AU2001287180A1 - Microarray detector and synthesizer - Google Patents

Microarray detector and synthesizer

Info

Publication number
AU2001287180A1
AU2001287180A1 AU2001287180A AU8718001A AU2001287180A1 AU 2001287180 A1 AU2001287180 A1 AU 2001287180A1 AU 2001287180 A AU2001287180 A AU 2001287180A AU 8718001 A AU8718001 A AU 8718001A AU 2001287180 A1 AU2001287180 A1 AU 2001287180A1
Authority
AU
Australia
Prior art keywords
synthesizer
microarray detector
microarray
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001287180A
Inventor
Perry Sandstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Able Signal Co LLC
Original Assignee
Able Signal Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27093588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001287180(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/640,617 external-priority patent/US6567163B1/en
Application filed by Able Signal Co LLC filed Critical Able Signal Co LLC
Publication of AU2001287180A1 publication Critical patent/AU2001287180A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/08—Integrated apparatus specially adapted for both creating and screening libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/021—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using plane or convex mirrors, parallel phase plates, or particular reflectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0229—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using masks, aperture plates, spatial light modulators or spatial filters, e.g. reflective filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
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    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00439—Maskless processes using micromirror arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00675—In-situ synthesis on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00693—Means for quality control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Composite Materials (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AU2001287180A 2000-08-17 2001-08-14 Microarray detector and synthesizer Abandoned AU2001287180A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09640617 2000-08-17
US09/640,617 US6567163B1 (en) 2000-08-17 2000-08-17 Microarray detector and synthesizer
US09679858 2000-10-05
US09/679,858 US6545758B1 (en) 2000-08-17 2000-10-05 Microarray detector and synthesizer
PCT/US2001/041698 WO2002014838A2 (en) 2000-08-17 2001-08-14 Microarray detector and synthesizer

Publications (1)

Publication Number Publication Date
AU2001287180A1 true AU2001287180A1 (en) 2002-02-25

Family

ID=27093588

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001287180A Abandoned AU2001287180A1 (en) 2000-08-17 2001-08-14 Microarray detector and synthesizer

Country Status (4)

Country Link
US (4) US6545758B1 (en)
EP (1) EP1311828A2 (en)
AU (1) AU2001287180A1 (en)
WO (1) WO2002014838A2 (en)

