AU2002302409A1 - Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability - Google Patents
Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stabilityInfo
- Publication number
- AU2002302409A1 AU2002302409A1 AU2002302409A AU2002302409A AU2002302409A1 AU 2002302409 A1 AU2002302409 A1 AU 2002302409A1 AU 2002302409 A AU2002302409 A AU 2002302409A AU 2002302409 A AU2002302409 A AU 2002302409A AU 2002302409 A1 AU2002302409 A1 AU 2002302409A1
- Authority
- AU
- Australia
- Prior art keywords
- zinc
- contain
- small quantity
- improved stability
- insulin preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 2
- 239000011701 zinc Substances 0.000 title 2
- 229910052725 zinc Inorganic materials 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10114178A DE10114178A1 (en) | 2001-03-23 | 2001-03-23 | Zinc-free and low-zinc insulin preparations with improved stability |
| DE10114178.5 | 2001-03-23 | ||
| PCT/EP2002/002625 WO2002076495A1 (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002302409A1 true AU2002302409A1 (en) | 2003-03-27 |
| AU2002302409B2 AU2002302409B2 (en) | 2007-01-04 |
Family
ID=7678654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002302409A Expired AU2002302409B2 (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
Country Status (32)
| Country | Link |
|---|---|
| US (5) | US6960561B2 (en) |
| EP (2) | EP1381385B1 (en) |
| JP (1) | JP4231292B2 (en) |
| KR (2) | KR20100061868A (en) |
| CN (1) | CN1273187C (en) |
| AR (2) | AR033059A1 (en) |
| AT (1) | ATE497777T1 (en) |
| AU (1) | AU2002302409B2 (en) |
| BR (1) | BRPI0208210B8 (en) |
| CA (1) | CA2441260C (en) |
| CY (2) | CY1111413T1 (en) |
| DE (2) | DE10114178A1 (en) |
| DK (2) | DK1381385T3 (en) |
| ES (2) | ES2393180T3 (en) |
| HK (1) | HK1061521A1 (en) |
| HR (1) | HRP20030765B1 (en) |
| HU (1) | HU228847B1 (en) |
| IL (2) | IL158057A0 (en) |
| ME (1) | ME00408B (en) |
| MX (1) | MXPA03007942A (en) |
| MY (1) | MY129417A (en) |
| NO (1) | NO326780B1 (en) |
| NZ (1) | NZ528335A (en) |
| PE (1) | PE20020968A1 (en) |
| PL (1) | PL205465B1 (en) |
| PT (2) | PT1381385E (en) |
| RS (1) | RS51579B (en) |
| RU (1) | RU2311922C2 (en) |
| SI (1) | SI1381385T1 (en) |
| TW (1) | TWI301761B (en) |
| WO (1) | WO2002076495A1 (en) |
| ZA (1) | ZA200306637B (en) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL131796A0 (en) * | 1997-03-20 | 2001-03-19 | Novo Nordisk As | Zinc free insulin crystals for use in pulmonary compositions |
| DE10114178A1 (en) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinc-free and low-zinc insulin preparations with improved stability |
| US20050250676A1 (en) * | 2001-11-19 | 2005-11-10 | Aventis Pharma Deutschland Gmbh | Method of activating insulin receptor substrate-2 to stimulate insulin production |
| DE10227232A1 (en) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Sour insulin preparations with improved stability |
| US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
| DE10250297A1 (en) * | 2002-10-29 | 2004-05-19 | Aventis Pharma Deutschland Gmbh | Insulin analog crystals and process for their preparation |
| WO2004096266A1 (en) * | 2003-05-02 | 2004-11-11 | Novo Nordisk A/S | Improved physical stability of insulin formulations |
| BRPI0413276B8 (en) | 2003-08-05 | 2021-05-25 | Novo Nordisk As | insulin derivative, zinc complex thereof, and pharmaceutical composition |
| WO2005072803A1 (en) * | 2004-01-16 | 2005-08-11 | Biodel, Inc. | Sublingual drug delivery device |
| WO2005084637A2 (en) * | 2004-02-13 | 2005-09-15 | Nod Pharmaceuticals, Inc. | Particles comprising a core of calcium phosphate nanoparticles, a biomolecule and a bile acid, methods of manufacturing, therapeutic use thereof |
| ATE433746T1 (en) * | 2004-03-12 | 2009-07-15 | Biodel Inc | INSULIN COMPOSITIONS WITH IMPROVED ACTIVE ABSORPTION |
