AU2002229573A1 - Pharmaceutical formulation containing pyrazolo(4,3-D)pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives - Google Patents

Pharmaceutical formulation containing pyrazolo(4,3-D)pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives

Info

Publication number
AU2002229573A1
AU2002229573A1 AU2002229573A AU2957302A AU2002229573A1 AU 2002229573 A1 AU2002229573 A1 AU 2002229573A1 AU 2002229573 A AU2002229573 A AU 2002229573A AU 2957302 A AU2957302 A AU 2957302A AU 2002229573 A1 AU2002229573 A1 AU 2002229573A1
Authority
AU
Australia
Prior art keywords
prostaglandins
pyrimidines
antagonists
calcium
pharmaceutical formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002229573A
Inventor
Hans-Michael Eggenweiler
Volker Eiermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10063224A external-priority patent/DE10063224A1/en
Priority claimed from DE2000163882 external-priority patent/DE10063882A1/en
Priority claimed from DE2000164993 external-priority patent/DE10064993A1/en
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2002229573A1 publication Critical patent/AU2002229573A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2002229573A 2000-12-19 2001-11-28 Pharmaceutical formulation containing pyrazolo(4,3-D)pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives Abandoned AU2002229573A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE10063224A DE10063224A1 (en) 2000-12-19 2000-12-19 Drug formulation useful e.g. for treating angina or hypertension contains pyrazolo (4,3-d) pyrimidine derivative phosphodiesterase V inhibitor and antithrombotic agent, calcium antagonist or prostaglandin
DE10063224 2000-12-19
DE10063882 2000-12-21
DE2000163882 DE10063882A1 (en) 2000-12-21 2000-12-21 Drug formulation useful e.g. for treating angina or hypertension contains pyrazolo (4,3-d) pyrimidine derivative phosphodiesterase V inhibitor and antithrombotic agent, calcium antagonist or prostaglandin
DE2000164993 DE10064993A1 (en) 2000-12-23 2000-12-23 Drug formulation useful e.g. for treating angina or hypertension contains pyrazolo (4,3-d) pyrimidine derivative phosphodiesterase V inhibitor and antithrombotic agent, calcium antagonist or prostaglandin
DE10064993 2000-12-23
PCT/EP2001/013916 WO2002049651A1 (en) 2000-12-19 2001-11-28 Pharmaceutical formulation containing pyrazolo[4,3-d]pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives

Publications (1)

Publication Number Publication Date
AU2002229573A1 true AU2002229573A1 (en) 2002-07-01

Family

ID=27214208

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002229573A Abandoned AU2002229573A1 (en) 2000-12-19 2001-11-28 Pharmaceutical formulation containing pyrazolo(4,3-D)pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives

Country Status (16)

Country Link
US (1) US20040063730A1 (en)
EP (1) EP1343506A1 (en)
JP (1) JP2004516270A (en)
KR (1) KR20030059349A (en)
CN (1) CN1481244A (en)
AR (1) AR035676A1 (en)
AU (1) AU2002229573A1 (en)
BR (1) BR0115995A (en)
CA (1) CA2431077A1 (en)
CZ (1) CZ20031776A3 (en)
HU (1) HUP0303315A2 (en)
MX (1) MXPA03005393A (en)
NO (1) NO20032773D0 (en)
PL (1) PL362513A1 (en)
SK (1) SK8192003A3 (en)
WO (1) WO2002049651A1 (en)

Families Citing this family (29)

