AU2001250020A1 - A nickel-rhenium catalyst for use in reductive amination processes - Google Patents

A nickel-rhenium catalyst for use in reductive amination processes

Info

Publication number
AU2001250020A1
AU2001250020A1 AU2001250020A AU5002001A AU2001250020A1 AU 2001250020 A1 AU2001250020 A1 AU 2001250020A1 AU 2001250020 A AU2001250020 A AU 2001250020A AU 5002001 A AU5002001 A AU 5002001A AU 2001250020 A1 AU2001250020 A1 AU 2001250020A1
Authority
AU
Australia
Prior art keywords
nickel
reductive amination
rhenium
rhenium catalyst
weight percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001250020A
Inventor
William J. Bartley
Ronald Gary Cook
Kendrick Edward Curry
Stefan Kent Mierau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Union Carbide Chemicals and Plastics Technology LLC
Original Assignee
Union Carbide Chemicals and Plastics Technology LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Carbide Chemicals and Plastics Technology LLC filed Critical Union Carbide Chemicals and Plastics Technology LLC
Publication of AU2001250020A1 publication Critical patent/AU2001250020A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023Preparation; Separation; Stabilisation; Use of additives
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/76Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups B01J23/02 - B01J23/36
    • B01J23/84Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups B01J23/02 - B01J23/36 with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
    • B01J23/889Manganese, technetium or rhenium
    • B01J23/8896Rhenium
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00Catalysts, in general, characterised by their form or physical properties
    • B01J35/60Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/12Silica and alumina
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00Catalysts, in general, characterised by their form or physical properties
    • B01J35/60Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/61Surface area
    • B01J35/61310-100 m2/g
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00Catalysts, in general, characterised by their form or physical properties
    • B01J35/60Catalysts, in general, characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J35/61Surface area
    • B01J35/615100-500 m2/g

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

A nickel/rhenium catalyst composition for the reductive amination of lower aliphatic alkane derivatives is described. The catalyst includes from about 2 to about 75 weight percent nickel and has a nickel to rhenium weight percent ratio of from about 1:1 to about 200:1. The nickel and rhenium are supported on an alumina-silica support which contains from about 5 to about 65 weight percent silica and has a BET surface area of from about 30 to about 450 m2/g. A process for the reductive amination of lower aliphatic alkane derivatives using such a catalyst composition is also provided.
AU2001250020A 2000-03-03 2001-03-02 A nickel-rhenium catalyst for use in reductive amination processes Abandoned AU2001250020A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/519,724 US6534441B1 (en) 1999-03-06 2000-03-03 Nickel-rhenium catalyst for use in reductive amination processes
US09/519,724 2000-03-03
PCT/US2001/040221 WO2001066247A2 (en) 2000-03-03 2001-03-02 A nickel-rhenium catalyst for use in reductive amination processes

Publications (1)

Publication Number Publication Date
AU2001250020A1 true AU2001250020A1 (en) 2001-09-17

Family

ID=24069505

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001250020A Abandoned AU2001250020A1 (en) 2000-03-03 2001-03-02 A nickel-rhenium catalyst for use in reductive amination processes

Country Status (8)

