AU2001276956A1 - Macrocyclic mri contrast agents - Google Patents
Macrocyclic mri contrast agentsInfo
- Publication number
- AU2001276956A1 AU2001276956A1 AU2001276956A AU7695601A AU2001276956A1 AU 2001276956 A1 AU2001276956 A1 AU 2001276956A1 AU 2001276956 A AU2001276956 A AU 2001276956A AU 7695601 A AU7695601 A AU 7695601A AU 2001276956 A1 AU2001276956 A1 AU 2001276956A1
- Authority
- AU
- Australia
- Prior art keywords
- macrocyclic
- contrast agents
- mri contrast
- mri
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21858100P | 2000-07-17 | 2000-07-17 | |
US60/218,581 | 2000-07-17 | ||
PCT/US2001/022491 WO2002006287A2 (en) | 2000-07-17 | 2001-07-17 | Macrocyclic mri contrast agents |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001276956A1 true AU2001276956A1 (en) | 2002-01-30 |
Family
ID=22815661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001276956A Abandoned AU2001276956A1 (en) | 2000-07-17 | 2001-07-17 | Macrocyclic mri contrast agents |
Country Status (3)
Country | Link |
---|---|
US (1) | US6656450B2 (US06656450-20031202-C00009.png) |
AU (1) | AU2001276956A1 (US06656450-20031202-C00009.png) |
WO (1) | WO2002006287A2 (US06656450-20031202-C00009.png) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
EP1032430A2 (en) | 1997-11-17 | 2000-09-06 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
US20040146463A1 (en) * | 2000-05-04 | 2004-07-29 | Meade Thomas J. | Functional MRI agents for cancer imaging |
DK1286704T3 (da) | 2000-06-02 | 2014-09-22 | Univ Texas | Ethylendicystein (EC)-glucose analoge konjugater |
JP2004509924A (ja) * | 2000-09-25 | 2004-04-02 | ザ、プロクター、エンド、ギャンブル、カンパニー | Mri画像増強組成物 |
US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
US20020197648A1 (en) * | 2001-05-02 | 2002-12-26 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
US20030198597A1 (en) * | 2002-04-22 | 2003-10-23 | Meade Thomas J. | Novel macrocyclic activatible magnetic resonance imaging contrast agents |
FR2856063B1 (fr) * | 2003-06-13 | 2005-10-07 | Air Liquide | Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises |
US9050378B2 (en) | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
US20060088475A1 (en) * | 2004-05-10 | 2006-04-27 | Northwestern University | Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase |
US7306785B2 (en) * | 2004-09-23 | 2007-12-11 | General Electric Company | Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using |
US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
US8834840B1 (en) | 2006-10-04 | 2014-09-16 | Northwestern University | Magnetic resonance imaging of self-assembled biomaterial scaffolds |
US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
WO2009036441A2 (en) * | 2007-09-14 | 2009-03-19 | Northwestern University | Contrast agents |
US8580231B2 (en) | 2008-05-23 | 2013-11-12 | Northwestern University | Compositions and methods comprising magnetic resonance contrast agents |
US20100029909A1 (en) * | 2008-05-23 | 2010-02-04 | Northwestern University | Compositions and methods comprising magnetic resonance contrast agents |
US20120095185A1 (en) * | 2010-09-20 | 2012-04-19 | Nordion (Canada) Inc. | Process for chelating copper ions using cb-te2a bifunctional chelate |
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US3919102A (en) | 1971-03-16 | 1975-11-11 | Henkel & Cie Gmbh | Composition and method for activating oxygen utilizing N-acylated tetraaza-bicyclo-nonandiones |
US4637988A (en) | 1981-07-01 | 1987-01-20 | Eastman Kodak Company | Fluorescent labels for immunoassay |
US4837169A (en) | 1981-07-01 | 1989-06-06 | Eastman Kodak Company | Polypyridine Fluorescent labels for immunoassay |
US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US5188816A (en) | 1984-10-18 | 1993-02-23 | Board Of Regents, The University Of Texas System | Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS |
US4678667A (en) | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
EP0247156B1 (en) | 1985-11-18 | 1993-06-23 | Access Pharmaceuticals Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
US4877872A (en) | 1986-06-24 | 1989-10-31 | The University Of Toledo | Production and use of dimers of hematoporophyrin, purpurins, chlorines and purpurin- and chlorin-complexes |
US5219553A (en) | 1986-08-04 | 1993-06-15 | Salutar, Inc. | Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI |
US5338532A (en) | 1986-08-18 | 1994-08-16 | The Dow Chemical Company | Starburst conjugates |
FR2604092B1 (fr) | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
US4822594A (en) | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
HU208947B (en) | 1987-07-16 | 1994-02-28 | Nycomed As | Diagnostical compositions and process for producing aminopolycarboxylic acids, their derivatives and metal-kelates |
US5531978A (en) | 1987-07-16 | 1996-07-02 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
US5162509A (en) | 1989-03-06 | 1992-11-10 | Board Of Regents, The University Of Texas System | Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
