AU2002253043A1 - New phenylpiperazines - Google Patents
New phenylpiperazinesInfo
- Publication number
- AU2002253043A1 AU2002253043A1 AU2002253043A AU2002253043A AU2002253043A1 AU 2002253043 A1 AU2002253043 A1 AU 2002253043A1 AU 2002253043 A AU2002253043 A AU 2002253043A AU 2002253043 A AU2002253043 A AU 2002253043A AU 2002253043 A1 AU2002253043 A1 AU 2002253043A1
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- AU
- Australia
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Description
New phenylpiperazines
The invention relates to novel phenylpiperazine derivatives of the formula (1 ):
wherein:
- R is a group of the formula (a) or (b)
(a)
(b)
and salts thereof.
It has been found that the compounds according to the invention show high affinity for both the dopamine D2 receptor and the serotonin reuptake site. This combination is useful for the treatment of psychotic disorders like schizophrenia (treating both positive and negative symptoms), and other psychiatric disorders.
The compounds show activity as (partial) agonists which makes them suited as well for the treatment of Parkinson's disease.
The compounds show antagonist activity at dopamine D2 receptors as they antagonize apomorphine-induced climbing behaviour in mice. The compounds also
show activity as inhibitors of serotonin reuptake as they potentiate 5-HTP induced behaviour in mice.
The compounds are active in therapeutic models sensitive to clinically relevant antipsychotics (e.g. the conditioned avoidance response; Van der Heyden & Bradford, Behav. Brain Res., 1988, 31 :61-67) and antidepressants or anxiolytics (e.g. suppression of stress-induced vocalization; van der Poel et al., Psychopharmacology, 1989, 97: 147-148).
The compounds are active in clinically relevant models for Parkinson's disease (e.g. turning rat behaviour; U. Ungerstedt, Acta Physiol. Scand., 1971 , 82 (suppl. 367): 69- 93).
In contrast to clinically relevant dopamine D2 receptor antagonists the described compounds have a low propensity to induce catalepsy in rodents and as such are likely to induce less extrapyrimidal side effects than existing antipsychotic agents.
The inhibitory activity of serotonin reuptake inherent in these compounds may be responsible for the therapeutic effects observed in behavioural models sensitive to either antidepressants or anxiolytics.
The compounds can be used for the treatment of affections or diseases of the central nervous system caused by disturbances in either the dopaminergic or serotonergic systems, for example: aggression, anxiety disorders, autism, vertigo, depression, disturbances of cognition or memory, Parkinson's disease and in schizophrenia and other psychotic disorders.
Pharmacologically acceptable acids with which the compounds of the invention can form suitable acid addition salts are for example hydrochloric acid, sulphuric acid, phosphoric acid, nitric acid, and organic acids such as citric acid, fumaric acid, maleic acid, tartaric acid, acetic acid, benzoic acid, p-toluene sulphonic acid, methanesulphonic acid and naphthalene sulphonic acid.
The compounds and their acid addition salts can be brought into forms suitable for administration by means of suitable processes using auxiliary substances such as liquid and solid carrier materials.
The compounds having formula (1) can be prepared by reaction of a compound of the formula
under basic conditions with a compound of the formula
L - (a) or L - (b)
in which formulae (a) and (b) have the meanings given above, and L is a so-called leaving group such as a halogen atom or a mesylate group.
The piperazine compound having formula (2) can be obtained as described in EP 0189612.
The starting materials of the formula L - (a) can be obtained according to the following scheme:
1p6 1p5 1 p4
Scheme A
Compound 1p2 can be obtained from 1p1 in the same manner as compound 2p4, i.e. compound L - (b) wherein L is the mesylate group, from compound 2p3 (see Scheme B below).
2p1 2p2 2p3 'v'c ^' 2p4
Scheme B The invention is illustrated by means of the following Examples.
