AU2001239885A1 - 4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity - Google Patents

4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity

Info

Publication number
AU2001239885A1
AU2001239885A1 AU2001239885A AU3988501A AU2001239885A1 AU 2001239885 A1 AU2001239885 A1 AU 2001239885A1 AU 2001239885 A AU2001239885 A AU 2001239885A AU 3988501 A AU3988501 A AU 3988501A AU 2001239885 A1 AU2001239885 A1 AU 2001239885A1
Authority
AU
Australia
Prior art keywords
chemokine receptor
receptor activity
alkyl piperidinyl
pyrrolidine
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001239885A
Inventor
Jennifer Chee
Jill N. Johanson
Frank Kayser
William H Parsons
Kathleen M. Rupprecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2001239885A1 publication Critical patent/AU2001239885A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2001239885A 2000-02-28 2001-02-27 4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity Abandoned AU2001239885A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18555500P 2000-02-28 2000-02-28
US60185555 2000-02-28
PCT/US2001/006115 WO2001064216A1 (en) 2000-02-28 2001-02-27 4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
AU2001239885A1 true AU2001239885A1 (en) 2001-09-12

Family

ID=22681479

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001239885A Abandoned AU2001239885A1 (en) 2000-02-28 2001-02-27 4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity

Country Status (3)

Country Link
US (1) US6455548B2 (en)
AU (1) AU2001239885A1 (en)
WO (1) WO2001064216A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2400553A (en) * 2003-04-14 2004-10-20 Cipla Ltd Antiviral pharmaceutical combination of lamivudine, stavudine and efavirenz, or derivatives thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001526178A (en) * 1997-08-28 2001-12-18 メルク エンド カムパニー インコーポレーテッド Pyrrolidine and piperidine chemokine receptor activity modulators
US6166037A (en) * 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
US6303593B1 (en) * 1999-03-02 2001-10-16 Merck & Co., Inc. 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
US6265434B1 (en) * 1999-04-06 2001-07-24 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity

Also Published As

Publication number Publication date
US6455548B2 (en) 2002-09-24
WO2001064216A1 (en) 2001-09-07
US20020013348A1 (en) 2002-01-31

Similar Documents

Publication Publication Date Title
AU4074200A (en) Pyrrolidine modulators of chemokine receptor activity
AU4201200A (en) Pyrrolidine modulators of chemokine receptor activity
HK1054032A1 (en) N-ureidoheterocycloaklyl-piperidines as modulators of chemokine receptor activity
EP1173170A4 (en) Pyrrolidine modulators of chemokine receptor activity
AU3386400A (en) 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
AU2056800A (en) Heterocyclic piperidines as modulators of chemokine receptor activity
HK1062559A1 (en) Piperidine derivatives useful as modulators of chemokine receptor activity
AU2482100A (en) N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU3126700A (en) N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2057200A (en) N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2002241724A1 (en) Diamines as modulators of chemokine receptor activity
IL152418A0 (en) Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity
AU3386700A (en) 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
AU3389300A (en) Pyrrolidine modulators of chemokine receptor activity
AU2002326948A1 (en) Piperizinones as modulators of chemokine receptor activity
MXPA03008109A (en) Modulators of chemokine receptor activity.
EP1003743A4 (en) 3,3-disubstituted piperidines as modulators of chemokine receptor activity
EP1009405A4 (en) Pyrrolidine and piperidine modulators of chemokine receptor activity
AU2001243145A1 (en) Human g-protein chemokine receptor (ccr5) hdgnr10
AU2056700A (en) 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
IL153789A0 (en) Chemokine receptor modulators, production and use
AU1201401A (en) Benzylcycloalkyl amines as modulators of chemokine receptor activity
IL161699A0 (en) Piperidine derivatives and their use as modulators of chemokine receptor activity (especially ccr5)
AU2001230704A1 (en) Pyrimidine compounds and their use as modulators of chemokine receptor activity
AU7135901A (en) N-ureidoalkyl-piperidines as modulators of chemokine receptor activity