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AR035531A1 (en) * 2001-01-22 2004-06-02 Novartis Ag COMPOSITION FOR THE CONTROL OF ENDOPARASITIC PESTS IN LIVESTOCK AND DOMESTIC ANIMALS, A METHOD FOR THEIR CONTROL AND THE USE OF SUCH COMPOSITION FOR THE PREPARATION OF MEDICINES
ATE478872T1 (en) * 2002-03-28 2010-09-15 Ustav Ex Botan Av Cr V V I I O PYRAZOLOA4,3-DÜPYRIMIDINES, METHOD FOR THE PRODUCTION THEREOF AND THERAPEUTIC USE
DE10229778A1 (en) * 2002-07-03 2004-01-29 Bayer Ag New use of imidazotriazinones
FR2842809A1 (en) * 2002-07-26 2004-01-30 Greenpharma Sas NOVEL SUBSTITUTED PYRAZOLO [1,5-a] -1,3,5-TRIAZINES AND THEIR ANALOGUES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, USE AS A MEDICAMENT AND METHODS FOR THEIR PREPARATION
KR100468352B1 (en) * 2002-09-24 2005-01-27 한국과학기술연구원 New pyrazolopyrimidine derivatives, process for their preparation and pharmaceutical composition comprising the same
OA13050A (en) 2003-04-29 2006-11-10 Pfizer Ltd 5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension.
DK1628663T3 (en) * 2003-05-15 2010-03-08 Roskamp Res Llc Process for the preparation of medicaments for reducing amyloid deposition, amyloid neurotoxicity and microgliosis
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
EP1742950B1 (en) * 2004-04-07 2008-12-17 Pfizer Limited Pyrazolo[4,3-d] pyrimidines
CA2681582C (en) 2007-03-30 2015-07-14 Amgen Inc. Methods of treating bowel disorders
CA2701620C (en) * 2007-10-05 2014-12-09 Alzheimer's Institute Of America, Inc. Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer
US20100093810A1 (en) * 2007-10-05 2010-04-15 Alzheimer's Institute Of America, Inc. Pharmaceutical Compositions for Reducing Amyloid Deposition, Amyloid Neurotoxicity, and Microgliosis
NO2315587T3 (en) * 2008-08-13 2018-03-24
TWI725008B (en) * 2015-01-28 2021-04-21 瑞采生技有限公司 COMPOUNDS FOR ENHANCING PPARγ EXPRESSION AND NUCLEAR TRANSLOCATION AND THERAPEUTIC USE THEREOF
AU2017322427B2 (en) 2016-09-09 2021-12-23 Incyte Corporation Pyrazolopyridine derivatives as HPK1 modulators and uses thereof for the treatment of cancer
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
TW201811799A (en) 2016-09-09 2018-04-01 美商英塞特公司 Pyrazolopyrimidine compounds and uses thereof
WO2018152220A1 (en) 2017-02-15 2018-08-23 Incyte Corporation Pyrazolopyridine compounds and uses thereof
MX2019012431A (en) * 2017-04-21 2020-08-03 Ikena Oncology Inc Indole ahr inhibitors and uses thereof.
WO2019051199A1 (en) 2017-09-08 2019-03-14 Incyte Corporation 6-cyano-indazole compounds as hematopoietic progenitor kinase 1 (hpk1) modulators
KR20200133747A (en) 2018-02-20 2020-11-30 인사이트 코포레이션 N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as HPK1 inhibitors for treating cancer
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
WO2020068729A1 (en) 2018-09-25 2020-04-02 Incyte Corporation Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators
KR20220059480A (en) 2019-08-06 2022-05-10 인사이트 코포레이션 HPK1 inhibitor in solid form
EP4065582A1 (en) 2019-11-26 2022-10-05 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
FR2353285A1 (en) * 1975-09-17 1977-12-30 Doms Laboratoires Coronary vasodilator controlled release dipyridamole compsn. - comprises film coated granules giving reduced side effects and also showing angina pectoris suppressing action
JPS5459266A (en) * 1977-10-14 1979-05-12 Ono Pharmaceut Co Ltd Prostaglandin i2 analogs and their preparation
FR2568774B2 (en) * 1984-05-30 1989-05-19 Choay Sa DRUGS THAT PROMOTE BLOOD FLOW PROPERTIES AND THEIR THERAPEUTIC USE
FR2672601B1 (en) * 1991-02-08 1994-10-14 Synthelabo BENZO-1,5-THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
DE19709877A1 (en) * 1997-03-11 1998-09-17 Bayer Ag 1,5-dihydro-pyrazolo [3,4-d] pyrimidinone derivatives
CA2305394C (en) * 1997-10-28 2006-12-12 Vivus, Incorporated Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
DE19942474A1 (en) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo [4,3-d] pyrimidines
DE10058662A1 (en) * 2000-11-25 2002-05-29 Merck Patent Gmbh Use of pyrazolo [4,3-d] pyrimidines
DE10103647A1 (en) * 2001-01-27 2002-08-01 Merck Patent Gmbh Process for the preparation of a pyrazolo (4,3-d) pyrimidine derivative

Also Published As

Publication number Publication date
CA2431077A1 (en) 2002-06-27
JP2004516270A (en) 2004-06-03
US20040063730A1 (en) 2004-04-01
PL362513A1 (en) 2004-11-02
CN1481244A (en) 2004-03-10
CZ20031776A3 (en) 2003-09-17
NO20032773L (en) 2003-06-18
EP1343506A1 (en) 2003-09-17
WO2002049651A1 (en) 2002-06-27
BR0115995A (en) 2004-01-13
AR035676A1 (en) 2004-06-23
NO20032773D0 (en) 2003-06-18
SK8192003A3 (en) 2003-10-07
MXPA03005393A (en) 2003-09-25
KR20030059349A (en) 2003-07-07
HUP0303315A2 (en) 2004-01-28

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