AU2001293797A1 - Method for measuring the activity of the blood clotting factor xiiia - Google Patents

Method for measuring the activity of the blood clotting factor xiiia

Info

Publication number
AU2001293797A1
AU2001293797A1 AU2001293797A AU9379701A AU2001293797A1 AU 2001293797 A1 AU2001293797 A1 AU 2001293797A1 AU 2001293797 A AU2001293797 A AU 2001293797A AU 9379701 A AU9379701 A AU 9379701A AU 2001293797 A1 AU2001293797 A1 AU 2001293797A1
Authority
AU
Australia
Prior art keywords
activity
fxiiia
measuring
blood clotting
clotting factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001293797A
Inventor
Dagmar Prasa
Jorg Sturzebecher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Friedrich Schiller Universtaet Jena FSU
Original Assignee
Friedrich Schiller Universtaet Jena FSU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friedrich Schiller Universtaet Jena FSU filed Critical Friedrich Schiller Universtaet Jena FSU
Publication of AU2001293797A1 publication Critical patent/AU2001293797A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method for measuring the activity of the blood clotting factor XIIIa. The aim of the invention is to provide a method for measuring the activity of FXIIIa which is simple to carry out and which is also suitable for use with testing systems that have a high throughput. It was found that activated FXIIIa influences the light transmitting power of fibrin clots. Fibrinogen is caused to clot with a fibrinogen-splitting enzyme. The change in the light transmitting power of the samples according to the concentration of FXIIIa present is registered and is used as a measure of the activity of FXIIIa. The inventive method can be used especially for screening for FXIIIa inhibitors.
AU2001293797A 2000-09-13 2001-09-06 Method for measuring the activity of the blood clotting factor xiiia Abandoned AU2001293797A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10046187.5 2000-09-13
DE10046187A DE10046187A1 (en) 2000-09-13 2000-09-13 Method for measuring the activity of coagulation factor XIIIa
PCT/EP2001/010285 WO2002022853A2 (en) 2000-09-13 2001-09-06 Method for measuring the activity of the blood clotting factor xiiia

Publications (1)

Publication Number Publication Date
AU2001293797A1 true AU2001293797A1 (en) 2002-03-26

Family

ID=7656684

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001293797A Abandoned AU2001293797A1 (en) 2000-09-13 2001-09-06 Method for measuring the activity of the blood clotting factor xiiia

Country Status (8)

Country Link
US (1) US20030190692A1 (en)
EP (1) EP1317672B1 (en)
JP (1) JP2004508832A (en)
AT (1) ATE291739T1 (en)
AU (1) AU2001293797A1 (en)
CA (1) CA2422523A1 (en)
DE (2) DE10046187A1 (en)
WO (1) WO2002022853A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6257418B2 (en) * 2014-04-01 2018-01-10 株式会社日立ハイテクノロジーズ Automatic analyzer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6035119B2 (en) * 1982-06-11 1985-08-13 株式会社 ヤトロン Method for measuring factor X3 in plasma
DE3330699A1 (en) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR THE SIMULTANEOUS DETERMINATION OF FIBRINOGEN AND FIBRINOGEN Fission Products in the Plasma
US5015588A (en) * 1987-10-29 1991-05-14 The Samuel Roberts Noble Foundation, Inc. Method for the detection of factor XIII in plasma
US5077285A (en) * 1989-07-31 1991-12-31 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5177092A (en) * 1989-07-31 1993-01-05 Merck & Co., Inc. Medicinal use of certain tetrazolium salts
US5047416A (en) * 1989-07-31 1991-09-10 Merck & Co., Inc. Triazole compounds and their use as transglutaminase inhibitors
US5620688A (en) * 1991-03-11 1997-04-15 Bristol-Myers Squibb Company Methods of inhibiting the activation of Factor XIII
GB9509271D0 (en) * 1995-05-05 1995-06-28 Biopharm Res & Dev Ltd Blood clot stabilisation inhibitors
US5710174A (en) * 1995-06-07 1998-01-20 Zymo Genetics, Inc. Factor XIIIA inhibitor
KR100222292B1 (en) * 1997-06-18 1999-10-01 허일섭 13th factor measuring method using fibrin single agent
EP0993311B1 (en) * 1997-06-18 2012-11-14 Angiotech Pharmaceuticals (US), Inc. Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof

Also Published As

Publication number Publication date
WO2002022853A9 (en) 2002-09-19
ATE291739T1 (en) 2005-04-15
CA2422523A1 (en) 2003-03-12
DE50105719D1 (en) 2005-04-28
DE10046187A1 (en) 2002-03-21
US20030190692A1 (en) 2003-10-09
JP2004508832A (en) 2004-03-25
EP1317672B1 (en) 2005-03-23
EP1317672A2 (en) 2003-06-11
WO2002022853A2 (en) 2002-03-21
WO2002022853A3 (en) 2002-12-12

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