Country Link
US (1) US6534441B1 (en)
EP (1) EP1385625B1 (en)
JP (1) JP5290486B2 (en)
CN (1) CN1192822C (en)
AT (1) ATE342128T1 (en)
AU (1) AU2001250020A1 (en)
DE (1) DE60123845T2 (en)
WO (1) WO2001066247A2 (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2819430B1 (en) * 2001-01-15 2003-02-28 Inst Francais Du Petrole CATALYST COMPRISING SILICA-ALUMINA AND ITS USE IN HYDROCRACKING OF HYDROCARBON CHARGES
US20020157535A1 (en) * 2001-02-28 2002-10-31 Kanazirev Vladislav I. Process and adsorbent for gas drying
SE524126C2 (en) 2001-07-24 2004-06-29 Akzo Nobel Nv Process for the preparation of diethylenetriamine and higher polyethylene polyamines by transamination of ethylenediamine
US7196033B2 (en) * 2001-12-14 2007-03-27 Huntsman Petrochemical Corporation Advances in amination catalysis
AU2003301248A1 (en) * 2002-10-16 2004-05-04 Conocophillips Company High hydrothermal stability catalyst support
TWI346574B (en) * 2003-03-31 2011-08-11 Shell Int Research A catalyst composition, a process for preparing the catalyst composition and a use of the catalyst composition
US20050032640A1 (en) * 2003-08-07 2005-02-10 He Huang Method and structure for desulfurizing gasoline or diesel fuel for use in a fuel cell power plant
US7897538B2 (en) * 2004-05-21 2011-03-01 Exxonmobil Research And Engineering Company Process for removing sulfur compounds from hydrocarbon streams and adsorbent used in this process
WO2006119311A2 (en) * 2005-05-02 2006-11-09 Symyx Technologies, Inc. High surface area metal and metal oxide materials and methods of making same
BRPI0811305B1 (en) 2007-05-09 2020-02-27 Shell Internationale Research Maatschappij B.V. EPOXIDATION CATALYST, A PROCESS FOR THE PREPARATION OF THE CATALYST AND A PROCESS FOR THE PRODUCTION OF AN OLEPHINE OXIDE, A 1,2-DIOL, A 1,2-DIOL ETHER, A 1,2-CARBONATE OR AN ALKANOLAMINE
US8119558B2 (en) * 2008-03-14 2012-02-21 Süd-Chemie Inc. Ultra high temperature shift catalyst with low methanation
CN102066348B (en) * 2008-05-07 2013-09-25 国际壳牌研究有限公司 A process for the production of an olefin oxide, a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine
KR20110030472A (en) * 2008-05-22 2011-03-23 다우 글로벌 테크놀로지스 엘엘씨 Metallic platinum on silica support catalyst and process for preparing it
EP2352585B1 (en) * 2008-10-06 2020-06-17 Union Carbide Corporation Low metal loaded, alumina supported, catalyst compositions and amination process
EP2344445B1 (en) 2008-10-06 2017-05-10 Union Carbide Chemicals & Plastics Technology LLC A process to selectively manufacture diethylenetriamine (deta) or other desirable ethylenamines via continuous transamination of ethylenediamine (eda), and other ethyleneamines over a heterogeneous catalyst system
WO2010042168A2 (en) 2008-10-06 2010-04-15 Dow Global Technologies Inc. Methods for making ethanolamine(s) and ethyleneamine(s) from ethylene oxide and ammonia, and related methods
JP2012504610A (en) * 2008-10-06 2012-02-23 ユニオン カーバイド ケミカルズ アンド プラスティックス テクノロジー エルエルシー Method for producing ethyleneamine
BRPI0914009A2 (en) * 2008-10-06 2015-07-28 Union Carbide Chem Plastic Method to repair a cyclic triamine
CN102227258B (en) * 2008-10-06 2014-02-19 联合碳化化学品及塑料技术公司 Low metal (nickel and rhenium) catalyst compositions including acidic mixed metal oxide as carrier
JP5806116B2 (en) * 2008-10-06 2015-11-10 ユニオン カーバイド ケミカルズ アンド プラスティックス テクノロジー エルエルシー Transalkoxylation of nucleophilic compounds
US20100292076A1 (en) * 2009-05-18 2010-11-18 Sud-Chemie Inc. Ultra high temperature shift catalyst with low methanation
CN101875014B (en) * 2009-11-17 2012-10-03 中国科学院大连化学物理研究所 Catalyst for use in conversion of monoethanolamine and ammonia into ethylenediamine in hydrogen atmosphere
CN102639231B (en) * 2009-12-03 2014-12-10 巴斯夫欧洲公司 Catalyst and method for producing an amine
CN102781571B (en) 2009-12-03 2015-06-17 巴斯夫欧洲公司 Catalyst and method for producing an amine
US8772548B2 (en) 2009-12-17 2014-07-08 Basf Se Reaction of glycolaldehyde with an aminating agent
CN103261174B (en) 2010-11-10 2016-04-20 陶氏环球技术有限责任公司 Nitrogenous compound turns amino and manufactures ring-type and ring-type/acyclic polyamine mixture
BR112013011669A2 (en) 2010-11-10 2019-09-24 Dow Global Technologies Llc method for making a mixture of products containing linear high molecular weight polyamine, method for making a mixture of high molecular weight polyamine congeners and method for making a mixture of high molecular weight acyclic polyamines
BR112014015064A2 (en) * 2011-12-22 2017-06-13 Dow Global Technologies Llc method for preparing composition containing piperazine and aminoethylethanolamine
WO2013102097A2 (en) 2011-12-29 2013-07-04 Dow Global Technologies Llc Cyclic amine compounds, compositions, and polyurethane foams made therefrom
US9162995B2 (en) 2011-12-29 2015-10-20 Dow Global Technologies Llc Formation of higher molecular weight cyclic polyamine compounds from cyclic polyamine compounds
WO2013102053A1 (en) 2011-12-29 2013-07-04 Dow Global Technologies Llc Amine polyether polyols and polyurethane foam compositions made from cyclic amine compounds
US10399064B2 (en) * 2012-03-27 2019-09-03 Dow Global Technologies Llc Rhenium recovery from used reductive amination catalysts
WO2014150384A1 (en) 2013-03-15 2014-09-25 Segetis, Inc. Method of manufacture of octanedioic acid, precursors, and derivatives
EP3077444B1 (en) 2013-12-02 2018-04-25 Dow Global Technologies LLC Preparation of high molecular weight, branched, acyclic polyalkyleneamines and mixtures thereof
CN103819344B (en) * 2013-12-18 2016-04-27 西安近代化学研究所 A kind of synthetic method of 1,2-propylene diamine
US20180148535A1 (en) 2015-06-19 2018-05-31 Dow Global Technologies Llc Autocatalytic polyol useful for polyurethane foam manufacture
JP7094894B2 (en) 2016-06-03 2022-07-04 アイオワ・コーン・プロモーション・ボード A continuous process for the highly selective conversion of carbohydrates producing aldohexose to ethylene glycol
US10472310B2 (en) 2016-06-03 2019-11-12 Iowa Corn Promotion Board Continuous processes for the highly selective conversion of sugars to propylene glycol or mixtures of propylene glycol and ethylene glycol
CN109476807B (en) 2016-06-13 2021-08-10 陶氏环球技术有限责任公司 Autocatalytic polyols
CN106242978B (en) * 2016-07-28 2018-08-31 南京工业大学 Method for preparing antioxidant 6PPD by using micro-reaction device
CN110072838B (en) 2016-12-15 2022-04-15 阿克苏诺贝尔化学品国际有限公司 Process for preparing ethyleneamines
US10995058B2 (en) 2016-12-15 2021-05-04 Nouryon Chemicals International B.V. Process for manufacturing hydroxyethyl ethylene amines
GB201904612D0 (en) 2019-04-02 2019-05-15 Univ Leuven Kath Reaction of glycoladehyde
CN111196763B (en) * 2018-11-16 2021-06-01 中国科学院大连化学物理研究所 Catalyst for producing 3-aminopropanol by hydrogenating 3-hydroxypropionitrile and preparation method thereof
EP3908641A4 (en) 2019-01-11 2022-04-20 Archer Daniels Midland Company Processes and catalysts for the selective hydrogenation of compounds having carbonyl carbon atoms
CN110052276A (en) * 2019-04-01 2019-07-26 天津大学 It prepares bimetallic catalyst and is applied to the method that conversion lignin prepares aromatic compounds or liquid alkane fuel
CN113993837A (en) * 2019-06-11 2022-01-28 巴斯夫欧洲公司 Gas phase process for conversion of glycolaldehyde with aminating agent
WO2020249428A1 (en) 2019-06-11 2020-12-17 Basf Se Products obtained by the conversion of glycolaldehyde derivatives and aminating agents and their conversion to ethyleneamines and ethanolamines
WO2020249426A1 (en) 2019-06-11 2020-12-17 Basf Se Conversion of glycolaldehyde with an aminating agent
CN113713853B (en) * 2021-09-16 2024-03-22 中触媒新材料股份有限公司 Method for preparing aliphatic diamine from cyclic imine and catalyst used in method

