AU2001293111A1 - Focused acoustic energy in the preparation and screening of combinatorial libraries - Google Patents

Focused acoustic energy in the preparation and screening of combinatorial libraries

Info

Publication number
AU2001293111A1
AU2001293111A1 AU2001293111A AU9311101A AU2001293111A1 AU 2001293111 A1 AU2001293111 A1 AU 2001293111A1 AU 2001293111 A AU2001293111 A AU 2001293111A AU 9311101 A AU9311101 A AU 9311101A AU 2001293111 A1 AU2001293111 A1 AU 2001293111A1
Authority
AU
Australia
Prior art keywords
screening
preparation
acoustic energy
combinatorial libraries
focused acoustic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001293111A
Inventor
Richard N. Ellson
James K. Foote
Mitchell W. Mutz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Picoliter Inc
Original Assignee
Picoliter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/727,392 external-priority patent/US20020061258A1/en
Application filed by Picoliter Inc filed Critical Picoliter Inc
Publication of AU2001293111A1 publication Critical patent/AU2001293111A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
    • B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
    • B41J2/01—Ink jet
    • B41J2/015—Ink jet characterised by the jet generation process
    • B41J2/04—Ink jet characterised by the jet generation process generating single droplets or particles on demand
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
    • B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
    • B41J2/01—Ink jet
    • B41J2/135—Nozzles
    • B41J2/14—Structure thereof only for on-demand ink jet heads
    • B41J2/14008—Structure of acoustic ink jet print heads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezo-electric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0615—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced at the free surface of the liquid or other fluent material in a container and subjected to the vibrations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
AU2001293111A 2000-09-25 2001-09-25 Focused acoustic energy in the preparation and screening of combinatorial libraries Abandoned AU2001293111A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US66999600A 2000-09-25 2000-09-25
US09/669,996 2000-09-25
US09/727,392 US20020061258A1 (en) 2000-09-25 2000-11-29 Focused acoustic energy in the preparation and screening of combinatorial libraries
US09/727,392 2000-11-29
US09/964,193 2001-09-24
US09/964,193 US6612686B2 (en) 2000-09-25 2001-09-25 Focused acoustic energy in the preparation and screening of combinatorial libraries
PCT/US2001/030094 WO2002024324A2 (en) 2000-09-25 2001-09-25 Focused acoustic energy in the preparation and screening of combinatorial libraries

Publications (1)

Publication Number Publication Date
AU2001293111A1 true AU2001293111A1 (en) 2002-04-02

Family

ID=27418199

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001293111A Abandoned AU2001293111A1 (en) 2000-09-25 2001-09-25 Focused acoustic energy in the preparation and screening of combinatorial libraries

Country Status (6)

