AU2001267043A1 - Stable isotope labeling of paclitaxel - Google Patents

Stable isotope labeling of paclitaxel

Info

Publication number
AU2001267043A1
AU2001267043A1 AU2001267043A AU6704301A AU2001267043A1 AU 2001267043 A1 AU2001267043 A1 AU 2001267043A1 AU 2001267043 A AU2001267043 A AU 2001267043A AU 6704301 A AU6704301 A AU 6704301A AU 2001267043 A1 AU2001267043 A1 AU 2001267043A1
Authority
AU
Australia
Prior art keywords
paclitaxel
stable isotope
isotope labeling
labeling
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001267043A
Inventor
Michael S. Alexander
James D Mcchesney
Jan Zygmunt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tapestry Pharmaceuticals Inc
Original Assignee
Tapestry Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tapestry Pharmaceuticals Inc filed Critical Tapestry Pharmaceuticals Inc
Publication of AU2001267043A1 publication Critical patent/AU2001267043A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2001267043A 2000-06-09 2001-06-07 Stable isotope labeling of paclitaxel Abandoned AU2001267043A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/591,159 US6358996B1 (en) 2000-06-09 2000-06-09 Stable isotope labeling of paclitaxel
US09591159 2000-06-09
PCT/US2001/040876 WO2001094328A1 (en) 2000-06-09 2001-06-07 Stable isotope labeling of paclitaxel

Publications (1)

Publication Number Publication Date
AU2001267043A1 true AU2001267043A1 (en) 2001-12-17

Family

ID=24365305

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001267043A Abandoned AU2001267043A1 (en) 2000-06-09 2001-06-07 Stable isotope labeling of paclitaxel

Country Status (7)

Country Link
US (1) US6358996B1 (en)
EP (1) EP1301499A4 (en)
JP (1) JP2003535854A (en)
AU (1) AU2001267043A1 (en)
CA (1) CA2409944A1 (en)
IL (1) IL153316A0 (en)
WO (1) WO2001094328A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1490348A1 (en) * 2002-03-21 2004-12-29 Pharmacia Italia S.p.A. Labelled taxanes
ES2503265T3 (en) * 2002-08-04 2014-10-06 Phyton Holdings, Llc Methods to convert taxane amides into paclitaxel or other taxanes
US20050014279A1 (en) * 2003-07-14 2005-01-20 Nguyen Hoa Duc Method of analysis of amine by mass spectrometry
US7494822B2 (en) * 2003-09-30 2009-02-24 Nguyen Hoa D Method of quantification of carboxylic acids by mass spectrometry
US7439074B2 (en) * 2003-09-30 2008-10-21 Hoa Duc Nguyen Method of analysis of alcohol by mass spectrometry
US7309608B2 (en) * 2003-09-30 2007-12-18 Hoa Duc Nguyen Method of analysis of aldehyde and ketone by mass spectrometry
US20050079544A1 (en) * 2003-10-13 2005-04-14 Nguyen Hoa Duc Automated method of metabolic stability analysis of library of compounds by isotope dilution mass spectrometry
WO2005114700A2 (en) * 2004-05-19 2005-12-01 Applera Corporation Expression quantification using mass spectrometry
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
JP4317083B2 (en) * 2004-06-04 2009-08-19 株式会社日立ハイテクノロジーズ Mass spectrometry method and mass spectrometry system
US20060156792A1 (en) * 2004-10-12 2006-07-20 Yongdong Wang Multi-dimensional liquid chromatography separation system and method
US20060183238A1 (en) * 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684175A (en) 1993-02-05 1997-11-04 Napro Biotherapeutics, Inc. C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
US5948919A (en) 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
EP1260507A1 (en) 1993-02-05 2002-11-27 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable A-nng side chains
US5675025A (en) 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US6107497A (en) 1996-02-29 2000-08-22 Napro Biotherapeutics, Inc. Intermediate for use in docetaxel synthesis and production method therefor
US5750736A (en) 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5750737A (en) 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
US5973170A (en) 1996-09-25 1999-10-26 Napro Biotherapuetics, Inc. C-7 metal alkoxides of baccatin III
US5914411A (en) 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
US6066749A (en) 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US6048990A (en) 1998-05-01 2000-04-11 Napro Biotherapeutics, Inc. Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position

Also Published As

Publication number Publication date
EP1301499A1 (en) 2003-04-16
IL153316A0 (en) 2003-07-06
EP1301499A4 (en) 2005-08-10
US6358996B1 (en) 2002-03-19
CA2409944A1 (en) 2001-12-13
WO2001094328A1 (en) 2001-12-13
JP2003535854A (en) 2003-12-02

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