Families Citing this family (192)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
DE69527585T2 (en) * 1994-06-08 2003-04-03 Affymetrix Inc Method and device for packaging chips
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US7245376B2 (en) * 1995-09-20 2007-07-17 J. A. Woollam Co., Inc. Combined spatial filter and relay systems in rotating compensator ellipsometer/polarimeter
US7336361B1 (en) * 1995-09-20 2008-02-26 J.A. Woollam Co., Inc. Spectroscopic ellipsometer and polarimeter systems
US7317530B2 (en) * 2003-08-28 2008-01-08 J.A. Woollam Co., Inc. Combined spatial filter and relay systems
US7193706B2 (en) * 2000-08-02 2007-03-20 Arizona Board Of Regents, Acting On Behalf Of Arizona State University Computer interfaced scanning fluorescence lifetime microscope applied to directed evolution
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US6781691B2 (en) * 2001-02-02 2004-08-24 Tidal Photonics, Inc. Apparatus and methods relating to wavelength conditioning of illumination
DE10127611C2 (en) * 2001-06-07 2003-08-07 Jena Optronik Gmbh Arrangement for exciting and reading out the fluorescent radiation of a sample carrier with a large number of individual samples
US7365849B2 (en) * 2001-12-27 2008-04-29 Taiwan Unison Biotechnology, Inc. Portable, scanning and analyzing apparatus
JP4423039B2 (en) * 2001-12-31 2010-03-03 ユロス・パテント・アクチボラゲット Method and apparatus for reducing noise in microfluidic devices
US7221783B2 (en) 2001-12-31 2007-05-22 Gyros Patent Ab Method and arrangement for reducing noise
US7157229B2 (en) 2002-01-31 2007-01-02 Nimblegen Systems, Inc. Prepatterned substrate for optical synthesis of DNA probes
JP2004003989A (en) * 2002-03-15 2004-01-08 Affymetrix Inc System, method, and product for scanning biological material
GB0209329D0 (en) * 2002-04-24 2002-06-05 Imp College Innovations Ltd A device
CA2484251C (en) 2002-04-30 2015-06-23 University Of South Florida Materials and methods for inhibition of respiratory syncytial virus infection
US7351379B2 (en) * 2002-06-14 2008-04-01 Agilent Technologies, Inc. Fluid containment structure
US20030232344A1 (en) * 2002-06-14 2003-12-18 Arthur Schleifer Hybridization process for arrays
US7371348B2 (en) * 2002-06-14 2008-05-13 Agilent Technologies Multiple array format
US20070275411A1 (en) 2006-05-25 2007-11-29 Mcgall Glenn H Silane mixtures
US7332273B2 (en) * 2002-06-20 2008-02-19 Affymetrix, Inc. Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
US20040023224A1 (en) * 2002-07-31 2004-02-05 Corson John F. Maintaining scale factor in an instrument for reading a biopolymer array
US7867754B1 (en) * 2002-08-01 2011-01-11 Purdue Research Foundation Microarrays for analyte detection
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7595303B1 (en) 2002-09-05 2009-09-29 University Of South Florida Genetic adjuvants for immunotherapy
US6678308B1 (en) * 2002-09-06 2004-01-13 The Boeing Company Laser resonator system using offner relay
WO2004024328A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US20040120577A1 (en) * 2002-10-06 2004-06-24 Igor Touzov Digital video based array detector for parallel process control and radiation driver for micro-scale devices
US7170598B2 (en) 2002-10-17 2007-01-30 Direvo Biotech Ag Multi-parameter fluorimetric analysis in a massively parallel multi-focal arrangement and the use thereof
DK1411345T3 (en) * 2002-10-17 2007-01-02 Direvo Biotech Ag Multiparameter fluorimetric analysis in parallel with multifocal arrangement
US6781094B2 (en) * 2002-12-30 2004-08-24 Texas Instruments Incorporated Analysis of MEMS mirror device using a laser for mirror removal
US8268551B2 (en) * 2003-01-27 2012-09-18 San Diego State University Foundation Sensitive sensing based on optical nonlinear wave mixing
JP3787631B2 (en) * 2003-03-07 2006-06-21 国立大学法人名古屋大学 Bioluminescence measurement / analysis program, computer-readable recording medium storing the program, and bioluminescence measurement / analysis apparatus including the program and the computer
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
