AU2002216125A1 - Joint utilization of the insulin gene and the glucokinase gene in the development of therapeutic approaches for diabetes mellitus - Google Patents
Joint utilization of the insulin gene and the glucokinase gene in the development of therapeutic approaches for diabetes mellitusInfo
- Publication number
- AU2002216125A1 AU2002216125A1 AU2002216125A AU1612502A AU2002216125A1 AU 2002216125 A1 AU2002216125 A1 AU 2002216125A1 AU 2002216125 A AU2002216125 A AU 2002216125A AU 1612502 A AU1612502 A AU 1612502A AU 2002216125 A1 AU2002216125 A1 AU 2002216125A1
- Authority
- AU
- Australia
- Prior art keywords
- gene
- development
- diabetes mellitus
- therapeutic approaches
- glucokinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010021582 Glucokinase Proteins 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 238000013459 approach Methods 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01002—Glucokinase (2.7.1.2)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200003056 | 2000-12-20 | ||
ES200003056A ES2170720B1 (en) | 2000-12-20 | 2000-12-20 | JOINT USE OF THE INSULIN GENE AND THE GLUCOQUINASE GENE IN THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS FOR MELLITUS DIABETES. |
PCT/ES2001/000493 WO2002049423A1 (en) | 2000-12-20 | 2001-12-19 | Joint utilization of the insulin gene and the glucokinase gene in the development of therapeutic approaches for diabetes mellitus |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002216125A1 true AU2002216125A1 (en) | 2002-07-01 |
Family
ID=8496075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002216125A Abandoned AU2002216125A1 (en) | 2000-12-20 | 2001-12-19 | Joint utilization of the insulin gene and the glucokinase gene in the development of therapeutic approaches for diabetes mellitus |
Country Status (6)
Country | Link |
---|---|
US (1) | US20040055023A1 (en) |
EP (1) | EP1360898A1 (en) |
AU (1) | AU2002216125A1 (en) |
CA (1) | CA2432506A1 (en) |
ES (1) | ES2170720B1 (en) |
WO (1) | WO2002049423A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007063225A (en) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | Imidazopyridine compound |
JP5302012B2 (en) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | Glucokinase activator |
WO2007143434A2 (en) | 2006-05-31 | 2007-12-13 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents |
EP2091947A2 (en) | 2006-12-20 | 2009-08-26 | Takeda San Diego, Inc. | Glucokinase activators |
WO2008116107A2 (en) | 2007-03-21 | 2008-09-25 | Takeda San Diego, Inc. | Piperazine derivatives as glucokinase activators |
AP3277A (en) * | 2009-01-07 | 2015-05-31 | Haidong Huang | Gene encoding human glucokinase mutant, enzyme encoded by the same, recombinant vectors and hosts, pharmaceutical compositions and uses thereof, methods for treating and preventing diseases |
WO2012007458A1 (en) | 2010-07-12 | 2012-01-19 | Universidad Autónoma De Barcelona | Gene therapy composition for use in diabetes treatment |
WO2013117776A1 (en) * | 2012-02-08 | 2013-08-15 | Fundación Pública Andaluza Progreso Y Salud | Glucokinase enzymes with increased activity and use thereof in the treatment and/or prevention of diabetes mellitus |
EP2692868A1 (en) | 2012-08-02 | 2014-02-05 | Universitat Autònoma De Barcelona | Adeno-associated viral (AAV) vectors useful for transducing adipose tissue |
EP3194430A1 (en) | 2014-09-16 | 2017-07-26 | Universitat Autònoma De Barcelona | Adeno-associated viral vectors for the gene therapy of metabolic diseases |
EP3242945B1 (en) | 2015-01-07 | 2021-09-01 | Universitat Autònoma de Barcelona | Single-vector gene construct comprising insulin and glucokinase genes |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0707646A1 (en) * | 1993-06-28 | 1996-04-24 | The Board Of Regents, The University Of Texas System | Vectors for genetically engineered cells that produce insulin in response to glucose |
AU6258894A (en) * | 1994-03-14 | 1995-10-03 | Universitat Autonoma De Barcelona | Chimeric gene using the gene or cdna of insuline, specially for the gene therapy of diabetes |
ZA969435B (en) * | 1995-11-16 | 1997-06-02 | Antonomous University Of Barce | Treatment of diabetes with a glucokinase gene |
AU1557000A (en) * | 1998-11-20 | 2000-06-13 | Autonomous University of Barcelona, The | Insulin production by engineered muscle cells |
-
2000
- 2000-12-20 ES ES200003056A patent/ES2170720B1/en not_active Expired - Fee Related
-
2001
- 2001-12-19 CA CA002432506A patent/CA2432506A1/en not_active Abandoned
- 2001-12-19 AU AU2002216125A patent/AU2002216125A1/en not_active Abandoned
- 2001-12-19 EP EP01271144A patent/EP1360898A1/en not_active Withdrawn
- 2001-12-19 WO PCT/ES2001/000493 patent/WO2002049423A1/en not_active Application Discontinuation
- 2001-12-19 US US10/451,091 patent/US20040055023A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2170720B1 (en) | 2003-12-16 |
CA2432506A1 (en) | 2002-06-27 |
US20040055023A1 (en) | 2004-03-18 |
ES2170720A1 (en) | 2002-08-01 |
EP1360898A1 (en) | 2003-11-12 |
WO2002049423A1 (en) | 2002-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU1516301A (en) | Use of a milk protein hydrolysate in the treatment of diabetes | |
AU2002353790A1 (en) | Syringe and reconstitution syringe | |
AU2314600A (en) | Sintered cemented carbide body and use thereof | |
AU4450700A (en) | Insulin crystals for pulmonary administration | |
AU2001241423A1 (en) | Needleless syringe | |
AP9901719A0 (en) | Treatment of diabetes with thiazolidinedione and metormin | |
AU4072799A (en) | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | |
AU2440700A (en) | Oral arginine and insulin secretion | |
AU2002213698A1 (en) | Needleless syringe for the subcutaneous delivery of therapeutic agents | |
AU2003221173A1 (en) | Placenta-origin mesenchymal cells and medicinal use thereof | |
AU2002216125A1 (en) | Joint utilization of the insulin gene and the glucokinase gene in the development of therapeutic approaches for diabetes mellitus | |
AU5840200A (en) | Treatment of diabetes and related pathologies | |
AU2002254942A1 (en) | Paracetamol solutions which are stable in storage and ready for infusion | |
AU2289601A (en) | The use of procyanidins in the modulation of cytokine gene expression and protein secretion | |
AU2003235307A1 (en) | Crystal of glucokinase protein, and method for drug design using the crystal | |
AU2003252182A1 (en) | Therapeutic treatment for the metabolic syndrome and type 2 diabetes | |
AU5453300A (en) | Insulin crystals for pulmonary administration | |
AU2001288061A1 (en) | Drug resistance-associated gene and use thereof | |
AU2002308891A1 (en) | Novel heterocyclic derivatives and medicinal use thereof | |
AP9901717A0 (en) | Treatment of diabetes with thiazolidinedione and sulphonylurea | |
IL134045A0 (en) | Treatment of diabetes with thiazolidinedione and sulphonylurea | |
AU2001268474A1 (en) | Use of amp kinase activators for treatment of type 2 diabetes and insulin resistance | |
HUP0203285A3 (en) | Pharmaceutical composition comprising an insulin sensitizer and its use | |
AU2001270903A1 (en) | Needleless syringe | |
AU1189101A (en) | Therapeutic applications of flint polypeptides |