AU2001269139A1 - Novel disaccharides with anti-arthritic action - Google Patents

Novel disaccharides with anti-arthritic action

Info

Publication number
AU2001269139A1
AU2001269139A1 AU2001269139A AU6913901A AU2001269139A1 AU 2001269139 A1 AU2001269139 A1 AU 2001269139A1 AU 2001269139 A AU2001269139 A AU 2001269139A AU 6913901 A AU6913901 A AU 6913901A AU 2001269139 A1 AU2001269139 A1 AU 2001269139A1
Authority
AU
Australia
Prior art keywords
hydrogen
group
coch3
so3m
so3h
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001269139A
Inventor
Narcis Arnau Pastor
Francesc Flores Salgado
Ramon Ruhi Roura
Francisco Javier Vila Pahi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioiberica SA
Original Assignee
Bioiberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioiberica SA filed Critical Bioiberica SA
Publication of AU2001269139A1 publication Critical patent/AU2001269139A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention refers to new disaccharides of formula (I), <CHEM> where R<1> is selected from the group consisting of hydrogen, linear or branched (C1-C4)-alkyl, phenylalkyl of less than ten carbon atoms and -COCH3; R<2> is selected from the group consisting of hydrogen, -COCH3 and SO3M; R<3> is selected from the group consisting of hydrogen, linear or branched (C1-C4)-alkyl, phenylalkyl of less than ten carbon atoms, -COCH3 and -COPh, where Ph is phenyl; G is selected from between -COOR<4> and -COOM, where R<4> is selected from the group consisting of hydrogen, (C1-C2)-alkyl and arylalkyl of less than sixteen carbon atoms; A is selected from the group consisting of hydrogen, -SO3H, -SOM and -COCH3; B is selected from the group consisting of hydrogen, -SO3H, -SO3M and -COCH3; where either A or B are necessarily either -SO3H or -SO3M, and where M is an organic or metallic cation. These compounds can be used as anti-arthrosic or anti-inflammatory drugs or to control blood clotting.
AU2001269139A 2000-07-13 2001-07-05 Novel disaccharides with anti-arthritic action Abandoned AU2001269139A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200001741A ES2167251B1 (en) 2000-07-13 2000-07-13 NEW DISCSED WITH ANTIARTROSIC ACTION.
ES200001741 2000-07-13
PCT/ES2001/000265 WO2002008239A1 (en) 2000-07-13 2001-07-05 Novel disaccharides with anti-arthritic action

Publications (1)

Publication Number Publication Date
AU2001269139A1 true AU2001269139A1 (en) 2002-02-05

Family

ID=8494247

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001269139A Abandoned AU2001269139A1 (en) 2000-07-13 2001-07-05 Novel disaccharides with anti-arthritic action

Country Status (10)

Country Link
US (1) US6680304B2 (en)
EP (1) EP1300411B1 (en)
AT (1) ATE335752T1 (en)
AU (1) AU2001269139A1 (en)
CA (1) CA2415752C (en)
DE (1) DE60122156T2 (en)
DK (1) DK1300411T3 (en)
ES (2) ES2167251B1 (en)
PT (1) PT1300411E (en)
WO (1) WO2002008239A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070082851A1 (en) * 2003-11-24 2007-04-12 Optimer Pharmaceuticals Inc. Treatment of a condition in a mammal with administration of Compounds and Methods of Use
EP1761550A2 (en) * 2004-05-26 2007-03-14 California Institute of Technology Small molecule stimulators of neuronal growth
ES2327480B1 (en) * 2007-06-15 2010-08-10 Bioiberica, S.A. "DISABLED FOR THE TREATMENT OF TENDONS, LIGAMENTS AND BONES".
US8912149B1 (en) 2007-11-28 2014-12-16 California Institute Of Technology Glycosaminoglycan mimetics
ES2364683B1 (en) 2009-12-29 2012-08-08 Bioibérica S.A. DISULATIZES SULFATED FOR THE TREATMENT OF NEURODEGENERATIVE AND / OR NEUROVASCULAR DISEASES.
US20130203695A1 (en) * 2010-10-29 2013-08-08 Opko Health, Inc. Hypersulfated disaccharides to treat elastase related disorders
US10227370B2 (en) 2013-08-02 2019-03-12 California Institute Of Technology Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
US9770461B2 (en) 2013-08-02 2017-09-26 California Institute Of Technology Tailored glycopolymers as anticoagulant heparin mimetics
ES2684097B1 (en) 2017-03-29 2019-07-04 Bioiberica S A U Sulfated disaccharides for the treatment of neuropathic pain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8519416D0 (en) * 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
WO1993009766A1 (en) * 1991-11-15 1993-05-27 Arthro Research And Development Corporation Method for treatment of acute and chronic painful arthropathic conditions in human and other mammals
IT1270095B (en) * 1994-09-28 1997-04-28 Ibsa Inst Biochimique Sa THERAPEUTIC COMPOSITIONS OF CHONDROITIN SULPHATE IN THE FORM OF ORAL ADMINISTRABLE GEL
FR2789587B1 (en) * 1999-02-11 2003-01-24 Inst Nat Sante Rech Med MEANS FOR THE REGULATION OF HEMATOPOIETIC DIFFERENTIATION
FR2792319B1 (en) * 1999-04-14 2001-07-06 Pf Medicament PROCESS FOR THE PREPARATION OF MONOSULFATE OF 4 OR 6 DISACCHARIDES, THEIR USE IN COSMETICS AND AS A MEDICAMENT, IN PARTICULAR FOR THE TREATMENT OF COLLAGEN DISEASES