US7189987B2 (en) * 2003-04-02 2007-03-13 Lucent Technologies Inc. Electrical detection of selected species
AU2004241602B2 (en) * 2003-05-20 2008-05-08 Syndiant, Inc. Digital backplane
US6989920B2 (en) * 2003-05-29 2006-01-24 Asml Holding N.V. System and method for dose control in a lithographic system
US7061591B2 (en) * 2003-05-30 2006-06-13 Asml Holding N.V. Maskless lithography systems and methods utilizing spatial light modulator arrays
US20050026154A1 (en) * 2003-07-31 2005-02-03 Laurakay Bruhn Masking chemical arrays
US7317415B2 (en) * 2003-08-08 2008-01-08 Affymetrix, Inc. System, method, and product for scanning of biological materials employing dual analog integrators
EP1713540A2 (en) * 2003-09-26 2006-10-25 Tidal Photonics, Inc. Apparatus and methods for performing phototherapy, photodynamic therapy and diagnosis
JP5089168B2 (en) * 2003-09-26 2012-12-05 タイダール フォトニクス，インク． Apparatus and method for extended dynamic range imaging endoscope system
WO2005031433A1 (en) * 2003-09-26 2005-04-07 Tidal Photonics, Inc. Apparatus and methods relating to color imaging endoscope systems
JP2007506947A (en) * 2003-09-26 2007-03-22 タイダール フォトニクス，インク． Apparatus and method for enhanced spectral measurement system
US7488607B2 (en) * 2003-09-30 2009-02-10 Agilent Technologies, Inc. Electronically readable microarray with electronic addressing function
KR100640153B1 (en) * 2004-05-03 2006-10-31 (주)나노스토리지 Apparatus for patterning bio-cell
US7157681B1 (en) * 2003-12-16 2007-01-02 Wolfgang Tetzlaff Photomultiplier tube gain stabilization for radiation dosimetry system
US20070295917A1 (en) * 2004-01-26 2007-12-27 Applera Corporation Single excitation wavelength fluorescent detection system
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US20070040924A1 (en) * 2005-08-19 2007-02-22 Stereo Display, Inc. Cellular phone camera with three-dimensional imaging function
WO2005105136A1 (en) * 2004-04-27 2005-11-10 University Of South Florida Nanogene therapy for cell proliferation disorders
US8634067B2 (en) * 2004-05-12 2014-01-21 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for detecting microscopic objects
US7221449B2 (en) * 2004-06-28 2007-05-22 Applera Corporation Apparatus for assaying fluorophores in a biological sample
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7169617B2 (en) 2004-08-19 2007-01-30 Fujitsu Limited Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules
WO2006033962A2 (en) * 2004-09-20 2006-03-30 Wisconsin Alumni Research Foundation Nonlinear spectroscopic methods for identifying and characterizing molecular interactions
WO2006050355A2 (en) * 2004-11-01 2006-05-11 David Jones A compact portable rugged fluorescence microscope sealed against dust and water
WO2006055735A2 (en) * 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
EP2194485B1 (en) 2004-11-16 2012-10-17 Illumina, Inc. Method and apparatus for reading coded microbeads
US20060134324A1 (en) * 2004-11-17 2006-06-22 Illumina, Inc. Filament with easily removed protective coating and methods for stripping the same
US7745143B2 (en) * 2004-11-19 2010-06-29 Plexera, Llc Plasmon resonance biosensor and method
US20060138349A1 (en) * 2004-12-27 2006-06-29 Asml Netherlands B.V. Lithographic apparatus and device manufacturing method
US8858495B2 (en) 2004-12-28 2014-10-14 St. Jude Medical, Atrial Fibrillation Division, Inc. Five degree of freedom ultrasound catheter and catheter control handle
US7507575B2 (en) * 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
JP2006292421A (en) * 2005-04-06 2006-10-26 Sharp Corp Fluorescence detector
US8351026B2 (en) 2005-04-22 2013-01-08 Affymetrix, Inc. Methods and devices for reading microarrays
WO2006116362A2 (en) * 2005-04-25 2006-11-02 The Trustees Of Boston University Structured substrates for optical surface profiling
CA2607045A1 (en) * 2005-05-04 2006-11-09 Stratagene California System and method for a pulsed light source used in fluorescence detection
US7858382B2 (en) * 2005-05-27 2010-12-28 Vidar Systems Corporation Sensing apparatus having rotating optical assembly
