AU2002223672A1 - Method for detecting methylation states for a toxicological diagnostic - Google Patents

Method for detecting methylation states for a toxicological diagnostic

Info

Publication number
AU2002223672A1
AU2002223672A1 AU2002223672A AU2367202A AU2002223672A1 AU 2002223672 A1 AU2002223672 A1 AU 2002223672A1 AU 2002223672 A AU2002223672 A AU 2002223672A AU 2367202 A AU2367202 A AU 2367202A AU 2002223672 A1 AU2002223672 A1 AU 2002223672A1
Authority
AU
Australia
Prior art keywords
toxicological
diagnostic
methylation states
detecting methylation
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002223672A
Inventor
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of AU2002223672A1 publication Critical patent/AU2002223672A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
AU2002223672A 2000-11-14 2001-11-08 Method for detecting methylation states for a toxicological diagnostic Abandoned AU2002223672A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10056802A DE10056802B4 (en) 2000-11-14 2000-11-14 Method for the detection of methylation conditions for toxicological diagnostics
DE10056802.5 2000-11-14
PCT/EP2001/012951 WO2002040710A2 (en) 2000-11-14 2001-11-08 Method for detecting methylation states for a toxicological diagnostic

Publications (1)

Publication Number Publication Date
AU2002223672A1 true AU2002223672A1 (en) 2002-05-27

Family

ID=7663517

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002223672A Abandoned AU2002223672A1 (en) 2000-11-14 2001-11-08 Method for detecting methylation states for a toxicological diagnostic

Country Status (6)

Country Link
US (1) US20040048279A1 (en)
EP (1) EP1337668A2 (en)
JP (1) JP2004513650A (en)
AU (1) AU2002223672A1 (en)
DE (1) DE10056802B4 (en)
WO (1) WO2002040710A2 (en)

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DE10128508A1 (en) * 2001-06-14 2003-02-06 Epigenomics Ag Methods and nucleic acids for the differentiation of prostate tumors
GB0215509D0 (en) * 2002-07-04 2002-08-14 Novartis Ag Marker genes
EP1428889A1 (en) * 2002-12-10 2004-06-16 Epigenomics AG Method for monitoring the transition of a cell from one state into another
JP4781267B2 (en) * 2003-08-14 2011-09-28 ケース ウエスタン リザーブ ユニバーシティ Method and composition for detecting colorectal cancer
US8415100B2 (en) 2003-08-14 2013-04-09 Case Western Reserve University Methods and compositions for detecting gastrointestinal and other cancers
WO2008053357A2 (en) * 2006-11-01 2008-05-08 Epigenomics Ag Methods, systems and computer program products for determining treatment response biomarkers
JP5211790B2 (en) * 2007-03-26 2013-06-12 住友化学株式会社 DNA methylation measurement method
US9115386B2 (en) 2008-09-26 2015-08-25 Children's Medical Center Corporation Selective oxidation of 5-methylcytosine by TET-family proteins
DE102010031354B3 (en) 2010-07-14 2012-02-02 Technische Universität Dresden Means and methods for diagnosis, prognosis and therapy control of tumor diseases
EP3425065B1 (en) 2011-12-13 2021-04-21 Oslo Universitetssykehus HF Methods and kits for detection of methylation status
US10563248B2 (en) 2012-11-30 2020-02-18 Cambridge Epigenetix Limited Oxidizing agent for modified nucleotides
KR101302173B1 (en) 2012-12-07 2013-08-30 이화여자대학교 산학협력단 Composition for diagnosing alzheimer's disease using methylation status of hmox1 gene and method for diagnosing alzheimer's disease using the same
US9169509B2 (en) 2013-01-15 2015-10-27 Board Of Regents, The University Of Texas System Topoisomerase 2b as a predictor of susceptibility to anthracycline-induced cardiotoxicity
WO2014139182A1 (en) 2013-03-15 2014-09-18 Shenzhen Hightide Biopharmaceutical, Ltd. Compositions and methods of using islet neogenesis peptides and analogs thereof
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
KR102390107B1 (en) 2013-05-30 2022-04-25 그라함 에이치. 크리시 Topical neurological stimulation
US20160281128A1 (en) * 2013-11-08 2016-09-29 Veterinary Diagnostics Institute, Inc. Method and apparatus for detecting vector-borne diseases in mammals
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
WO2017059245A2 (en) 2015-09-30 2017-04-06 Trustees Of Boston University Deadman and passcode microbial kill switches
CN107177679A (en) * 2017-06-07 2017-09-19 北京呈诺医学科技有限公司 A kind of kit for detecting esophageal squamous cell carcinoma related gene TFPI2 and HSPB2 promoter methylation degree
EP3706856A4 (en) 2017-11-07 2021-08-18 Neurostim Oab, Inc. Non-invasive nerve activator with adaptive circuit
WO2020264214A1 (en) 2019-06-26 2020-12-30 Neurostim Technologies Llc Non-invasive nerve activator with adaptive circuit
WO2021126921A1 (en) 2019-12-16 2021-06-24 Neurostim Solutions, Llc Non-invasive nerve activator with boosted charge delivery
CA3187549A1 (en) 2020-07-30 2022-02-03 Cambridge Epigenetix Limited Compositions and methods for nucleic acid analysis
CN114878840A (en) * 2022-07-12 2022-08-09 昆明思安生物科技有限公司 Kit and method for measuring triiodothyronine by magnetic particle chemiluminescence

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532204A (en) * 1982-07-19 1985-07-30 Massachusetts Institute Of Technology Mutation assays involving blood cells that metabolize toxic substances
US6020139A (en) * 1995-04-25 2000-02-01 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
DE19754482A1 (en) * 1997-11-27 1999-07-01 Epigenomics Gmbh Process for making complex DNA methylation fingerprints
US6074831A (en) * 1998-07-09 2000-06-13 Agilent Technologies, Inc. Partitioning of polymorphic DNAs
US6143504A (en) * 1998-10-27 2000-11-07 Arch Development Corporation Methods and compositions for the diagnosis of fragile X syndrome
DE19905082C1 (en) * 1999-01-29 2000-05-18 Epigenomics Gmbh Identification of methylation patterns of cytosine in genome DNA comprises chemical treatment to produce different base pairing behavior between cytosine and 5-methylcytosine
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
DE19935772C2 (en) * 1999-07-26 2002-11-07 Epigenomics Ag Method for the relative quantification of the methylation of cytosine bases in DNA samples
EP1268818A2 (en) * 2000-03-24 2003-01-02 Millennium Pharmaceuticals, Inc. 18221, dual specificity phosphatase and uses thereof
US6451588B1 (en) * 2000-06-30 2002-09-17 Pe Corporation (Ny) Multipartite high-affinity nucleic acid probes
AU2002210700B2 (en) * 2000-10-23 2006-09-21 Cancer Research Technology Limited Nucleic acid amplification-based methods for the determination of a methylation profile and reagents therefor

Also Published As

Publication number Publication date
WO2002040710A3 (en) 2003-05-30
EP1337668A2 (en) 2003-08-27
DE10056802B4 (en) 2005-06-16
JP2004513650A (en) 2004-05-13
DE10056802A1 (en) 2002-05-29
US20040048279A1 (en) 2004-03-11
WO2002040710A2 (en) 2002-05-23

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted