KR100729977B1
(en)
*
|
1999-12-22 |
2007-06-20 |
넥타르 테라퓨틱스 에이엘, 코포레이션 |
Method for the preparation of 1-benzotriazolyl carbonate esters of polyethylene glycol
|
JP2003523544A
(en)
*
|
2000-02-17 |
2003-08-05 |
レックスマーク・インターナショナル・インコーポレーテツド |
Composition containing fine particles for supporting biologically active substance thereon or having the same supported thereon and method for preparing these
|
US7829074B2
(en)
*
|
2001-10-18 |
2010-11-09 |
Nektar Therapeutics |
Hydroxypatite-targeting poly(ethylene glycol) and related polymers
|
US7311892B2
(en)
*
|
2001-10-26 |
2007-12-25 |
The Uab Research Foundation |
Multidrug multiligand conjugates for targeted drug delivery
|
WO2004024889A2
(en)
*
|
2002-09-16 |
2004-03-25 |
Elusys Therapeutics, Inc. |
Production of bispecific molecules using polyethylene glycol linkers
|
WO2004089345A1
(en)
*
|
2003-04-03 |
2004-10-21 |
Semafore Pharmaceuticals Inc. |
Bone targeting of biodegradable drug-containing nanoparticles
|
EP1615639A2
(en)
*
|
2003-04-03 |
2006-01-18 |
Semafore Pharmaceuticals, Inc. |
Targeted bone marrow protection agents
|
JP4463274B2
(en)
*
|
2003-06-27 |
2010-05-19 |
明 小谷 |
Bisphosphonate complex
|
JP4604238B2
(en)
*
|
2003-09-19 |
2011-01-05 |
独立行政法人産業技術総合研究所 |
Polymer composite containing calcium phosphate and physiologically active substance, method for producing the same, and medical material using the same
|
WO2005074650A2
(en)
|
2004-02-02 |
2005-08-18 |
Ambrx, Inc. |
Modified human four helical bundle polypeptides and their uses
|
US20070265200A1
(en)
*
|
2004-03-17 |
2007-11-15 |
Eli Lilly And Company |
Glycol Linked Fgf-21 Compounds
|
ES2641570T3
(en)
|
2004-03-31 |
2017-11-10 |
University Of Utah Research Foundation |
Macromolecular delivery systems for non-invasive imaging, evaluation and treatment of arthritis and other inflammatory diseases
|
HUE039448T2
(en)
*
|
2004-04-21 |
2018-12-28 |
Alexion Pharma Inc |
Bone delivery conjugates and method of using same to target proteins to bone
|
US20070081984A1
(en)
|
2005-10-11 |
2007-04-12 |
Shunji Tomatsu |
Compositions and methods for treating hypophosphatasia
|
AU2005265163B2
(en)
|
2004-06-18 |
2009-10-01 |
Ambrx, Inc. |
Novel antigen-binding polypeptides and their uses
|
AU2005275062A1
(en)
|
2004-07-14 |
2006-02-23 |
University Of Utah Research Foundation |
Netrin-related compositions and uses
|
CN101087875B
(en)
|
2004-12-22 |
2012-08-22 |
Ambrx公司 |
Compositions of aminoacyl-tRNA synthetase and uses thereof
|
BRPI0519430A2
(en)
|
2004-12-22 |
2009-02-10 |
Ambrx Inc |
modified human growth hormone
|
BRPI0518661A2
(en)
|
2004-12-22 |
2008-12-02 |
Ambrx Inc |
Methods for expression and purification of recombinant human growth hormone
|
US7816320B2
(en)
|
2004-12-22 |
2010-10-19 |
Ambrx, Inc. |
Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
|
US8183340B2
(en)
|
2005-05-13 |
2012-05-22 |
Eli Lilly And Company |
GLP-1 pegylated compounds
|
KR20080026135A
(en)
|
2005-06-03 |
2008-03-24 |
암브룩스, 인코포레이티드 |
Improved human interferon molecules and their uses
|
EP2339014B1
(en)
|
2005-11-16 |
2015-05-27 |
Ambrx, Inc. |
Methods and compositions comprising non-natural amino acids
|
RU2457854C2
(en)
*
|
2005-12-30 |
2012-08-10 |
Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи Лимитед |
Prolonged release of neuregulin for improvement in cardiac function
|
US20100040668A1
(en)
*
|
2006-01-12 |
2010-02-18 |
Rutgers, The State University Of New Jersey |
Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
|
US8287914B2
(en)
*
|
2006-01-12 |
2012-10-16 |
Rutgers, The State University Of New Jersey |
Biomimetic hydroxyapatite synthesis
|
WO2007124461A2
(en)
|
2006-04-20 |
2007-11-01 |
Amgen Inc. |
Glp-1 compounds
|
WO2008005509A2
(en)
*
|
2006-07-06 |
2008-01-10 |
Massachusetts Institute Of Technology |
Methods and compositions for altering biological surfaces
|
WO2008017029A2
(en)
*
|
2006-08-02 |
2008-02-07 |
Board Of Regents Of The University Of Nebraska |
Drug carriers, their synthesis, and methods of use thereof
|
MX2009002526A
(en)
|
2006-09-08 |
2009-04-16 |
Ambrx Inc |
Suppressor trna transcription in vertebrate cells.
|
KR20090060294A
(en)
|
2006-09-08 |
2009-06-11 |
암브룩스, 인코포레이티드 |
Modified human plasma polypeptide or fc scaffolds and their uses
|
KR20090051227A
(en)
|
2006-09-08 |
2009-05-21 |
암브룩스, 인코포레이티드 |
Hybrid suppressor trna for vertebrate cells
|
US7999085B2
(en)
*
|
2007-01-09 |
2011-08-16 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
WO2008088983A1
(en)
|
2007-01-18 |
2008-07-24 |
Eli Lilly And Company |
PEGYLATED Aβ FAB
|
US20080182823A1
(en)
*
|
2007-01-26 |
2008-07-31 |
Hidesmasa Katsumi |
Polymer-linked-biophosphonate inhalant formulations and methods for using the same
|
CN101265331B
(en)
*
|
2007-03-12 |
2010-10-13 |
中国科学院化学研究所 |
PEG modifying PHPMA material and preparation method thereof
|
BRPI0809583B1
(en)
|
2007-03-30 |
2022-02-22 |
Ambrx, Inc |
Modified fgf-21 polypeptide, composition comprising the same, method for producing said fgf-21 polypeptide, and cell comprising a polynucleotide
|
BRPI0810622A2
(en)
|
2007-05-02 |
2020-10-13 |
Ambrx, Inc. |
modified interferon beta polypeptides and their uses
|
AU2008258285B2
(en)
|
2007-06-08 |
2013-03-21 |
Queensland University Of Technology |
Wound repair composition and method
|
EP2177525A1
(en)
|
2007-07-06 |
2010-04-21 |
TMRC Co., Ltd. |
Metal complex compound, cancer therapeutic composition comprising the metal complex compound as active ingredient, and intermediate for production of the metal complex compound
|
KR101165455B1
(en)
*
|
2007-09-10 |
2012-07-12 |
한스바이오메드 주식회사 |
Calcium phosphate microspheres drug delivery system and process for preparing the same
|
EP2214716B1
(en)
*
|
2007-10-23 |
2021-11-17 |
Nektar Therapeutics |
Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom
|
JP2011010549A
(en)
*
|
2007-10-29 |
2011-01-20 |
Univ Of Tokyo |
Organic-inorganic hybrid nano particle composed of nucleic acid conjugate having polyethylene glycol bound thereto and calcium phosphate
|
CN101918026B
(en)
|
2007-11-20 |
2016-03-02 |
Ambrx公司 |
Modified insulin polypeptides and its purposes
|
JP5328672B2
(en)
*
|
2007-12-10 |
2013-10-30 |
コスメディ製薬株式会社 |
Transdermal absorption preparation
|
JP2010018772A
(en)
*
|
2008-01-25 |
2010-01-28 |
Ebara Corp |
Peg-modified hydroxyapatite, pharmaceutical using the same as base material and production process thereof
|
JP5702150B2
(en)
|
2008-02-08 |
2015-04-15 |
アンブルックス, インコーポレイテッドAmbrx, Inc. |
Modified leptin polypeptides and their use
|
US11033631B2
(en)
|
2008-06-09 |
2021-06-15 |
Nektar Therapeutics |
Methods of treating CYP2D6 alternative metabolizers
|
PL2318837T4
(en)
|
2008-07-11 |
2016-10-31 |
|
Enhanced immunoassay sensor
|
UA103774C2
(en)
|
2008-07-23 |
2013-11-25 |
Амбркс, Інк. |
Modified bovine g-csf polypeptides and their uses
|
CN107022020A
(en)
|
2008-09-26 |
2017-08-08 |
Ambrx公司 |
The animal erythropoietin polypeptides and its purposes of modification
|
MX343802B
(en)
|
2008-09-26 |
2016-11-23 |
Ambrx Inc |
Non-natural amino acid replication-dependent microorganisms and vaccines.
|
CA2778678A1
(en)
|
2009-10-30 |
2011-05-05 |
Cns Therapeutics, Inc. |
Improved neurturin molecules
|
EA201290541A1
(en)
|
2009-12-21 |
2013-05-30 |
Амбркс, Инк. |
MODIFIED BULL SOMATOTROPINE POLYPEPTIDES AND THEIR APPLICATION
|
CN104017063A
(en)
|
2009-12-21 |
2014-09-03 |
Ambrx公司 |
Modified porcine somatotropin polypeptides and their uses
|
AR079345A1
(en)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
OXINTOMODULINE PEPTIDAL ANALOG
|
AR079344A1
(en)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
PEPTIDAL ANALOG OF OXINTOMODULIN, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS AND USES TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT NON-INSULINED INDEPENDENT DIABETES AND / OR OBESITY
|
EP2563380B1
(en)
|
2010-04-26 |
2018-05-30 |
aTyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
|
JP6294074B2
(en)
|
2010-04-27 |
2018-03-14 |
エータイアー ファーマ, インコーポレイテッド |
Innovative discovery of therapeutic, diagnostic and antibody compositions related to protein fragments of isoleucyl-tRNA synthetase
|
AU2011248489B2
(en)
|
2010-04-28 |
2016-10-06 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases
|
AU2011248490B2
(en)
|
2010-04-29 |
2016-11-10 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
|
JP5991963B2
(en)
|
2010-04-29 |
2016-09-14 |
エータイアー ファーマ, インコーポレイテッド |
Innovative discovery of therapeutic, diagnostic and antibody compositions related to protein fragments of valyl tRNA synthetase
|
CA2797865A1
(en)
|
2010-04-30 |
2011-11-03 |
Alexion Pharma International Sarl |
Methods, compositions, and kits for the treatment of matrix mineralization disorders
|
JP6008841B2
(en)
|
2010-05-03 |
2016-10-19 |
エータイアー ファーマ, インコーポレイテッド |
Innovative discovery of therapeutic, diagnostic and antibody compositions related to protein fragments of methionyl tRNA synthetase
|
CN103096912A
(en)
|
2010-05-03 |
2013-05-08 |
Atyr医药公司 |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
|
EP2566515B1
(en)
|
2010-05-03 |
2017-08-02 |
aTyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
|
CA2798139C
(en)
|
2010-05-04 |
2019-09-24 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
|
WO2011143482A2
(en)
|
2010-05-14 |
2011-11-17 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
|
CN103119055A
(en)
|
2010-05-17 |
2013-05-22 |
塞比克斯公司 |
Pegylated C-Peptide
|
US9034598B2
(en)
|
2010-05-17 |
2015-05-19 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
|
CA2800375C
(en)
|
2010-05-27 |
2021-03-09 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
|
CN103118694B
(en)
|
2010-06-01 |
2016-08-03 |
Atyr医药公司 |
