AU2001247243A1 - Improved mobility spectrometer - Google Patents
Improved mobility spectrometerInfo
- Publication number
- AU2001247243A1 AU2001247243A1 AU2001247243A AU4724301A AU2001247243A1 AU 2001247243 A1 AU2001247243 A1 AU 2001247243A1 AU 2001247243 A AU2001247243 A AU 2001247243A AU 4724301 A AU4724301 A AU 4724301A AU 2001247243 A1 AU2001247243 A1 AU 2001247243A1
- Authority
- AU
- Australia
- Prior art keywords
- mobility spectrometer
- improved mobility
- improved
- spectrometer
- mobility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/623—Ion mobility spectrometry combined with mass spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
- H01J49/401—Time-of-flight spectrometers characterised by orthogonal acceleration, e.g. focusing or selecting the ions, pusher electrode
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18578100P | 2000-02-29 | 2000-02-29 | |
US60185781 | 2000-02-29 | ||
US19365900P | 2000-03-31 | 2000-03-31 | |
US60193659 | 2000-03-31 | ||
PCT/US2001/006405 WO2001064320A1 (en) | 2000-02-29 | 2001-02-28 | Improved mobility spectrometer |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001247243A1 true AU2001247243A1 (en) | 2001-09-12 |
Family
ID=26881466
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001247243A Abandoned AU2001247243A1 (en) | 2000-02-29 | 2001-02-28 | Improved mobility spectrometer |
AU2001243328A Abandoned AU2001243328A1 (en) | 2000-02-29 | 2001-02-28 | A periodic field focusing ion mobility spectrometer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001243328A Abandoned AU2001243328A1 (en) | 2000-02-29 | 2001-02-28 | A periodic field focusing ion mobility spectrometer |
Country Status (5)
Country | Link |
---|---|
US (2) | US6639213B2 (en) |
EP (1) | EP1268041B1 (en) |
AU (2) | AU2001247243A1 (en) |
CA (1) | CA2401610C (en) |
WO (2) | WO2001065589A1 (en) |
Families Citing this family (84)
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---|---|---|---|---|
US6504149B2 (en) | 1998-08-05 | 2003-01-07 | National Research Council Canada | Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer |
AU2001247243A1 (en) * | 2000-02-29 | 2001-09-12 | Ionwerks, Inc. | Improved mobility spectrometer |
US7164122B2 (en) * | 2000-02-29 | 2007-01-16 | Ionwerks, Inc. | Ion mobility spectrometer |
US6803565B2 (en) * | 2001-05-18 | 2004-10-12 | Battelle Memorial Institute | Ionization source utilizing a multi-capillary inlet and method of operation |
US7084395B2 (en) | 2001-05-25 | 2006-08-01 | Ionwerks, Inc. | Time-of-flight mass spectrometer for monitoring of fast processes |
US7586088B2 (en) | 2001-06-21 | 2009-09-08 | Micromass Uk Limited | Mass spectrometer and method of mass spectrometry |
GB2392305B (en) * | 2001-06-21 | 2004-04-14 | Micromass Ltd | Mass spectrometer |
US7635841B2 (en) * | 2001-12-12 | 2009-12-22 | Micromass Uk Limited | Method of mass spectrometry |
US6727495B2 (en) | 2002-01-17 | 2004-04-27 | Agilent Technologies, Inc. | Ion mobility spectrometer with high ion transmission efficiency |
US6924479B2 (en) * | 2002-01-25 | 2005-08-02 | William C. Blanchard | Ion detecting apparatus and methods |
US6831274B2 (en) * | 2002-03-05 | 2004-12-14 | Battelle Memorial Institute | Method and apparatus for multispray emitter for mass spectrometry |
US6867419B2 (en) * | 2002-03-29 | 2005-03-15 | The Regents Of The University Of California | Laser driven compact ion accelerator |
US6797943B2 (en) * | 2002-05-07 | 2004-09-28 | Siemens Ag | Method and apparatus for ion mobility spectrometry |
US6906319B2 (en) * | 2002-05-17 | 2005-06-14 | Micromass Uk Limited | Mass spectrometer |
