AU2002239342A1 - Treatment of mucositis - Google Patents

Treatment of mucositis

Info

Publication number
AU2002239342A1
AU2002239342A1 AU2002239342A AU3934202A AU2002239342A1 AU 2002239342 A1 AU2002239342 A1 AU 2002239342A1 AU 2002239342 A AU2002239342 A AU 2002239342A AU 3934202 A AU3934202 A AU 3934202A AU 2002239342 A1 AU2002239342 A1 AU 2002239342A1
Authority
AU
Australia
Prior art keywords
mucositis
treatment
therapeutic composition
treating
biocompatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002239342A
Inventor
Jeffrey B. Etter
Timothy C Rodell
Gary J Rosenthal
Adrian Samaniego
Wren H. Schauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RxKinetix Inc
Original Assignee
RxKinetix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RxKinetix Inc filed Critical RxKinetix Inc
Publication of AU2002239342A1 publication Critical patent/AU2002239342A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides a therapeutic composition comprising a sulfur-containing antioxidant for use in the treatment of mucositis and the use of said composition for the manufacture of a medicament for treating different forms of mucositis. The therapeutic composition includes a pharmaceutical substance effective for treating mucositis formulated with a biocompatible polymer, such as a biocompatible reverse-thermal gelation polymer.
AU2002239342A 2000-11-22 2001-11-21 Treatment of mucositis Abandoned AU2002239342A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72151600A 2000-11-22 2000-11-22
US09/721,516 2000-11-22
PCT/US2001/044186 WO2002041837A2 (en) 2000-11-22 2001-11-21 Treatment of mucositis

Publications (1)

Publication Number Publication Date
AU2002239342A1 true AU2002239342A1 (en) 2002-06-03

Family

ID=24898290

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002239342A Abandoned AU2002239342A1 (en) 2000-11-22 2001-11-21 Treatment of mucositis

Country Status (11)