US5554748A (en) | 1989-04-07 | 1996-09-10 | Nycomed Salutar, Inc. | Adducts of macrocyclic chelants |
US5230883A (en) | 1989-05-04 | 1993-07-27 | Wisconsin Alumni Research Foundation | Method for localization and treatment of tumors using polylysine complexes |
US5087440A (en) | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
US5332567A (en) | 1989-08-24 | 1994-07-26 | Immunomedics | Detection and treatment of infections with immunoconjugates |
US5446145A (en) | 1990-01-19 | 1995-08-29 | Nycomed Salutar, Inc. | Polychelant compounds |
WO1991010669A1 (en) | 1990-01-19 | 1991-07-25 | Cockbain, Julian, Roderick, Michaelson | Chelating compounds |
US5095099A (en) | 1990-12-10 | 1992-03-10 | E. I. Du Pont De Nemours And Company | Fluorescent compounds for absorption and re-emission of radiation |
US5310539A (en) | 1991-04-15 | 1994-05-10 | Board Of Regents, The University Of Texas System | Melanin-based agents for image enhancement |
WO1992019264A1 (en) | 1991-05-01 | 1992-11-12 | University Of New Mexico | Biomodulators as universal imaging agents |
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US5133956A (en) | 1991-05-30 | 1992-07-28 | The Dow Chemical Company | Radiolabeled metal-binding protein for the treatment of arthritis |
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US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
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US5407657A (en) | 1992-09-22 | 1995-04-18 | Unger; Evan C. | Hybrid magnetic resonance contrast agents |
US5466439A (en) | 1992-11-12 | 1995-11-14 | Magnetic Research, Inc. | Polymeric contrast enhancing agents for magnetic resonance images |
US5358704A (en) | 1993-09-30 | 1994-10-25 | Bristol-Myers Squibb | Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents |
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EP0661279B1 (fr) | 1993-12-30 | 2001-03-07 | Guerbet | Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques |
US5554749A (en) | 1994-01-14 | 1996-09-10 | Mallinckrodt Medical, Inc. | Functionalized macrocyclic ligands for imaging applications |
AU1681795A (en) | 1994-01-14 | 1995-08-01 | Mallinckrodt Medical, Inc. | Functionalized aza-macrobicyclic ligands for imaging applications |
AU1694895A (en) | 1994-01-28 | 1995-08-15 | Mallinckrodt Medical, Inc. | Functionalized aza-bimacrocyclic ligands for imaging applications |
DE4403789A1 (de) | 1994-02-03 | 1995-08-10 | Schering Ag | Mittel zur visuellen Markierung von Körpergewebe |
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GB9407812D0 (en) | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
US6693190B1 (en) | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
IT1269839B (it) | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
US5622821A (en) | 1994-06-29 | 1997-04-22 | The Regents Of The University Of California | Luminescent lanthanide chelates and methods of use |
DE4428874A1 (de) | 1994-08-08 | 1996-02-22 | Schering Ag | Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel |
TW319763B (US06656450-20031202-C00009.png) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
US5955605A (en) | 1995-02-21 | 1999-09-21 | Neorx Corporation | Biotinidase resistant biotin-DOTA conjugates |
US5707605A (en) | 1995-06-02 | 1998-01-13 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
US5980862A (en) | 1995-06-02 | 1999-11-09 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
EP1382332A1 (en) | 1995-06-26 | 2004-01-21 | Chelator LLC | Method for inhibiting bacterial or fungal growth using a polyamine derivative as complexing agent |
AU720841B2 (en) | 1995-12-12 | 2000-06-15 | California Institute Of Technology | Cobalt schiff base compounds |
IT1283218B1 (it) | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
CN1108824C (zh) | 1996-04-01 | 2003-05-21 | Epix医学公司 | 生物活化的诊断成像造影剂 |
AU750686B2 (en) | 1997-10-27 | 2002-07-25 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the delivery of therapeutic agents |
US6093382A (en) | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
BR0013171A (pt) | 1999-07-29 | 2002-05-28 | Epix Medical Inc | Agentes multimericos para formação de imagem de objetivação através de ligação multi-local |
WO2001052906A2 (en) | 2000-01-22 | 2001-07-26 | Epix Medical, Inc. | Magnetic resonance imaging using contrast agents prodrugs bioactivated by enzymatic cleavage |
-
2001
- 2001-07-17 US US09/908,436 patent/US6656450B2/en not_active Expired - Fee Related
- 2001-07-17 AU AU2001276956A patent/AU2001276956A1/en not_active Abandoned
- 2001-07-17 WO PCT/US2001/022491 patent/WO2002006287A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2002006287A9 (en) | 2002-07-18 |
US6656450B2 (en) | 2003-12-02 |
WO2002006287A3 (en) | 2002-10-17 |
US20020049308A1 (en) | 2002-04-25 |
WO2002006287A2 (en) | 2002-01-24 |
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