AU2001244675A1 - Aids virus vaccine with the use of sendai virus vector - Google Patents

Aids virus vaccine with the use of sendai virus vector

Info

Publication number
AU2001244675A1
AU2001244675A1 AU2001244675A AU4467501A AU2001244675A1 AU 2001244675 A1 AU2001244675 A1 AU 2001244675A1 AU 2001244675 A AU2001244675 A AU 2001244675A AU 4467501 A AU4467501 A AU 4467501A AU 2001244675 A1 AU2001244675 A1 AU 2001244675A1
Authority
AU
Australia
Prior art keywords
aids
sendai
vaccine
virus
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001244675A
Inventor
Mamoru Hasegawa
Munehide Kano
Atsushi Kato
Tetsuro Matano
Yoshiyuki Nagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dnavec Research Inc
National Institute of Infectious Diseases
Original Assignee
Agency of Industrial Science and Technology
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency of Industrial Science and Technology, Dnavec Research Inc filed Critical Agency of Industrial Science and Technology
Publication of AU2001244675A1 publication Critical patent/AU2001244675A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18871—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2001244675A 2000-03-30 2001-03-30 Aids virus vaccine with the use of sendai virus vector Abandoned AU2001244675A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19312700P 2000-03-30 2000-03-30
US60193127 2000-03-30
PCT/JP2001/002769 WO2001072340A1 (en) 2000-03-30 2001-03-30 Aids virus vaccine with the use of sendai virus vector

Publications (1)

Publication Number Publication Date
AU2001244675A1 true AU2001244675A1 (en) 2001-10-08

Family

ID=22712366

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001244675A Abandoned AU2001244675A1 (en) 2000-03-30 2001-03-30 Aids virus vaccine with the use of sendai virus vector

Country Status (8)