| US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| EP2626368B1 (en) | 2004-07-19 | 2016-12-21 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
| JP2006087815A (en) * | 2004-09-27 | 2006-04-06 | Canon Inc | Spraying method, and spraying apparatus based on the method |
| US20060194762A1 (en) * | 2004-12-23 | 2006-08-31 | Olaf Reer | Composition comprising an epothilone and methods for producing a composition comprising an epothilone |
| US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| ES2371361T3 (en) * | 2005-12-28 | 2011-12-30 | Novo Nordisk A/S | COMPOSITIONS THAT INCLUDE AN INSULIN ACILADA AND ZINC AND METHOD OF PRODUCTION OF SUCH COMPOSITIONS. |
| CA2649109A1 (en) | 2006-04-12 | 2007-10-25 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
| WO2007121318A2 (en) | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| US7714025B2 (en) * | 2006-05-10 | 2010-05-11 | Arizona Biomedical Research Commission | Modified chalcone compounds as antimitotic agents |
| WO2008132229A2 (en) * | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Highly concentrated insulin solutions and compositions |
| EP2167032B1 (en) * | 2007-06-13 | 2019-08-07 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
| WO2009065126A2 (en) * | 2007-11-16 | 2009-05-22 | Boston Protein Solutions | Excipients for protein stabilization |
| EP2231191A2 (en) * | 2007-12-11 | 2010-09-29 | ConjuChem Biotechnologies Inc. | Formulation of insulinotropic peptide conjugates |
| CA2711749A1 (en) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Novel insulin derivatives having an extremely delayed time-action profile |
| KR101239008B1 (en) * | 2008-03-31 | 2013-03-04 | 한양대학교 산학협력단 | Bile acid derivatives and their applications |
| JP2010063762A (en) * | 2008-09-12 | 2010-03-25 | Yoshiharu Masui | Antibacterial deodorant |
| RS56632B1 (en) | 2008-10-17 | 2018-03-30 | Sanofi Aventis Deutschland | Combination of an insulin and a glp-1 agonist |
| BRPI0919946A2 (en) | 2008-10-30 | 2016-02-16 | Novo Nordisk As | diabetes mellitus treatment using insulin injections with less than daily injection frequency |
| US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| ES2543705T3 (en) * | 2009-06-26 | 2015-08-21 | Novo Nordisk A/S | Preparation containing insulin, nicotinamide and arginine |
| SG177567A1 (en) * | 2009-07-06 | 2012-02-28 | Sanofi Aventis Deutschland | Aqueous insulin preparations containing methionine |
| AU2010317995B2 (en) | 2009-11-13 | 2014-04-17 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine |
| CN102711804B (en) | 2009-11-13 | 2015-09-16 | 赛诺菲-安万特德国有限公司 | Comprise the pharmaceutical composition of GLP-1 agonist and methionine |
| CN101912600B (en) * | 2010-01-11 | 2014-01-29 | 杨国汉 | Method for improving stability of insulin in solution |
| JP6199186B2 (en) | 2010-08-30 | 2017-09-20 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes |
| RU2013123515A (en) | 2010-10-27 | 2014-12-10 | Ново Нордиск А/С | DIABETES TREATMENT USING INSULIN INJECTIONS INJECTED WITH VARIOUS INTERVALS |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| JP6367115B2 (en) | 2011-08-29 | 2018-08-01 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Combination medicine used for blood glucose control in patients with type 2 diabetes |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| EP2771026A4 (en) | 2011-10-27 | 2015-08-05 | Univ Case Western Reserve | Ultra-concentrated rapid-acting insulin analogue formulations |
| CN104902922B (en) | 2012-11-13 | 2017-12-12 | 阿道恰公司 | Include the Insulin Aspart for being substituted anionic compound |
| TWI780236B (en) | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| JP6457484B2 (en) | 2013-04-03 | 2019-01-23 | サノフイＳａｎｏｆｉ | Treatment of diabetes with long-acting insulin preparations |