Country Link
US (1) US6612686B2 (en)
EP (1) EP1324823B1 (en)
JP (1) JP4990476B2 (en)
AU (1) AU2001293111A1 (en)
CA (1) CA2423063C (en)
WO (1) WO2002024324A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197651B1 (en) * 1999-08-30 2001-03-06 Taiwan Semiconductor Manufacturing Company Structure and method for forming a capacitor dielectric using yttrium barium copper oxide
US6746104B2 (en) 2000-09-25 2004-06-08 Picoliter Inc. Method for generating molecular arrays on porous surfaces
DE60126110T2 (en) * 2000-09-25 2007-07-05 Picoliter, Inc., Sunnyvale FOCUSED SOIL ENERGY METHOD AND APPARATUS FOR PRODUCING DROPS OF TWO MIXABLE LIQUIDS
US6806051B2 (en) 2000-09-25 2004-10-19 Picoliter Inc. Arrays of partially nonhybridizing oligonucleotides and preparation thereof using focused acoustic energy
US20020037359A1 (en) 2000-09-25 2002-03-28 Mutz Mitchell W. Focused acoustic energy in the preparation of peptide arrays
US6623700B1 (en) * 2000-11-22 2003-09-23 Xerox Corporation Level sense and control system for biofluid drop ejection devices
US6849423B2 (en) 2000-11-29 2005-02-01 Picoliter Inc Focused acoustics for detection and sorting of fluid volumes
US20020064808A1 (en) * 2000-11-29 2002-05-30 Mutz Mitchell W. Focused acoustic energy for ejecting cells from a fluid
US6893836B2 (en) 2000-11-29 2005-05-17 Picoliter Inc. Spatially directed ejection of cells from a carrier fluid
US6596239B2 (en) * 2000-12-12 2003-07-22 Edc Biosystems, Inc. Acoustically mediated fluid transfer methods and uses thereof
US6869551B2 (en) * 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
WO2003006164A1 (en) * 2001-07-11 2003-01-23 Universisty Of Southern California Dna probe synthesis on chip on demand by mems ejector array
US6976639B2 (en) 2001-10-29 2005-12-20 Edc Biosystems, Inc. Apparatus and method for droplet steering
US20030085952A1 (en) * 2001-11-05 2003-05-08 Williams Roger O Apparatus and method for controlling the free surface of liquid in a well plate
US6925856B1 (en) 2001-11-07 2005-08-09 Edc Biosystems, Inc. Non-contact techniques for measuring viscosity and surface tension information of a liquid
US7354141B2 (en) * 2001-12-04 2008-04-08 Labcyte Inc. Acoustic assessment of characteristics of a fluid relevant to acoustic ejection
EP1464069A2 (en) * 2001-12-21 2004-10-06 Sense Proteomic Limited Probe for mass spectrometry
US20040081966A1 (en) * 2002-10-25 2004-04-29 Peck Bill J. Chemical array linking layers
US7429359B2 (en) * 2002-12-19 2008-09-30 Edc Biosystems, Inc. Source and target management system for high throughput transfer of liquids
US7275807B2 (en) * 2002-11-27 2007-10-02 Edc Biosystems, Inc. Wave guide with isolated coupling interface
JP4711326B2 (en) * 2003-12-22 2011-06-29 キヤノン株式会社 Preparation method of calibration sample and calibration curve
US7445315B2 (en) * 2004-11-15 2008-11-04 Palo Alto Research Center Incorporated Thin film and thick film heater and control architecture for a liquid drop ejector
US7095018B2 (en) * 2004-12-29 2006-08-22 Wisconsin Alumni Research Foundation Deposition of samples and sample matrix for enhancing the sensitivity of matrix assisted laser desorption/ionization mass spectrometry
US7180447B1 (en) 2005-04-29 2007-02-20 Lockhead Martin Corporation Shared phased array beamformer
JP4641476B2 (en) * 2005-09-15 2011-03-02 キヤノン株式会社 Probe array manufacturing equipment
US9192932B2 (en) * 2007-06-20 2015-11-24 Labcyte Inc. Closures which contain reservoirs and allow acoustic ejection
TWI537203B (en) * 2007-11-27 2016-06-11 惠普研發公司 Preparing a titration series
US7753636B2 (en) * 2008-03-25 2010-07-13 Hennig Emmett D Adjustable bale mover spikes
US8282999B2 (en) * 2008-04-04 2012-10-09 Micron Technology, Inc. Spin-on film processing using acoustic radiation pressure
US9293301B2 (en) 2013-12-23 2016-03-22 Varian Semiconductor Equipment Associates, Inc. In situ control of ion angular distribution in a processing apparatus
US10649497B2 (en) * 2014-07-23 2020-05-12 Apple Inc. Adaptive processes for improving integrity of surfaces
US10162343B2 (en) 2014-07-23 2018-12-25 Apple Inc. Adaptive processes for improving integrity of surfaces
LT3557262T (en) 2014-12-09 2022-11-10 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
US10743109B1 (en) * 2020-03-10 2020-08-11 Recursion Pharmaceuticals, Inc. Ordered picklist for liquid transfer