Country Link
US (2) US20020002143A1 (en)
EP (1) EP1270016A4 (en)
JP (2) JPWO2001072340A1 (en)
KR (2) KR100854917B1 (en)
CN (1) CN1248740C (en)
AU (1) AU2001244675A1 (en)
HK (1) HK1046243B (en)
WO (1) WO2001072340A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE470704T1 (en) * 1995-11-01 2010-06-15 Dnavec Research Inc RECOMBINANT SENDAI VIRUS
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
JP3748535B2 (en) * 1999-09-06 2006-02-22 株式会社ディナベック研究所 Paramyxovirus with altered transcription initiation sequence
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
EP1251174A4 (en) * 2000-01-19 2003-05-02 Dnavec Research Inc Use of paramyxovirus vector in gene transfer into blood vessel
ES2430991T3 (en) * 2000-06-01 2013-11-22 Dnavec Research Inc. Pseudotype retroviral vector containing membrane protein that has hemagglutinin activity
EP1297852A4 (en) * 2000-06-27 2004-12-29 Dnavec Research Inc Virus vector for introducing gene into renal cells
CA2424992A1 (en) * 2000-10-06 2003-04-04 Dnavec Research Inc. Paramyxovirus vectors for introducing foreign genes into skeletal muscle
JP2002142770A (en) * 2000-11-08 2002-05-21 Dnavec Research Inc Paramyxovirus vector for transporting gene to circulatory system
CN100358581C (en) * 2002-04-30 2008-01-02 株式会社载体研究所 Drug- or gene-carrier composition having lowered hemagglutinin activity
AU2003261931A1 (en) * 2002-09-04 2004-03-29 Dnavec Research Inc. Process for producing virus vector containing membrane protein having sialic acid-binding activitiy in envelope with the use of gram-positive bacterium-origin neuraminidase
CN1732267A (en) * 2002-10-24 2006-02-08 株式会社载体研究所 Method of transferring gene into t cells
CA2530627A1 (en) * 2003-06-30 2005-01-06 Dnavec Research Inc. Minus strand rna viral vectors carrying a gene with altered hypermutable regions
EP1690937B1 (en) * 2003-11-04 2012-10-17 Dnavec Research Inc. Method of constructing transgenic dendritic cell
KR20070004637A (en) * 2004-01-22 2007-01-09 가부시키가이샤 디나벡크 겐큐쇼 Process for producing virus vector
AU2005257105A1 (en) * 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing minus-strand RNA virus
US8643595B2 (en) * 2004-10-25 2014-02-04 Sipix Imaging, Inc. Electrophoretic display driving approaches
DE602006010064D1 (en) * 2005-04-20 2009-12-10 Dnavec Corp HIGHLY SAFE INTRANASAL ADMINISTRATIVE VACCINES FOR THE TREATMENT OF MORBUS ALZHEIMER
CN101228272A (en) * 2005-04-20 2008-07-23 生物载体株式会社 Highly safe intranasally administrable gene vaccines for treating alzheimer's disease
CA2612168A1 (en) * 2005-06-14 2006-12-21 Dnavec Corporation Methods for producing antibodies
EP2993235B1 (en) * 2005-10-28 2019-02-13 ID Pharma Co., Ltd. Gene transfer into airway epithelial stem cell by using simian lentiviral vector pseudotyped with sendai rna virus spike protein
CA2636600A1 (en) * 2006-01-17 2007-07-26 Dnavec Corporation Novel protein expression system
US20090257982A1 (en) * 2008-04-11 2009-10-15 Scheiber Lane Bernard medical device for treating diabetes mellitus, obesity, chronic fatigue, aging, and other medical conditions by utilizing modified virus virions to insert messenger ribonucleic acid molecules into cells
US20090257983A1 (en) * 2008-04-11 2009-10-15 Scheiber Lane Bernard Medical treatment device for treating aids by utilizing modified human immunodeficiency virus virions to insert anti-viral medications into t-helper cells
US20090258879A1 (en) * 2008-04-12 2009-10-15 Scheiber Lane Bernard Method for treating cancer, rheumatoid arthritis and other medical diseases by utilizing modified virus virions to insert medications into targeted cells
US20120088819A1 (en) * 2008-10-31 2012-04-12 Makoto Inoue Method for enhancing expression of recombinant protein
US9460666B2 (en) * 2009-05-11 2016-10-04 E Ink California, Llc Driving methods and waveforms for electrophoretic displays
EP2631290A4 (en) * 2010-10-22 2015-06-10 Univ Hokkaido Nat Univ Corp Virus vector for prime/boost vaccines, which comprises vaccinia virus vector and sendai virus vector
DK2702159T3 (en) 2011-04-28 2018-11-19 St Jude Childrens Res Hospital MODIFIED SENDAI VIRUS VACCINE AND IMAGE VECTOR
CN103159859B (en) * 2013-03-22 2014-03-12 中国医学科学院医学实验动物研究所 Sendai virus antigen peptide composition and application thereof in detecting Sendai virus infection
CN103193865B (en) * 2013-03-22 2014-09-17 中国医学科学院医学实验动物研究所 Sendai virus antigen peptide and application thereof in Sendai virus infection detection
JP2017534284A (en) * 2014-10-27 2017-11-24 インターナショナル エイズ バクシーン イニシアティブ Genetically stable replicable Sendai virus vector containing and expressing an optimized HIV gene
CN106063932B (en) * 2015-04-20 2021-07-13 上海市公共卫生临床中心 Anti-mycobacterium tuberculosis vaccine using sendai virus as vector
JP7150241B2 (en) 2016-11-17 2022-10-11 国立感染症研究所長 Infectious disease vaccine using non-infectious paramyxovirus particles