Example 1
18.1 g (0.1 mol) of 2p1 was dissolved in 250 ml of CH2CI2 and brought to 0 °C. A solution, made from 50 ml of concentrated sulfuric acid poured on 200 g of ice, was added to the CH2CI2 solution. The resulting mixture was maintained at 0 °C by applying an ice/acetone cooling bath. To the latter solution, 8.3 g (0.12 mol) of NaNO2 dissolved in 50 ml of water, was added dropwise, while the temperature was kept below 2 °C. Stirring was continued for 1 hour. Subsequently, the organic layer was separated, the water layer extracted (CH2CI2) once, the combined organic fractions were dried on MgSO . Removal of the drying agent by filtration and concentration in vacuo of the fillrate yielded 17.8 g (99%) of crude dark yellow 2p2. Under a nitrogen atmosphere, a solution of 17.8 g (0.099 mol) of 2p2 in 100 ml of dry THF was added dropwise very carefully to a suspension of LiAIH4 (9.75 g, 244 mmol) in refluxing dry THF. After the addition was complete, the resulting mixture was allowed to react for another 40 minutes. The reaction mixture was brought to room temperature and further cooled by an ice/ethanol cooling bath. Subsequently were added: 9.75 ml of water/THF (1/1 ), 18.5 ml of 2N NaOH(aq) and 18.5 ml of water. The resulting mixture was brought to reflux for 20 minutes. After cooling down, the reaction mixture was filtered (Hyflo), the resulting filtrate was concentrated in vacuo, yielding 15.9 g of residue. The latter was dissolved in 98 ml of 1 N HCI in EtOAc, the resulting precipitate was filtered yielding 17.5 g (87%) of 2p3.HCI.
17.5 g (86 mmol) of 2p3.HCI were dissolved in a mixture 190 ml of ethyleneglycol and 90 ml of water, the resulting solution was heated to 95 °C. Subsequently 7.96 g (94.6 mmol) of (3,4)-dihydro-2H-pyran carefully was added dropwise. After the addition was complete, stirring was continued for 3 hours at 95 °C. After the reaction mixture reached room temperature, water and some brine were added and extraction was performed with EtOAc (3x). The combined organic fractions were washed with water, NaHSO3(aq), water, NaHCO3(aq), NaCI(aq) respectively after which the organic fraction was dried on Na2SO4. Removal of the drying agent and solvent yielded a residue which was purified by column chromatogaphy (SiO2, eluent MeOH/CH2CI2 3/97), resulting in 12 g (63%) of a dark red oil containing the corresponding alcohol of 2p4 which solidified on standing. Subsequently the alcohol was converted into its mesylate by standard procedures (MsCI, diisopropylethylamine in CH2CI2, 0 °C) yielding 2p4 (98% yield). The phenylpiperazine having formula (2) was reacted with 2p4 according to the procedure mentioned in EP 0900792, yielding compound (1) wherein R is the group of formula (b); (m.p.: 182-5 °C).
Example 2
1p1 was converted into 1p2 analogously to the preparation of 2p4 (in Example 1 ). 1p2 was converted into 1p3 (98%) according to the procedure described in RajanBabu et.al., J.Org.Chem. 51 , (1986), 1704.
Under a nitrogen atmosphere, 31.9 g (103 mmol) of 1p3 were dissolved in 49 ml of DMF. The resulting solution was added slowly to a solution containing 5.88 g (134 mmol, 1.3 eq) of an oily suspension containing 55% of NaH in 148 ml of DMF, after which stirring was continued for one hour at room temperature, after which the reaction mixture was cooled (ice/water). To the latter solution, 8.34 ml (19.02 g, 134 mmol, 1.3 eq) of Mel diluted in 49 ml of DMF, were added dropwise. The reaction mixture was stirred for an additional 16 hours at room temperature. To the latter, water was added and extraction performed; Et2O (2x), the organic fraction was washed with water (2x) and brine (1x), and eventually dried on MgSO4. After removal of the drying agent and solvent in vacuo, the residu was subjected to column chromatography (SiO2, eluent: CH2CI2/hexane 3/1 ) yielding 26.2 g (79%) of 1p4 as a yellowish oil. Under a nitrogen atmosphere, 25.03 g (78 mmol) of 1p4 were dissolved in 110 ml of THF after which 93 ml (0.93 mmol, 1.2 eq.) of 1 N (nBut)4N+F in THF were added. After one hour of stirring, Et2O was added, and the resulting mixture washed with water (3x) and brine (1x). The organic layer was dried on Na2SO4. After removal of