| US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
| AR098168A1 (en) | 2013-10-25 | 2016-05-04 | Sanofi Sa | STABLE FORMULATION OF GLULISINE INSULIN |
| MX2016008978A (en) | 2014-01-09 | 2016-10-04 | Sanofi Sa | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives. |
| CN112957455A (en) | 2014-01-09 | 2021-06-15 | 赛诺菲 | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| CN105899190B (en) | 2014-01-09 | 2022-06-14 | 赛诺菲 | Stabilized pharmaceutical formulations of insulin aspart |
| AR099569A1 (en) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | INSULIN DERIVATIVES AND THE MEDICAL USES OF THESE |
| US10314911B2 (en) | 2014-04-08 | 2019-06-11 | Healthpartners Research & Education | Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin |
| MX2017007699A (en) | 2014-12-12 | 2017-09-18 | Sanofi Aventis Deutschland | Insulin glargine/lixisenatide fixed ratio formulation. |
| AR102869A1 (en) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | QUICK ACTION INSULIN COMPOSITIONS |
| TWI748945B (en) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | Treatment type 2 diabetes mellitus patients |
| TW201705975A (en) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | Treatment of type 2 diabetes mellitus patients |
| US20180244743A1 (en) | 2015-08-25 | 2018-08-30 | Novo Nordisk A/S | Novel Insulin Derivatives and the Medical Uses Hereof |
| US20190010206A1 (en) | 2015-08-25 | 2019-01-10 | Novo Nordisk A/S | Novel Insulin Derivatives and the Medical Uses Hereof |
| TW201717998A (en) | 2015-08-25 | 2017-06-01 | 諾佛 儂迪克股份有限公司 | Novel insulin derivatives and the medical uses hereof |
| JO3749B1 (en) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | Rapid-acting insulin compositions |
| CN105749292A (en) * | 2016-02-29 | 2016-07-13 | 苏州市贝克生物科技有限公司 | Composition for promoting insulin absorption and preparation method of composition |
| GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| EP3518893A1 (en) | 2016-09-29 | 2019-08-07 | Arecor Limited | Novel formulations |
| GB201707187D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| GB201707188D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| GB201707189D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| AU2018275545B2 (en) | 2017-06-01 | 2021-02-04 | Eli Lilly And Company | Rapid-acting insulin compositions |
| US20210113763A1 (en) | 2018-04-04 | 2021-04-22 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
| KR20200139700A (en) | 2018-04-04 | 2020-12-14 | 아레콜 리미티드 | Medical infusion pump system for delivery of insulin compounds |
| WO2019193353A1 (en) | 2018-04-04 | 2019-10-10 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| FR3083700B1 (en) * | 2018-07-13 | 2021-03-12 | Adocia | THERMOSTABLE FORMULATION OF HUMAN INSULIN A21G |
| WO2020106704A2 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| BR112022007593A2 (en) | 2019-10-25 | 2022-08-23 | Cercacor Lab Inc | INDICATOR COMPOUNDS, DEVICES INCLUDING INDICATOR COMPOUNDS AND MANUFACTURING AND USE METHODS |
| BR112022009510A2 (en) | 2019-12-11 | 2022-08-16 | Novo Nordisk As | INSULIN ANALOG, PHARMACEUTICAL COMPOSITION, AND, METHOD OF TREATMENT, PREVENTION, OR ALLIEF OF A DISEASE OR DISORDER OR CONDITION |
| WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| GB202004814D0 (en) | 2020-04-01 | 2020-05-13 | Arecor Ltd | Novel formulations |
Family Cites Families (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3758683A (en) | 1971-04-30 | 1973-09-11 | R Jackson | Insulin product |
| US3868358A (en) | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
| US4153689A (en) * | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
| GB1527605A (en) | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
| US4783441A (en) | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
