AU2002217823A1 - Methods for the synthesis of a modified hemoglobin solution - Google Patents

Methods for the synthesis of a modified hemoglobin solution

Info

Publication number
AU2002217823A1
AU2002217823A1 AU2002217823A AU1782302A AU2002217823A1 AU 2002217823 A1 AU2002217823 A1 AU 2002217823A1 AU 2002217823 A AU2002217823 A AU 2002217823A AU 1782302 A AU1782302 A AU 1782302A AU 2002217823 A1 AU2002217823 A1 AU 2002217823A1
Authority
AU
Australia
Prior art keywords
synthesis
methods
hemoglobin solution
modified hemoglobin
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002217823A
Inventor
Christopher Thomas Privalle
Cyrus John Stacey
Todd Lewis Talarico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apex Bioscience Inc
Original Assignee
Apex Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apex Bioscience Inc filed Critical Apex Bioscience Inc
Publication of AU2002217823A1 publication Critical patent/AU2002217823A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Materials Engineering (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2002217823A 2000-11-29 2001-11-14 Methods for the synthesis of a modified hemoglobin solution Abandoned AU2002217823A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25375800P 2000-11-29 2000-11-29
US60253758 2000-11-29
US09/930,905 US6747132B2 (en) 2000-11-29 2001-08-16 Methods for the synthesis of a modified hemoglobin solution
US09930905 2001-08-16
PCT/US2001/043877 WO2002044214A1 (en) 2000-11-29 2001-11-14 Methods for the synthesis of a modified hemoglobin solution

Publications (1)

Publication Number Publication Date
AU2002217823A1 true AU2002217823A1 (en) 2002-06-11

Family

ID=26943534

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002217823A Abandoned AU2002217823A1 (en) 2000-11-29 2001-11-14 Methods for the synthesis of a modified hemoglobin solution

Country Status (6)

Country Link
US (1) US6747132B2 (en)
EP (2) EP1358212B1 (en)
JP (1) JP2004521088A (en)
AU (1) AU2002217823A1 (en)
ES (1) ES2482098T3 (en)
WO (1) WO2002044214A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0028361D0 (en) * 2000-11-21 2001-01-03 Glaxo Group Ltd Method of separating extra chromosomal dna from other cellular components
US7038016B2 (en) 2001-08-21 2006-05-02 Apex Bioscience, Inc. Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
US7678888B2 (en) * 2004-04-21 2010-03-16 Albert Einstein College Of Medicine Of Yeshiva University Stable oxidation resistant powdered hemoglobin, methods of preparing same, and uses thereof
WO2006003926A1 (en) * 2004-06-30 2006-01-12 Terumo Kabushiki Kaisha Virus-inactivated hemoglobin and method of producing the same
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
WO2007087570A2 (en) * 2006-01-24 2007-08-02 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090186395A1 (en) * 2006-06-26 2009-07-23 Israel Nur Virus Removal by Nanofiltration
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8048856B1 (en) 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
AU2013290463B2 (en) * 2012-07-16 2016-08-11 Clemson University Research Foundation Novel food and feed antioxidants and preservatives based on antioxidant enzymes extracted from animal blood
WO2019018403A1 (en) * 2017-07-18 2019-01-24 Virtech Bio, Llc Blood substitutes comprising hemoglobin and methods of making
CN111471732A (en) * 2020-04-24 2020-07-31 上海交通大学 Novel selenium-rich tea source ACE inhibitory peptide and preparation method thereof
CN113813372A (en) * 2021-09-26 2021-12-21 云锦华彰(北京)生物科技有限公司 Heme composition, pharmaceutical composition and application thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
SE457041B (en) 1981-03-05 1988-11-21 Abb Stal Ab PHASING DEVICE CONTAINS A POWER PLANT WITH PRE-BURNING OF A BRAENLE IN A FLUIDIZED BED.
JPS57206622A (en) 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
US4529719A (en) 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
US5281579A (en) 1984-03-23 1994-01-25 Baxter International Inc. Purified virus-free hemoglobin solutions and method for making same
DE3412144A1 (en) 1984-03-31 1985-10-10 Biotest Pharma GmbH, 6000 Frankfurt METHOD FOR PRODUCING HIGHLY CLEANED, ELECTRICITY-FREE, HEPATITIC-SAFE HUMAN AND ANIMAL HEMOGLOBIN SOLUTIONS
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US5464814A (en) 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
US4826811A (en) 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5194590A (en) 1986-06-20 1993-03-16 Northfield Laboratories, Inc. Acellular red blood cell substitute
CA1312009C (en) 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
US5084558A (en) 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
GB8710598D0 (en) 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5061688A (en) 1988-08-19 1991-10-29 Illinois Institute Of Technology Hemoglobin multiple emulsion
DK0431129T3 (en) 1989-06-15 1996-06-17 Rorer Int Overseas Methods for inactivating viruses in virus-contaminated pharmaceutical compositions
US5312808A (en) 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
US5386014A (en) 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
SK280313B6 (en) 1990-04-24 1999-11-08 �Stav Organick� Chemie A Biochemie Av �R N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, process for their preparation and their use
US5264565A (en) 1991-01-22 1993-11-23 Affymax Technologies, N.V. Nucleic acid encoding the D2 /Ml chimeric receptor
US5334706A (en) 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5296466A (en) 1992-02-19 1994-03-22 Board Of Regents, The University Of Texas System Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
US5264555A (en) 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification
US5612310A (en) 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5840701A (en) 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
CA2106612C (en) 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5545328A (en) 1993-09-21 1996-08-13 Hemosol Inc. Purification of hemoglobin by displacement chromatography
CA2135739C (en) 1994-11-14 1997-10-21 Felice D'agnillo Hemoglobin-enzyme complexes
US5741894A (en) 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
US5998361A (en) 1996-10-18 1999-12-07 University Of Maryland At Baltimore Polymerized hemoglobin
BR7702151U (en) 1997-10-30 2000-12-12 Vale Do Rio Doce Co Split loading easel for conveyor belt

Also Published As

Publication number Publication date
EP1358212B1 (en) 2014-04-30
US20020099175A1 (en) 2002-07-25
US6747132B2 (en) 2004-06-08
EP2261251A2 (en) 2010-12-15
WO2002044214A1 (en) 2002-06-06
EP1358212A1 (en) 2003-11-05
EP2261251A3 (en) 2011-01-12
ES2482098T3 (en) 2014-08-01
JP2004521088A (en) 2004-07-15

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