AU2001247522A1 - Chimeric nontoxic mutants of enterotoxins as mucosal adjuvants for cell-mediatedor humoral immunity - Google Patents

Chimeric nontoxic mutants of enterotoxins as mucosal adjuvants for cell-mediatedor humoral immunity

Info

Publication number
AU2001247522A1
AU2001247522A1 AU2001247522A AU4752201A AU2001247522A1 AU 2001247522 A1 AU2001247522 A1 AU 2001247522A1 AU 2001247522 A AU2001247522 A AU 2001247522A AU 4752201 A AU4752201 A AU 4752201A AU 2001247522 A1 AU2001247522 A1 AU 2001247522A1
Authority
AU
Australia
Prior art keywords
mediatedor
enterotoxins
chimeric
cell
humoral immunity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001247522A
Inventor
Hiroshi Kiyono
Jerry Mcghee
Mari Ohmura
Yoshifumi Takeda
Shingo Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAB Research Foundation
Original Assignee
UAB Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UAB Research Foundation filed Critical UAB Research Foundation
Publication of AU2001247522A1 publication Critical patent/AU2001247522A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/29—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Richettsiales (O)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
AU2001247522A 2000-03-17 2001-03-16 Chimeric nontoxic mutants of enterotoxins as mucosal adjuvants for cell-mediatedor humoral immunity Abandoned AU2001247522A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19005800P 2000-03-17 2000-03-17
US60190058 2000-03-17
PCT/US2001/008582 WO2001070257A1 (en) 2000-03-17 2001-03-16 Chimeric nontoxic mutants of enterotoxins as mucosal adjuvants for cell-mediated or humoral immunity

Publications (1)

Publication Number Publication Date
AU2001247522A1 true AU2001247522A1 (en) 2001-10-03

Family

ID=22699856

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001247522A Abandoned AU2001247522A1 (en) 2000-03-17 2001-03-16 Chimeric nontoxic mutants of enterotoxins as mucosal adjuvants for cell-mediatedor humoral immunity

Country Status (4)

Country Link
US (1) US20020142006A1 (en)
EP (1) EP1272210A1 (en)
AU (1) AU2001247522A1 (en)
WO (1) WO2001070257A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009011707A1 (en) * 2007-07-18 2009-01-22 Development Center For Biotechnology Mutated e. coli heat-labile enterotoxin
US8110197B2 (en) 2006-10-27 2012-02-07 Development Center For Biotechnology Mutated E. coli heat-labile enterotoxin
TWI304838B (en) 2006-10-27 2009-01-01 Dev Center Biotechnology Nucleotide acid sequence and amino acid sequence of e. coli heat-labile enterotoxin, and recombinant protein
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
IT1253009B (en) * 1991-12-31 1995-07-10 Sclavo Ricerca S R L DETOXIFIED IMMUNOGENIC MUTANTS OF COLERIC TOXIN AND TOXIN LT, THEIR PREPARATION AND USE FOR THE PREPARATION OF VACCINES

Also Published As

Publication number Publication date
US20020142006A1 (en) 2002-10-03
WO2001070257A1 (en) 2001-09-27
EP1272210A1 (en) 2003-01-08

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