AU2001276488A1 - Pleckstrin homology polypeptides and dna encoding such - Google Patents

Pleckstrin homology polypeptides and dna encoding such

Info

Publication number
AU2001276488A1
AU2001276488A1 AU2001276488A AU7648801A AU2001276488A1 AU 2001276488 A1 AU2001276488 A1 AU 2001276488A1 AU 2001276488 A AU2001276488 A AU 2001276488A AU 7648801 A AU7648801 A AU 7648801A AU 2001276488 A1 AU2001276488 A1 AU 2001276488A1
Authority
AU
Australia
Prior art keywords
ptdins
polypeptides
pleckstrin homology
dna encoding
ptdins3p
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001276488A
Inventor
Dario Alessi
David Campbell
Simon Dowler
Peter Downes
Alexander Gray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0018908A external-priority patent/GB0018908D0/en
Priority claimed from GB0021685A external-priority patent/GB0021685D0/en
Application filed by Medical Research Council filed Critical Medical Research Council
Publication of AU2001276488A1 publication Critical patent/AU2001276488A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The use of polypeptides capable of binding to PtdIns(3,4)P2, PtdIns3P, PtdIns4P or but not capable of binding to PtdIns(3,4,5)P3, in a screening method for identifying a compound suitable for modulating signalling by PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The polypeptides preferably comprises a PH (pleckstrin homology) domain which binds specifically to one of PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The PH domain preferably has at least five of the six residues of a Putative PtdIns(3,4,5)P3 Binding Motif (PPBM).
AU2001276488A 2000-08-03 2001-08-03 Pleckstrin homology polypeptides and dna encoding such Abandoned AU2001276488A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0018908.4 2000-08-03
GB0018908A GB0018908D0 (en) 2000-08-03 2000-08-03 Polypeptides
GB0021685.3 2000-09-05
GB0021685A GB0021685D0 (en) 2000-09-05 2000-09-05 Polypeptides
PCT/GB2001/003481 WO2002012276A2 (en) 2000-08-03 2001-08-03 Pleckstrin homology polypeptides and dna encoding such

Publications (1)

Publication Number Publication Date
AU2001276488A1 true AU2001276488A1 (en) 2002-02-18

Family

ID=26244779

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001276488A Abandoned AU2001276488A1 (en) 2000-08-03 2001-08-03 Pleckstrin homology polypeptides and dna encoding such

Country Status (6)

Country Link
US (2) US20040106148A1 (en)
EP (1) EP1385877B1 (en)
AT (1) ATE483728T1 (en)
AU (1) AU2001276488A1 (en)
DE (1) DE60143225D1 (en)
WO (1) WO2002012276A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067269B2 (en) 2001-11-26 2006-06-27 Echelon Biosciences, Inc. Assaying apparatus, kit, and method for lipids and associated enzymes
US20050009124A1 (en) * 2001-11-26 2005-01-13 Echelon Biosciences Incorporated Assays for detection of phosphoinositide kinase and phosphatase activity
GB0322689D0 (en) * 2003-09-27 2003-10-29 Medical Res Council Methods
WO2011085070A2 (en) * 2010-01-06 2011-07-14 Virginia Tech Intellectual Properties, Inc. Methods and compositions to improve the health of plants, animals and microbes by manipulating protein entry into symbionts and their hosts

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10155491A (en) * 1996-11-29 1998-06-16 Shionogi & Co Ltd New protein and dna coding for the same
JP2002513554A (en) * 1998-05-05 2002-05-14 インサイト・ファーマスーティカルズ・インコーポレイテッド Human transcription regulatory molecule

Also Published As

Publication number Publication date
WO2002012276A3 (en) 2003-11-06
EP1385877B1 (en) 2010-10-06
US20040106148A1 (en) 2004-06-03
ATE483728T1 (en) 2010-10-15
EP1385877A2 (en) 2004-02-04
DE60143225D1 (en) 2010-11-18
WO2002012276A2 (en) 2002-02-14
US20100047823A1 (en) 2010-02-25

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