AU2002224759A1 - Animal model and cell-line expressing modified chlorine channel - Google Patents

Animal model and cell-line expressing modified chlorine channel

Info

Publication number
AU2002224759A1
AU2002224759A1 AU2002224759A AU2002224759A AU2002224759A1 AU 2002224759 A1 AU2002224759 A1 AU 2002224759A1 AU 2002224759 A AU2002224759 A AU 2002224759A AU 2002224759 A AU2002224759 A AU 2002224759A AU 2002224759 A1 AU2002224759 A1 AU 2002224759A1
Authority
AU
Australia
Prior art keywords
cell
animal model
line expressing
expressing modified
chlorine channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002224759A
Other languages
English (en)
Inventor
Thomas J. Jentsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordic Bioscience AS
Original Assignee
Nordic Bioscience AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordic Bioscience AS filed Critical Nordic Bioscience AS
Publication of AU2002224759A1 publication Critical patent/AU2002224759A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2002224759A 2001-01-23 2002-01-17 Animal model and cell-line expressing modified chlorine channel Abandoned AU2002224759A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10102977A DE10102977A1 (de) 2001-01-23 2001-01-23 Testsystem zur Entwicklung von Therapeutika, insbesondere von Wirkstoffen zur Behandlung von Osteoporose
DE10102977.2 2001-01-23
PCT/DK2002/000038 WO2002059612A2 (en) 2001-01-23 2002-01-17 Animal model and cell-line expressing modified chlorine channel

Publications (1)

Publication Number Publication Date
AU2002224759A1 true AU2002224759A1 (en) 2002-08-06

Family

ID=7671497

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002224759A Abandoned AU2002224759A1 (en) 2001-01-23 2002-01-17 Animal model and cell-line expressing modified chlorine channel

Country Status (6)

Country Link
US (1) US7534425B2 (https=)
EP (1) EP1360204B1 (https=)
JP (1) JP4138485B2 (https=)
AU (1) AU2002224759A1 (https=)
DE (1) DE10102977A1 (https=)
WO (1) WO2002059612A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1360504B1 (en) * 2001-01-23 2006-09-13 Pharmos Bioscience A/S Method for screening compounds for activity in treating an osteoclast related bone disease
US20030215787A1 (en) * 2002-01-23 2003-11-20 Wen-Pin Yang Modulators of the CLC-7 chloride channel and methods for their identification and use in the treatment and prevention of osteoporosis and related disease states
AU2003214920A1 (en) 2002-02-04 2003-09-02 Millennium Pharmaceuticals Inc. Methods and compositions for treating hematological disorders
GB0227243D0 (en) * 2002-11-21 2002-12-31 Univ Aberdeen Genetic markers for bone mass
US7785807B2 (en) * 2004-12-13 2010-08-31 Monell Chemical Senses Center Voltage-gated, pH-sensitive anion channel and its novel splice variant involved in taste sensation
WO2008101022A2 (en) * 2007-02-13 2008-08-21 The Nielsen Company (Us), Llc Methods and apparatus to reach through to business logic services
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
EP2420830B1 (en) * 2010-08-16 2016-11-16 Forschungsverbund Berlin e.V. Chloride transporter ClC-7 and cell-based screening method
WO2017049178A1 (en) * 2015-09-16 2017-03-23 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Method of making trabecular bone
US10640766B2 (en) * 2017-04-12 2020-05-05 Tempo Bioscience, Inc. Biosensors for chloride ions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434058A (en) * 1993-02-09 1995-07-18 Arch Development Corporation Apolipoprotein B MRNA editing protein compositions and methods
CA2305714A1 (en) * 1997-10-01 1999-04-08 Yale University Methods to modulate blood pressure and diagnose bartter's syndrome type iii
OA11665A (en) 1998-10-22 2004-12-08 Neurosearch As Substituted phenyl derivatives, their preparation and use.
US6686193B2 (en) * 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels

Also Published As

Publication number Publication date
EP1360204A2 (en) 2003-11-12
WO2002059612A2 (en) 2002-08-01
WO2002059612A3 (en) 2002-12-12
DE10102977A1 (de) 2002-08-01
JP2004531227A (ja) 2004-10-14
US20040265837A1 (en) 2004-12-30
US7534425B2 (en) 2009-05-19
JP4138485B2 (ja) 2008-08-27
EP1360204B1 (en) 2014-04-30

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase