AU2001247467A1 - Peptides targeting specifically tumor-derived endothelial cells - Google Patents

Peptides targeting specifically tumor-derived endothelial cells

Info

Publication number
AU2001247467A1
AU2001247467A1 AU2001247467A AU4746701A AU2001247467A1 AU 2001247467 A1 AU2001247467 A1 AU 2001247467A1 AU 2001247467 A AU2001247467 A AU 2001247467A AU 4746701 A AU4746701 A AU 4746701A AU 2001247467 A1 AU2001247467 A1 AU 2001247467A1
Authority
AU
Australia
Prior art keywords
endothelial cells
derived endothelial
peptides targeting
targeting specifically
specifically tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001247467A
Inventor
Charles Komen Brown
Candace S. Johnson
Ruth A. Modzelewski
Donald L. Trump
Michael K. Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of AU2001247467A1 publication Critical patent/AU2001247467A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU2001247467A 2000-03-16 2001-03-16 Peptides targeting specifically tumor-derived endothelial cells Abandoned AU2001247467A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18979300P 2000-03-16 2000-03-16
US60/189,793 2000-03-16
PCT/US2001/008385 WO2001068679A2 (en) 2000-03-16 2001-03-16 Peptides targeting specifically tumor-derived endothelial cells

Publications (1)

Publication Number Publication Date
AU2001247467A1 true AU2001247467A1 (en) 2001-09-24

Family

ID=22698796

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001247467A Abandoned AU2001247467A1 (en) 2000-03-16 2001-03-16 Peptides targeting specifically tumor-derived endothelial cells

Country Status (6)

Country Link
US (1) US6974791B2 (en)
EP (1) EP1263776A2 (en)
JP (1) JP2003527398A (en)
AU (1) AU2001247467A1 (en)
CA (1) CA2402327A1 (en)
WO (1) WO2001068679A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598341B2 (en) * 2003-10-31 2009-10-06 Burnham Institue For Medical Research Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs
ATE467641T1 (en) * 2004-03-26 2010-05-15 Molecular Templates Inc LIBRARY OF TOXIN MUTANTS AND THEIR USE
US7101966B2 (en) * 2004-09-21 2006-09-05 Vista Biologicals Corporation Selection of peptide ligands specific for baculovirus DNA-binding protein from the FliTrx™ random peptide display library
WO2006049498A1 (en) * 2004-11-05 2006-05-11 Modiquest B.V. Means and methods for isolating and/or identifying a target molecule
EP2402367A1 (en) * 2005-09-26 2012-01-04 Molecular Templates, Inc. Library from toxin mutants, and methods of using same
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
US7531505B2 (en) 2006-01-11 2009-05-12 Affinergy, Inc. Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices
CN101597323B (en) * 2008-06-05 2012-05-30 北京大学第一医院 Radioactive isotope labeling polypeptide for tumor imaging
WO2011143111A1 (en) * 2010-05-10 2011-11-17 Medical College Of Georgia Research Institute, Inc. Endothelial nitric oxide synthase antagonists and uses thereof for inhibiting oxygen toxicity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL91933A (en) * 1988-10-11 1994-12-29 Univ Southern California Vasoactive immunoconjugates useful for increasing the vascular permeability or the blood supply to neoplastic or otherwise diseased tissues
US6022541A (en) * 1991-10-18 2000-02-08 Beth Israel Deaconess Medical Center Immunological preparation for concurrent specific binding to spatially exposed regions of vascular permeability factor bound in-vivo to a tumor associated blood vessel
DK0627940T3 (en) * 1992-03-05 2003-09-01 Univ Texas Use of immunoconjugates for diagnosis and / or therapy of vascularized tumors
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US6350450B1 (en) * 1997-09-19 2002-02-26 Genentech, Inc. TIE ligand homologue antibody
US6348350B1 (en) * 1997-09-19 2002-02-19 Genentech, Inc. Ligand homologues
GB9815505D0 (en) * 1998-07-16 1998-09-16 Adprotech Plc Polypeptide derivatives
DE69941877D1 (en) * 1998-10-16 2010-02-11 Otsuka Pharma Co Ltd NEOVASCULAR-SPECIFIC PEPTIDES
IL151389A0 (en) * 2000-02-25 2003-04-10 Crucell Holland Bv Activated vitronectin as a marker of angiogenesis detected with phage antibodies

Also Published As

Publication number Publication date
JP2003527398A (en) 2003-09-16
EP1263776A2 (en) 2002-12-11
WO2001068679A9 (en) 2002-12-19
WO2001068679A2 (en) 2001-09-20
WO2001068679A3 (en) 2002-05-30
US6974791B2 (en) 2005-12-13
US20020058615A1 (en) 2002-05-16
CA2402327A1 (en) 2001-09-20

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