| EP0018609B1 (en) | 1979-04-30 | 1983-09-21 | Hoechst Aktiengesellschaft | Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization |
| JPS55153712A (en) | 1979-05-18 | 1980-11-29 | Kao Corp | Insulin pharmaceutical preparation and its production |
| DE3033127A1 (en) | 1980-09-03 | 1982-04-08 | Hoechst Ag, 6000 Frankfurt | NEW INSULIN ANALOG |
| AU558474B2 (en) | 1981-07-17 | 1987-01-29 | Nordisk Insulinlaboratorium | A stable aqueous, therapeutic insulin preparation and a process for preparing it |
| NL193099C (en) | 1981-10-30 | 1998-11-03 | Novo Industri As | Stabilized insulin solution. |
| DE3316363A1 (en) | 1983-05-05 | 1984-11-08 | Deutsche Babcock Anlagen Ag, 4200 Oberhausen | ROLLER GRID FOR WASTE COMBUSTION PLANTS |
| DE3326473A1 (en) | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | PHARMACEUTICAL AGENT FOR TREATING THE DIABETES MELLITUS |
| DE3326472A1 (en) | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | NEW INSULIN DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR TREATING THE DIABETES MELLITUS |
| DE3327709A1 (en) | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | INSULIN DERIVATIVE CRYSTAL SUSPENSIONS, METHOD FOR THE PRODUCTION AND USE THEREOF |
| DE3327713A1 (en) | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | WATER-SOLUBLE DISAZO COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS DYES |
| CA1244347A (en) * | 1984-05-29 | 1988-11-08 | Eddie H. Massey | Stabilized insulin formulations |
| US4839341A (en) | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
| ATE50502T1 (en) | 1984-06-09 | 1990-03-15 | Hoechst Ag | INSULIN PREPARATIONS, PROCESSES FOR THEIR MANUFACTURE AND THEIR USE. |
| KR860001166B1 (en) * | 1984-06-15 | 1986-08-20 | 곽성일 | A method of manufacturing eyelets for footwears |
| DE3440988A1 (en) | 1984-11-09 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | METHOD FOR CLEAVING PEPTIDES AND PROTEINS ON THE METHIONYL BOND |
| US5008241A (en) | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| DK113585D0 (en) | 1985-03-12 | 1985-03-12 | Novo Industri As | NEW PEPTIDES |
| DK347086D0 (en) | 1986-07-21 | 1986-07-21 | Novo Industri As | NOVEL PEPTIDES |
| EP0200383A3 (en) * | 1985-04-15 | 1987-09-02 | Eli Lilly And Company | An improved method for administering insulin |
| DE3526995A1 (en) | 1985-07-27 | 1987-02-05 | Hoechst Ag | FUSION PROTEINS, METHOD FOR THEIR PRODUCTION AND THEIR USE |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US5496924A (en) | 1985-11-27 | 1996-03-05 | Hoechst Aktiengesellschaft | Fusion protein comprising an interleukin-2 fragment ballast portion |
| DE3541856A1 (en) | 1985-11-27 | 1987-06-04 | Hoechst Ag | EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS |
| CA1275922C (en) | 1985-11-28 | 1990-11-06 | Harunobu Amagase | Treatment of cancer |
| DE3544295A1 (en) | 1985-12-14 | 1987-06-19 | Bayer Ag | THERMOPLASTIC MOLDS WITH HIGH CROSS-CURRENT RESISTANCE |
| PH23446A (en) | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| IE62879B1 (en) | 1987-02-25 | 1995-03-08 | Novo Nordisk As | Novel insulin derivatives |
| US5034415A (en) | 1987-08-07 | 1991-07-23 | Century Laboratories, Inc. | Treatment of diabetes mellitus |
| DE3726655A1 (en) | 1987-08-11 | 1989-02-23 | Hoechst Ag | METHOD FOR ISOLATING BASIC PROTEINS FROM PROTEIN MIXTURES CONTAINING SUCH BASIC PROTEINS |
| DK257988D0 (en) | 1988-05-11 | 1988-05-11 | Novo Industri As | NEW PEPTIDES |
| US6875589B1 (en) | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
| DE3827533A1 (en) | 1988-08-13 | 1990-02-15 | Hoechst Ag | PHARMACEUTICAL PREPARATION FOR TREATING THE DIABETES MELLITUS |
| DE3837825A1 (en) | 1988-11-08 | 1990-05-10 | Hoechst Ag | NEW INSULIN DERIVATIVES, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM |
| JPH04502465A (en) | 1988-12-23 | 1992-05-07 | ノボ ノルディスク アクティーゼルスカブ | human insulin analogue |
