AU2001243701A1 - Radiographic assessment of tissue response to compounds - Google Patents
Radiographic assessment of tissue response to compoundsInfo
- Publication number
- AU2001243701A1 AU2001243701A1 AU2001243701A AU4370101A AU2001243701A1 AU 2001243701 A1 AU2001243701 A1 AU 2001243701A1 AU 2001243701 A AU2001243701 A AU 2001243701A AU 4370101 A AU4370101 A AU 4370101A AU 2001243701 A1 AU2001243701 A1 AU 2001243701A1
- Authority
- AU
- Australia
- Prior art keywords
- tissue
- radiographic
- compound
- imaging agent
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/481—Diagnostic techniques involving the use of contrast agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/40—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4035—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis the source being combined with a filter or grating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/4241—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using energy resolving detectors, e.g. photon counting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/482—Diagnostic techniques involving multiple energy imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/508—Clinical applications for non-human patients
Abstract
Radiographic system and method for noninvasively assessing the response of tissue to a compound, such as a therapeutic compound. In one embodiment, a non-radioactive, radio-opaque imaging agent accumulates in tissue in proportion to the tissue concentration of a predefined cellular target. The imaging agent is administered to a live organism, and after an accumulation interval, radiographic images are acquired. The image processing procedure isolates the radiographic density contributed solely by differential tissue accumulation of the imaging agent. A compound is administered to the organism, and after a selected interval, a second radiographic image of the tissue is acquired. Differences in radiographic density between the images reflect changes in the concentration of the cellular target that have occurred after administration of the compound. The system and method may be used to assess therapeutic efficacy of compounds in the drug discovery process, in clinical trials, and in the evaluation of clinical treatment.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19033000P | 2000-03-16 | 2000-03-16 | |
US60190330 | 2000-03-16 | ||
PCT/US2001/008663 WO2001067959A2 (en) | 2000-03-16 | 2001-03-16 | Radiographic assessment of tissue response to compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001243701A1 true AU2001243701A1 (en) | 2001-09-24 |
Family
ID=22700894
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001245805A Abandoned AU2001245805A1 (en) | 2000-03-16 | 2001-03-15 | Radiographic assessment of tissue response to compounds |
AU2001243701A Abandoned AU2001243701A1 (en) | 2000-03-16 | 2001-03-16 | Radiographic assessment of tissue response to compounds |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001245805A Abandoned AU2001245805A1 (en) | 2000-03-16 | 2001-03-15 | Radiographic assessment of tissue response to compounds |
Country Status (5)
Country | Link |
---|---|
EP (2) | EP1263324B1 (en) |
AT (1) | ATE450201T1 (en) |
AU (2) | AU2001245805A1 (en) |
DE (1) | DE60140658D1 (en) |
WO (2) | WO2001067958A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6226352B1 (en) | 1998-09-08 | 2001-05-01 | Veritas Pharmaceuticals, Inc. | System and method for radiographic imaging of tissue |
US6723746B2 (en) | 1998-09-08 | 2004-04-20 | Veritas Pharmaceuticals, Inc. | Functional radiographic imaging methods and agents |
US6751290B2 (en) | 1998-09-08 | 2004-06-15 | Veritas Pharmaceuticals, Inc. | Radiographic assessment of tissue after exposure to a compound |
EP1263478A2 (en) * | 2000-03-16 | 2002-12-11 | Veritas Pharmaceuticals | Functional radiographic imaging methods and agents |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES381202A1 (en) | 1969-06-27 | 1973-04-16 | Nyegaard & Co As | N-(2,4,6-triiodobenzoyl)-sugar amines |
GB1548594A (en) | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
DE2909439A1 (en) | 1979-03-08 | 1980-09-18 | Schering Ag | NEW NON-ionic x-ray contrast agents |
FR2511871A1 (en) | 1981-08-28 | 1983-03-04 | Guerbet Sa | PROCESS FOR INCREASING THE TOLERANCE OF OPACIFYING PRODUCTS AND OPACIFYING PRODUCTS THUS OBTAINED |
US4716225A (en) | 1984-12-27 | 1987-12-29 | Georgetown University | Radioopaque sugar derivatives and a method of metabolic mapping using the same |
US5043152A (en) | 1988-06-02 | 1991-08-27 | Guerbet S.A. | Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them |
EP0942000B1 (en) | 1989-10-24 | 2004-06-23 | Isis Pharmaceuticals, Inc. | 2'-Modified oligonucleotides |
US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
FR2687669B1 (en) | 1992-02-24 | 1997-12-19 | Guerbet Sa | COMPOUNDS FOR USE IN CONTRAST PRODUCTS FOR RADIOGRAPHY. |
US5633360A (en) | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
US5408996A (en) * | 1993-03-25 | 1995-04-25 | Salb; Jesse | System and method for localization of malignant tissue |
WO1995003428A1 (en) | 1993-07-20 | 1995-02-02 | University Of Massachusetts Medical Center | In vivo nucleic acid hybridization method |
GB9501560D0 (en) | 1995-01-26 | 1995-03-15 | Nycomed Imaging As | Contrast agents |
US5796862A (en) * | 1996-08-16 | 1998-08-18 | Eastman Kodak Company | Apparatus and method for identification of tissue regions in digital mammographic images |
IL121084A0 (en) * | 1997-06-15 | 1997-11-20 | Yeda Res & Dev | Compositions and methods for diagnosis of tumors by X-ray imaging |
-
2001
- 2001-03-15 DE DE60140658T patent/DE60140658D1/en not_active Expired - Lifetime
- 2001-03-15 WO PCT/US2001/008485 patent/WO2001067958A2/en active Application Filing
- 2001-03-15 AT AT01918766T patent/ATE450201T1/en not_active IP Right Cessation
- 2001-03-15 AU AU2001245805A patent/AU2001245805A1/en not_active Abandoned
- 2001-03-15 EP EP01918766A patent/EP1263324B1/en not_active Expired - Lifetime
- 2001-03-16 WO PCT/US2001/008663 patent/WO2001067959A2/en active Application Filing
- 2001-03-16 AU AU2001243701A patent/AU2001243701A1/en not_active Abandoned
- 2001-03-16 EP EP01916713A patent/EP1263323A2/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1263323A2 (en) | 2002-12-11 |
WO2001067959A3 (en) | 2002-02-14 |
ATE450201T1 (en) | 2009-12-15 |
EP1263324A2 (en) | 2002-12-11 |
AU2001245805A1 (en) | 2001-09-24 |
EP1263324B1 (en) | 2009-12-02 |
WO2001067958A2 (en) | 2001-09-20 |
WO2001067958A3 (en) | 2002-02-07 |
DE60140658D1 (en) | 2010-01-14 |
WO2001067959A2 (en) | 2001-09-20 |
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