AU2001289189A1 - Scleral clip and procedures for using same - Google Patents
Scleral clip and procedures for using sameInfo
- Publication number
- AU2001289189A1 AU2001289189A1 AU2001289189A AU2001289189A AU2001289189A1 AU 2001289189 A1 AU2001289189 A1 AU 2001289189A1 AU 2001289189 A AU2001289189 A AU 2001289189A AU 2001289189 A AU2001289189 A AU 2001289189A AU 2001289189 A1 AU2001289189 A1 AU 2001289189A1
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- Australia
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- sclera
- clip
- lens
- overlying
- eye
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Description
SCLERAL CLIP AND PROCEDURES FOR USING SAME
The present invention is directed to a surgical method for treating vision disorders, such as presbyopia and/or glaucoma, and to the associated devices used in conjunction with the method.
BACKGROUND OF THE INVENTION Presbyopia is a vision disorder associated with aging resulting from the failure of the accommodation mechanism of the eye. The accommodative mechanism is driven principally by parasympathetic innervation of the ciliary smooth muscle. In the non-presbyopic eye, this causes the muscle to slide forward in a unified manner and produces an inward movement of the muscle. The result is a reduction in the diameter of the ciliary muscle collar that instigates a series of events leading to an ability to see near objects clearly. While it is clear that the capsular elasticity of the lens of the eye, i.e., the ability of the lens capsule to mold the lens, diminishes with age, the precise cause of presbyopia remains the subject of debate.
Presbyopia is most frequently treated by the use of reading glasses, bifocals, and progressive multi-focal contact lenses. However, the inconveniences associated with eyeglasses and contact lenses have prompted investigation ' into, and the development of, surgical techniques aimed at correcting presbyopia. One such method is anterior ciliary sclerotomy ("ACS") . ACS is based on the theory that accommodation results primarily from ciliary body contraction, with the resulting forward movement of the lens . Its underlying rationale is based on the observation that the lens constantly grows throughout life, gradually crowding the
posterior chamber and eventually preventing full function of the ciliary body/zonular complex. The "crowded" state causes the reduction of lens power change with attempt at accommodation. ACS utilizes a series of symmetrical radial, partial-thickness scleral incisions to attempt to make more room for the ciliary body- -which in turn allows more space for the lens--by expanding the globe in the area of the ciliary body. However, this procedure has many potential complications, ranging from infection and hemorrhaging to perforation, which could result in retinal detachment, iris injury or prolapse.
Another proposed method for surgical reversal of presbyopia is based on the theory that presbyopia results when the distance between the ciliary body and the equator of the lens and its capsule becomes less with age as a result of the normal growth of the lens. Thus, under this theory presbyopia is treated by increasing the effective working distance of the ciliary muscle. This is accomplished by implanting a series of scleral expansion bands just below the surface of the sclera and outside the cornea. The bands stretch the sclera so that the diameter of the circle describing the intersection of the plane of the ciliary body with the sclera is slightly increased. See, U.S. Patent Nos . 5,354,331 and 5,489,299 to Schachar. However, at least one study has called into question the accuracy of the theory on which scleral expansion surgery is premised. See, Mathews, "Scleral Expansion Surgery Does Not Restore Accommodation in Human Presbyopia, " Opthamology, Vol. 106, No. 5, May, 1999, pages 873-877. This study concludes that, if scleral expansion surgery does alleviate presbyopia, an explanation other than the restoration of accommodation needs to be found. Schachar also believes that his scleral expansion bands may have utility in the treatment of primary open-angle glaucoma by restoring the level of force which the ciliary muscle exerts on the trabecular meshwork, thus opening the
drainage pores and relieving the intra ocular pressure (IOP) .
Regardless of the theory employed, there is a need for correcting presbyopia without the use of eyeglasses or contact lenses through a relatively safe and simple procedure that is easily reversible. There is also a need for treating glaucoma that is safe, effective, and simple.
Accordingly, it is the principal object of the present invention to provide a surgical method for the treatment of ophthalmic disorders that can be ameliorated by supporting or reinforcing the scleral .
More specifically, it is an object of the present invention to provide a surgical method for treating presbyopia and/or glaucoma. It is a further object to provide such a method that has a reduced potential for complications and is easily reversible .
It is a still further object of the invention to provide a clip uniquely suited for use in the treatment of presbyopia and/or glaucoma.