US6791078B2 (en) | 2002-06-27 | 2004-09-14 | Micromass Uk Limited | Mass spectrometer |
US7071467B2 (en) | 2002-08-05 | 2006-07-04 | Micromass Uk Limited | Mass spectrometer |
US7378651B2 (en) * | 2002-09-25 | 2008-05-27 | Thermo Finnigan Llc | High field asymmetric waveform ion mobility spectrometer FAIMS |
US7358504B2 (en) * | 2002-09-25 | 2008-04-15 | Thermo Finnigan Llc | FAIMS apparatus and method for separating ions |
AU2003249796A1 (en) * | 2002-09-25 | 2004-04-19 | Ionalytics Corporation | Faims apparatus and method for separating ions |
US6818887B2 (en) * | 2002-11-25 | 2004-11-16 | DRäGERWERK AKTIENGESELLSCHAFT | Reflector for a time-of-flight mass spectrometer |
CA2527701A1 (en) * | 2003-06-06 | 2005-01-06 | J. Albert Schultz | Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues |
WO2004109255A2 (en) * | 2003-06-06 | 2004-12-16 | Ionwerks | Rapid screening of biogenic particles in collected aerosols |
WO2004109254A2 (en) | 2003-06-06 | 2004-12-16 | Ionwerks | Fullerene-based maldi matrices for peptides and proteins |
US6914243B2 (en) * | 2003-06-07 | 2005-07-05 | Edward W. Sheehan | Ion enrichment aperture arrays |
US7071465B2 (en) | 2003-10-14 | 2006-07-04 | Washington State University Research Foundation | Ion mobility spectrometry method and apparatus |
US6992284B2 (en) * | 2003-10-20 | 2006-01-31 | Ionwerks, Inc. | Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions |
CA2547389A1 (en) * | 2003-11-25 | 2005-06-09 | Sionex Corporation | Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample |
CA2552005A1 (en) * | 2003-12-31 | 2005-07-21 | Ionwerks, Inc. | Maldi-im-ortho-tof mass spectrometry with simultaneaous positive and negative mode detection |
US20100090101A1 (en) * | 2004-06-04 | 2010-04-15 | Ionwerks, Inc. | Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues |
US20070187591A1 (en) * | 2004-06-10 | 2007-08-16 | Leslie Bromberg | Plasma ion mobility spectrometer |
JP2006032109A (en) * | 2004-07-15 | 2006-02-02 | Jeol Ltd | Orthogonal acceleration time-of-flight mass spectroscope |
KR20070052774A (en) | 2004-08-02 | 2007-05-22 | 올스톤 리미티드 | Ion mobility spectrometer |
DE102004045315A1 (en) * | 2004-09-17 | 2006-03-30 | Gesellschaft zur Förderung angewandter Optik, Optoelektronik, Quantenelektronik und Spektroskopie e.V. | Time of Flight Mass Spectrometer |
DE102004048496B4 (en) * | 2004-10-05 | 2008-04-30 | Bruker Daltonik Gmbh | Ion guide with RF diaphragm stacks |
GB0424426D0 (en) | 2004-11-04 | 2004-12-08 | Micromass Ltd | Mass spectrometer |
GB2458602B (en) * | 2005-02-03 | 2009-11-18 | Bruker Daltonik Gmbh | Transport of ions into a vacuum |
EP1894224A4 (en) * | 2005-05-27 | 2011-08-03 | Ionwerks Inc | Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection |
WO2006130475A2 (en) * | 2005-05-27 | 2006-12-07 | Ionwerks, Inc. | Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording |
GB0808344D0 (en) | 2008-05-08 | 2008-06-18 | Owlstone Ltd | Sensor |
US20070125943A1 (en) * | 2005-12-07 | 2007-06-07 | Hagerman James G | Horn mass spectrometer having blade deflectors |
US7863558B2 (en) * | 2006-02-08 | 2011-01-04 | Dh Technologies Development Pte. Ltd. | Radio frequency ion guide |
US10073056B2 (en) * | 2006-02-14 | 2018-09-11 | Excellims Corporation | Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection |
US8785848B2 (en) * | 2007-07-11 | 2014-07-22 | Excellims Corporation | Parallel ion mass and ion mobility analysis |
WO2007095203A2 (en) * | 2006-02-14 | 2007-08-23 | Excellims Corporation | Ion mobility spectrometer apparatus and methods |
