AU2002216912A1 - Method for the production of 4-(17alpha-alkoxymethyl-17beta-substituted 3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1e)-oxime derivatives - Google Patents

Method for the production of 4-(17alpha-alkoxymethyl-17beta-substituted 3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1e)-oxime derivatives

Info

Publication number
AU2002216912A1
AU2002216912A1 AU2002216912A AU1691202A AU2002216912A1 AU 2002216912 A1 AU2002216912 A1 AU 2002216912A1 AU 2002216912 A AU2002216912 A AU 2002216912A AU 1691202 A AU1691202 A AU 1691202A AU 2002216912 A1 AU2002216912 A1 AU 2002216912A1
Authority
AU
Australia
Prior art keywords
sub
oxoestra
11beta
17alpha
17beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002216912A
Inventor
Sven Ring
Dr. Gerd Schubert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Jenapharm GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Publication of AU2002216912A1 publication Critical patent/AU2002216912A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

This invention relates to a process for the production of 4-(17alpha-alkoxymethyl-17beta-substituted-3-oxoestra-4,9-dien-11beta-yl)benzaldehyde-(1E)-oxime derivatives of general formula (I) in which R means an amino group, an O-C<SUB>1-7</SUB>-alkyl- or O-aryl radical, an S-C<SUB>1-7</SUB>-alkyl- or S-aryl radical, an NH-C<SUB>1-7</SUB>-alkyl- or NH-aryl radical or an N-di-C<SUB>1-7</SUB>-alkyl radical, and R<SUB>1 </SUB>means a hydrogen atom or a C<SUB>1-6</SUB>-alkyl radical, which yields the target compounds of formula (I) with high yield and selectivity.
AU2002216912A 2000-11-10 2001-11-09 Method for the production of 4-(17alpha-alkoxymethyl-17beta-substituted 3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1e)-oxime derivatives Abandoned AU2002216912A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10056677 2000-11-10
DE10056677A DE10056677A1 (en) 2000-11-10 2000-11-10 Preparation of estradienyl-benzaldoxime urethane or carbonate derivative, for use e.g. in treating endometriosis, involves reacting corresponding oxime with trichloromethyl chloroformate then alcohol, thiol or amine
PCT/DE2001/004219 WO2002038583A1 (en) 2000-11-10 2001-11-09 Method for the production of 4-(17$g(a)-alkoxymethyl-17$g(b)-substituted 3-oxoestra-4,9-dien-11$g(b)-yl)benzaldehyd-(1e)-oxime derivatives

Publications (1)

Publication Number Publication Date
AU2002216912A1 true AU2002216912A1 (en) 2002-05-21

Family

ID=7663442

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002216912A Abandoned AU2002216912A1 (en) 2000-11-10 2001-11-09 Method for the production of 4-(17alpha-alkoxymethyl-17beta-substituted 3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1e)-oxime derivatives

Country Status (8)

Country Link
US (1) US7053229B2 (en)
EP (1) EP1341805B1 (en)
JP (1) JP4263479B2 (en)
AT (1) ATE267208T1 (en)
AU (1) AU2002216912A1 (en)
DE (2) DE10056677A1 (en)
NO (1) NO20032081L (en)
WO (1) WO2002038583A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110804146B (en) * 2019-12-06 2021-09-07 万华化学集团股份有限公司 Storage-stable closed isocyanate composition and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE61263C (en) 1890-12-05 1892-03-19 E. BROCKMANN in Ellrich a. H Pole frame for hanging up smokers' and other goods
DE1618340A1 (en) 1967-01-10 1971-03-11 Bayer Ag Process for the preparation of new oxime derivatives
DE4332284C2 (en) 1993-09-20 1997-05-28 Jenapharm Gmbh 11-Benzaldoxime-17beta-methoxy-17alpha-methoxymethyl-estradiene derivatives, process for their preparation and medicaments containing these compounds

Also Published As

Publication number Publication date
DE50102362D1 (en) 2004-06-24
DE10056677A1 (en) 2002-05-16
EP1341805B1 (en) 2004-05-19
ATE267208T1 (en) 2004-06-15
US7053229B2 (en) 2006-05-30
JP2004513180A (en) 2004-04-30
NO20032081D0 (en) 2003-05-09
JP4263479B2 (en) 2009-05-13
NO20032081L (en) 2003-05-09
US20040059141A1 (en) 2004-03-25
WO2002038583A1 (en) 2002-05-16
EP1341805A1 (en) 2003-09-10

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