Country Link
US (5) US6685917B2 (en)
EP (2) EP1609468A3 (en)
JP (1) JP4822652B2 (en)
AT (1) ATE316786T1 (en)
AU (1) AU2002239342A1 (en)
BR (1) BRPI0115531B1 (en)
DE (1) DE60117043T2 (en)
DK (1) DK1343492T3 (en)
ES (1) ES2254523T3 (en)
MX (1) MXPA03004546A (en)
WO (1) WO2002041837A2 (en)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
US20030186882A1 (en) * 2001-07-31 2003-10-02 Podolsky Daniel K. Methods and compositions for treating and preventing distal bowel lesions
US20030185838A1 (en) * 2001-11-28 2003-10-02 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
JP4822652B2 (en) * 2000-11-22 2011-11-24 エンド ファーマシューティカルズ インコーポレイテッド Treatment of mucositis
US7538082B2 (en) * 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
JP2005503340A (en) * 2001-04-24 2005-02-03 ザ ジェネラル ホスピタル コーポレーション Methods and compositions for the treatment of oral and esophageal lesions
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
WO2003030824A2 (en) * 2001-10-05 2003-04-17 The General Hospital Corporation Methods and compositions for treating dermal lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
US6620405B2 (en) * 2001-11-01 2003-09-16 3M Innovative Properties Company Delivery of hydrogel compositions as a fine mist
CN1655675A (en) * 2002-03-26 2005-08-17 综合医院公司 Combination therapy using trefoil peptides
FR2837709B1 (en) * 2002-03-26 2005-05-13 Innovations Pharma Ag THERMOREVERSIBLE COMPOSITION FOR COMPENSATING THE HYPOSIALIES AND ASIALIES CAUSED BY XEROSTOMIES
US20060275370A1 (en) * 2002-07-25 2006-12-07 Yih-Lin Chung Method and compositions for treatment of epithelial damage
US20040057983A1 (en) 2002-09-25 2004-03-25 David Schmidt Biomolecular wearable apparatus
KR20040028336A (en) * 2002-09-30 2004-04-03 김종국 Novel composite of thermosensitive antifungal gel for vaginal administration
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
US7591999B2 (en) * 2003-03-04 2009-09-22 Mitsubishi Tanabe Pharma Corporation Powdery preparation for nasal administration
US20040198841A1 (en) * 2003-03-13 2004-10-07 Oregon Health & Science University Use of thiol-based compositions in ameliorating mucosal injury
US20050118261A1 (en) * 2003-06-12 2005-06-02 Oien Hal J. Compositions and methods of administering doxepin to mucosal tissue
US6984628B2 (en) 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
EP1675480B1 (en) * 2003-10-16 2018-06-13 Nestec S.A. Nutritional composition against side effects of chemotherapy of radiotherapy
US20050090551A1 (en) * 2003-10-27 2005-04-28 Board Of Trustees Of Southern Illinois University Therapeutic use of methionine for the treatment or prevention of mucositis
US20070003582A1 (en) * 2003-11-25 2007-01-04 Heng Madalene C Medicine for the treatment of acne and for reversing the signs of age and sun damage and method for using same
EP2813231A1 (en) 2004-01-28 2014-12-17 The Regents of The University of California Novel interstitial therapy for immediate symptom relief and chronic therapy in interstitial cystitis
WO2005087221A1 (en) * 2004-03-15 2005-09-22 Christine Allen Biodegradable biocompatible implant and method of manufacturing same
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
EP2422789B1 (en) * 2004-05-19 2017-11-22 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Injectable coposition comprising sodium deoxycholate
RU2007128819A (en) * 2005-02-16 2009-03-27 Вайет (Us) APPLICATION OF SELECTIVE BETRO-RECEPTORS OF ESTROGEN AGONISTS FOR RADIATION OR CHEMOTHERAPY CAUSED BY MUKOZYTE OR RADIATION CYSTITIS
US8075771B2 (en) * 2005-02-17 2011-12-13 E. I. Du Pont De Nemours And Company Apparatus for magnetic field gradient enhanced centrifugation
JP4732784B2 (en) * 2005-04-21 2011-07-27 興和株式会社 Panthenol-containing oral mucosal adhesive preparation
JP5032003B2 (en) * 2005-06-15 2012-09-26 株式会社琉球バイオリソース開発 Analgesic and anti-inflammatory lozenges for oral mucosa