the drying agent and the solvent, the residue was taken up in toluene and subsequently concentrated in vacuo to remove traces of (-ert.)butyltrimethylsilylfluoride. The residu was subjected to flashchromatography (SiO2, eluent Et2O), eventually yielding 14.8 g (92%) of 1p5. 1.69 g (6.45 mmol) of PPh3 and 0.44 g (6.44 mmol) of imidazole were dissolved in 20 ml of CH2CI2, after which 1.64 g (6.45 mmol) of iodine were added portionwise. The reaction mixture was stirred for another 30 minutes at room temperature. To the latter mixture 1.07 g (5.16 mmol) of 1 5 dissolved in 10 ml of CH2CI2 were added slowly. After 30 minutes the reaction mixture was washed with NaHCO3(aq), NaHSO3(aq) and brine, the remaining organic fraction dried on Na2SO4. After removal of the drying agent and the solvent in vacuo, the residu was dissolved in Et2O, the precipitate which formed (Ph3PO) was removed by filtration. The filtrate was concentrated in vacuo, the residue purified by flash chromatography (SiO2), eluent CH2CI2/hexane 1/1 ), yielding 1.45 g (88%) of the desired iodide 1p6. The phenylpiperazine having formula (2) was reacted with 1p6 according to the procedure described in EP 0900792, yielding compound 1 wherein R is group (a) (m.p.: 202-4 °C).
Claims (5)
1. Phenylpiperazine derivatives having formula (1)
wherein R is a group of the formula (a) or (b)
and salts thereof.
2. Method for the preparation of a compound as claimed in claim 1 , characterized in that a compound having formula (2)
is reacted under basic conditions with a compound of the formula
L - (a) or L - (b)
in which formulae L is a leaving group and (a) and (b) have the meaning given in claim 1.
3. A pharmaceutical composition containing at least one compound as claimed in claim 1 as the active component.
4. A method of treating Parkinson Disease, characterized in that a compound as claimed in claim 1 is used.
5. A method of treating CNS-disorders such as schizophrenia, anxiety and depression, characterized in that a compound as claimed in claim 1 is used.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01200609 | 2001-02-21 | ||
EP01200609.4 | 2001-02-21 | ||
PCT/EP2002/001793 WO2002066472A1 (en) | 2001-02-21 | 2002-02-19 | New phenylpiperazines |
Publications (3)
Publication Number | Publication Date |
---|---|
AU2002253043A1 true AU2002253043A1 (en) | 2003-02-27 |
AU2002253043A2 AU2002253043A2 (en) | 2003-06-19 |
AU2002253043B2 AU2002253043B2 (en) | 2006-06-08 |
Family
ID=8179908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002253043A Ceased AU2002253043B2 (en) | 2001-02-21 | 2002-02-19 | New phenylpiperazines |
Country Status (29)
Country | Link |
---|---|
US (1) | US6828325B2 (en) |
EP (1) | EP1395583B1 (en) |
JP (1) | JP4178033B2 (en) |
KR (1) | KR100848482B1 (en) |
CN (1) | CN1190433C (en) |
AR (1) | AR032711A1 (en) |
AT (1) | ATE289604T1 (en) |
AU (1) | AU2002253043B2 (en) |
BR (1) | BR0205220A (en) |
CA (1) | CA2411973A1 (en) |
CZ (1) | CZ299487B6 (en) |
DE (1) | DE60203042T2 (en) |
DK (1) | DK1395583T3 (en) |
DZ (1) | DZ3441A1 (en) |
ES (1) | ES2235029T3 (en) |
HK (1) | HK1059781A1 (en) |
HU (1) | HUP0303329A3 (en) |
IL (1) | IL153176A (en) |
MX (1) | MXPA03004242A (en) |
NO (1) | NO323781B1 (en) |
NZ (1) | NZ523135A (en) |
PL (1) | PL359650A1 (en) |
PT (1) | PT1395583E (en) |