SUMMARY OF THE INVENTION
These objects, as well as others which will become apparent upon reference to the following detailed description and accompanying drawings, are accomplished by a method for treating presbyopia and glaucoma in which the sclera is supported or reinforced, while the spacial relationship between the ciliary muscle and the lens is substantially unchanged. Specifically, the method includes making an incision in the conjunctiva to gain access to the sclera overlying the ciliary muscle. The Tenon's capsules are moved laterally to expose the sclera, and the sclera is extended outwardly. A clip, or series of clips, is provided for grasping the outwardly-extended sclera. The clip includes a series of teeth or similar structures that engage a portion of the sclera, thus securing the clip
thereto, and then the Tenon's capsules are slid over the clip and the conjunctiva is closed. Preferably, four such scleral clips are applied to the sclera substantially equally spaced about the lens between the medial, inferior, lateral and superior rectus muscles . When applied to the sclera, the clips serve to prevent the sclera from buckling under tension applied by the ciliary muscle when trying to accommodate the eye to near vision.
In another aspect of the invention, a scleral clip is provided for applying to the sclera. The clips have a length of typically between 4 to 5 mm, and no longer than approximately 6.0 mm, so as to fit between adjacent rectus muscles. The clips are provided with means, such as teeth or spurs, for grasping --but not penetrating through--the sclera.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is a horizontal sectional view of an eyeball. Fig. 2 is an anterior view of the eye showing the extrinsic eye muscles.
Fig. 3 is a simplified diagram showing two scleral clips attached to an eye.
Figs. 4-14 are views of clips of various configurations to be applied to the sclera in accordance with the present invention.
DETAILED DESCRIPTION
The method of the present invention is based upon a theory for the cause of presbyopia different from those set forth above. Speci ically, presbyopia is caused by the failure of the ciliary body to adjust the lens diameter in order to focus images onto the retina for close objects. The ciliary muscles change the lens diameter by using the sclera as a support or fixation structure. As the sclera of the eye weakens due to age, the ciliary muscles lack the support needed in order to alter the lens diameter for
focusing on close objects. Thus, in order to allow the ciliary muscle to alter the lens diameter to see close objects, the sclera must be supported or reinforced. Accordingly, a method is provided that utilizes a unique clip for reinforcing the sclera, so as to form a stronger and more stable support for the ciliary muscles. In effect, the sclera is strengthened, and the ciliary muscles are then able to again function properly to provide near vision. It is believed that the method and its associated clip may also be advantageously used for the treatment of open angle glaucoma. Glaucoma, like presbyopia, is an age- related disease and is caused by a buildup of fluid pressure in the eye which damages the optic nerve. Over time, glaucoma destroys peripheral vision, thus shrinking the field of vision. In a healthy eye, the fluid produced by the ciliary tissues surrounding the lens is drained out of the eye by a series of drainage canals around the outer edge of the iris. With age, because the ciliary muscles lack support, they are less capable of maintaining these drainage canals in an open condition to allow free drainage of fluid. By tensioning the sclera according to the present method, the support is provided for the ciliary muscles, and the tissues of the eye that provide for drainage are stretched, thus reducing blockage of the fluid drainage canals and facilitating the drainage of fluid from the eye.
With reference to Fig. 1, there is seen a simplified sectional view of a human eye 10 having a lens 12 contained within a lens capsule 14. The ciliary body and ciliary muscle 16 are connected to the lens capsule 14 and also to the choroid 18. The sclera 20 overlies the choroid 18 and, at the front of the eye, the ciliary muscles 16, and terminates in the scleral spur 22 at the cornea 24 of the eye. The conjunctiva 26 surrounds the cornea 24 and overlies the bulbar sheath (or Tenon's capsule) 28 which, in turn, overlies the sclera 20 on the front of the eye 10.
Blood is supplied to the sclera by arteries in the superior, inferior, medial and lateral rectus muscles 30, 32, 34, and 36 respectively, best seen in Fig. 2.
In the method of the invention, the eye is treated by first making a series generally linear incisions (such as incisions 38 in Fig. 2) in the conjunctiva 26 to gain access to the sclera 20. Preferably, prior to making the incisions, a generally standard preoperative procedure is performed that includes marking the limbus and cornea at 10:00, 2:00, 5:00 and 8:00 with violet blue to indicate the location of the incisions.
The incisions 38 are made radially outwardly from the cornea so as to generally bisect the area between the adjacent rectus muscles (e.g., between the superior and medial rectus muscles 30, 34 as shown by the incisions 38 in Fig. 2) . For each incision 38, an initial incision is made to dissect to the conjunctiva 26, bypassing the Tenon's capsule 28. Then the incision is deepened to open the incision into the episclera, creating an incision of from 3 to 7 mm in length in the episclera. The incision is opened and, if necessary, the Tenon's capsule 28 is then moved laterally to expose the sclera 20.
