AU2001239392A1 - Inflammation-inducible hybrid promoters, vectors containing same and uses thereof - Google Patents
Inflammation-inducible hybrid promoters, vectors containing same and uses thereofInfo
- Publication number
- AU2001239392A1 AU2001239392A1 AU2001239392A AU3939201A AU2001239392A1 AU 2001239392 A1 AU2001239392 A1 AU 2001239392A1 AU 2001239392 A AU2001239392 A AU 2001239392A AU 3939201 A AU3939201 A AU 3939201A AU 2001239392 A1 AU2001239392 A1 AU 2001239392A1
- Authority
- AU
- Australia
- Prior art keywords
- inflammation
- vectors containing
- containing same
- hybrid promoters
- promoters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Abstract
The invention concerns gene expression regulating and is based particularly on the use of constructs enabling to activate transcription of a transgene in cells, tissues or organs in inflammatory condition. The inventive promoters preferably contain: a) an element of response to a PPAR and b) all or part of a promoter of gene PLA2sIIA. The invention also concerns vectors, cells and compositions comprising said promoters and their use for regulating expression of genes in vitro, ex vivo or in vivo.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0003262A FR2806418B1 (en) | 2000-03-14 | 2000-03-14 | HYBRID INFLAMMATION INDUCIBLE PROMOTERS, VECTORS CONTAINING THEM, AND USES |
FR0003262 | 2000-03-14 | ||
US19695900P | 2000-04-13 | 2000-04-13 | |
US60196959 | 2000-04-13 | ||
PCT/FR2001/000759 WO2001068845A2 (en) | 2000-03-14 | 2001-03-14 | Inflammation-inducible hybrid promoters, vectors containing same and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001239392A1 true AU2001239392A1 (en) | 2001-09-24 |
Family
ID=26212255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001239392A Abandoned AU2001239392A1 (en) | 2000-03-14 | 2001-03-14 | Inflammation-inducible hybrid promoters, vectors containing same and uses thereof |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1263978B1 (en) |
JP (1) | JP2003526368A (en) |
AT (1) | ATE312187T1 (en) |
AU (1) | AU2001239392A1 (en) |
CA (1) | CA2403189A1 (en) |
DE (1) | DE60115610T2 (en) |
DK (1) | DK1263978T3 (en) |
ES (1) | ES2254378T3 (en) |
WO (1) | WO2001068845A2 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2269897A (en) * | 1992-08-13 | 1994-02-23 | Merck Frosst Canada Inc | Assay to detect peroxisome proliferator activity |
FR2755699B1 (en) * | 1996-11-08 | 1998-12-18 | Rhone Poulenc Rorer Sa | NEW CONSTRUCTIONS AND VECTORS FOR TARGETED AND INDUCTIBLE GENE EXPRESSION |
US5925657A (en) * | 1997-06-18 | 1999-07-20 | The General Hospital Corporation | Use of PPARγ agonists for inhibition of inflammatory cytokine production |
CZ20014609A3 (en) * | 1999-06-22 | 2002-05-15 | Aventis Pharma S. A. | Composition containing nucleic acid encoding PPAR nuclear receptor and user thereof for expression control |
-
2001
- 2001-03-14 AU AU2001239392A patent/AU2001239392A1/en not_active Abandoned
- 2001-03-14 DK DK01914000T patent/DK1263978T3/en active
- 2001-03-14 ES ES01914000T patent/ES2254378T3/en not_active Expired - Lifetime
- 2001-03-14 JP JP2001567329A patent/JP2003526368A/en active Pending
- 2001-03-14 WO PCT/FR2001/000759 patent/WO2001068845A2/en active IP Right Grant
- 2001-03-14 CA CA002403189A patent/CA2403189A1/en not_active Abandoned
- 2001-03-14 EP EP01914000A patent/EP1263978B1/en not_active Expired - Lifetime
- 2001-03-14 DE DE60115610T patent/DE60115610T2/en not_active Expired - Lifetime
- 2001-03-14 AT AT01914000T patent/ATE312187T1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2001068845A2 (en) | 2001-09-20 |
DK1263978T3 (en) | 2006-04-18 |
CA2403189A1 (en) | 2001-09-20 |
ATE312187T1 (en) | 2005-12-15 |
WO2001068845A3 (en) | 2002-02-28 |
DE60115610D1 (en) | 2006-01-12 |
DE60115610T2 (en) | 2006-10-19 |
JP2003526368A (en) | 2003-09-09 |
ES2254378T3 (en) | 2006-06-16 |
EP1263978B1 (en) | 2005-12-07 |
EP1263978A2 (en) | 2002-12-11 |
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