RU (1) | RU2279431C2 (en) |
SI (1) | SI1395583T1 (en) |
SK (1) | SK286064B6 (en) |
UA (1) | UA74426C2 (en) |
WO (1) | WO2002066472A1 (en) |
ZA (1) | ZA200209897B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2246494C2 (en) * | 1999-08-23 | 2005-02-20 | Солвей Фармасьютикалс Б.В. | New phenylpiperazines |
AR032712A1 (en) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | A MESILATE OF PHENYLPIPERAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT |
DE60231507D1 (en) | 2001-07-20 | 2010-07-01 | Psychogenics Inc | TREATMENT OF HYPERACTIVITY DISORDERS AND ATTENTION DEFICITS |
EP1683790A1 (en) * | 2005-01-24 | 2006-07-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands |
GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
US8563567B2 (en) | 2009-12-30 | 2013-10-22 | Arqule, Inc. | Substituted heterocyclic compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0900792B1 (en) | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
HUP0101475A3 (en) | 1998-06-19 | 2003-01-28 | Lundbeck & Co As H | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
AR020773A1 (en) | 1998-10-16 | 2002-05-29 | Duphar Int Res | COMPOUND DERIVED FROM 3- (TETRAHYDROPIRIDIN-4-IL) INDOL, METHOD TO PREPARE IT, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, METHOD TO PREPARE SUCH COMPOSITION AND USE OF THE COMPOUND |
RU2246494C2 (en) | 1999-08-23 | 2005-02-20 | Солвей Фармасьютикалс Б.В. | New phenylpiperazines |
EP1336406A1 (en) | 2002-02-14 | 2003-08-20 | Solvay Pharmaceuticals B.V. | Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity |
-
2002
- 2002-02-18 AR ARP020100547A patent/AR032711A1/en active IP Right Grant
- 2002-02-19 IL IL153176A patent/IL153176A/en not_active IP Right Cessation
- 2002-02-19 DK DK02722107T patent/DK1395583T3/en active
- 2002-02-19 EP EP02722107A patent/EP1395583B1/en not_active Expired - Lifetime
- 2002-02-19 BR BR0205220-2A patent/BR0205220A/en not_active Application Discontinuation
- 2002-02-19 KR KR1020027016845A patent/KR100848482B1/en not_active IP Right Cessation
- 2002-02-19 CN CNB02801684XA patent/CN1190433C/en not_active Expired - Fee Related
- 2002-02-19 SI SI200230087T patent/SI1395583T1/xx unknown
- 2002-02-19 DZ DZ023441A patent/DZ3441A1/en active
- 2002-02-19 JP JP2002565986A patent/JP4178033B2/en not_active Expired - Fee Related
- 2002-02-19 UA UA2003098663A patent/UA74426C2/en unknown
- 2002-02-19 WO PCT/EP2002/001793 patent/WO2002066472A1/en active IP Right Grant
- 2002-02-19 DE DE60203042T patent/DE60203042T2/en not_active Expired - Lifetime
- 2002-02-19 CA CA002411973A patent/CA2411973A1/en not_active Abandoned
- 2002-02-19 PT PT02722107T patent/PT1395583E/en unknown
- 2002-02-19 AU AU2002253043A patent/AU2002253043B2/en not_active Ceased
- 2002-02-19 NZ NZ523135A patent/NZ523135A/en unknown
- 2002-02-19 PL PL02359650A patent/PL359650A1/en not_active IP Right Cessation
- 2002-02-19 US US10/343,232 patent/US6828325B2/en not_active Expired - Fee Related
- 2002-02-19 HU HU0303329A patent/HUP0303329A3/en unknown
- 2002-02-19 ES ES02722107T patent/ES2235029T3/en not_active Expired - Lifetime
- 2002-02-19 AT AT02722107T patent/ATE289604T1/en active
- 2002-02-19 SK SK1805-2002A patent/SK286064B6/en not_active IP Right Cessation
- 2002-02-19 RU RU2003106194/04A patent/RU2279431C2/en not_active IP Right Cessation
- 2002-02-19 CZ CZ20023933A patent/CZ299487B6/en not_active IP Right Cessation
- 2002-02-19 MX MXPA03004242A patent/MXPA03004242A/en active IP Right Grant
- 2002-12-05 ZA ZA200209897A patent/ZA200209897B/en unknown
- 2002-12-09 NO NO20025902A patent/NO323781B1/en not_active IP Right Cessation
-
2004
- 2004-04-15 HK HK04102632A patent/HK1059781A1/en not_active IP Right Cessation
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