The sclera 20 is then extended outwardly either mechanically with, e.g., a forceps, or by the application of a vacuum. A clip 40 is applied to the outwardly- extended sclera so as to put the sclera 20 under tension. The Tenon's capsule 28 is then reapposed over the clip and the conjunctiva 26 closed. No suturing is needed as the conjunctive self seals. The procedure is then repeated for each of the marked quadrants so that four clips are applied to the eye equally spaced about the cornea 24 between the adjacent rectus muscles.
Fig. 3 is a simplified drawing showing two clips 40 attached to the eye 10. The clips 40 grasp the sclera overlying the ciliary body 16 adjacent the iris 39. The applied clips 40 have a generally low profile, closely
adhering to the curvature of the eye, thus providing reinforcement to the sclera.
With reference to Figs. 4-9, the clips for use in the procedure can take many different forms. In general, it is contemplated that the clip 40 will have an overall dimension of approximately 1.5 - 2.5 mm in height (h) , 0.4 - 0.6 mm in thickness (t) and no longer than 5.0 - 6.0 mm in length (1) . The size of the clip is constrained by the distance between the adjacent rectus muscles. Specifically, the intent is to have the clip fit between the rectus muscles, so as to not impede the flow of blood to the eye through the arteries in the rectus muscles . Thus, instead of a single clip having a length of approximately 5.0 to 6.0 mm, a series of clips can be used the sum of whose total length fits between the adjacent rectus muscles. Of course, it is anticipated that the use of a single clip of the appropriate length will allow the procedure to be performed more easily and quickly.
As can be readily appreciated, the procedure can be simply reversed by merely again gaining access to the sclera by making an incision in the conjunctiva over the clip, moving, the Tenon's capsule to expose the clip, and then removing the clip. No incision into the sclera is required. In each of the Figs. 4-9, the clip 40 includes two arms 42, 44 joined together for relative movement to each other. On the inside portions of the clip are teeth, serrations, spurs, barbs, fingers, points 46 or other structures or projections for engaging and securely holding or gripping the sclera to the arms of the clip as it is affixed to the sclera. The teeth 46 are sized to engage the sclera, but not be of a size or configuration to penetrate through the sclera (which might cause erosion of the sclera) . Consequently, the teeth 46 may be as small as 20-80 μm . The clips are originally in their "open" position and then "closed" on the sclera with a forceps or other applicator, the clips remaining in their closed
condition in the absence of an external force being applied to separate the arms of the clip. It is contemplated that the arms of the clips will be closed on the order of 10 to 15 degrees . This should prolapse the uvea and move the sclera outward approximately 0.5 mm, for a total of 2 mm if four clips are applied. This will increase the amplitude of accommodation, thus reversing the effects of presbyopia. This outward movement of the sclera should also increase the angle of the canals of Schlemn, thus increasing the aqueous flow and decreasing the intra-ocular pressure, to ameliorate the effects of glaucoma. The clips 40 may be made of any biocompatible material, including tantalum, polymethyl methacrylate (PMMA) , and, preferably, titanium, that has sufficient deformability and resilience characteristics to permit the clip to be "opened" and then remain closed when applied to the sclera. Turning to Fig. 4, a first embodiment for the scleral clip 40 is shown in which each of the legs 42, 44 is bowed inward so as to impart some resiliency to the clip 40. Each leg 42, 44 also includes a series of teeth 46 for gripping into the sclera. The scleral clip of Fig. 5 is similar to that of Fig. 4, except resiliency is imparted to the clip 40 by having the legs 42, 44 bow outwardly.
Fig. 6 shows a further embodiment of a clip 40 that comprises a central portion in the shape of a rectangle folded along a diagonal, with a tooth 46 at each of the lower corners. A pair of staple-like members also having teeth 46 depend from the opposite ends of the rectangular portion so as to provide further means for gripping the sclera.
Fig. 7 illustrates a clip embodiment similar to Figs. 3 and 4 except that the clip 40 includes a resilient band 48 that connects one leg to the other. The band 48 serves to keep tension on the legs 42, 44 of the clip when the teeth engage the sclera.
Fig. 8 shows a clip 40 that has a spider-like configuration with a plurality (4, shown) of legs depending from a central body, each leg terminating in a tooth 46.
Fig. 9 shows a clip 40 similar to those of Figs. 3, 4 and 6, except that central portions of the clip 40 are removed to give it a fork-like appearance.
