-07-07 |
United Arab Emirates University |
Pyrimidine derivatives as anti-diabetic agents
|
US20230145793A1
(en)
*
|
2020-03-16 |
2023-05-11 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. |
Substituted pyrimidine or pyridine amine derivative, composition thereof, and medical use thereof
|