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308547A (en) 1978-04-13 1981-12-29 Recognition Equipment Incorporated Liquid drop emitter
US4697195A (en) 1985-09-16 1987-09-29 Xerox Corporation Nozzleless liquid droplet ejectors
US4719476A (en) 1986-04-17 1988-01-12 Xerox Corporation Spatially addressing capillary wave droplet ejectors and the like
US4877745A (en) * 1986-11-17 1989-10-31 Abbott Laboratories Apparatus and process for reagent fluid dispensing and printing
US4751529A (en) 1986-12-19 1988-06-14 Xerox Corporation Microlenses for acoustic printing
US4751534A (en) 1986-12-19 1988-06-14 Xerox Corporation Planarized printheads for acoustic printing
US4751530A (en) 1986-12-19 1988-06-14 Xerox Corporation Acoustic lens arrays for ink printing
US4797693A (en) 1987-06-02 1989-01-10 Xerox Corporation Polychromatic acoustic ink printing
US4801953A (en) * 1987-06-02 1989-01-31 Xerox Corporation Perforated ink transports for acoustic ink printing
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5122818A (en) 1988-12-21 1992-06-16 Xerox Corporation Acoustic ink printers having reduced focusing sensitivity
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US4959674A (en) 1989-10-03 1990-09-25 Xerox Corporation Acoustic ink printhead having reflection coating for improved ink drop ejection control
US5041849A (en) 1989-12-26 1991-08-20 Xerox Corporation Multi-discrete-phase Fresnel acoustic lenses and their application to acoustic ink printing
JPH06102378B2 (en) * 1989-12-27 1994-12-14 ゼロックス コーポレーション Acoustic ink print head
US5087931A (en) 1990-05-15 1992-02-11 Xerox Corporation Pressure-equalized ink transport system for acoustic ink printers
US5229793A (en) 1990-12-26 1993-07-20 Xerox Corporation Liquid surface control with an applied pressure signal in acoustic ink printing
US5231426A (en) 1990-12-26 1993-07-27 Xerox Corporation Nozzleless droplet projection system
US5229016A (en) 1991-08-08 1993-07-20 Microfab Technologies, Inc. Method and apparatus for dispensing spherical-shaped quantities of liquid solder
US5392064A (en) 1991-12-19 1995-02-21 Xerox Corporation Liquid level control structure
US5339101A (en) 1991-12-30 1994-08-16 Xerox Corporation Acoustic ink printhead
US5629724A (en) * 1992-05-29 1997-05-13 Xerox Corporation Stabilization of the free surface of a liquid
US5216451A (en) 1992-12-27 1993-06-01 Xerox Corporation Surface ripple wave diffusion in apertured free ink surface level controllers for acoustic ink printers
US5377902A (en) 1994-01-14 1995-01-03 Microfab Technologies, Inc. Method of making solder interconnection arrays
US5498444A (en) 1994-02-28 1996-03-12 Microfab Technologies, Inc. Method for producing micro-optical components
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5669971A (en) * 1994-04-06 1997-09-23 Specialty Coating Systems, Inc. Selective coating apparatus
EP0682988B1 (en) 1994-05-18 2001-11-14 Xerox Corporation Acoustic deposition of material layers
US5643353A (en) 1994-05-31 1997-07-01 Microfab Technologies, Inc. Controlling depoling and aging of piezoelectric transducers
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5415679A (en) 1994-06-20 1995-05-16 Microfab Technologies, Inc. Methods and apparatus for forming microdroplets of liquids at elevated temperatures
US5520715A (en) 1994-07-11 1996-05-28 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Directional electrostatic accretion process employing acoustic droplet formation
US5608433A (en) 1994-08-25 1997-03-04 Xerox Corporation Fluid application device and method of operation
US6030917A (en) 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US6045671A (en) 1994-10-18 2000-04-04 Symyx Technologies, Inc. Systems and methods for the combinatorial synthesis of novel materials
US6004617A (en) 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5631678A (en) 1994-12-05 1997-05-20 Xerox Corporation Acoustic printheads with optical alignment
JPH08254446A (en) 1995-03-16 1996-10-01 Fujitsu Ltd Ultrasonic printing method and device as well as formation of acoustic lens
US5658802A (en) 1995-09-07 1997-08-19 Microfab Technologies, Inc. Method and apparatus for making miniaturized diagnostic arrays
US6010316A (en) 1996-01-16 2000-01-04 The Board Of Trustees Of The Leland Stanford Junior University Acoustic micropump
US5808636A (en) 1996-09-13 1998-09-15 Xerox Corporation Reduction of droplet misdirectionality in acoustic ink printing
EP1669738A3 (en) 1996-10-09 2007-12-12 Symyx Technologies, Inc. Infrared spectroscopy and imaging of libraries
JP3296213B2 (en) * 1996-10-30 2002-06-24 三菱電機株式会社 Liquid ejector and printing apparatus using liquid ejector
US5877580A (en) * 1996-12-23 1999-03-02 Regents Of The University Of California Micromachined chemical jet dispenser
US6028189A (en) 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
JP3242859B2 (en) * 1997-04-03 2001-12-25 三菱電機株式会社 Liquid ejection device and printer device
US6187164B1 (en) 1997-09-30 2001-02-13 Symyx Technologies, Inc. Method for creating and testing a combinatorial array employing individually addressable electrodes
US6029896A (en) 1997-09-30 2000-02-29 Microfab Technologies, Inc. Method of drop size modulation with extended transition time waveform
US6087181A (en) 1998-03-16 2000-07-11 Symyx Technologies Sampling and detection of trace gas species by optical spectroscopy
DE29823691U1 (en) * 1998-04-16 1999-09-23 Evotec Biosystems Ag Device for generating and ejecting small drops of fluid with a pressure chamber designed as a reflective acoustic element
JPH11320868A (en) * 1998-05-15 1999-11-24 Mitsubishi Electric Corp Ink-jet head-driving apparatus
US6364454B1 (en) * 1998-09-30 2002-04-02 Xerox Corporation Acoustic ink printing method and system for improving uniformity by manipulating nonlinear characteristics in the system
US6048699A (en) * 1998-10-19 2000-04-11 Motorola, Inc. Method of fabricating bio-chip arrays
US6276779B1 (en) * 1999-11-24 2001-08-21 Xerox Corporation Acoustic fluid emission head and method of forming same
US6416164B1 (en) * 2001-07-20 2002-07-09 Picoliter Inc. Acoustic ejection of fluids using large F-number focusing elements

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