Fig. 10 is a further embodiment of a scleral clip 40 according to the present invention that is similar to the clip of Fig. 7, except that it does not include the resilient tensioning band. The clip 40 includes an indentation 50 in the center of each arm 42, 44 for cooperation with a tensioning instrument for application of the clip. Also, the teeth 46 have a length of 200 μm and are rounded, beveled, or blunted, so as to not present a sharp edge that could penetrate the sclera. The clip may be provided with a latex-free silicone polymer or acrylic coating, preferably white in color, on the outer or upper surface thereof in order to make the clip less conspicuous when attached to the eye . Figs. 11a and lib are a perspective view and end view, respectively, of a further embodiment of a clip 40. This embodiment is similar to that in Fig. 4, except that the arms 42, 44 are not bowed, but are substantially flat. The clip 40 is preformed so that the angle between the two arms is approximately 175 degrees, so that, when applied to the sclera and the arms are closed 10 to 15 degrees, the angle between the arms is between approximately 160 to 165 degrees. This angle provides for a clip that, when applied more closely approximates the curvature of the eyeball . This is likely to be perceived by the wearer as more comfortable, and may also reduce any erosion of tissue that overlies the applied clip. The angle of the teeth 46 to their respective arms 42, 44 is approximately 90 degrees. Fig. 12 is a perspective view of a clip 40 similar to that of Figs. 11a, lib, except that the end portions of the arms 42, 44 are relieved inwardly at 52. ■ This reduces the portion of the clip 40 that, when attached to the eye,
extends beyond the radius of curvature of the eye, to achieve the benefits of wearer comfort and reduction of tissue erosion discussed above.
Fig. 13 is a further embodiment of a clip 54 in accordance with the present invention. The clip 54 has the same overall dimensions as the clip disclosed above, i.e., approximately 3 to 5 mm by 5 to 6 mm, so as to fit between adjacent rectus muscles. However, the clip is oval or round in shape and has a central opening 56 enclosed by a continuous outer portion so that the clip 54 has a ringlike appearance. This clip is applied to the sclera by prolapsing the sclera through the central opening in the clip by mechanical means, such as a twist hook or forceps, or by the application of a vacuum. One or both of the central opening 56 or outer edge 58 may be provided with teeth 60, which are similar to teeth 46 described above, for securing the clip to the sclera. Further, the teeth may be bent out of the plane generally defined by the clip so that they more firmly grip the sclera. With reference to Fig. 14, the teeth on the outer edge or periphery 58 may be bent downwardly an angle from between approximately 90 degrees to approximately 135 degrees, while the teeth on the central opening or inner periphery 56 are bent downwardly an angle β between approximately 20 degrees to 45 degrees.
The clip 54 is generally flat, with little or no angle between the two arms or sides 62, 64, as defined by the center line through the clip, thus providing a very low profile. Preferably, the clip 54 is sufficiently thin so that it conforms to the natural shape or curvature of the eye.
Thus, a method and a clip for performing the method have been provided that fully meet the objects of the present invention. While the invention has been described in terms of a preferred method and clip, there is no intent to limit the invention to the same. Instead, the invention is defined by the scope of the following claims.
Claims (30)
1. A method for treatment of ophthalmic disorders in an eye having a lens, ciliary muscles supporting the lens, sclera overlying the ciliary muscles, canals of Schlemn and trabecular meshwork, comprising supporting the sclera to thereby increase the amplitude of accommodation and posteriorly displace the ciliary muscles to increase the flow of the canals of Schlemn and the trabecular meshwork.
2. The method of Claim 1 wherein the sclera is supported at least two locations overlying the ciliary muscles .
3. The method o°f Claim 1 wherein the sclera is supported at four locations substantially equally spaced about the lens.
4. The method of Claims 1, 2, or 3 wherein the sclera is supported by a clip that grips the sclera.
5. A method for treating presbyopia in an eye having a lens, ciliary muscles supporting the lens, and sclera overlying the ciliary muscles by providing support to the sclera while substantially maintaining the spacial relationship between the ciliary muscle and the lens .
6. The method of Claim 5 wherein the sclera is supported in at least two locations overlying the ciliary muscles .
7. The method of Claim 5 wherein the sclera is supported at four locations substantially equally spaced about the lens .
8. The method of Claims 5, 6, or 7 wherein the sclera is supported by a clip that grips the sclera.
9. A method of treating presbyopia in a eye having a lens, ciliary muscles suspending the lens, sclera overlying the ciliary muscles and conjunctiva overlying the sclera comprising the steps of: making an incision in the conjunctiva to gain access to the sclera overlying the ciliary muscle; exposing the sclera; providing a clip for attachment to the sclera; securing the clip to the sclera; and closing the conjunctiva over the clip.
10. The method of Claim 9 wherein a plurality of clips are applied to the sclera.
11. The method of Claim 10 wherein at least four clips are applied to the sclera substantially equally spaced about the lens .
12. A clip for applying to the sclera of the eye comprising two arms relatively moveable with respect to each other from an open position to a closed position, and at least one tooth on each of said arms for grasping the sclera, the arms remaining in the closed position in the absence of an external force applied therebetween.