| US4994439A (en) | 1989-01-19 | 1991-02-19 | California Biotechnology Inc. | Transmembrane formulations for drug administration |
| NZ232375A (en) | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| US5358857A (en) | 1989-08-29 | 1994-10-25 | The General Hospital Corp. | Method of preparing fusion proteins |
| ATE164080T1 (en) | 1990-05-10 | 1998-04-15 | Bechgaard Int Res | PHARMACEUTICAL PREPARATION CONTAINING N-GLYCOFUROLES AND N-ETHYLENE GLYCOLS |
| US5397771A (en) | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
| DK155690D0 (en) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | NEW PEPTIDES |
| DK10191D0 (en) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | HIS UNKNOWN PEPTIDES |
| US5614219A (en) | 1991-12-05 | 1997-03-25 | Alfatec-Pharma Gmbh | Oral administration form for peptide pharmaceutical substances, in particular insulin |
| US6468959B1 (en) | 1991-12-05 | 2002-10-22 | Alfatec-Pharm Gmbh | Peroral dosage form for peptide containing medicaments, in particular insulin |
| DK0615445T3 (en) | 1991-12-05 | 1996-06-03 | Alfatec Pharma Gmbh | Pharmaceutically manageable nanosol and method of preparation thereof |
| ES2097426T3 (en) | 1992-12-02 | 1997-04-01 | Hoechst Ag | PROCEDURE FOR OBTAINING PROINSULIN WITH CORRECTLY UNITED CYSTINE BRIDGES. |
| PL310007A1 (en) | 1992-12-18 | 1995-11-13 | Lilly Co Eli | Insulin analogues |
| DE4400709B4 (en) * | 1993-01-13 | 2005-06-23 | Denso Corp., Kariya | Screw fastening device |
| US5606203A (en) * | 1993-01-20 | 1997-02-25 | Kabushiki Kaisha Toshiba | Semiconductor device having Al-Cu wiring lines where Cu concentration is related to line width |
| US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
| US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| DE4405179A1 (en) | 1994-02-18 | 1995-08-24 | Hoechst Ag | Method of obtaining insulin with correctly connected cystine bridges |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5559094A (en) | 1994-08-02 | 1996-09-24 | Eli Lilly And Company | AspB1 insulin analogs |
| ES2151079T3 (en) | 1994-09-09 | 2000-12-16 | Takeda Chemical Industries Ltd | PREPARATION OF SUSTAINED RELEASE CONTAINING A METALLIC SALT OF A PEPTIDE. |
| US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
| US5824638A (en) | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
| WO1996041606A2 (en) | 1995-06-08 | 1996-12-27 | Therexsys Limited | Improved pharmaceutical compositions for gene therapy |
| CA2224381A1 (en) | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
| DE19545257A1 (en) | 1995-11-24 | 1997-06-19 | Schering Ag | Process for the production of morphologically uniform microcapsules and microcapsules produced by this process |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5866538A (en) | 1996-06-20 | 1999-02-02 | Novo Nordisk A/S | Insulin preparations containing NaCl |
| US5948751A (en) | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
| US5783556A (en) | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
| DE19707245A1 (en) * | 1997-02-25 | 1998-08-27 | Patent Treuhand Ges Fuer Elektrische Gluehlampen Mbh | Method of making an electric light bulb |
| US6310038B1 (en) | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
| US6043214A (en) | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
| IL131796A0 (en) * | 1997-03-20 | 2001-03-19 | Novo Nordisk As | Zinc free insulin crystals for use in pulmonary compositions |
| PE79099A1 (en) | 1997-06-13 | 1999-08-24 | Lilly Co Eli | STABLE INSULIN FORMULATIONS |
| DE19726167B4 (en) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, process for its preparation and pharmaceutical preparation containing it |
| ZA989744B (en) | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