The discovery for the treatment of, diagnosis and the antibody compositions relevant to the protein fragments of lysyl-tRNA synzyme
|
EP2593125B1
(en)
|
2010-07-12 |
2017-11-01 |
aTyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
MA34521B1
(en)
|
2010-08-17 |
2013-09-02 |
Ambrx Inc |
MODIFIED RELAXINE POLYPEPTIDES AND USES THEREOF
|
WO2012027611A2
(en)
|
2010-08-25 |
2012-03-01 |
Atyr Pharma, Inc. |
INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
|
TWI480288B
(en)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
Formulations for bovine granulocyte colony stimulating factor and variants thereof
|
EP2658979B1
(en)
|
2010-12-27 |
2018-02-14 |
Alexion Pharmaceuticals, Inc. |
Compositions comprising natriuretic peptides and methods of use thereof
|
CN104220086A
(en)
|
2011-11-17 |
2014-12-17 |
塞比克斯股份公司 |
PEGylated C-peptide
|
EP2814514B1
(en)
|
2012-02-16 |
2017-09-13 |
Atyr Pharma, Inc. |
Histidyl-trna synthetases for treating autoimmune and inflammatory diseases
|
US10052366B2
(en)
|
2012-05-21 |
2018-08-21 |
Alexion Pharmaceuticsl, Inc. |
Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
|
EP2859017B1
(en)
|
2012-06-08 |
2019-02-20 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
WO2014036492A1
(en)
|
2012-08-31 |
2014-03-06 |
Sutro Biopharma, Inc. |
Modified amino acids comprising an azido group
|
US9764039B2
(en)
|
2013-07-10 |
2017-09-19 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
CN104448296B
(en)
*
|
2013-12-02 |
2018-01-05 |
北京键凯科技股份有限公司 |
alkynyl multi-arm polyethylene glycol derivative
|
US10626156B2
(en)
|
2013-12-06 |
2020-04-21 |
Jie Han |
Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs
|
CN104086763A
(en)
*
|
2014-04-03 |
2014-10-08 |
西南交通大学 |
Amino-containing diphosphonate modified Brij compound used as surfactant, and preparation method thereof
|
WO2016007873A1
(en)
|
2014-07-11 |
2016-01-14 |
The Regents Of The University Of Michigan |
Compositions and methods for treating craniosynostosis
|
CN114805533A
(en)
|
2014-10-24 |
2022-07-29 |
百时美施贵宝公司 |
Modified FGF-21 polypeptides and uses thereof
|
JP6787894B2
(en)
|
2014-12-05 |
2020-11-18 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
Treatment of seizures with recombinant alkaline phosphatase
|
AU2016211447B2
(en)
|
2015-01-28 |
2021-09-23 |
Alexion Pharmaceuticals, Inc. |
Methods of treating a subject with an alkaline phosphatase deficiency
|
KR102644116B1
(en)
|
2015-08-17 |
2024-03-05 |
알렉시온 파마슈티칼스, 인코포레이티드 |
Preparation of alkaline phosphatase
|
EP3355904A4
(en)
|
2015-09-28 |
2019-06-12 |
Alexion Pharmaceuticals, Inc. |
Identifying effective dosage regimens for tissue non-specific alkaline phosphatase (tnsalp)-enzyme replacement therapy of hypophosphatasia
|
EP3368062A4
(en)
|
2015-10-30 |
2019-07-03 |
Alexion Pharmaceuticals, Inc. |
Methods for treating craniosynostosis in a patient
|
EP3426286A4
(en)
|
2016-03-08 |
2019-12-04 |
Alexion Pharmaceuticals, Inc. |
Methods for treating hypophosphatasia in children
|
EP3436020A4
(en)
|
2016-04-01 |
2019-12-25 |
Alexion Pharmaceuticals, Inc. |
Methods for treating hypophosphatasia in adolescents and adults
|
MX2018011833A
(en)
|
2016-04-01 |
2019-02-13 |
Alexion Pharma Inc |
Treating muscle weakness with alkaline phosphatases.