13. The clip of Claim 12 wherein the teeth are sized and configured to not penetrate through the sclera.
14. The clip of Claim 13 wherein the teeth are between approximately 20 to 80 μm in length.
15. A method for treating glaucoma in an eye having a lens, ciliary muscles supporting the lens, and sclera overlying the ciliary muscles by providing support to the sclera while substantially maintaining the spacial relationship between the ciliary muscle and the lens.
16. The method of Claim 15 wherein the sclera is supported in at least two locations overlying the ciliary muscles.
17. The method of Claim 15 wherein the sclera is supported at four locations substantially equally spaced about the lens .
18. The method of Claims 15, 16, or 17 wherein the sclera is supported by a clip that grips the sclera.
19. A method of treating glaucoma in a eye having a lens, ciliary muscles suspending the lens, sclera overlying the ciliary muscles and conjunctiva overlying the sclera comprising the steps of: making an incision in the conjunctiva to gain access to the sclera overlying the ciliary muscle; exposing the sclera; providing a clip for attachment to the sclera; securing the clip to the sclera; and closing the conjunctiva over the clip.
20. The method of Claim 19 wherein a plurality of clips are applied to the sclera.
21. The method of Claim 20 wherein at least four clips are applied to the sclera substantially equally spaced about the lens .
22. A clip for attachment to an eye having a plurality of rectus muscles, scleral tissue, and a curvature, the clip being sized to fit between adjacent rectus muscles, having a shape so as to closely conform to the curvature of the eye, and being adapted to be secured to the scleral tissue.
23. The clip of Claim 22 wherein the clip is adapted to be secured to the scleral tissue without penetrating through the scleral tissue.
24. The clip of Claim 22 or 23 further comprising two arms relatively moveable with respect to each other from an open position to a closed position, and at least one tooth on each of said arms for securing the clip to the sclera tissue, the arms remaining in the closed position in the absence of an external force applied therebetween.
25. The clip of Claim 24 wherein the teeth are sized and configured to not penetrate through the sclera.
26. The clip of Claim 25 wherein the teeth are between approximately 20 to 80 μm in length.
27. The ' clip of Claim 22 wherein the clip has an outer periphery that includes a plurality of teeth along at least a portion thereof for securing the clip to the scleral tissue.
28. The clip of Claim 27 wherein the clip comprises two arms relatively moveable with respect to each other from an open position to a closed position, each arm having at least one tooth associated therewith for securing the clip to the scleral tissue, the arms remaining in the closed position in the absence of an external force applied therebetween.
29. The clip of claim 28 wherein the clip is generally rectangular in shape with four edges, with each arm being defined by a line bisecting the rectangle into two generally equal halves, the clip being bendable about the bisecting line and having a plurality of teeth associated with two of the opposed edges.
30. The clip of Claim 29 wherein the opposed edges of the clip that do not have a plurality of teeth associated therewith are relieved inwardly.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/655,377 | 2000-09-05 | ||
US09/655,377 US6517555B1 (en) | 2000-09-05 | 2000-09-05 | Method for treating presbyopia |
PCT/US2001/042021 WO2002019950A1 (en) | 2000-09-05 | 2001-09-05 | Scleral clip and procedures for using same |
Publications (2)
Publication Number | Publication Date |
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AU2001289189A1 true AU2001289189A1 (en) | 2002-06-13 |
AU2001289189B2 AU2001289189B2 (en) | 2006-07-20 |
Family
ID=24628641
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001289189A Ceased AU2001289189B2 (en) | 2000-09-05 | 2001-09-05 | Scleral clip and procedures for using same |
AU8918901A Pending AU8918901A (en) | 2000-09-05 | 2001-09-05 | Scleral clip and procedures for using same |