JP2008544254A (en) * 2005-06-13 2008-12-04 ストラタジーン カリフォルニア System and method for fluorescence excitation and detection having separate optical paths
US7527763B2 (en) * 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US20070009382A1 (en) * 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7414715B2 (en) * 2005-07-14 2008-08-19 Kla-Tencor Technologies Corp. Systems, circuits and methods for extending the detection range of an inspection system by avoiding detector saturation
US7436508B2 (en) 2005-07-14 2008-10-14 Kla-Tencor Technologies Corp. Systems, circuits and methods for reducing thermal damage and extending the detection range of an inspection system
US7423250B2 (en) * 2005-07-14 2008-09-09 Kla-Tencor Technologies Corp. Systems, circuits and methods for extending the detection range of an inspection system by avoiding circuit saturation
DE102005034829A1 (en) * 2005-07-26 2007-02-01 Leica Microsystems (Schweiz) Ag Microscope for use in ophthalmology for surgery and diagnosis, has laser diode for emitting coherent light beam bundle for travel along defined illumination beam path, which is modified by spatial light modulator
US9234852B2 (en) 2005-07-29 2016-01-12 Mitutoyo Corporation Systems and methods for controlling strobe illumination
US8045002B2 (en) * 2005-07-29 2011-10-25 Mitutoyo Corporation Systems and methods for controlling strobe illumination
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
US7595473B2 (en) * 2005-08-22 2009-09-29 Tufts University Method and system of array imaging
US20070196834A1 (en) * 2005-09-09 2007-08-23 Francesco Cerrina Method and system for the generation of large double stranded DNA fragments
EP4071458A1 (en) 2005-09-21 2022-10-12 Luminex Corporation Methods and systems for image data processing
US7544330B2 (en) * 2005-09-28 2009-06-09 Idexx Laboratories, Inc. Microplate sample tracking system
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US8372340B2 (en) * 2005-10-19 2013-02-12 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
KR100818351B1 (en) * 2005-10-28 2008-04-01 굿젠 주식회사 Multiple channel bio chip scanner
KR100671286B1 (en) 2005-11-08 2007-01-19 재단법인서울대학교산학협력재단 Single crystalline silicon micro-mirror for peptide synthesis applications and manufacturing method of the same
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463357B2 (en) * 2005-11-29 2008-12-09 Agilent Technologies, Inc. Wide dynamic range chemical array reader
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
JP2009520350A (en) * 2005-12-15 2009-05-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Analytical device with an array of focused microstructures
DE102005060312A1 (en) * 2005-12-16 2007-06-28 Siemens Ag Scanning device for optical scanning of surfaces
US20070178480A1 (en) * 2006-01-31 2007-08-02 Corson John F Extended dynamic range reading of chemical arrays
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) * 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7528374B2 (en) * 2006-03-03 2009-05-05 Vidar Systems Corporation Sensing apparatus having optical assembly that collimates emitted light for detection
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
CA2648814A1 (en) * 2006-04-10 2007-10-18 Mycrolab Diagnostics Pty Ltd Imaging apparatus with a plurality of shutter elements
CN101467089B (en) * 2006-04-10 2012-05-16 迈克罗拉布诊断有限公司 Imaging apparatus with a plurality of shutter elements
US20080260242A1 (en) * 2006-06-22 2008-10-23 Tidal Photonics Inc. Apparatus and methods for measuring and controlling illumination for imaging objects, performances and the like
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
US8213017B2 (en) 2006-07-17 2012-07-03 Max Wiki Analytical system comprising an arrangement for temporally variable spatial light modulation and detection method executable therewith
CA2662521C (en) * 2006-09-01 2016-08-09 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US20080080059A1 (en) * 2006-09-28 2008-04-03 Pacific Biosciences Of California, Inc. Modular optical components and systems incorporating same
