AU2001281275A1 - Processes for the preparation of oligonucleotides - Google Patents

Processes for the preparation of oligonucleotides

Info

Publication number
AU2001281275A1
AU2001281275A1 AU2001281275A AU8127501A AU2001281275A1 AU 2001281275 A1 AU2001281275 A1 AU 2001281275A1 AU 2001281275 A AU2001281275 A AU 2001281275A AU 8127501 A AU8127501 A AU 8127501A AU 2001281275 A1 AU2001281275 A1 AU 2001281275A1
Authority
AU
Australia
Prior art keywords
oligonucleotides
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001281275A
Inventor
Yogesh S Sanghvi
Quanlai Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of AU2001281275A1 publication Critical patent/AU2001281275A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
AU2001281275A 2000-08-16 2001-08-16 Processes for the preparation of oligonucleotides Abandoned AU2001281275A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09640279 2000-08-16
US09/640,279 US6809195B1 (en) 2000-08-16 2000-08-16 Process for the preparation of oligonucleotides
PCT/US2001/025623 WO2002014340A1 (en) 2000-08-16 2001-08-16 Processes for the preparation of oligonucleotides_______________

Publications (1)

Publication Number Publication Date
AU2001281275A1 true AU2001281275A1 (en) 2002-02-25

Family

ID=24567595

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001281275A Abandoned AU2001281275A1 (en) 2000-08-16 2001-08-16 Processes for the preparation of oligonucleotides

Country Status (4)

Country Link
US (2) US6809195B1 (en)
EP (1) EP1311526A1 (en)
AU (1) AU2001281275A1 (en)
WO (1) WO2002014340A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6809195B1 (en) * 2000-08-16 2004-10-26 Isis Pharmaceuticals, Inc. Process for the preparation of oligonucleotides
WO2004074303A2 (en) * 2003-02-20 2004-09-02 Eisai Co, Ltd. Reagents and methods for preparing lps antagonist b1287 and stereoisomers thereof
EP2013161A1 (en) * 2006-05-02 2009-01-14 DSMIP Assets B.V. Process for the deprotection of protected amines
WO2009099329A1 (en) * 2008-02-08 2009-08-13 Prosensa Holding Bv Sulfurization agent and its use
BRPI0923225A2 (en) 2008-12-02 2016-10-04 Chiralgen Ltd Phosphorus-modified nucleic acid synthesis method
MX342945B (en) 2009-07-06 2016-10-18 Ontorii Inc * Novel nucleic acid prodrugs and methods use thereof.
JP5868324B2 (en) 2010-09-24 2016-02-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ Asymmetric auxiliary group
WO2013012758A1 (en) 2011-07-19 2013-01-24 Ontorii, Inc. Methods for the synthesis of functionalized nucleic acids
RU2677639C2 (en) 2012-07-13 2019-01-18 Шин Ниппон Биомедикал Лэбораториз, Лтд. Chiral nucleic acid adjuvant
CN104684893B (en) 2012-07-13 2016-10-26 日本波涛生命科学公司 Asymmetric auxiliary group
KR102450907B1 (en) 2012-07-13 2022-10-04 웨이브 라이프 사이언시스 리미티드 Chiral control
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108047A1 (en) 2014-01-15 2017-03-23 株式会社新日本科学 Chiral nucleic acid adjuvant having immunity induction activity and immunity induction activator
US10149905B2 (en) 2014-01-15 2018-12-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
KR20230152178A (en) 2014-01-16 2023-11-02 웨이브 라이프 사이언시스 리미티드 Chiral design
KR20230133947A (en) * 2016-06-24 2023-09-19 바이오젠 엠에이 인코포레이티드 Synthesis of thiolated oligonucleotides without a capping step
CN116333006A (en) * 2023-04-07 2023-06-27 苏州欧利生物医药科技有限公司 Solid phase synthesis method of oligonucleotide with fluorescent marker

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4816571A (en) 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
US5750666A (en) * 1988-05-26 1998-05-12 Competitve Technologies, Inc. Polynucleotide phosphorodithioate compounds
US5149798A (en) * 1989-04-06 1992-09-22 Worcester Foundation For Experimental Biology Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses
US5859221A (en) 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5166387A (en) * 1990-01-12 1992-11-24 Applied Biosystems, Inc. Method of synthesizing sulfurized oligonucleotide analogs with thiuram disulfides
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5424184A (en) * 1991-05-08 1995-06-13 Regents Of The University Of Minnesota DNA sequence-based HLA class I typing method
AU2916292A (en) 1991-10-24 1993-05-21 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US5614621A (en) * 1993-07-29 1997-03-25 Isis Pharmaceuticals, Inc. Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents
US6653458B1 (en) * 1993-09-03 2003-11-25 Isis Pharmaceuticals, Inc. Modified oligonucleotides
US6399765B1 (en) * 1999-03-17 2002-06-04 Isis Pharmaceuticals, Inc. Methods for removing dimethoxytrityl groups from oligonucleotides
US6809195B1 (en) * 2000-08-16 2004-10-26 Isis Pharmaceuticals, Inc. Process for the preparation of oligonucleotides

Also Published As

Publication number Publication date
WO2002014340A1 (en) 2002-02-21
US6809195B1 (en) 2004-10-26
US20040198972A1 (en) 2004-10-07
EP1311526A1 (en) 2003-05-21

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