CA2615319A1 (en) * 2005-07-13 2007-01-18 Al Czap Compositions for oral administration of sustained release glutathione, methods for their production and uses thereof
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
AU2006320538B2 (en) * 2005-11-30 2013-07-04 Endo Pharmaceuticals Inc. Treatment of xerostomia with a sulfur-containing antioxidant
WO2007107012A1 (en) * 2006-03-23 2007-09-27 Citagenix Inc. Reverse phase osteoconductive composition
EP2037941B8 (en) * 2006-05-30 2015-07-01 OraHealth Corporation Cobalamin compositions for treating or preventing mucositis
PL2035006T3 (en) 2006-06-01 2010-07-30 Nobera Pharma Sl Use of allopurinol for the treatment of palmar plantar erythrodysesthesia
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
CA2701583A1 (en) * 2007-10-03 2009-04-09 Myrex Pharmaceuticals Inc. Mouthwash and method of using same for the treatment of mucositis or stomatitis
EP2200533A1 (en) * 2007-10-22 2010-06-30 Koninklijke Philips Electronics N.V. Interproximal teeth cleaning apparatus with an air-driven spray
CN101156834B (en) * 2007-10-30 2010-08-11 深圳南粤药业有限公司 Ammonia temperature responsive form gel and its preparation method
US20090123551A1 (en) * 2007-11-13 2009-05-14 Meritage Pharma, Inc. Gastrointestinal delivery systems
SI3354276T1 (en) 2007-11-13 2020-09-30 Meritage Pharma, Inc. Compositions for the treatment of gastrointestinal inflammation
US20090123390A1 (en) * 2007-11-13 2009-05-14 Meritage Pharma, Inc. Compositions for the treatment of gastrointestinal inflammation
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20090148530A1 (en) 2007-12-08 2009-06-11 Jamie Koufman Method for prevention and treatment of reflux injury in the aerodigestive tract and laryngopharynx caused by pepsin
EP2254651A4 (en) * 2008-02-29 2013-03-06 Pluromed Inc Local embolization using thermosensitive polymers
WO2009111173A2 (en) * 2008-02-29 2009-09-11 Pluromed, Inc. Local embolization via heating of thermosensitive polymers
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
US8602961B2 (en) 2008-05-15 2013-12-10 Lifewave Products Llc Apparatus and method of stimulating elevation of glutathione levels in a subject
US20100204286A1 (en) 2009-02-12 2010-08-12 Donahue Stephen R Method for reducing gastrointestinal adverse effects of cytotoxic agents
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
EP2246057A1 (en) * 2009-04-29 2010-11-03 Nobera Pharma, S.L. Use of allopurinol for the treatment of hand foot skin reaction
RU2011150521A (en) * 2009-05-13 2013-06-20 ПРОТЕИН ДЕЛИВЕРИ СОЛЮШНЗ, ЭлЭлСи PHARMACEUTICAL SYSTEM FOR TRANSMEMBRANE DELIVERY
WO2011094504A2 (en) * 2010-01-28 2011-08-04 Ora, Inc. Antimicrobial sinus irrigation compositions, methods, and devices
US10080718B2 (en) 2010-09-01 2018-09-25 Try This First, Inc. Method of treating ear infections
US12016950B2 (en) 2010-09-01 2024-06-25 Try This First, Inc. Devices and methods for treating ear pain
IT1401894B1 (en) 2010-10-18 2013-08-28 Straccia PHARMACOLOGICAL PRESIDIUM FOR THE PREVENTION OF CARIOUS INCIDIENT LESION AND DENTAL IPERSENSIBILITY
IT1401895B1 (en) 2010-10-18 2013-08-28 Straccia NATURAL PHARMACOLOGICAL PRESIDIUM FOR THE PREVENTION OF INFLAMMATORY DISEASES OF PARODONTO.
IT1405758B1 (en) * 2010-11-03 2014-01-24 Stewart Italia Srl NAC BASED PHARMACEUTICAL PREPARATION IN HYPERTONIC SOLUTION FOR THE TREATMENT OF RINOFARINGEAL AFFECTIONS
JP2012116818A (en) * 2010-12-03 2012-06-21 Feng Chia Univ Pharmaceutical composition for treatment of urinary system disease
CA2827643C (en) 2011-02-18 2019-05-07 Kythera Biopharmaceuticals, Inc. Treatment of submental fat
FR2972327B1 (en) * 2011-03-11 2017-08-11 Laboratoires Le Stum MUCOADHESIVE NUTRACEUTICAL COMPOSITION COMPRISING ANTIOXIDANT ASSOCIATION
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