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
JP5100757B2 (en) 2006-11-30 2012-12-19 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッド System and method for monitoring amplification and dissociation reactions of DNA molecules
GB2458855B (en) * 2007-02-05 2011-06-08 Intelligent Bio Systems Inc A system for imaging treated bio-molecules in a flow-cell using a non-lasing light source
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
TW200837349A (en) * 2007-03-07 2008-09-16 Nat Univ Tsing Hua Biochip and manufacturing method thereof
JP5026851B2 (en) * 2007-04-23 2012-09-19 株式会社日立製作所 Chemiluminescence detector
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
US9505606B2 (en) 2007-06-13 2016-11-29 Angstrom, Inc. MEMS actuator with discretely controlled multiple motions
US8098375B2 (en) * 2007-08-06 2012-01-17 Lumencor, Inc. Light emitting diode illumination system
US7778512B2 (en) * 2007-08-28 2010-08-17 Scenterra, Inc. Light-pipe array system
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
US8380457B2 (en) * 2007-08-29 2013-02-19 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
US20090139311A1 (en) * 2007-10-05 2009-06-04 Applied Biosystems Inc. Biological Analysis Systems, Devices, and Methods
US20090112482A1 (en) * 2007-10-26 2009-04-30 Sandstrom Perry L Microarray detector and synthesizer
EP2208054B1 (en) * 2007-10-31 2019-01-02 PerkinElmer Singapore Pte. Ltd. Sample measurement system
DE102007055386B4 (en) * 2007-11-20 2015-07-16 Boehringer Ingelheim Vetmedica Gmbh Method for calibrating a sensor element
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2009082242A2 (en) * 2007-12-21 2009-07-02 University Of Otago Optical analyte detection incorporating a micromirror device
US7760342B2 (en) * 2007-12-21 2010-07-20 Wisconsin Alumni Research Foundation Multidimensional spectrometer
US8810908B2 (en) 2008-03-18 2014-08-19 Stereo Display, Inc. Binoculars with micromirror array lenses
EP2276849B1 (en) * 2008-04-24 2014-12-03 3M Innovative Properties Company Analysis of nucleic acid amplification curves using wavelet transformation
US8622557B2 (en) 2008-05-20 2014-01-07 Stereo Display, Inc. Micromirror array lens with self-tilted micromirrors
US20090303569A1 (en) * 2008-05-20 2009-12-10 Stereo Didplay, Inc. Self-tilted micromirror device
WO2010005865A1 (en) * 2008-07-07 2010-01-14 Smithkline Beecham Corporation Methods, apparatus and systems employing multiple energy sources for analyzing compositions
EP3629011B1 (en) 2008-09-16 2023-11-01 Pacific Biosciences Of California, Inc. Integrated optical device
CN104328109A (en) * 2008-09-22 2015-02-04 霍夫曼-拉罗奇有限公司 Selective processing of biological material on a microarray substrate
GB2464747B (en) * 2008-10-10 2013-05-15 Hai Kang Life Corp Ltd Method for detection of analyte in microarray of samples and apparatus for performing such method
KR101520028B1 (en) * 2008-10-28 2015-05-14 삼성전자주식회사 Fabricating and optical detecting apparatus for bio-chip
US8796011B2 (en) * 2008-10-20 2014-08-05 Samsung Electronics Co., Ltd. Apparatus for fabricating and optically detecting biochip
KR101008024B1 (en) * 2008-10-20 2011-01-14 삼성전자주식회사 Apparatus for fabricating bio-chip
WO2010120391A2 (en) 2009-01-09 2010-10-21 San Diego State University Foundation Ultrasensitive detection of isotopes, chemical substances and biological substances using laser wave-mixing detectors
US8449842B2 (en) * 2009-03-19 2013-05-28 Thermo Scientific Portable Analytical Instruments Inc. Molecular reader
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
JP6059014B2 (en) 2009-06-19 2017-01-11 アリゾナ ボード オブ リージェンツ ア ボディー コーポレート アクティング オン ビハーフ オブ アリゾナ ステイト ユニバーシティＡＲＩＺＯＮＡ ＢＯＡＲＤ ＯＦ ＲＥＧＥＮＴＳ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ ａｃｔｉｎｇ ｏｎ ｂｅｈａｌｆ ｏｆ ＡＲＩＺＯＮＡ ＳＴＡＴＥ ＵＮＩＶＥＲＳＩＴＹ Method for producing devices used in the detection of sample constituents and peptide arrays
EP2315065B1 (en) * 2009-10-26 2015-05-13 Olympus Corporation Microscope
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
AU2011217862B9 (en) 2010-02-19 2014-07-10 Pacific Biosciences Of California, Inc. Integrated analytical system and method