US10309929B2 (en) * | 2006-02-14 | 2019-06-04 | Excellims Corporation | Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection |
DE102006006683B4 (en) * | 2006-02-14 | 2008-02-21 | Bruker Daltonik Gmbh | Drift tube for ion mobility spectrometer with integrated gas channel |
CA2656565A1 (en) * | 2006-06-29 | 2008-08-07 | Ionwerks, Inc. | Neutral/ion reactor in adiabatic supersonic gas flow for ion mobility time-of-flight mass spectrometry |
US10794862B2 (en) * | 2006-11-28 | 2020-10-06 | Excellims Corp. | Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection |
WO2009054913A1 (en) * | 2007-10-19 | 2009-04-30 | The Charles Stark Draper Laboratory, Inc. | Rapid detection of volatile organic compounds for identification of bacteria in a sample |
US7880137B2 (en) * | 2007-12-28 | 2011-02-01 | Morpho Detection, Inc. | Electrode design for an ion spectrometer |
CN101471222B (en) * | 2007-12-29 | 2010-11-24 | 同方威视技术股份有限公司 | Migration tube structure used for ion mobility spectrometer |
CN101603943B (en) * | 2008-06-12 | 2012-11-21 | 同方威视技术股份有限公司 | Electrode structure for migration tube in mobility spectrum instrument |
US10566169B1 (en) * | 2008-06-30 | 2020-02-18 | Nexgen Semi Holding, Inc. | Method and device for spatial charged particle bunching |
WO2010042303A1 (en) * | 2008-10-06 | 2010-04-15 | Shimadzu Corporation | Curtain gas filter for mass- and mobility-analyzers that excludes ion-source gases and ions of high mobility |
US7838823B1 (en) * | 2008-12-16 | 2010-11-23 | Sandia Corporation | Ion mobility spectrometer with virtual aperture grid |
WO2010126856A1 (en) * | 2009-04-27 | 2010-11-04 | The Charles Stark Draper Laboratory, Inc. | Rapid detection of volatile organic compounds for identification of mycobacterium tuberculosis in a sample |
US8138472B2 (en) * | 2009-04-29 | 2012-03-20 | Academia Sinica | Molecular ion accelerator |
CN101937823B (en) * | 2009-06-30 | 2012-05-23 | 同方威视技术股份有限公司 | Ion collecting device of ion mobility spectrometer and ion mobility spectrometer |
CN102522308B (en) * | 2009-06-30 | 2014-07-30 | 同方威视技术股份有限公司 | Ion mobility spectrometer and ion collection device thereof |
CN102522309B (en) * | 2009-06-30 | 2014-11-19 | 同方威视技术股份有限公司 | Ion collection device of ion mobility spectrometer and ion mobility spectrometer |
GB201021360D0 (en) | 2010-12-16 | 2011-01-26 | Thermo Fisher Scient Bremen Gmbh | Apparatus and methods for ion mobility spectrometry |
CN103165394B (en) * | 2011-12-16 | 2015-12-02 | 同方威视技术股份有限公司 | The electrode structure of transference tube and comprise the transference tube of this structure |
GB2509412B (en) | 2012-02-21 | 2016-06-01 | Thermo Fisher Scient (Bremen) Gmbh | Apparatus and methods for ion mobility spectrometry |
GB201205009D0 (en) * | 2012-03-22 | 2012-05-09 | Micromass Ltd | Multi-dimensional survey scans for improved data dependent acquisitions (DDA) |
DE112013003813T5 (en) * | 2012-07-31 | 2015-05-13 | Leco Corporation | Ion mobility spectrometer with high throughput |
US9459194B2 (en) | 2013-03-14 | 2016-10-04 | Cardio Metrix | Apparatuses, processes, and systems for measuring particle size distribution and concentration |
US20140262971A1 (en) * | 2013-03-18 | 2014-09-18 | Micropen Technologies Corporation | Tubular structure component with patterned resistive film on interior surface and systems and methods |
EP3005403B1 (en) * | 2013-05-30 | 2022-04-06 | PerkinElmer Health Sciences, Inc. | Reflectron |
US9281173B2 (en) | 2013-05-30 | 2016-03-08 | Agilent Technologies, Inc. | Ion processing utilizing segmented vacuum manifold |
