AU2001264163A1 - Lipid uptake assays - Google Patents

Lipid uptake assays

Info

Publication number
AU2001264163A1
AU2001264163A1 AU2001264163A AU6416301A AU2001264163A1 AU 2001264163 A1 AU2001264163 A1 AU 2001264163A1 AU 2001264163 A AU2001264163 A AU 2001264163A AU 6416301 A AU6416301 A AU 6416301A AU 2001264163 A1 AU2001264163 A1 AU 2001264163A1
Authority
AU
Australia
Prior art keywords
lipid uptake
uptake assays
lipid
assays
elegans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001264163A
Inventor
Cindy Anthonissen
Thierry Bogaert
Beatrice Bonnet
Benoit Deprez
Philippe Verwaerde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Devgen NV
Original Assignee
Devgen NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Devgen NV filed Critical Devgen NV
Publication of AU2001264163A1 publication Critical patent/AU2001264163A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
    • G01N2333/43534—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to the use of microscopic nematodes such as C. elegans in functional high throughput in vivo assays suitable for the detection of inhibitors or activators of intestinal lipid uptake.
AU2001264163A 2000-05-19 2001-05-21 Lipid uptake assays Abandoned AU2001264163A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0012229.1A GB0012229D0 (en) 2000-05-19 2000-05-19 Lipid uptake assays
GB0012229 2000-05-19
PCT/IB2001/001061 WO2001088533A2 (en) 2000-05-19 2001-05-21 Lipid uptake assays

Publications (1)

Publication Number Publication Date
AU2001264163A1 true AU2001264163A1 (en) 2001-11-26

Family

ID=9891997

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001262601A Abandoned AU2001262601A1 (en) 2000-05-19 2001-05-21 Improved assay techniques using nematode worms
AU2001264163A Abandoned AU2001264163A1 (en) 2000-05-19 2001-05-21 Lipid uptake assays

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2001262601A Abandoned AU2001262601A1 (en) 2000-05-19 2001-05-21 Improved assay techniques using nematode worms

Country Status (8)

Country Link
US (1) US6703214B2 (en)
EP (2) EP1282816A2 (en)
JP (2) JP2004524803A (en)
AT (1) ATE288587T1 (en)
AU (2) AU2001262601A1 (en)
DE (1) DE60108746T2 (en)
GB (2) GB0012229D0 (en)
WO (2) WO2001088533A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002031202A2 (en) * 2000-10-10 2002-04-18 Thomas Jefferson University High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds
WO2003100094A2 (en) * 2002-05-23 2003-12-04 Devgen Nv Method for determining the influence of a compound on cholesterol transport
WO2004033654A2 (en) * 2002-10-09 2004-04-22 Buck Institute Automated method for high throughput screening of nematodes
CA2592350A1 (en) * 2004-12-15 2006-06-22 Schering Corporation Functional assays for cholesterol absorption inhibitors
EP2160607B1 (en) * 2007-05-31 2011-09-07 Sanofi Assay methods for identifying agents that modify the activity of nape-pld or abh4
JP5120889B2 (en) * 2008-06-12 2013-01-16 独立行政法人産業技術総合研究所 Boron dipyrromethane derivative and lipid peroxide measuring reagent using the same
CN102288749B (en) * 2011-07-28 2013-07-31 山东农业大学 Dipterex bionic enzyme linked immunosorbent detection method
GB201301043D0 (en) * 2013-01-21 2013-03-06 Chronos Therapeutics Ltd Method for assessing cell aging
EP2775302A1 (en) * 2013-03-08 2014-09-10 Assistance Publique - Hôpitaux de Paris Compound-carrier systems for assays in nematodes
CN108794518B (en) * 2018-04-04 2020-06-19 安徽师范大学 Organic conjugated molecular material with BODIPY as basic skeleton and preparation method thereof
CN109799295A (en) * 2019-01-28 2019-05-24 江南大学 A kind of sample-pretreating method for Caenorhabditis elegans metabonomic analysis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
WO1990009096A2 (en) * 1989-02-03 1990-08-23 Cambridge Neuroscience Research, Inc. Method of screening and classifying compounds
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5338854A (en) 1991-02-13 1994-08-16 Molecular Probes, Inc. Fluorescent fatty acids derived from dipyrrometheneboron difluoride dyes
US5583008A (en) * 1993-05-19 1996-12-10 Nemapharm, Inc. Rapid diagnostic procedure for ivermectin resistance
US6342379B1 (en) * 1995-06-07 2002-01-29 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US5994063A (en) * 1995-06-23 1999-11-30 Metzker; Michael L. Substituted 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene compounds for homogenous amplification/detection assays
US5929062A (en) * 1997-06-19 1999-07-27 University Of Western Ontario Oxysterol inhibition of dietary cholesterol uptake
US6114177A (en) * 1997-11-12 2000-09-05 Phytochem Technologies, Inc. Fluorometric assay for measurement of antioxidant activity
CN1285001A (en) * 1997-12-18 2001-02-21 塞普拉科有限公司 Methods for simultaneous identification of novel biological targets and lead structures for drug development
US6348321B1 (en) * 1998-01-15 2002-02-19 Whitehead Institute For Biomedical Research Methods of identifying agents inhibiting fatty acid transport proteins
GB9827152D0 (en) 1998-07-03 1999-02-03 Devgen Nv Characterisation of gene function using double stranded rna inhibition
GB9908677D0 (en) 1999-04-15 1999-06-09 Devgen Nv Compound assay
AU780574B2 (en) 1999-04-15 2005-04-07 Devgen N.V. Compound screening method
US6323186B1 (en) * 1999-09-17 2001-11-27 Molecular Probes, Inc. Phosphate-bound polyazaindacene derivatives of nucleotides

Also Published As

Publication number Publication date
DE60108746D1 (en) 2005-03-10
WO2001088533A2 (en) 2001-11-22
DE60108746T2 (en) 2006-03-30
EP1285269B1 (en) 2005-02-02
GB2366615A (en) 2002-03-13
ATE288587T1 (en) 2005-02-15
EP1285269A2 (en) 2003-02-26
GB0112360D0 (en) 2001-07-11
AU2001262601A1 (en) 2001-11-26
WO2001088533A3 (en) 2002-05-16
US20020137205A1 (en) 2002-09-26
JP2003533696A (en) 2003-11-11
JP2004524803A (en) 2004-08-19
WO2001088532A3 (en) 2002-04-04
GB2366615B (en) 2002-07-24
US6703214B2 (en) 2004-03-09
EP1282816A2 (en) 2003-02-12
WO2001088532A2 (en) 2001-11-22
GB0012229D0 (en) 2000-07-12

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