AU2001280242A1 - Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone - Google Patents

Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone

Info

Publication number
AU2001280242A1
AU2001280242A1 AU2001280242A AU8024201A AU2001280242A1 AU 2001280242 A1 AU2001280242 A1 AU 2001280242A1 AU 2001280242 A AU2001280242 A AU 2001280242A AU 8024201 A AU8024201 A AU 8024201A AU 2001280242 A1 AU2001280242 A1 AU 2001280242A1
Authority
AU
Australia
Prior art keywords
hormone
producing
recombinant human
human parathyroid
yeast transformant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001280242A
Inventor
Bong Hyun Chung
Hyun Ah Kana
Su Min Ko
Sang Ki Rhee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong Kook Pharmaceutical Co Ltd
Korea Research Institute of Bioscience and Biotechnology KRIBB
Original Assignee
Dong Kook Pharmaceutical Co Ltd
Korea Research Institute of Bioscience and Biotechnology KRIBB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Kook Pharmaceutical Co Ltd, Korea Research Institute of Bioscience and Biotechnology KRIBB filed Critical Dong Kook Pharmaceutical Co Ltd
Publication of AU2001280242A1 publication Critical patent/AU2001280242A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/94—Saccharomyces
    • Y10S435/942—Saccharomyces cerevisiae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2001280242A 2000-08-31 2001-08-27 Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone Abandoned AU2001280242A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2000-0051267A KR100386836B1 (en) 2000-08-31 2000-08-31 Transformant of Yeast Producing Recombinant human parathyroid hormone and Method for Producing Said hormone
KR0000512 2000-08-31
PCT/KR2001/001447 WO2002018570A1 (en) 2000-08-31 2001-08-27 Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone

Publications (1)

Publication Number Publication Date
AU2001280242A1 true AU2001280242A1 (en) 2002-03-13

Family

ID=36829916

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001280242A Abandoned AU2001280242A1 (en) 2000-08-31 2001-08-27 Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone

Country Status (10)

Country Link
US (1) US7244591B2 (en)
EP (1) EP1313848B1 (en)
JP (1) JP3957630B2 (en)
KR (1) KR100386836B1 (en)
CN (1) CN1449441A (en)
AU (1) AU2001280242A1 (en)
DE (1) DE10196565B4 (en)
ES (1) ES2258371B1 (en)
GB (1) GB2381273B (en)
WO (1) WO2002018570A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258371B1 (en) * 2000-08-31 2007-05-16 Dong Kook Pharmaceutical Co. Ltd. TRANSFORMING YEAST PRODUCING HUMAN PARTIROID HORMONE AND PROCEDURE TO PRODUCE THE HORMONE.
KR100470978B1 (en) * 2003-01-02 2005-03-10 한국생명공학연구원 Yeast mutant strains deficient in the multiple yapsin genes and method for the production of recombinant proteins using the same
US7318925B2 (en) * 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
MXPA06001353A (en) 2003-08-08 2006-05-04 Abgenix Inc Antibodies directed to parathyroid hormone (pth) and uses thereof.
EP2182060B1 (en) * 2005-08-03 2012-10-24 Asahi Glass Company, Limited Transformed yeast host cells and method of producing foreign protein
KR101811057B1 (en) 2007-04-03 2017-12-20 옥시레인 유케이 리미티드 Glycosylation of molecules
BR112012007099A2 (en) 2009-09-29 2015-09-15 Oxyrane Uk Ltd hydrolysis of the mannose-1-phospho-6-mannose to phospho-mannose bond
KR20130055555A (en) 2009-11-19 2013-05-28 옥시레인 유케이 리미티드 Yeast strains producing mammalian-like complex n-glycans
CA2812872C (en) 2010-09-29 2021-08-03 Oxyrane Uk Limited De-mannosylation of phosphorylated n-glycans
CA2812870C (en) 2010-09-29 2020-06-09 Oxyrane Uk Limited Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
BR112014015933A2 (en) * 2011-12-30 2019-09-24 Oxyrane Uk Ltd methods and materials to reduce recombinant protein degradation
AU2013234042B2 (en) 2012-03-15 2017-11-02 Oxyrane Uk Limited Methods and materials for treatment of Pompe's disease
WO2023215221A2 (en) * 2022-05-02 2023-11-09 North Carolina State University Engineered microorganisms with enhanced protein expression and secretion

