AU2001261749A1 - Crystal structures of p- selectin,ep0105895-selectin complexes, and uses thereof - Google Patents

Crystal structures of p- selectin,ep0105895-selectin complexes, and uses thereof

Info

Publication number
AU2001261749A1
AU2001261749A1 AU2001261749A AU6174901A AU2001261749A1 AU 2001261749 A1 AU2001261749 A1 AU 2001261749A1 AU 2001261749 A AU2001261749 A AU 2001261749A AU 6174901 A AU6174901 A AU 6174901A AU 2001261749 A1 AU2001261749 A1 AU 2001261749A1
Authority
AU
Australia
Prior art keywords
selectin
complexes
crystal structures
crystal
structures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001261749A
Inventor
Raymond Camphausen
Jasbir Seehra
William S. Somers
Jin Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of AU2001261749A1 publication Critical patent/AU2001261749A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G01N23/207—Diffractometry using detectors, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001261749A 2000-05-19 2001-05-17 Crystal structures of p- selectin,ep0105895-selectin complexes, and uses thereof Abandoned AU2001261749A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20587500P 2000-05-19 2000-05-19
US60205875 2000-05-19
PCT/US2001/016108 WO2001089531A1 (en) 2000-05-19 2001-05-17 Crystal structures of p- selectin,ep0105895-selectin complexes, and uses thereof

Publications (1)

Publication Number Publication Date
AU2001261749A1 true AU2001261749A1 (en) 2001-12-03

Family

ID=22764010

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001261749A Abandoned AU2001261749A1 (en) 2000-05-19 2001-05-17 Crystal structures of p- selectin,ep0105895-selectin complexes, and uses thereof

Country Status (9)

Country Link
US (1) US20040096894A1 (en)
EP (1) EP1282425A4 (en)
JP (1) JP2004509069A (en)
CN (1) CN1430516A (en)
AU (1) AU2001261749A1 (en)
BR (1) BR0110963A (en)
CA (1) CA2407545A1 (en)
MX (1) MXPA02010989A (en)
WO (1) WO2001089531A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003089450A2 (en) * 2002-04-22 2003-10-30 Recopharma Ab Fusion polypeptides and methods for inhibiting microbial adhesion
PL1797115T3 (en) * 2004-09-28 2017-12-29 Janssen Pharmaceutica N.V. A bacterial atp synthase binding domain
CN101139391B (en) * 2007-08-21 2012-07-25 陈志南 CD147 extracellular domain crystal structure and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124267A (en) * 1991-02-05 2000-09-26 Southpac Trust Internationals, Inc. O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1
ATE194168T1 (en) * 1992-04-30 2000-07-15 Genentech Inc VARIANTS IN THE LELTIN DOMAIN OF SELEKTIN
WO1995014787A1 (en) * 1993-11-22 1995-06-01 Centocor, Inc. Peptide inhibitors of selecting binding

Also Published As

Publication number Publication date
WO2001089531A1 (en) 2001-11-29
US20040096894A1 (en) 2004-05-20
EP1282425A4 (en) 2004-09-15
CN1430516A (en) 2003-07-16
BR0110963A (en) 2003-11-25
JP2004509069A (en) 2004-03-25
CA2407545A1 (en) 2001-11-29
EP1282425A1 (en) 2003-02-12
MXPA02010989A (en) 2003-03-10

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