AU2001278435A1 - Muteins of a chain of a protein from the superfamily of growth factor tgf-beta - Google Patents

Muteins of a chain of a protein from the superfamily of growth factor tgf-beta

Info

Publication number
AU2001278435A1
AU2001278435A1 AU2001278435A AU7843501A AU2001278435A1 AU 2001278435 A1 AU2001278435 A1 AU 2001278435A1 AU 2001278435 A AU2001278435 A AU 2001278435A AU 7843501 A AU7843501 A AU 7843501A AU 2001278435 A1 AU2001278435 A1 AU 2001278435A1
Authority
AU
Australia
Prior art keywords
muteins
superfamily
beta
protein
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001278435A
Inventor
Joachim Nickel
Prof. Dr. Walter Sebald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WALTER SEBALD PROF DR
Original Assignee
WALTER SEBALD PROF DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WALTER SEBALD PROF DR filed Critical WALTER SEBALD PROF DR
Publication of AU2001278435A1 publication Critical patent/AU2001278435A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001278435A 2000-05-30 2001-05-30 Muteins of a chain of a protein from the superfamily of growth factor tgf-beta Abandoned AU2001278435A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10026713.0 2000-05-30
DE2000126713 DE10026713A1 (en) 2000-05-30 2000-05-30 Mutein a chain of a protein from the superfamily of the growth factor TGF-beta
PCT/EP2001/006166 WO2001092298A2 (en) 2000-05-30 2001-05-30 MUTEINS OF A CHAIN OF A PROTEIN FROM THE SUPERFAMILY OF GROWTH FACTOR TGF-$g(b)

Publications (1)

Publication Number Publication Date
AU2001278435A1 true AU2001278435A1 (en) 2001-12-11

Family

ID=7644050

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001278435A Abandoned AU2001278435A1 (en) 2000-05-30 2001-05-30 Muteins of a chain of a protein from the superfamily of growth factor tgf-beta

Country Status (3)

Country Link
AU (1) AU2001278435A1 (en)
DE (1) DE10026713A1 (en)
WO (1) WO2001092298A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1571159A1 (en) 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
JP2007530055A (en) 2004-03-26 2007-11-01 アクセルロン ファーマ インコーポレーテッド BMP-3 propeptide and related methods
WO2005113590A2 (en) 2004-05-12 2005-12-01 Acceleron Pharma Inc. Bmp10 propeptides and related methods
EP1751185A2 (en) * 2004-05-27 2007-02-14 Acceleron Pharma Inc. Tgf derepressors and uses related thereto
US7465706B2 (en) 2004-06-24 2008-12-16 Acceleron Pharma Inc. GDF3 propeptides and related methods
US7795389B2 (en) 2004-09-28 2010-09-14 The Board Of Regents Of The University Of Texas System Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins
EP1721909A1 (en) * 2005-05-10 2006-11-15 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Growth factor mutants with altered biological attributes
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604938D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
CA2708549C (en) * 2007-12-21 2014-04-01 Stryker Corporation Bmp mutants with decreased susceptibility to noggin
CN102369212B (en) * 2009-03-12 2015-12-16 哈瑟投资公司 There is bone morphogenetic protein2 (BMP2) variant of the bmp antagonist susceptibility of reduction
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
EP2949338B1 (en) 2010-08-20 2017-10-25 Wyeth LLC Designer osteogenic proteins
EP2602264A1 (en) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5 mutant for inducing cartilage formation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284763A (en) * 1985-03-22 1994-02-08 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US5631142A (en) * 1986-07-01 1997-05-20 Genetics Institute, Inc. Compositions comprising bone morphogenetic protein-2 (BMP-2)
DE01201555T1 (en) * 1988-04-08 2004-07-08 Stryker Corp., Kalamazoo Biosynthetic osteogenic proteins and osteogenic devices containing them
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
EP0691349A3 (en) * 1994-07-04 1997-09-10 Hoechst Japan Dimeric bone morphogenic proteins and fragments and analogs thereof and pharmaceutical compositions comprising them
TW517059B (en) * 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
WO2000001410A1 (en) * 1998-07-06 2000-01-13 Beth Israel Deaconess Medical Center Methods of inhibiting proliferative diseases by inhibiting tgf-beta mediated angiogenesis
US6677432B1 (en) * 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
JP2000119192A (en) * 1998-10-09 2000-04-25 Aventis Pharma Ltd Mature type protein having antagonistic activity for bone morphogenetic protein
ES2226467T5 (en) * 1998-11-13 2009-08-27 Stryker Corporation RELIEF OF THE SYMPTOMS OF CANCER DE PROSTATA.
EP1292330A1 (en) * 2000-03-31 2003-03-19 Vaccine Chip Technology APS Immunostimulating properties of a fragment of tgf- beta

Also Published As

Publication number Publication date
WO2001092298A9 (en) 2002-08-08
DE10026713A1 (en) 2001-12-06
WO2001092298A2 (en) 2001-12-06
WO2001092298A3 (en) 2002-12-12

Similar Documents

Publication Publication Date Title
AU2001296178A1 (en) Harvester combine
AUPR510601A0 (en) Egg harvester
AU2001278435A1 (en) Muteins of a chain of a protein from the superfamily of growth factor tgf-beta
AU6890100A (en) Suture spear
AU2002317759A1 (en) Ophthalmoscope
WO2003045973A8 (en) Peptides with growth inhibitory action
HUP0200178A3 (en) Combine harvester
AU2002340101A1 (en) Launcher platform
GB0106730D0 (en) Combine harvester
AU2002320230A1 (en) Distal anastomosis system
AU2002364599A1 (en) Suture trimmer
GB0106722D0 (en) Combine harvester
AUPQ990000A0 (en) Combine harvesters
AU2002360025A1 (en) Famotidine injection
AU2002360333A1 (en) Human angiomotin-like protein 1
AU3141000A (en) Shaker
AU2001284748A1 (en) Reaper protein
GB0106691D0 (en) Combine harvester
AU2002257630A1 (en) Human mrp5-like protein
AU2574100A (en) Novel cytokine recfptor-like protein
AUPR887301A0 (en) Bucket conveyor and harvester
AU2002221351A1 (en) Retinoblastoma-binding protein
AUPR736401A0 (en) Variable inclined lift 1-3
AU2002243466A1 (en) Cytoskeleton-associated proteins
AU2001267192A1 (en) Extensible crank