WO2011113007A2 (en) * 2010-03-12 2011-09-15 Board Of Regents Of The University Of Texas System Modification of a flow cell to measure adsorption kinetics under stagnation point flow and development of a setup correction procedure for obtaining adsorption kinetics at the stagnation point
EP2439514A1 (en) * 2010-10-01 2012-04-11 Aqsens Oy Method, apparatus, and system for examining optically a sample carried in a plurality of wells
US8619359B2 (en) * 2011-04-27 2013-12-31 Howard Letovsky Electronic microscope filter
CN104023834B (en) 2011-05-04 2016-09-28 卢米耐克斯公司 The apparatus and method for prepared for integrated sample, react and detect
US8531753B1 (en) 2011-05-09 2013-09-10 Los Alamos National Security, Llc Adaptive optical filter
WO2012178210A1 (en) * 2011-06-23 2012-12-27 Anitoa Systems, Llc Apparatus for amplification of nucleic acids
CA2852915C (en) 2011-10-18 2018-05-15 Luminex Corporation Methods and systems for image data processing
GB2495998B (en) * 2012-02-24 2013-09-25 Kp Technology Ltd Measurement apparatus
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
US20140085629A1 (en) * 2012-09-27 2014-03-27 Bodkin Design & Engineering, Llc Active Hyperspectral Imaging Systems
WO2014099776A1 (en) 2012-12-18 2014-06-26 Pacific Biosciences Of California, Inc. Illumination of optical analytical devices
EP2959283B1 (en) 2013-02-22 2022-08-17 Pacific Biosciences of California, Inc. Integrated illumination of optical analytical devices
CA2918243A1 (en) * 2013-06-28 2014-12-31 Life Technologies Corporation Methods and systems for visualizing data quality
US9387451B2 (en) 2014-02-03 2016-07-12 International Business Machines Corporation Flow cell array and uses thereof
CN107003241B (en) 2014-08-27 2022-01-11 加利福尼亚太平洋生物科学股份有限公司 Integrated analytical device array
CN106662530A (en) 2014-09-05 2017-05-10 特莫费希尔科学公司 Method and apparatus for optical measurement of liquid sample
WO2016149397A1 (en) 2015-03-16 2016-09-22 Pacific Biosciences Of California, Inc. Integrated devices and systems for free-space optical coupling
US10264190B2 (en) * 2015-04-24 2019-04-16 Omnitek Partners Llc Adaptive optical methods and devices for enhancing image contrast in the presence of bright background
CN107683340A (en) 2015-05-07 2018-02-09 加利福尼亚太平洋生物科学股份有限公司 Multi-processor pipeline framework
CA2989344C (en) 2015-06-12 2023-09-26 Pacific Biosciences Of California, Inc. Integrated target waveguide devices and systems for optical coupling
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
US11058093B2 (en) * 2015-10-30 2021-07-13 Brandeis University Systems and methods for monitoring and controlling drosophila activity
CA3012212A1 (en) 2016-02-05 2017-08-10 Nanoview Diagnostics Inc. Detection of exosomes having surface markers
WO2017143347A1 (en) 2016-02-19 2017-08-24 San Diego State University Foundation Applications of optical detection of low-level chemical and biological substances by nonlinear laser wave mixing in medicine and food safety
EP3208604B1 (en) 2016-02-22 2019-07-10 F. Hoffmann-La Roche AG Optics for analysis of microwells
EP3472201A4 (en) 2016-06-20 2020-05-13 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
US11774446B2 (en) 2016-06-20 2023-10-03 Cowper Sciences Inc. Methods for diagnosis and treatment of autoimmune diseases
CA3043264A1 (en) 2016-11-11 2018-05-17 Healthtell Inc. Methods for identifying candidate biomarkers
US10520436B2 (en) * 2016-11-29 2019-12-31 Caduceus Biotechnology Inc. Dynamic focusing confocal optical scanning system
US20200209241A1 (en) 2017-09-15 2020-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
US10921453B2 (en) * 2018-05-29 2021-02-16 Huawei Technologies Co., Ltd. Liquid crystal on silicon (LCOS) lidar scanner with multiple light sources
JP6581707B2 (en) * 2018-09-27 2019-09-25 株式会社日立ハイテクノロジーズ Nucleic acid analyzer and nucleic acid analysis method
EP3887385B1 (en) 2018-11-30 2024-03-20 Geneinfosec, Inc. A method for generating random oligonucleotides and determining their sequence