CA2860373C (en) 2011-04-29 2017-08-15 Moberg Pharma Ab Pharmaceutical compositions comprising a local anaesthetic such as bupivacaine for local administration to the mouth or throat
ITMI20110954A1 (en) * 2011-05-26 2012-11-27 Professional Dietetics Srl COMBINATIONS FOR THE TREATMENT OF VAGINAL OR RECTAL MUCOSITES
ITMI20111151A1 (en) * 2011-06-24 2012-12-25 Lo Li Pharma Srl N-ACETYL CISTEIN AND ITS COMPOSITION FOR USE IN THE TREATMENT OF VAGINAL DISORDERS.
FI20115680L (en) * 2011-06-29 2012-12-30 Biohit Oyj Liquid pharmaceutical compositions or combination products
US20130177599A1 (en) * 2012-01-06 2013-07-11 Insite Vision Incorporated Methods and kits for extending contact lens use
JP2013170156A (en) * 2012-02-22 2013-09-02 Terumo Corp Solid composition
SG11201407326XA (en) * 2012-05-23 2014-12-30 Cellix Bio Private Ltd Compositions and methods for treatment of mucositis
KR101320945B1 (en) * 2012-07-03 2013-10-23 주식회사파마킹 Composition comprising s-allyl-l-cysteine for preventing or treating colitis and medicinal products
KR101423631B1 (en) * 2012-08-17 2014-07-25 주식회사파마킹 Composition comprising s-allyl-l-cysteine for preventing or treating Eye disease and medicinal products
CN103027891A (en) * 2012-11-25 2013-04-10 天津坤健生物制药有限公司 Acetylcysteine gargle for treating dental ulcers, and preparation method thereof
CN105392478A (en) * 2013-07-31 2016-03-09 味之素株式会社 Agent for reducing side effects in cancer chemotherapy
US9457011B2 (en) * 2014-02-25 2016-10-04 Muslim D. Shahid Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor
CN106456837B (en) 2014-03-21 2020-04-10 匹兹堡大学-联邦高等教育体系 Method for preparing final sterilized hydrogel from extracellular matrix
US20180050019A1 (en) * 2015-03-06 2018-02-22 Repoceuticals Aps Melatonin for Preventing and Treating Radiation Vaginitis and Proctitis
WO2016146573A1 (en) * 2015-03-13 2016-09-22 Repoceuticals Aps Melatonin for preventing and treating radiation cystitis
JP6773269B2 (en) * 2015-05-14 2020-10-21 プロフェッショナル ダイエテティクス エス．ピー．エー． Compositions comprising amino acids for use in the treatment of mucositis in tumor patients undergoing radiation therapy and / or chemotherapy
MA43574A (en) 2015-08-05 2018-11-14 Childrens Medical Center COMPOSITIONS WITH PERMEATION AMPLIFIERS FOR THE DELIVERY OF MEDICINAL PRODUCTS
CN105380957A (en) * 2015-12-04 2016-03-09 天津坤健生物制药有限公司 Acetylcysteine gel, and preparation method and application thereof
US10239847B1 (en) 2016-03-03 2019-03-26 Cellactin Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione
JP7032406B2 (en) 2016-09-13 2022-03-08 ラスナ・リサーチ・インコーポレイテッド Dactinomycin composition and method for treating myelodysplastic syndrome and acute myeloid leukemia
CA3036696A1 (en) * 2016-09-14 2018-03-22 Children's Medical Center Corporation Compositions with permeation enhancers for drug delivery
EP3330251A1 (en) * 2016-11-30 2018-06-06 Clevexel Pharma Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol
CA3052489A1 (en) * 2017-03-02 2018-09-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ecm hydrogel for treating esophageal inflammation
EP3628314B1 (en) * 2017-04-19 2023-07-26 Otsuka Pharmaceutical Factory, Inc. Olanexidine as anti-inflammatory agent
IT201700124424A1 (en) * 2017-10-31 2019-05-01 Sofar Swiss Sa Compress to suck and / or dissolve in the mouth based on hyaluronic acid and chondroitin sulfate and their salts
WO2019124605A1 (en) * 2017-12-22 2019-06-27 경상대학교병원 Pharmaceutical composition for preventing or treating mouth ulcer, containing alpha-lipoic acid as active ingredient
WO2019124609A1 (en) * 2017-12-22 2019-06-27 경상대학교병원 Pharmaceutical composition containing alpha-lipoic acid as active ingredient for preventing or treating sialadenitis
EP3834887A1 (en) * 2019-12-12 2021-06-16 Koninklijke Philips N.V. Topical oral composition
WO2022040584A1 (en) * 2020-08-21 2022-02-24 Neuronasal, Inc. Methods of administering glutathione precursors
JP7544345B2 (en) 2021-01-22 2024-09-03 三洋化成工業株式会社 Esophageal Coolant