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492314A (en) 1965-08-23 1970-01-27 Mitsubishi Petrochemical Co Process for catalytic hydrogenation of dicarboxylic acid anhydride and catalyst therefor
BE765482A (en) 1970-04-20 1971-08-30 Du Pont RHENIUM MODIFIED REFORMING CATALYST
US4123462A (en) 1976-01-07 1978-10-31 Union Carbide Corporation Amination process using nickel-rhenium catalysts
US4255357A (en) 1980-03-24 1981-03-10 Pennwalt Corporation Catalytic process for preparing ethyl amines
SE461095B (en) 1983-09-09 1990-01-08 Berol Kemi Ab AMINING PROCEDURE USING A RUTENIUM DOPPED NICKEL AND / OR COVOLT CATALYST
US4863890A (en) 1983-09-09 1989-09-05 Berol Kemi Ab Process for preparing a ruthenium-promoted, halogen-containing nickel and/or cobalt catalyst and a catalyst prepared by the process
US4665195A (en) 1983-12-23 1987-05-12 Exxon Research And Engineering Company Process for preparing di-amino-polyalkenyl ethers
US4625030A (en) 1984-05-23 1986-11-25 Union Carbide Corporation Potentiated nickel catalysts for amination
US4657880A (en) * 1985-03-18 1987-04-14 Corning Glass Works Preparation of high surface area agglomerates for catalyst support and preparation of monolithic support structures containing them
US4708945A (en) * 1985-12-31 1987-11-24 Exxon Research And Engineering Company Catalysts comprising silica supported on a boehmite-like surface, their preparation and use
GB8707304D0 (en) 1987-03-26 1987-04-29 Bp Chem Int Ltd Chemical process
US5202491A (en) 1987-09-30 1993-04-13 Union Carbide Chemicals & Plastics Technology Corporation Process for the manufacture of diethylenetriamine
US5196588A (en) * 1987-09-30 1993-03-23 Union Carbide Chemicals & Plastics Technology Corporation Ethylenediamine and diethylenetriamine producers composition and method for producing same
US4918234A (en) 1987-10-13 1990-04-17 Air Products And Chemicals, Inc. Shape selective catalysts for C2 to C4 alkanol amination
US4795733A (en) 1987-11-27 1989-01-03 Gaf Corporation Hydrogenation catalyst and process for its preparation
US5321160A (en) 1991-07-31 1994-06-14 Tosoh Corporation Process for producing an ethylenamine
DE69521289T2 (en) * 1993-12-22 2002-05-02 Union Carbide Chem Plastic Reductive amination for the selective production of aminoethylethanolamine
CA2146903C (en) * 1993-12-22 2000-01-25 Stephen Wayne King Reductive amination catalysts for the selective production of aminoethylethanolamine
US5600000A (en) 1993-12-22 1997-02-04 Union Carbide Chemicals & Plastics Technology Corporation Reductive amination processes for the selective production of amino-ethylethanolamine
DE4429547A1 (en) 1994-08-19 1996-02-22 Basf Ag Process for the production of amines
US5817593A (en) 1995-06-02 1998-10-06 The Dow Chemical Company Catalyst and process for producing amines
JPH11514401A (en) * 1995-10-04 1999-12-07 ザ ダウ ケミカル カンパニー Amine-terminated polyether and method for producing the same
US6117814A (en) * 1998-02-10 2000-09-12 Exxon Research And Engineering Co. Titania catalysts their preparation and use in fischer-tropsch synthesis