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871746A (en) * 1990-12-18 1999-02-16 Institut National De La Sainte Et De La Recherche Medicale (Inserm) Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines
US6300090B1 (en) 1994-07-29 2001-10-09 The Rockefeller University Methods of use of viral vectors to deliver antigen to dendritic cells
KR100552387B1 (en) * 1995-10-31 2006-04-21 가부시끼가이샤 디나벡 겡뀨쇼 (-)-Strand RNA Virus Vector Having Autonomously Replicating Activity
ATE470704T1 (en) * 1995-11-01 2010-06-15 Dnavec Research Inc RECOMBINANT SENDAI VIRUS
US5766945A (en) * 1996-02-13 1998-06-16 Fred Hutchinson Cancer Research Center 10A1 Retroviral packaging cells and uses thereof
US6828138B1 (en) * 1998-08-11 2004-12-07 Dnavec Research Inc. Recombinant sendai virus vector including a gene encoding a chemokine
EP1141313A2 (en) 1998-12-31 2001-10-10 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
JP2000253876A (en) 1999-03-08 2000-09-19 Dnavec Research Inc Vaccine using sendai virus vector, and vaccine protein
ATE367445T1 (en) 1999-05-18 2007-08-15 Dnavec Research Inc VIRAL PARAMYXOVIRIDAE VECTOR WITH A DEFECTIVE ENVELOPE PROTEIN GENE
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
EP1067179A1 (en) 1999-07-09 2001-01-10 Pierre Fabre Medicament Method to select attenuated paramyxoviridae useful for vaccines and therapeutics
JP3748535B2 (en) 1999-09-06 2006-02-22 株式会社ディナベック研究所 Paramyxovirus with altered transcription initiation sequence
US7314614B1 (en) * 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
EP1251174A4 (en) * 2000-01-19 2003-05-02 Dnavec Research Inc Use of paramyxovirus vector in gene transfer into blood vessel
CA2322057A1 (en) * 2000-05-18 2001-11-18 Dnavec Research Inc. Paramyxovirus vectors used for transfer of foreign genes
ES2430991T3 (en) * 2000-06-01 2013-11-22 Dnavec Research Inc. Pseudotype retroviral vector containing membrane protein that has hemagglutinin activity
EP1297852A4 (en) * 2000-06-27 2004-12-29 Dnavec Research Inc Virus vector for introducing gene into renal cells
CA2424992A1 (en) 2000-10-06 2003-04-04 Dnavec Research Inc. Paramyxovirus vectors for introducing foreign genes into skeletal muscle
JP2002142770A (en) 2000-11-08 2002-05-21 Dnavec Research Inc Paramyxovirus vector for transporting gene to circulatory system
ATE393235T1 (en) 2000-11-27 2008-05-15 Dnavec Research Inc PARAMYXOVIRUS VECTOR ENCODING FIBROBLAST GROWTH FACTOR 2 (FGF2) AND USE THEREOF
CA2462259A1 (en) * 2001-09-28 2003-04-10 Dnavec Research Inc. Mammalian cell-infecting virus vector encoding epitope-bound .beta.2m and utilization thereof
EP1690937B1 (en) * 2003-11-04 2012-10-17 Dnavec Research Inc. Method of constructing transgenic dendritic cell
AU2005257105A1 (en) * 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing minus-strand RNA virus
DE602006010064D1 (en) * 2005-04-20 2009-12-10 Dnavec Corp HIGHLY SAFE INTRANASAL ADMINISTRATIVE VACCINES FOR THE TREATMENT OF MORBUS ALZHEIMER
US20090246170A1 (en) 2006-05-31 2009-10-01 Dnavec Corporation Therapeutic Agent For Alzheimer's Disease

Also Published As

Publication number Publication date
JP2012144541A (en) 2012-08-02
KR20020086207A (en) 2002-11-18
US8217019B2 (en) 2012-07-10
EP1270016A1 (en) 2003-01-02
CN1362885A (en) 2002-08-07
JPWO2001072340A1 (en) 2004-01-08
US20020002143A1 (en) 2002-01-03
KR100854917B1 (en) 2008-08-27
HK1046243B (en) 2006-08-18
CN1248740C (en) 2006-04-05
EP1270016A4 (en) 2005-10-19
HK1046243A1 (en) 2003-01-03
KR20070094989A (en) 2007-09-27
WO2001072340A1 (en) 2001-10-04
US20100266633A1 (en) 2010-10-21

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