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091569A (en) * 1960-08-26 1963-05-28 Mead Johnson & Co Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus
US3591686A (en) * 1967-08-01 1971-07-06 Mead Johnson & Co Anti-inflammatory compositions and methods utilizing n-acylcysteines and the beta-alkyl and carboxyl derivatives thereof
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4176197A (en) * 1978-02-03 1979-11-27 Dominion Pharmacal, Inc. Method for treating acne vulgaris
US4512968A (en) * 1982-11-30 1985-04-23 Lion Corporation Oral compositions
DE3486448T2 (en) * 1983-11-14 1997-10-09 Columbia Lab Inc Bioadhesive agents
US4708965A (en) * 1985-09-16 1987-11-24 Morgan Lee R Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
US4724239A (en) * 1985-09-16 1988-02-09 Morgan Lee R Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine
US5300494A (en) * 1986-06-06 1994-04-05 Union Carbide Chemicals & Plastics Technology Corporation Delivery systems for quaternary and related compounds
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US5508031A (en) * 1986-11-21 1996-04-16 Cetus Oncology Corporation Method for treating biological damage using a free-radial scavenger and interleukin-2
DE3727896A1 (en) * 1987-08-21 1989-03-02 Degussa METHOD FOR PRODUCING SALTS OF N-ACETYLCYSTONE OR HOMOCYSTONE
US5061729A (en) * 1988-06-08 1991-10-29 Biogal Gyogyszergyar Pharmaceutical composition and process for preparing the same
SE462779B (en) * 1988-10-10 1990-09-03 Lejus Medical Ab PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL CYSTEIN IN A CERNA COATED WITH HYDROXIPROPYLMETHYL CELLULOS AGREEMENT
US5221722A (en) * 1988-11-28 1993-06-22 The B. F. Goodrich Company Crosslinked polyacrylic acid
US5580577A (en) * 1990-01-11 1996-12-03 Herzenberg; Leonard A. Method of treating the symptoms of human rhinovirus infection
US5256396A (en) * 1990-01-24 1993-10-26 Colgate-Palmolive Company Topical composition
US5593683A (en) * 1990-05-01 1997-01-14 Mdv Technologies, Inc. Method of making thermoreversible polyoxyalkylene gels
US5346703A (en) * 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5143731A (en) * 1990-08-07 1992-09-01 Mediventures Incorporated Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5071644A (en) * 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
IT1250421B (en) * 1991-05-30 1995-04-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION WITH BIO-ADHESIVE PROPERTIES.
US5296500A (en) * 1991-08-30 1994-03-22 The Procter & Gamble Company Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy
AU675210B2 (en) * 1991-10-16 1997-01-30 Richardson-Vicks Inc. Low pH aqueous cosmetic gel containing non-ionic polyacrylamide derivatives
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IT1258781B (en) * 1992-01-16 1996-02-29 Zambon Spa OPHTHALMIC PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYLCISTEIN AND POLYVINYL ALCOHOL
US5466680A (en) * 1992-03-26 1995-11-14 Cytologics, Inc. Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
US5286480A (en) * 1992-06-29 1994-02-15 The Procter & Gamble Company Use of N-acetylated amino acid complexes in oral care compositions
IT1255460B (en) * 1992-07-28 1995-11-02 Poli Ind Chimica Spa PHARMACEUTICAL COMPOSITIONS IN THE FORM OF MICROEMULSIONS OR BIOADHESIVE LIPOSOMIAL DISPERSIONS FOR THE TRANSMUCOSAL ADMINISTRATION OF PEPTIDAL SUBSTANCES AND PHARMACOLOGICALLY ACTIVE PROTEINS
US5817625A (en) * 1992-09-21 1998-10-06 Oncogene Science, Inc. Methods of prevention of oral mucositis with transforming growth factor beta
US5807894A (en) * 1992-12-02 1998-09-15 Zambon Group S.P.A. Syrup containing N-acetyl-cysteine