Also Published As

Publication number Publication date
US6534441B1 (en) 2003-03-18
WO2001066247A3 (en) 2002-04-11
WO2001066247A2 (en) 2001-09-13
JP2003525738A (en) 2003-09-02
DE60123845D1 (en) 2006-11-23
DE60123845T2 (en) 2007-05-16
CN1192822C (en) 2005-03-16
ATE342128T1 (en) 2006-11-15
WO2001066247A8 (en) 2003-04-10
EP1385625B1 (en) 2006-10-11
JP5290486B2 (en) 2013-09-18
EP1385625A2 (en) 2004-02-04
CN1441698A (en) 2003-09-10

Similar Documents

Publication Publication Date Title
AU2001250020A1 (en) A nickel-rhenium catalyst for use in reductive amination processes
CA2401048A1 (en) 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
DK0472918T3 (en) Carrier catalysts and a process for their preparation
TWI256891B (en) 17alpha-alkyl-17beta-oxy-estratrienes and intermediate products for their production, use of the 17alpha-alkyl-17beta-oxy-estratrienes for the production of pharmaceutical agents as well as pharmaceutical preparations
MX9801912A (en) HYDROGENATION OF AROMATIC COMPOUNDS IN WHICH AT LEAST ONE AMINO GROUP IS JOINED TO AN AROMATIC NUCLEUS.
CA2165207A1 (en) Low Pressure Process for the Hydrogenation of Dimethyl Benzenedicarboxylates to the Corresponding Dimethyl Cyclohexanedicarboxylates
AU8898001A (en) Novel prkag3 alleles and use of the same as genetic markers for reproductive andmeat quality traits
DK0775018T4 (en) Process for the preparation of cobalt catalysts on alumina
MXPA04005306A (en) Substituted benzoxazoles and analogues as estrogenic agents.
MXPA02012628A (en) Process for the preparation of substituted octanoyl amides.
YU7804A (en) Stable polymorph of flibanserin, technical process for its preparation and the use thereof for preparing medicaments
DE50000478D1 (en) Fixed bed catalysts
DE69926482D1 (en) Adjustable cushioning of the whole seat
MXPA04005784A (en) Substituted 2-phenyl benzofurans as estrogenic agents.
IL158324A0 (en) Arylsulphonamides as anttiviral agents
YU30203A (en) Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
CA2344875A1 (en) Lithium aluminate as the catalyst support for hydrogenation of aromatic amines
MXPA02000907A (en) Hydrogenation catalysts.
BG104243A (en) Method for the synthesis of quinoline derivatives
AU5100201A (en) Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods ofuse thereof
ZA200005110B (en) Process for preparing intermediates.
EP0618188A3 (en) Process for the preparation of cyclohexylamines by catalytic hydrogenation of anilines.
AU4938400A (en) Aluminium alloy sheet
NZ236329A (en) Process for the preparation of synergistin derivatives
MXPA01004626A (en) Enzymatic resolution of selective estrogen receptor modulators.