US10338028B2 (en) * | 2013-07-19 | 2019-07-02 | Hitachi, Ltd. | Ion mobility separation device |
CN105981483B (en) * | 2014-01-02 | 2019-06-28 | Dh科技发展私人贸易有限公司 | Ring stacks homogenizing for the impulse electric field generated in ion accelerator |
WO2015179709A1 (en) | 2014-05-22 | 2015-11-26 | Benner W Henry | Instruments for measuring ion size distribution and concentration |
US9704700B2 (en) * | 2014-06-16 | 2017-07-11 | Purdue Research Foundation | Sample analysis systems and methods of use thereof |
US9564305B2 (en) * | 2014-07-29 | 2017-02-07 | Smiths Detection Inc. | Ion funnel for efficient transmission of low mass-to-charge ratio ions with reduced gas flow at the exit |
CN104576286A (en) * | 2014-12-31 | 2015-04-29 | 同方威视技术股份有限公司 | Electrode rings for ion migration spectrometer, iron migration tube and iron migration spectrometer |
GB201519830D0 (en) * | 2015-11-10 | 2015-12-23 | Micromass Ltd | A method of transmitting ions through an aperture |
CN106971935A (en) | 2016-01-13 | 2017-07-21 | 株式会社岛津制作所 | Ion mobility spectrometry apparatus and method |
US10060879B2 (en) | 2016-04-28 | 2018-08-28 | Bruker Daltonics, Inc. | Ion storage for a mobility separator of a mass spectrometric system |
US10049868B2 (en) * | 2016-12-06 | 2018-08-14 | Rapiscan Systems, Inc. | Apparatus for detecting constituents in a sample and method of using the same |
CN109243960B (en) | 2017-07-10 | 2020-11-17 | 株式会社岛津制作所 | Proton transfer reaction mass spectrometer |
WO2019222274A1 (en) * | 2018-05-14 | 2019-11-21 | MOBILion Systems, Inc. | Coupling of ion mobility spectrometer with mass spectrometer |
EP3924997A4 (en) * | 2019-02-15 | 2022-11-09 | Ohio State Innovation Foundation | Surface-induced dissociation devices and methods |
US11480544B2 (en) | 2020-02-05 | 2022-10-25 | Battelle Memorial Institute | Atmospheric pressure ion focusing device employing nonlinear DC voltage sequences |
EP4089408A1 (en) | 2021-05-14 | 2022-11-16 | Thermo Finnigan LLC | Flow recirculation for mobility separation improvement |
Family Cites Families (34)
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DE1498870A1 (en) * | 1962-02-22 | 1969-03-27 | Max Planck Gesellschaft | Reflection mass spectrometer |
US3935452A (en) * | 1973-11-14 | 1976-01-27 | Barringer Research Limited | Quadrupole mobility spectrometer |
DE2654057B1 (en) * | 1976-11-29 | 1978-04-27 | Varian Mat Gmbh | Process for the ionization of organic substances, as well as analyzer using this process |
US4390784A (en) | 1979-10-01 | 1983-06-28 | The Bendix Corporation | One piece ion accelerator for ion mobility detector cells |
US4855595A (en) | 1986-07-03 | 1989-08-08 | Allied-Signal Inc. | Electric field control in ion mobility spectrometry |
US5095208A (en) * | 1988-06-24 | 1992-03-10 | Hitachi, Ltd. | Charged particle generating device and focusing lens therefor |
US5037611A (en) | 1988-11-29 | 1991-08-06 | Icr Research Associates, Inc. | Sample handling technique |
US5118937A (en) * | 1989-08-22 | 1992-06-02 | Finnigan Mat Gmbh | Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules |
US5109157A (en) * | 1991-03-21 | 1992-04-28 | Loen Andrew E | Ion mobility detector |
IL97742A0 (en) | 1991-04-01 | 1992-06-21 | Israel Atomic Energy Comm | Spectrometer |
US5189301A (en) | 1991-08-20 | 1993-02-23 | Cpad Holdings, Ltd. | Simple compact ion mobility spectrometer having a focusing electrode which defines a non-uniform field for the drift region |
DE4130810C1 (en) * | 1991-09-17 | 1992-12-03 | Bruker Saxonia Analytik Gmbh, O-7050 Leipzig, De | |