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US577456A (en) * 1897-02-23 Process of milling
US4011011A (en) 1973-03-09 1977-03-08 The Perkin-Elmer Corporation Optical projection apparatus
US4288148A (en) 1979-08-29 1981-09-08 The Perkin-Elmer Corporation Beam-splitting optical system
US5096279A (en) 1984-08-31 1992-03-17 Texas Instruments Incorporated Spatial light modulator and method
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5083857A (en) 1990-06-29 1992-01-28 Texas Instruments Incorporated Multi-level deformable mirror device
JP2873884B2 (en) 1991-03-22 1999-03-24 日立ソフトウェアエンジニアリング 株式会社 Multicolor electrophoresis pattern reader
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5371543A (en) * 1993-03-03 1994-12-06 Texas Instruments Incorporated Monolithic color wheel
US5424841A (en) 1993-05-28 1995-06-13 Molecular Dynamics Apparatus for measuring spatial distribution of fluorescence on a substrate
US5923466A (en) 1993-10-20 1999-07-13 Biophysica Technologies, Inc. Light modulated confocal optical instruments and method
US5583688A (en) 1993-12-21 1996-12-10 Texas Instruments Incorporated Multi-level digital micromirror device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
DE4416314C2 (en) 1994-05-09 1997-06-12 Agfa Gevaert Ag Method and device for recording an image scene and use of the device in a copier
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
KR100220675B1 (en) 1994-10-31 1999-09-15 전주범 Projection type image display apparatus
US5535047A (en) 1995-04-18 1996-07-09 Texas Instruments Incorporated Active yoke hidden hinge digital micromirror device
EP0902885A4 (en) 1996-05-16 2006-09-27 Affymetrix Inc Systems and methods for detection of labeled materials
US6038067A (en) 1996-05-23 2000-03-14 The Regents Of The University Of California Scanning computed confocal imager
US5770156A (en) * 1996-06-04 1998-06-23 In Usa, Inc. Gas detection and measurement system
US5872623A (en) 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
US5780857A (en) 1996-10-04 1998-07-14 Wallac Oy Apparatus for imaging biochemical samples on substrates
US5912181A (en) 1997-12-23 1999-06-15 Petcavich; Robert J. Method for molecule detection utilizing digital micromirror technology
ES2656439T3 (en) 1998-02-23 2018-02-27 Wisconsin Alumni Research Foundation Apparatus for synthesis of DNA probe matrices
WO1999063385A1 (en) * 1998-06-04 1999-12-09 Board Of Regents, The University Of Texas System Digital optical chemistry micromirror imager
DE19940749A1 (en) 1998-08-28 2000-05-18 Febit Ferrarius Biotech Gmbh Integrated synthesis and analysis method e.g. for polymers, comprises a carrier body provided with immobilized receptors to provide respective channels before contact with sample and subsequent analysis
DE19913279B4 (en) 1999-03-24 2006-07-27 Wratil, Peter, Dr. Control device with monitoring unit for error detection and error suppression
DE19914279C1 (en) * 1999-03-25 2000-09-07 Jena Optronik Gmbh Sensor for optical examination of stimulated sample pixels on e.g. nano-titration screening plates or bio-chips for gene analysis, employs e.g. a liquid crystal matrix shutter and fiber optics with photomultiplier detection
US6046808A (en) * 1999-04-09 2000-04-04 Three Lc, Inc. Radiation filter, spectrometer and imager using a micro-mirror array
DE19922942A1 (en) 1999-05-14 2000-11-30 Epigenomics Gmbh Apparatus for the photolithographic illumination of biological substances, useful in the manufacture of DNA chips, includes a micromirror array controlled to produce any given illumination pattern
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer

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US6545758B1 (en) 2003-04-08
WO2002014838A2 (en) 2002-02-21
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US20030174324A1 (en) 2003-09-18
WO2002014838A8 (en) 2002-07-18
US7081954B2 (en) 2006-07-25
US6806954B2 (en) 2004-10-19
US7522271B2 (en) 2009-04-21
US20060256332A1 (en) 2006-11-16
WO2002014838A3 (en) 2002-06-06
US20050079603A1 (en) 2005-04-14

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