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420242A (en) * 1986-10-22 1995-05-30 Kaare M. Gautvik Production of human parathyroid hormone from microorganisms
EP0383751B1 (en) * 1986-10-22 1994-03-09 GAUTVIK, Kaare M., Dr. Production of human parathyroid hormone from microorganisms
KR100246932B1 (en) * 1997-09-12 2000-03-15 박호군 Novel Yeast Strain defected YAP3 gene and recombinamt human parathy roid hormone therefrom
WO1999037758A2 (en) * 1998-01-27 1999-07-29 The Board Of Regents Of The University And Community College System Of Nevada On Behalf Of The University Of Nevada-Reno Expression of proteolytically-sensitive peptides
ES2258371B1 (en) * 2000-08-31 2007-05-16 Dong Kook Pharmaceutical Co. Ltd. TRANSFORMING YEAST PRODUCING HUMAN PARTIROID HORMONE AND PROCEDURE TO PRODUCE THE HORMONE.

Also Published As

Publication number Publication date
US20040029252A1 (en) 2004-02-12
ES2258371A1 (en) 2006-08-16
DE10196565T1 (en) 2003-07-03
JP2004507270A (en) 2004-03-11
DE10196565B4 (en) 2007-02-01
WO2002018570A1 (en) 2002-03-07
CN1449441A (en) 2003-10-15
GB0303081D0 (en) 2003-03-19
EP1313848B1 (en) 2006-07-05
US7244591B2 (en) 2007-07-17
GB2381273A (en) 2003-04-30
ES2258371B1 (en) 2007-05-16
EP1313848A1 (en) 2003-05-28
GB2381273B (en) 2004-12-22
JP3957630B2 (en) 2007-08-15
KR100386836B1 (en) 2003-06-09
KR20020017754A (en) 2002-03-07

Similar Documents

Publication Publication Date Title
AU2003278766A1 (en) Method and device for the controlled delivery of parathyroid hormone
AU2002363405A1 (en) Composite oxide catalyst and method for preparation thereof
AU2001296005A1 (en) Composite structure and method for manufacture thereof
AU2001282424A1 (en) Wireless interactive system and method
AU2001280242A1 (en) Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone
AU2045499A (en) Cuff electrode and method for manufacturing the same
AU1140201A (en) Method and device for creating the reinforcing structure components for the manufacture of fibre-plastic composite components
AU2002230953A1 (en) Recombinant phytases and uses thereof
WO2003099841A9 (en) Peptides and the use thereof in darkening the skin
AU2002232596A1 (en) Secreted human proteins
AU8384701A (en) Codon optimised recombinant dermaphagoides allergens
AU7416700A (en) Insulating shaped body and method for producing the same
AU4338100A (en) Secreted human proteins
AU2002341215A1 (en) Growth hormone variations in humans and their uses
AU7709000A (en) Methods for producing recombinant proteins
AU1907901A (en) Sandwich construction and method for its manufacture
AU5750200A (en) Secreted proteins and uses thereof
AU2001236817A1 (en) Insulin homolog polypeptide zins4
AU2001288220A1 (en) Hyperglycosylated polypeptides
AU2001294719A1 (en) Secreted human proteins
MXPA03006157A (en) Hormone replacement therapy method and its administration form.
AU2002223140A1 (en) Method for mass-producing human ferritin using recombinant nethylotropic yeasts
AU1274801A (en) Method for producing recombinant interleucin-8 and interleucin-8 muteins
AU3382800A (en) Secreted proteins and uses thereof
AU2002338127A1 (en) A method for preparing the recombinant human glucagon like peptide-1 (7-37)