AU2001280812A1 - Gsk3 polypeptides - Google Patents
Gsk3 polypeptidesInfo
- Publication number
- AU2001280812A1 AU2001280812A1 AU2001280812A AU8081201A AU2001280812A1 AU 2001280812 A1 AU2001280812 A1 AU 2001280812A1 AU 2001280812 A AU2001280812 A AU 2001280812A AU 8081201 A AU8081201 A AU 8081201A AU 2001280812 A1 AU2001280812 A1 AU 2001280812A1
- Authority
- AU
- Australia
- Prior art keywords
- gsk3
- polypeptides
- amino acid
- substituted amino
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01037—Protein kinase (2.7.1.37)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
Abstract
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3± and GSK3² polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22124200P | 2000-07-27 | 2000-07-27 | |
US60/221,242 | 2000-07-27 | ||
PCT/US2001/023539 WO2002010357A2 (en) | 2000-07-27 | 2001-07-25 | Gsk3 polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001280812A1 true AU2001280812A1 (en) | 2002-02-13 |
Family
ID=22826991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001280812A Abandoned AU2001280812A1 (en) | 2000-07-27 | 2001-07-25 | Gsk3 polypeptides |
Country Status (10)
Country | Link |
---|---|
US (6) | US6465231B2 (en) |
EP (2) | EP1319064B1 (en) |
JP (1) | JP2004504838A (en) |
CN (1) | CN1276974C (en) |
AT (1) | ATE450604T1 (en) |
AU (1) | AU2001280812A1 (en) |
DE (2) | DE60131550T2 (en) |
ES (1) | ES2295191T3 (en) |
PT (2) | PT1319064E (en) |
WO (1) | WO2002010357A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001292906B2 (en) * | 2000-09-19 | 2007-08-16 | Novartis Vaccines And Diagnostics, Inc. | Characterization of the GSK-3beta protein and methods of use thereof |
JP2005532265A (en) * | 2002-02-11 | 2005-10-27 | カイロン コーポレイション | Method for crystallizing human GSK3 and its novel crystal structure |
WO2005083111A1 (en) * | 2004-02-26 | 2005-09-09 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with glycogen synthase kinase 3 alpha (gsk3a) |
US20060127388A1 (en) * | 2004-12-10 | 2006-06-15 | Wyeth | Variants of glycogen synthase kinase 3 and uses thereof |
US20100105745A1 (en) * | 2005-01-04 | 2010-04-29 | Toshinari Minamoto | Suppression of cancer and method for evaluating anticancer agent based on the effect of inhibiting gsk3 beta |
JPWO2006073202A1 (en) * | 2005-01-04 | 2008-08-07 | 国立大学法人金沢大学 | Cancer suppression based on GSK3β inhibitory effect and method for evaluating anticancer agent |
EA016397B1 (en) * | 2005-06-20 | 2012-04-30 | Декоуд Дженетикс Ехф. | Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus |
JP2009504657A (en) * | 2005-08-09 | 2009-02-05 | メタプロテオミクス,エルエルシー | Protein kinase regulation by hops and acacia products |
JP5933544B2 (en) | 2010-07-26 | 2016-06-08 | バイオマトリカ, インコーポレーテッド | Compositions for stabilizing blood DNA, RNA and proteins and other biological samples shipped and stored at ambient temperature |
WO2012018639A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
EP2934572A4 (en) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | Formulations and methods for stabilizing pcr reagents |
CA2915250A1 (en) | 2013-06-13 | 2015-01-08 | Biomatrica, Inc. | Cell stabilization |
WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
EP3656215B1 (en) | 2014-06-10 | 2021-08-04 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
AU2016368265B2 (en) | 2015-12-08 | 2021-10-28 | Biomatrica, Inc. | Reduction of erythrocyte sedimentation rate |
CN117384983B (en) * | 2023-12-07 | 2024-02-23 | 中国中医科学院中药研究所 | Preparation method of GSK-3 alpha inhibitor |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591872A (en) * | 1993-08-09 | 1997-01-07 | The University Of Iowa Research Foundation | Autoinducer molecule |
US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
US5693496A (en) * | 1994-06-20 | 1997-12-02 | Merck & Co., Inc. | DNA encoding the mouse and human PH30 beta chain protein |
US5698396A (en) * | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
US6057117A (en) | 1996-04-04 | 2000-05-02 | Chiron Corporation | Identification and use of selective inhibitors of glycogen synthase kinase 3 |
CA2329694A1 (en) * | 1998-05-28 | 1999-12-02 | Zymogenetics, Inc. | Kunitz domain polypeptide and materials and methods for making it |
EP1087963B1 (en) | 1998-06-19 | 2004-08-25 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
US6057218A (en) * | 1999-05-07 | 2000-05-02 | Vanguard International Semiconductor Corporation | Method for simultaneously manufacturing poly gate and polycide gate |