| EP1030688B1 (en) | 1997-11-12 | 2004-09-29 | Alza Corporation | Method for dermally administering polypeptides |
| DE69924232D1 (en) | 1998-01-09 | 2005-04-21 | Novo Nordisk As | STABILIZED INSULIN PREPARATIONS |
| CN1210058C (en) | 1998-10-16 | 2005-07-13 | 诺沃挪第克公司 | Stable concentrated insulin preparations for pulmonary delivery |
| EP1121145B1 (en) | 1998-10-16 | 2002-04-17 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
| US6211144B1 (en) * | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
| US6635617B1 (en) | 1998-10-16 | 2003-10-21 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
| JP2002529514A (en) | 1998-11-18 | 2002-09-10 | ノボ ノルディスク アクティーゼルスカブ | Stable aqueous insulin preparation without phenol and cresol |
| US6489292B1 (en) | 1998-11-18 | 2002-12-03 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
| DE19908041A1 (en) * | 1999-02-24 | 2000-08-31 | Hoecker Hartwig | Covalently bridged insulin dimers |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6485706B1 (en) * | 1999-06-04 | 2002-11-26 | Delrx Pharmaceutical Corp. | Formulations comprising dehydrated particles of pharma-ceutical agents and process for preparing the same |
| AU5760900A (en) | 1999-06-25 | 2001-01-31 | Minimed, Inc. | Multiple agent diabetes therapy |
| US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| KR100801588B1 (en) | 1999-09-21 | 2008-02-05 | 스키에파마 캐나다 인코포레이티드 | Surface Modified Particulate Compositions of Biological Active Substances |
| US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| AU2001220765A1 (en) | 2000-01-24 | 2001-07-31 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
| WO2001093837A2 (en) | 2000-06-08 | 2001-12-13 | Eli Lilly And Company | Protein powder for pulmonary delivery |
| KR100508695B1 (en) | 2001-02-13 | 2005-08-17 | 한국과학기술연구원 | Formulation for oral delivery of insulin and preparation method thereof |
| DE10114178A1 (en) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinc-free and low-zinc insulin preparations with improved stability |
| CN1160122C (en) | 2001-04-20 | 2004-08-04 | 清华大学 | Method of preparing oil-phase oral insulin preparation |
| US20040265268A1 (en) | 2001-08-18 | 2004-12-30 | Deepak Jain | Compositions and methods for skin rejuvenation and repair |
| US20050123509A1 (en) | 2001-10-19 | 2005-06-09 | Lehrman S. R. | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
| AU2002335046A1 (en) | 2001-10-19 | 2003-05-06 | Inhale Therapeutic Systems, Inc. | The use of proton sequestering agents in drug formulations |
| US20060287221A1 (en) | 2003-11-13 | 2006-12-21 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia |
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2001
- 2001-03-23 DE DE10114178A patent/DE10114178A1/en not_active Ceased
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2002
- 2002-03-09 RU RU2003131187/15A patent/RU2311922C2/en active
- 2002-03-09 ES ES10178836T patent/ES2393180T3/en not_active Expired - Lifetime
- 2002-03-09 KR KR1020107011428A patent/KR20100061868A/en not_active Application Discontinuation
- 2002-03-09 KR KR1020037012339A patent/KR100987311B1/en active IP Right Grant
- 2002-03-09 DK DK02729985.8T patent/DK1381385T3/en active
- 2002-03-09 IL IL15805702A patent/IL158057A0/en unknown
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- 2002-03-09 EP EP02729985A patent/EP1381385B1/en not_active Expired - Lifetime
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- 2002-03-09 WO PCT/EP2002/002625 patent/WO2002076495A1/en active Application Filing
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- 2002-03-09 CA CA2441260A patent/CA2441260C/en not_active Expired - Lifetime
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2004
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2007
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