US5200614A (en) * | 1992-01-16 | 1993-04-06 | Ion Track Instruments, Inc. | Ion mobility spectrometers |
ES2331494T3 (en) * | 1994-02-28 | 2010-01-05 | Perkinelmer Health Sciences, Inc. | MULTIPOLAR ION GUIDE FOR MASS SPECTROMETRY. |
KR0156602B1 (en) * | 1994-07-08 | 1998-12-01 | 황해웅 | Ion mobility analyzer |
DE19515271C2 (en) | 1995-04-26 | 1999-09-02 | Bruker Daltonik Gmbh | Device for the gas-guided transport of ions through a capillary tube |
EP0843887A1 (en) * | 1995-08-11 | 1998-05-27 | Mds Health Group Limited | Spectrometer with axial field |
US5654545A (en) | 1995-09-19 | 1997-08-05 | Bruker-Franzen Analytik Gmbh | Mass resolution in time-of-flight mass spectrometers with reflectors |
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WO1997049111A1 (en) | 1996-06-17 | 1997-12-24 | Battelle Memorial Institute | Method and apparatus for ion and charged particle focusing |
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US6040573A (en) | 1997-09-25 | 2000-03-21 | Indiana University Advanced Research & Technology Institute Inc. | Electric field generation for charged particle analyzers |
US5789745A (en) | 1997-10-28 | 1998-08-04 | Sandia Corporation | Ion mobility spectrometer using frequency-domain separation |
US6331702B1 (en) * | 1999-01-25 | 2001-12-18 | University Of Manitoba | Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use |
US6040575A (en) | 1998-01-23 | 2000-03-21 | Analytica Of Branford, Inc. | Mass spectrometry from surfaces |
US6348688B1 (en) * | 1998-02-06 | 2002-02-19 | Perseptive Biosystems | Tandem time-of-flight mass spectrometer with delayed extraction and method for use |
CA2275140C (en) * | 1998-06-18 | 2008-04-29 | Micromass Limited | Multi-inlet mass spectrometer |
AU5144399A (en) | 1998-08-05 | 2000-02-28 | National Research Council Of Canada | Apparatus and method for atmospheric pressure 3-dimensional ion trapping |
CA2255122C (en) * | 1998-12-04 | 2007-10-09 | Mds Inc. | Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer |
US6512224B1 (en) * | 1999-07-21 | 2003-01-28 | The Charles Stark Draper Laboratory, Inc. | Longitudinal field driven field asymmetric ion mobility filter and detection system |
AU2001247243A1 (en) * | 2000-02-29 | 2001-09-12 | Ionwerks, Inc. | Improved mobility spectrometer |
CA2364676C (en) * | 2000-12-08 | 2010-07-27 | Mds Inc., Doing Business As Mds Sciex | Ion mobility spectrometer incorporating an ion guide in combination with an ms device |
-
2001
- 2001-02-28 AU AU2001247243A patent/AU2001247243A1/en not_active Abandoned
- 2001-02-28 WO PCT/US2001/006398 patent/WO2001065589A1/en active Application Filing
- 2001-02-28 CA CA002401610A patent/CA2401610C/en not_active Expired - Fee Related
- 2001-02-28 US US09/798,032 patent/US6639213B2/en not_active Expired - Fee Related
- 2001-02-28 EP EP01920160A patent/EP1268041B1/en not_active Expired - Lifetime
- 2001-02-28 WO PCT/US2001/006405 patent/WO2001064320A1/en active Application Filing
- 2001-02-28 US US09/798,030 patent/US6897437B2/en not_active Expired - Lifetime
- 2001-02-28 AU AU2001243328A patent/AU2001243328A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6897437B2 (en) | 2005-05-24 |
US20010032929A1 (en) | 2001-10-25 |
US20010032930A1 (en) | 2001-10-25 |
WO2001064320A1 (en) | 2001-09-07 |
CA2401610A1 (en) | 2001-09-07 |
US6639213B2 (en) | 2003-10-28 |
WO2001065589A1 (en) | 2001-09-07 |
EP1268041A4 (en) | 2008-02-06 |
EP1268041B1 (en) | 2012-09-05 |
AU2001243328A1 (en) | 2001-09-12 |
EP1268041A1 (en) | 2003-01-02 |
CA2401610C (en) | 2009-10-06 |
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