AU2001289186A Abandoned AU2001289186A1 (en) | 2000-09-05 | 2001-09-05 | Scleral clip and procedures for using same |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU8918901A Pending AU8918901A (en) | 2000-09-05 | 2001-09-05 | Scleral clip and procedures for using same |
AU2001289186A Abandoned AU2001289186A1 (en) | 2000-09-05 | 2001-09-05 | Scleral clip and procedures for using same |
Country Status (11)
Country | Link |
---|---|
US (1) | US6517555B1 (en) |
EP (2) | EP1315457A4 (en) |
JP (1) | JP2004508094A (en) |
KR (2) | KR20030038726A (en) |
CN (1) | CN1230127C (en) |
AU (3) | AU2001289189B2 (en) |
BR (1) | BR0114044A (en) |
CA (1) | CA2420000A1 (en) |
HK (1) | HK1062135A1 (en) |
MX (2) | MXPA03001922A (en) |
WO (2) | WO2002019950A1 (en) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6391048B1 (en) | 2000-01-05 | 2002-05-21 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant and methods of use |
US7842068B2 (en) | 2000-12-07 | 2010-11-30 | Integrated Vascular Systems, Inc. | Apparatus and methods for providing tactile feedback while delivering a closure device |
US6461364B1 (en) | 2000-01-05 | 2002-10-08 | Integrated Vascular Systems, Inc. | Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use |
US8758400B2 (en) | 2000-01-05 | 2014-06-24 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US9579091B2 (en) | 2000-01-05 | 2017-02-28 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
ATE361702T1 (en) * | 2000-09-08 | 2007-06-15 | Nova Science Ltd | SURGICAL STAPLE DEVICE |
US20020082621A1 (en) | 2000-09-22 | 2002-06-27 | Schurr Marc O. | Methods and devices for folding and securing tissue |
US6626918B1 (en) * | 2000-10-06 | 2003-09-30 | Medical Technology Group | Apparatus and methods for positioning a vascular sheath |
US20020138086A1 (en) * | 2000-12-06 | 2002-09-26 | Robert Sixto | Surgical clips particularly useful in the endoluminal treatment of gastroesophageal reflux disease (GERD) |
US6716226B2 (en) * | 2001-06-25 | 2004-04-06 | Inscope Development, Llc | Surgical clip |
US7727246B2 (en) * | 2000-12-06 | 2010-06-01 | Ethicon Endo-Surgery, Inc. | Methods for endoluminal treatment |
US8062314B2 (en) * | 2000-12-06 | 2011-11-22 | Ethicon Endo-Surgery, Inc. | Methods for the endoluminal treatment of gastroesophageal reflux disease (GERD) |
US20020068945A1 (en) * | 2000-12-06 | 2002-06-06 | Robert Sixto | Surgical clips particularly useful in the endoluminal treatment of gastroesophageal reflux disease (GERD) |
US7232445B2 (en) | 2000-12-06 | 2007-06-19 | Id, Llc | Apparatus for the endoluminal treatment of gastroesophageal reflux disease (GERD) |
US6695867B2 (en) | 2002-02-21 | 2004-02-24 | Integrated Vascular Systems, Inc. | Plunger apparatus and methods for delivering a closure device |
US7905900B2 (en) | 2003-01-30 | 2011-03-15 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US7211101B2 (en) | 2000-12-07 | 2007-05-01 | Abbott Vascular Devices | Methods for manufacturing a clip and clip |
US6623510B2 (en) * | 2000-12-07 | 2003-09-23 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US8690910B2 (en) | 2000-12-07 | 2014-04-08 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US6692524B2 (en) * | 2001-01-19 | 2004-02-17 | Georges Baikoff | Techniques and implants for correcting presbyopia |
US6808491B2 (en) * | 2001-05-21 | 2004-10-26 | Syntheon, Llc | Methods and apparatus for on-endoscope instruments having end effectors and combinations of on-endoscope and through-endoscope instruments |
IES20010547A2 (en) | 2001-06-07 | 2002-12-11 | Christy Cummins | Surgical Staple |
US7338506B2 (en) * | 2001-09-05 | 2008-03-04 | Caro Nicholas C | Scleral clip and procedures for using same |
EP1513453B1 (en) | 2002-06-04 | 2008-12-17 | Abbott Vascular Inc | Blood vessel closure clip and delivery device |
US8202293B2 (en) | 2003-01-30 | 2012-06-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8398656B2 (en) * | 2003-01-30 | 2013-03-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8905937B2 (en) | 2009-02-26 | 2014-12-09 | Integrated Vascular Systems, Inc. | Methods and apparatus for locating a surface of a body lumen |
US8758398B2 (en) * | 2006-09-08 | 2014-06-24 | Integrated Vascular Systems, Inc. | Apparatus and method for delivering a closure element |