US5324746A (en) * 1993-02-12 1994-06-28 Mckee Rex N Method of treating damaged mucosal and epithelial tissues with misoprostol
US5637616A (en) * 1993-06-18 1997-06-10 Arcturus Pharmaceutical Corporation Method for treating diseases mediated by proteases
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
US5490978A (en) * 1993-10-15 1996-02-13 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Block copolymers of polysaccharides and polyalkylene oxides
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US5541181A (en) * 1994-05-26 1996-07-30 Bristol-Myers Squibb Company Compound produced by a strain of micromonospora
US5597849A (en) * 1994-11-14 1997-01-28 Medical Polymer Technologies, Inc. Stick formulations for topical drug delivery of therapeutic agents and uses thereof
WO1996020295A1 (en) * 1994-12-23 1996-07-04 Cookson Group Plc Process for the corrosion protection of copper or copper alloys
US5939485A (en) * 1995-06-19 1999-08-17 Medlogic Global Corporation Responsive polymer networks and methods of their use
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
US6150472A (en) * 1995-12-22 2000-11-21 Holland Biomaterials Group B.V. Multi-functional site containing polymers, and applications thereof
SE9601527D0 (en) * 1996-04-23 1996-04-23 Pharmacia Ab Transdermally alministered acetylcysteine as a mucolytic agent
US5869029A (en) * 1996-06-21 1999-02-09 Hercules Incorporated Dispersible water-soluble or water-swellable polymers and process for making toothpastes containing them
US6797729B1 (en) * 1996-06-28 2004-09-28 Baxter International Inc. Therapeutic glutamine and N-actyl-cysteine composition
CN1230123A (en) * 1996-07-11 1999-09-29 荷兰发马克有限公司 Inclusion complex containing indole selective serotonin agonist
US5861174A (en) * 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
CA2264592C (en) * 1996-08-27 2012-02-21 University Of Utah Research Foundation Bioconjugates and delivery of bioactive agents
US6743422B1 (en) * 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
SE9604610D0 (en) * 1996-12-16 1996-12-16 Noviscens Ab Medical composition
GB2320431B (en) * 1996-12-20 2000-08-30 Johnson & Johnson Medical Compositions for the treatment of chronic wounds
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
ATE444760T1 (en) * 1997-01-13 2009-10-15 Univ Emory GLUTATHIONE FOR THE TREATMENT OF INFLUENCE INFECTIONS
US6126930A (en) 1997-02-13 2000-10-03 The Procter & Gamble Company Spray compositions
US5843881A (en) * 1997-02-13 1998-12-01 The Procter & Gamble Company Spray compositions
AU6436998A (en) * 1997-02-20 1998-09-09 Yale University Therapeutic uses for antioxidants
US5904927A (en) * 1997-03-14 1999-05-18 Northeastern University Drug delivery using pH-sensitive semi-interpenetrating network hydrogels
US6197331B1 (en) * 1997-07-24 2001-03-06 Perio Products Ltd. Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
PT1024814E (en) * 1997-10-22 2007-11-29 Mayo Foundation Use of antifungal agents for the topical treatment of fungus-induced mucositis
WO1999026657A1 (en) * 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
US6228347B1 (en) * 1997-12-01 2001-05-08 Thione International, Inc. Antioxidant gel for gingival conditions
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
AU1905799A (en) * 1997-12-22 1999-07-12 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
EP0938896A1 (en) * 1998-01-15 1999-09-01 Novartis AG Autoclavable pharmaceutical compositions containing a chelating agent
GB9812426D0 (en) * 1998-06-10 1998-08-05 Reckitt & Colmann Prod Ltd Improvements in or relating to organic compositions