Also Published As

Publication number Publication date
US6680304B2 (en) 2004-01-20
DE60122156D1 (en) 2006-09-21
EP1300411B1 (en) 2006-08-09
ES2167251A1 (en) 2002-05-01
PT1300411E (en) 2006-12-29
DE60122156T2 (en) 2007-08-23
EP1300411A1 (en) 2003-04-09
WO2002008239A1 (en) 2002-01-31
ATE335752T1 (en) 2006-09-15
ES2267788T3 (en) 2007-03-16
DK1300411T3 (en) 2006-12-04
ES2167251B1 (en) 2003-09-16
US20030181400A1 (en) 2003-09-25
CA2415752C (en) 2009-09-15
CA2415752A1 (en) 2003-01-10

Similar Documents

Publication Publication Date Title
AU3461697A (en) Heterocyclic compounds, their production and use
CA2418770A1 (en) Acylacetonitrile compound, process for preparation thereof, and miticide containing the same
HK1072770A1 (en) Bicyclic compound
ATE427992T1 (en) DNA SYNTHESIS PROMOTORS, DNA POLYMERASE ASSOCIATED FACTORS AND USE THEREOF
BR0016871A (en) Compound of trifluoromethylpyrrolcarboxamide, process for the preparation of compounds, composition to control microorganisms and prevent the attack and infestation of plants by them, use of a compound, and method of controlling or preventing infestation of plants grown by phytopathogenic microorganisms
AU2001269139A1 (en) Novel disaccharides with anti-arthritic action
HUP9903836A2 (en) New process of preparing phenyl substituted 2(5h)-furanones having cox-2 inhibitor activity
FI931765A0 (en) STEROIDDERIVAT FOER BEHANDLING AV PROSTATAHYPERTROFI, DERAS FRAMSTAELLNING OCH ANVAENDNINGAR
CA2261032A1 (en) Dibenzodihydropyridinecarboxylic esters and their use in chemiluminescent assay methods
CA2026778A1 (en) Dioxaphosphorinane compounds and polyolefin compositions stabilized therewith
DE69904818D1 (en) THIENODIPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE
WO2003097806A3 (en) Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2002002098A3 (en) Antibacterial method and composition with phenolic compounds
GR3031390T3 (en) Fluoropropene compound, an insecticide containing the same and an intermediate for production thereof
AU1586588A (en) Fungicidal derivatives of propenoic acid and processes for their preparation
CA2013743A1 (en) Preparation of glutaric acid derivatives
ATE48420T1 (en) 5-ISOXAZOLECARBONIC ACIDS, THEIR PRODUCTION AND USE AS FUNGICIDES.
ATE111456T1 (en) N-ALKYLTHIAZOLIDEINDIVATES.
ES2037823T3 (en) BETA-LACTAMA COMPOUNDS AND PROCEDURE FOR THEIR PRODUCTION.