US20040193188A1 (en) * | 2003-03-25 | 2004-09-30 | Inscope Development, Llc | Laminated surgical clip |
US7799042B2 (en) * | 2004-05-13 | 2010-09-21 | The Cleveland Clinic Foundation | Skin lesion exciser and skin-closure device therefor |
IES20040368A2 (en) | 2004-05-25 | 2005-11-30 | James E Coleman | Surgical stapler |
BRPI0512945A (en) * | 2004-07-01 | 2008-04-15 | Nicholas C Caro | ophthalmic staple and associated surgical method |
US20060004386A1 (en) * | 2004-07-01 | 2006-01-05 | Caro Nicholas C | Ophthalmic clip and associated surgical method |
US7252662B2 (en) | 2004-11-02 | 2007-08-07 | Lenticular Research Group Llc | Apparatus and processes for preventing or delaying one or more symptoms of presbyopia |
US7392350B2 (en) * | 2005-02-10 | 2008-06-24 | International Business Machines Corporation | Method to operate cache-inhibited memory mapped commands to access registers |
AU2006213997A1 (en) | 2005-02-19 | 2006-08-24 | Lenticular Research Group Llc | Apparatus and processes for preventing or delaying onset or progression of age-related cataract |
US8926633B2 (en) | 2005-06-24 | 2015-01-06 | Abbott Laboratories | Apparatus and method for delivering a closure element |
US8313497B2 (en) | 2005-07-01 | 2012-11-20 | Abbott Laboratories | Clip applier and methods of use |
WO2007076533A2 (en) * | 2005-12-29 | 2007-07-05 | Caro Nicholas C | Ophthalmic clip and associated surgical method |
US8808310B2 (en) | 2006-04-20 | 2014-08-19 | Integrated Vascular Systems, Inc. | Resettable clip applier and reset tools |
US8556930B2 (en) | 2006-06-28 | 2013-10-15 | Abbott Laboratories | Vessel closure device |
MX2009000378A (en) | 2006-07-11 | 2009-08-12 | Refocus Group Inc | Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods. |
US8911496B2 (en) | 2006-07-11 | 2014-12-16 | Refocus Group, Inc. | Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods |
US20090157101A1 (en) * | 2007-12-17 | 2009-06-18 | Abbott Laboratories | Tissue closure system and methods of use |
US8893947B2 (en) | 2007-12-17 | 2014-11-25 | Abbott Laboratories | Clip applier and methods of use |
US7841502B2 (en) | 2007-12-18 | 2010-11-30 | Abbott Laboratories | Modular clip applier |
US9282965B2 (en) | 2008-05-16 | 2016-03-15 | Abbott Laboratories | Apparatus and methods for engaging tissue |
US9241696B2 (en) | 2008-10-30 | 2016-01-26 | Abbott Vascular Inc. | Closure device |
CA2744245A1 (en) * | 2008-11-19 | 2010-05-27 | Refocus Group, Inc. | Artificial intraocular lens, altered natural crystalline lens, or refilled natural crystalline lens capsule with one or more scleral prostheses for improved performance |
US8858594B2 (en) | 2008-12-22 | 2014-10-14 | Abbott Laboratories | Curved closure device |
US9414820B2 (en) | 2009-01-09 | 2016-08-16 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US20100179589A1 (en) | 2009-01-09 | 2010-07-15 | Abbott Vascular Inc. | Rapidly eroding anchor |
US9173644B2 (en) * | 2009-01-09 | 2015-11-03 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9089311B2 (en) | 2009-01-09 | 2015-07-28 | Abbott Vascular Inc. | Vessel closure devices and methods |
US9486191B2 (en) | 2009-01-09 | 2016-11-08 | Abbott Vascular, Inc. | Closure devices |
US20100179567A1 (en) * | 2009-01-09 | 2010-07-15 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US20110218568A1 (en) * | 2009-01-09 | 2011-09-08 | Voss Laveille K | Vessel closure devices, systems, and methods |
US20100185234A1 (en) | 2009-01-16 | 2010-07-22 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US20110054492A1 (en) * | 2009-08-26 | 2011-03-03 | Abbott Laboratories | Medical device for repairing a fistula |
US8758399B2 (en) | 2010-08-02 | 2014-06-24 | Abbott Cardiovascular Systems, Inc. | Expandable bioabsorbable plug apparatus and method |
US8603116B2 (en) | 2010-08-04 | 2013-12-10 | Abbott Cardiovascular Systems, Inc. | Closure device with long tines |
US9149276B2 (en) | 2011-03-21 | 2015-10-06 | Abbott Cardiovascular Systems, Inc. | Clip and deployment apparatus for tissue closure |
US9039737B2 (en) * | 2011-03-29 | 2015-05-26 | Ocunetics, Inc. | Fasteners, deployment systems, and methods for ophthalmic tissue closure and fixation of ophthalmic prostheses and other uses |
US9332976B2 (en) | 2011-11-30 | 2016-05-10 | Abbott Cardiovascular Systems, Inc. | Tissue closure device |
