AU2001293033A1 - Method of producing non-human mammals - Google Patents

Method of producing non-human mammals

Info

Publication number
AU2001293033A1
AU2001293033A1 AU2001293033A AU9303301A AU2001293033A1 AU 2001293033 A1 AU2001293033 A1 AU 2001293033A1 AU 2001293033 A AU2001293033 A AU 2001293033A AU 9303301 A AU9303301 A AU 9303301A AU 2001293033 A1 AU2001293033 A1 AU 2001293033A1
Authority
AU
Australia
Prior art keywords
human mammals
producing non
producing
mice
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001293033A
Inventor
Kevin C. Eggan
Rudolf Jaenisch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitehead Institute for Biomedical Research
Original Assignee
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Institute for Biomedical Research filed Critical Whitehead Institute for Biomedical Research
Publication of AU2001293033A1 publication Critical patent/AU2001293033A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Feed For Specific Animals (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A method of producing mutant/targeted non-human mammals, such as mutant mice that does not require production of chimera and permits the introduction of multiple mutations in embryos and, thus, avoids the necessity of breeding to combine all of the desired mutations in a single animal. The method is efficient in producing ES mice.
AU2001293033A 2000-09-20 2001-09-20 Method of producing non-human mammals Abandoned AU2001293033A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23437800P 2000-09-20 2000-09-20
US60/234,378 2000-09-20
US25597000P 2000-12-15 2000-12-15
US60/255,970 2000-12-15
US09/755,003 2001-01-05
US09/755,003 US6784336B2 (en) 2000-09-20 2001-01-05 Method of producing mutant mice
PCT/US2001/029864 WO2002023983A2 (en) 2000-09-20 2001-09-20 Method of producing non-human mammals

Publications (1)

Publication Number Publication Date
AU2001293033A1 true AU2001293033A1 (en) 2002-04-02

Family

ID=27398562

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001293033A Abandoned AU2001293033A1 (en) 2000-09-20 2001-09-20 Method of producing non-human mammals

Country Status (7)

Country Link
US (5) US6784336B2 (en)
EP (1) EP1322151B1 (en)
AT (1) ATE377943T1 (en)
AU (1) AU2001293033A1 (en)
DE (1) DE60131429T2 (en)
DK (1) DK1322151T3 (en)
WO (1) WO2002023983A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6784336B2 (en) 2000-09-20 2004-08-31 Whitehead Institute For Biomedical Research Method of producing mutant mice
US20060110375A1 (en) * 2002-08-09 2006-05-25 Herbert Zech Method for producing cell lines and organs by means of differentiable cells
JP2007533291A (en) * 2003-07-08 2007-11-22 マクギル ユニバーシティ Outbred embryonic stem cells with good developmental potential
PT2767161T (en) * 2004-10-19 2018-04-20 Regeneron Pharma Method for generating an non-human animal homozygous for a genetic modification
WO2010008486A2 (en) 2008-06-24 2010-01-21 Parkinsons Institute Pluripotent cell lines and methods of use thereof
CA3026103A1 (en) 2016-06-10 2017-12-14 Saunders, Ann M. Methods for detecting structural variants in neurodegenerative disease
CN108070617A (en) * 2016-11-16 2018-05-25 中国科学院海洋研究所 A kind of exopalaemon carinicauda embryo micro-injection method and Application way structure mRNA are overexpressed model
CN111778287B (en) * 2020-04-30 2021-05-07 生物岛实验室 Preparation method of chimeric embryo or animal

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
DE19632532A1 (en) 1996-08-13 1998-02-19 Boehringer Ingelheim Int Process for the production of mammals with defined genetic properties
US6784336B2 (en) * 2000-09-20 2004-08-31 Whitehead Institute For Biomedical Research Method of producing mutant mice

Also Published As

Publication number Publication date
ATE377943T1 (en) 2007-11-15
DK1322151T3 (en) 2008-03-25
WO2002023983A2 (en) 2002-03-28
US20020062493A1 (en) 2002-05-23
WO2002023983A8 (en) 2002-07-11
DE60131429T2 (en) 2008-09-18
US6784336B2 (en) 2004-08-31
US20020078470A1 (en) 2002-06-20
EP1322151B1 (en) 2007-11-14
EP1322151A2 (en) 2003-07-02
DE60131429D1 (en) 2007-12-27
US20040231014A1 (en) 2004-11-18
US20050081257A1 (en) 2005-04-14
US20110061119A1 (en) 2011-03-10
WO2002023983A3 (en) 2002-10-17

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