FR2781156B1 (en) * 1998-07-20 2001-06-29 Lafon Labor PHARMACEUTICAL COMPOSITION FOR PARTICULARLY FOR THE PREVENTION AND TREATMENT OF RADIOMUCITES AND CHEMOMUCITES
CA2339125A1 (en) * 1998-07-30 2000-02-10 E-Nutriceuticals, Inc. Novel chitosan-containing liquid compositions and methods for their preparation and use
WO2000007603A2 (en) * 1998-08-04 2000-02-17 Madash Llp End modified thermal responsive hydrogels
US6319513B1 (en) * 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
US6231889B1 (en) * 1998-09-21 2001-05-15 Chronorx, Llc Unit dosage forms for the treatment of herpes simplex
US5945089A (en) * 1998-11-05 1999-08-31 I-Dent International Corporation Method of treating mucositis
US6669927B2 (en) * 1998-11-12 2003-12-30 3M Innovative Properties Company Dental compositions
US6159485A (en) * 1999-01-08 2000-12-12 Yugenic Limited Partnership N-acetyl aldosamines, n-acetylamino acids and related n-acetyl compounds and their topical use
US20030229141A1 (en) * 1999-01-08 2003-12-11 Yu Ruey J. N-acetyl cysteine and its topical use
US6270781B1 (en) 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
US6194382B1 (en) * 1999-03-03 2001-02-27 Albert Einstein College Of Medicine Of Yeshiva University Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists
US6297337B1 (en) * 1999-05-19 2001-10-02 Pmd Holdings Corp. Bioadhesive polymer compositions
US6117415A (en) * 1999-06-17 2000-09-12 Alpharx Inc. Toothpaste comprising bioadhesive submicron emulsion for improved delivery of antibacterial and anticaries agents
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6391860B1 (en) * 1999-09-09 2002-05-21 Mcgrath Patrick D. Method for preparation and use of paste formed by controlled reaction of sucralfate with hydrochloric acid
AU770516B2 (en) * 1999-09-11 2004-02-26 Procter & Gamble Company, The Polyoxyalkylene copolymers containing pourable liquid vehicles
US6258342B1 (en) * 1999-11-03 2001-07-10 Hercules Incorporated Process for making toothpaste using agglomerated dispersible polymers
US6432415B1 (en) * 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
WO2001066108A1 (en) * 2000-03-07 2001-09-13 Mucosal Therapeutics Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation
IT1318447B1 (en) 2000-04-04 2003-08-25 Paolo Farina FORMULATIONS FOR REMOVAL OF DENTAL PLATE AND TARTAR.
KR20030014208A (en) * 2000-04-26 2003-02-15 오레곤 헬스 사이언시즈 유니버시티 Administration of a thiol-based chemoprotectant compound
PT1395289E (en) * 2000-06-08 2011-03-16 Sang Dr Christine Treatment of neuropathic pain with a n-methyl-d-aspartate (nmda) receptor antagonists
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US6479068B1 (en) * 2000-06-30 2002-11-12 Baxter International Inc. Therapeutic nutrient regimen for alleviating mucositis, stomatitis and cachexia in oncology patients
FI121528B (en) 2000-10-30 2010-12-31 Biohit Oyj Pharmaceutical composition to reduce the risk of sunk in cancer by binding acetaldehyde in saliva, stomach and colon
JP4822652B2 (en) * 2000-11-22 2011-11-24 エンド ファーマシューティカルズ インコーポレイテッド Treatment of mucositis
DK1997478T3 (en) 2001-02-15 2013-12-09 Access Pharma Inc Liquid formulations for the prevention and treatment of mucosal diseases and disorders
US6623754B2 (en) * 2001-05-21 2003-09-23 Noveon Ip Holdings Corp. Dosage form of N-acetyl cysteine
US6841578B2 (en) 2001-08-16 2005-01-11 Stephen T. Sonis Treatment and prevention of mucositis in cancer patients
US20040062764A1 (en) * 2001-08-30 2004-04-01 Neuwelt Edward A Chemoprotectant for gastric toxicity
US6857784B2 (en) * 2002-09-30 2005-02-22 Reliance Electric Technologies, Llc. Adapter mounted bearing assembly