JP2015502821A (en) | 2011-12-08 | 2015-01-29 | イリデックス・コーポレーション | Fasteners, installation systems and methods for ocular tissue closure and ocular prosthesis fixation and other uses |
US9364209B2 (en) | 2012-12-21 | 2016-06-14 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device |
CN105125341B (en) * | 2015-09-08 | 2018-02-27 | 中山大学中山眼科中心 | A kind of operation device for ophthalmologic operation |
US10426473B2 (en) * | 2017-10-19 | 2019-10-01 | Abbott Cardiovascular Systems Inc. | System and method for plicating a heart valve |
EP3984504A1 (en) * | 2020-10-13 | 2022-04-20 | GlauVue, Inc. | Scleral device for treatment of open angle glaucoma |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3378010A (en) * | 1965-07-28 | 1968-04-16 | Coldling | Surgical clip with means for releasing the clamping pressure |
US4413635A (en) | 1980-04-07 | 1983-11-08 | Hughes Aircraft Company | Ophthalmic clip |
US4414985A (en) | 1980-04-07 | 1983-11-15 | Hughes Aircraft Company | Ophthalmic clip |
US4762260A (en) | 1986-09-11 | 1988-08-09 | Ophthalmic Ventures Limited Partnership | Surgical microstapler |
US4895289A (en) | 1986-12-22 | 1990-01-23 | Ophthalmic Ventures Limited Partnership | Ophthalmic stapler |
US6051023A (en) | 1987-06-15 | 2000-04-18 | Keravision, Inc. | Corneal curvature adjustment ring and apparatus for making a cornea |
IE893270L (en) * | 1988-10-11 | 1990-04-11 | Seamus Geoghegan | Ophthalmic staple and instruments for implementing use |
US5383898A (en) | 1991-12-13 | 1995-01-24 | Sarfarazi; Faezeh M. | Sarfarazi corneal incision closure |
US6197056B1 (en) | 1992-07-15 | 2001-03-06 | Ras Holding Corp. | Segmented scleral band for treatment of presbyopia and other eye disorders |
US5354331A (en) | 1992-07-15 | 1994-10-11 | Schachar Ronald A | Treatment of presbyopia and other eye disorders |
US5489399A (en) * | 1994-11-02 | 1996-02-06 | Rengo Co., Ltd. | Carbon dioxide gas generating compositions |
US5774274A (en) | 1995-05-12 | 1998-06-30 | Schachar; Ronald A. | Variable focus lens by small changes of the equatorial lens diameter |
US5609599A (en) * | 1995-07-27 | 1997-03-11 | Levin; John M. | Leak clip |
US5797932A (en) | 1995-11-24 | 1998-08-25 | Jong-Deok Park | Muscle clamping device |
US5916224A (en) * | 1997-07-09 | 1999-06-29 | The United States Of America As Represented By The Secretary Of The Army | Tendon repair clip implant |
US6007578A (en) | 1997-10-08 | 1999-12-28 | Ras Holding Corp | Scleral prosthesis for treatment of presbyopia and other eye disorders |
US6146366A (en) | 1998-11-03 | 2000-11-14 | Ras Holding Corp | Device for the treatment of macular degeneration and other eye disorders |
US6217594B1 (en) * | 1999-10-21 | 2001-04-17 | Retinalabs.Com, Inc. | Apparatus, system and method for securing scleral tissue |
-
2000
- 2000-09-05 US US09/655,377 patent/US6517555B1/en not_active Expired - Lifetime
-
2001
- 2001-09-05 CN CNB018151876A patent/CN1230127C/en not_active Expired - Fee Related
- 2001-09-05 EP EP01968987A patent/EP1315457A4/en not_active Withdrawn
- 2001-09-05 JP JP2002524413A patent/JP2004508094A/en active Pending
- 2001-09-05 BR BR0114044-2A patent/BR0114044A/en not_active Application Discontinuation
- 2001-09-05 KR KR10-2003-7003201A patent/KR20030038726A/en not_active Application Discontinuation
- 2001-09-05 WO PCT/US2001/042021 patent/WO2002019950A1/en not_active Application Discontinuation
- 2001-09-05 KR KR1020037003200A patent/KR100813426B1/en not_active IP Right Cessation
- 2001-09-05 AU AU2001289189A patent/AU2001289189B2/en not_active Ceased
- 2001-09-05 AU AU8918901A patent/AU8918901A/en active Pending
- 2001-09-05 EP EP01968990A patent/EP1339359A4/en not_active Ceased
- 2001-09-05 MX MXPA03001922A patent/MXPA03001922A/en not_active Application Discontinuation
- 2001-09-05 MX MXPA03001921A patent/MXPA03001921A/en unknown
- 2001-09-05 CA CA002420000A patent/CA2420000A1/en not_active Abandoned
- 2001-09-05 WO PCT/US2001/042018 patent/WO2002019925A1/en not_active Application Discontinuation
- 2001-09-05 AU AU2001289186A patent/AU2001289186A1/en not_active Abandoned
-
2004
- 2004-05-28 HK HK04103811A patent/HK1062135A1/en not_active IP Right Cessation
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