-
2001
- 2001-07-25 PT PT01959230T patent/PT1319064E/en unknown
- 2001-07-25 PT PT07022387T patent/PT1914305E/en unknown
- 2001-07-25 ES ES01959230T patent/ES2295191T3/en not_active Expired - Lifetime
- 2001-07-25 JP JP2002516276A patent/JP2004504838A/en active Pending
- 2001-07-25 US US09/916,109 patent/US6465231B2/en not_active Expired - Lifetime
- 2001-07-25 EP EP01959230A patent/EP1319064B1/en not_active Expired - Lifetime
- 2001-07-25 EP EP07022387A patent/EP1914305B1/en not_active Expired - Lifetime
- 2001-07-25 AT AT07022387T patent/ATE450604T1/en not_active IP Right Cessation
- 2001-07-25 DE DE60131550T patent/DE60131550T2/en not_active Expired - Lifetime
- 2001-07-25 AU AU2001280812A patent/AU2001280812A1/en not_active Abandoned
- 2001-07-25 WO PCT/US2001/023539 patent/WO2002010357A2/en active IP Right Grant
- 2001-07-25 DE DE60140707T patent/DE60140707D1/en not_active Expired - Lifetime
- 2001-07-25 CN CNB018134637A patent/CN1276974C/en not_active Expired - Fee Related
-
2002
- 2002-07-31 US US10/211,412 patent/US6716624B2/en not_active Expired - Fee Related
-
2003
- 2003-10-20 US US10/689,461 patent/US7135321B2/en not_active Expired - Fee Related
- 2003-12-10 US US10/733,816 patent/US7195886B2/en not_active Expired - Fee Related
-
2007
- 2007-02-08 US US11/704,724 patent/US7361484B2/en not_active Expired - Fee Related
-
2008
- 2008-03-03 US US12/074,543 patent/US7807430B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20060088932A1 (en) | 2006-04-27 |
DE60131550D1 (en) | 2008-01-03 |
CN1468302A (en) | 2004-01-14 |
WO2002010357A2 (en) | 2002-02-07 |
US7361484B2 (en) | 2008-04-22 |
ES2295191T3 (en) | 2008-04-16 |
US7195886B2 (en) | 2007-03-27 |
EP1914305A1 (en) | 2008-04-23 |
DE60131550T2 (en) | 2008-10-23 |
US6716624B2 (en) | 2004-04-06 |
US20030077798A1 (en) | 2003-04-24 |
EP1319064A2 (en) | 2003-06-18 |
EP1319064B1 (en) | 2007-11-21 |
US20070249004A1 (en) | 2007-10-25 |
US20020082408A1 (en) | 2002-06-27 |
DE60140707D1 (en) | 2010-01-14 |
EP1914305B1 (en) | 2009-12-02 |
US7135321B2 (en) | 2006-11-14 |
US6465231B2 (en) | 2002-10-15 |
CN1276974C (en) | 2006-09-27 |
JP2004504838A (en) | 2004-02-19 |
ATE450604T1 (en) | 2009-12-15 |
US20080182313A1 (en) | 2008-07-31 |
WO2002010357A3 (en) | 2003-04-03 |
US20050048511A1 (en) | 2005-03-03 |
PT1914305E (en) | 2010-01-29 |
US7807430B2 (en) | 2010-10-05 |
PT1319064E (en) | 2008-02-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2001280812A1 (en) | Gsk3 polypeptides | |
GB0117326D0 (en) | Napthoquinone-type inhibitors of protein aggregation | |
WO2004112701A3 (en) | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | |
BR9713186A (en) | 1,3-diheterocyclic metalloprotease inhibitors | |
DE60330485D1 (en) | FOR THE TREATMENT OF DIABETES | |
AU3986493A (en) | Protease and related DNA compounds | |
ATE231496T1 (en) | SACCHARINE DERIVATIVES AS PROTEOLYTIC ENZYMIN HIBITORS | |
WO2003009855A3 (en) | Organo-phosphorous compounds for activating gamma/delta t cells | |
WO2003039454A3 (en) | Beta-secretase inhibitors and methods of use | |
DE60025008D1 (en) | DETERMINATION OF ADRENOMEDULLIN-BINDING PROTEINS | |
AU7934900A (en) | Method of screening for inhibitors of asp2 | |
WO2000034511A3 (en) | Aβ-PEPTIDE SCREENING ASSAY | |
HUP9901751A3 (en) | Novel substituted n-methyl-n-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases | |
WO1998020034A3 (en) | Novel serine protease inhibitor nucleic acid molecules, proteins and uses thereof | |
BR0112123A (en) | Compound | |
ATE323505T1 (en) | USE OF RECOMBINANT LUNG SURFACTANT FOR EARLY TREATMENT OF ACUTE LUNG DISEASE | |
DE69809785D1 (en) | USE OF A RETINOIDIDE IN VIVO INCREASING THE UNCOVERING OF THE UCP2 PROTEIN | |
DE59609977D1 (en) | TRAPIDIL FOR USE IN THE THERAPY OF IMMUNO-MODULATABLE INFLUENCES | |
BR9915572A (en) | Process of treatment of sickle cell disease and thalassemia | |
WO2002058323A3 (en) | Method for identifying modulators of bace | |
ATE391915T1 (en) | USE OF GRF-1 PROTEIN TO SELECT MOLECULES | |
ATE180478T1 (en) | USE OF SUBSTITUTED 6-AMINO-4H-PYRANES | |
ATE311901T1 (en) | USE OF TGF-BETA INHIBITORS TO TREAT CEREBRAL DISEASES | |
WO2004047854A3 (en) | Methods for the treatment of alzheimers disease and compositions therefore | |
DE60203726D1 (en) | TOPICAL COMPOSITION CONTAINING BRUCIN AND ITS USE FOR THE TREATMENT OF SKIN DAMAGE |