Also Published As

Publication number Publication date
US6685917B2 (en) 2004-02-03
DK1343492T3 (en) 2006-03-06
DE60117043D1 (en) 2006-04-13
ES2254523T3 (en) 2006-06-16
BR0115531A (en) 2004-02-03
US20040141949A1 (en) 2004-07-22
WO2002041837A3 (en) 2003-03-06
BRPI0115531B1 (en) 2015-10-13
EP1609468A2 (en) 2005-12-28
EP1343492A4 (en) 2004-05-06
US20070014860A1 (en) 2007-01-18
US20070014861A1 (en) 2007-01-18
JP4822652B2 (en) 2011-11-24
MXPA03004546A (en) 2003-09-10
WO2002041837A2 (en) 2002-05-30
DE60117043T2 (en) 2006-07-13
EP1609468A3 (en) 2006-01-25
EP1343492B1 (en) 2006-02-01
ATE316786T1 (en) 2006-02-15
US20020119104A1 (en) 2002-08-29
US20070071824A1 (en) 2007-03-29
EP1343492A2 (en) 2003-09-17
JP2004513957A (en) 2004-05-13

Similar Documents

Publication Publication Date Title
AU2002239342A1 (en) Treatment of mucositis
DE60239707D1 (en) ANTIMICROBIAL CATIONIC PEPTIDES AND FORMULATIONS CONTAINING THEM
BR0116370A (en) Compound, pharmaceutical composition, use of a compound, and method of treating an hppar-mediated disease or condition in a patient.
AU2002236765A1 (en) Pharmaceutical combination for the treatment of cancer containing a 4-quinazolineamine and another anti-neoplastic agent
UA56989C2 (en) PHYSIOLOGICALLY ACTIVE PEG-CONJUGATE OF a-INTERFERON, A METHOD FOR PREPARING THE SAME, A PHARMACEUTICAL COMPOSITION BASED THEREON AND A METHOD FOR TREATMENT OR PROPHYLAXIS OF IMMUNOMODULAR DISEASES
BR0207961A (en) Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases.
HUP0401192A3 (en) Use of photosenzitizing agent for preparation ot, of pharmaceutical composition for treating wounds
BRPI9908182B8 (en) wound healing matrix protein compositions
BRPI0412526A (en) compound, use of a compound, pharmaceutical composition, pharmaceutical aerosol formulation, and method for treating a human or animal patient with an anti-inflammatory and / or allergic condition
EP1399414A4 (en) Substituted tetracycline compounds for the treatment of malaria
WO2002098345A8 (en) Use of an antioxidant for treating and/or preventing surface ocular disorders
IL137869A0 (en) Matrix protein compositions for wound healing
WO2001041753A3 (en) Therapeutic compositions and methods for treating periodontitis with antiinflamatory compounds
AU2001247968A1 (en) Use of asiatic acid or asiaticoside for treatment of cancer
HK1047707A1 (en) Use of (+)-tramadol, o-demethyltramadol or (+)-o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol or (+)-o-desmethyl-n-mono-desmethyl-tramadol for treating urinary incontinence
BRPI0407178A (en) Osteogenic Pharmaceutical Composition
WO2004110373A3 (en) Therapeutic vaccine compositions for the treatment of type 1 diabetes
AR003001A1 (en) PHARMACEUTICAL COMPOSITION STIMULATING OSTEOGENESIS.
HK1065305A1 (en) Substituted 4-aminocyclohexanol derivatives
ZA983753B (en) Medicinal composition for treatment of burns, cuts and like wounds.
AU2001276323A1 (en) Use of n-oleoylethanolamine for treating psoriasis
EP1512413A3 (en) Pharmaceutical combination containing a 4-quinazolineamine and another anti-neoplastic agent for the treatment of cancer
ZA982679B (en) Medicinal composition for treatment of burns, cuts and like wounds.
LT2002105A (en) Novel use of siberian fir oil
UA32302A (en) Method for preventing postoperative deformities of soft tissues