|
US10988744B2
(en)
|
2016-06-06 |
2021-04-27 |
Alexion Pharmaceuticals, Inc. |
Method of producing alkaline phosphatase
|
EP3492166A4
(en)
*
|
2016-08-01 |
2020-03-11 |
Kaneka Corporation |
Adsorbent for calciprotein particles, adsorption removal system, and method of using same
|
EP3496750A2
(en)
|
2016-08-09 |
2019-06-19 |
Eli Lilly and Company |
Combination therapy
|
US11116821B2
(en)
|
2016-08-18 |
2021-09-14 |
Alexion Pharmaceuticals, Inc. |
Methods for treating tracheobronchomalacia
|
TW201837051A
(en)
|
2017-02-08 |
2018-10-16 |
美商必治妥美雅史谷比公司 |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
AU2018243320A1
(en)
|
2017-03-31 |
2019-10-10 |
Alexion Pharmaceuticals, Inc. |
Methods for treating hypophosphatasia (HPP) in adults and adolescents
|
EP3688007A1
(en)
|
2017-09-27 |
2020-08-05 |
The University of York |
Bioconjugation of polypeptides
|
WO2019190752A1
(en)
|
2018-03-30 |
2019-10-03 |
Alexion Pharmaceuticals, Inc. |
Manufacturing of glycoproteins
|
KR102167755B1
(en)
|
2018-05-23 |
2020-10-19 |
주식회사 큐어바이오 |
Fragmented GRS polypeptide, mutants thereof and use thereof
|
CN108786713B
(en)
*
|
2018-06-08 |
2021-04-27 |
南京师范大学 |
Amphiphilic adsorption type sulfhydryl modified nano hydroxyapatite adsorbent and preparation method and application thereof
|
PT3849614T
(en)
|
2018-09-11 |
2024-02-28 |
Ambrx Inc |
Interleukin-2 polypeptide conjugates and their uses
|
JP2022512746A
(en)
|
2018-10-19 |
2022-02-07 |
アンブルックス,インコーポレイテッド |
Interleukin-10 polypeptide complex, its dimer, and their use
|
US20200262887A1
(en)
|
2018-11-30 |
2020-08-20 |
Opko Ireland Global Holdings, Ltd. |
Oxyntomodulin peptide analog formulations
|
US20220226488A1
(en)
|
2019-02-12 |
2022-07-21 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-tlr agonist conjugates
|
WO2021018922A1
(en)
*
|
2019-07-30 |
2021-02-04 |
Gatt Technologies B.V. |
Polyoxazoline copolymer comprising calcium binding groups
|
IL294659A
(en)
|
2020-01-14 |
2022-09-01 |
Synthekine Inc |
Biased il2 muteins methods and compositions
|
JP2023517595A
(en)
|
2020-03-11 |
2023-04-26 |
アンブルックス,インコーポレイテッド |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
KR20230073200A
(en)
|
2020-08-20 |
2023-05-25 |
암브룩스, 인코포레이티드 |
Antibody-TLR agonist conjugates, methods and uses thereof
|
JP2024512775A
(en)
|
2021-04-03 |
2024-03-19 |
アンブルックス,インコーポレイテッド |
Anti-HER2 antibody drug conjugate and its use
|
CN115043908B
(en)
*
|
2022-06-10 |
2023-10-13 |
浙江大学 |
Hydroxyapatite targeting peptide and application thereof
|