AU2001261457A1 - A homeodomain protein code specifying progenitor cell identity and neuronal fatein the ventral neural tube - Google Patents

A homeodomain protein code specifying progenitor cell identity and neuronal fatein the ventral neural tube

Info

Publication number
AU2001261457A1
AU2001261457A1 AU2001261457A AU6145701A AU2001261457A1 AU 2001261457 A1 AU2001261457 A1 AU 2001261457A1 AU 2001261457 A AU2001261457 A AU 2001261457A AU 6145701 A AU6145701 A AU 6145701A AU 2001261457 A1 AU2001261457 A1 AU 2001261457A1
Authority
AU
Australia
Prior art keywords
fatein
neuronal
progenitor cell
cell identity
neural tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001261457A
Inventor
James Briscoe
Johan Ericson
Thomas M. Jessell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of AU2001261457A1 publication Critical patent/AU2001261457A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2001261457A 2000-05-11 2001-05-11 A homeodomain protein code specifying progenitor cell identity and neuronal fatein the ventral neural tube Abandoned AU2001261457A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09569259 2000-05-11
US09/569,259 US6955802B1 (en) 2000-05-11 2000-05-11 Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
PCT/US2001/015290 WO2001084933A1 (en) 2000-05-11 2001-05-11 A homeodomain protein code specifying progenitor cell identity and neuronal fate in the ventral neural tube

Publications (1)

Publication Number Publication Date
AU2001261457A1 true AU2001261457A1 (en) 2001-11-20

Family

ID=24274693

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001261457A Abandoned AU2001261457A1 (en) 2000-05-11 2001-05-11 A homeodomain protein code specifying progenitor cell identity and neuronal fatein the ventral neural tube

Country Status (3)

Country Link
US (1) US6955802B1 (en)
AU (1) AU2001261457A1 (en)
WO (1) WO2001084933A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6955802B1 (en) 2000-05-11 2005-10-18 The Trustees Of Columbia University In The City Of New York Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
US7312081B2 (en) 2000-05-11 2007-12-25 The Trustees Of Columbia University In The City Of New York Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation
US7393686B1 (en) * 2000-05-11 2008-07-01 Trustees Of Columbia University In The City Of New York Genetic demonstration of requirement for NKX6.1 and NKX2.2 in ventral neuron generation
CN115141803B (en) * 2022-05-26 2023-09-01 武汉泓宸创新生物科技有限公司 Method for obtaining myeloglutamatergic interneurons by induction of human pluripotent stem cells and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2184092A1 (en) 1994-02-25 1995-08-31 Thomas M. Jessell Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof
US20040005602A1 (en) 1997-02-27 2004-01-08 The Trustees Of Columbia University DNA encoding the vertebrate homolog of hedgehog, Vhh-1, expressed by the notocord, and uses thereof
GB9713469D0 (en) 1997-06-25 1997-09-03 Medical Res Council Neuronal stem cell gene
WO2000009676A2 (en) 1998-08-14 2000-02-24 California Institute Of Technology Methods of forming neurons
US6387656B1 (en) 1998-09-29 2002-05-14 The Trustees Of Columbia University In The City Of New York Gene encoding MNR2 and uses thereof
US6955802B1 (en) 2000-05-11 2005-10-18 The Trustees Of Columbia University In The City Of New York Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
AU2001288634A1 (en) 2000-09-01 2002-03-13 The Trustees Of Columbia University In The City Of New York Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation

Also Published As

Publication number Publication date
US6955802B1 (en) 2005-10-18
WO2001084933A1 (en) 2001-11-15

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