AU2001229494A1 - Chimeric prostate-homing peptides with pro-apoptotic activity - Google Patents

Chimeric prostate-homing peptides with pro-apoptotic activity

Info

Publication number
AU2001229494A1
AU2001229494A1 AU2001229494A AU2949401A AU2001229494A1 AU 2001229494 A1 AU2001229494 A1 AU 2001229494A1 AU 2001229494 A AU2001229494 A AU 2001229494A AU 2949401 A AU2949401 A AU 2949401A AU 2001229494 A1 AU2001229494 A1 AU 2001229494A1
Authority
AU
Australia
Prior art keywords
pro
apoptotic activity
homing peptides
chimeric prostate
prostate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001229494A
Inventor
Wadih Arap
Dale E Bredesen
H. Michael Ellerby
Renata Pasqualini
Erkki I. Ruoslahti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Publication of AU2001229494A1 publication Critical patent/AU2001229494A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2001229494A 2000-01-21 2001-01-16 Chimeric prostate-homing peptides with pro-apoptotic activity Abandoned AU2001229494A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48958200A 2000-01-21 2000-01-21
US09/489,582 2000-01-21
PCT/US2001/001362 WO2001053342A1 (en) 2000-01-21 2001-01-16 Chimeric prostate-homing peptides with pro-apoptotic activity

Publications (1)

Publication Number Publication Date
AU2001229494A1 true AU2001229494A1 (en) 2001-07-31

Family

ID=23944433

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001229494A Abandoned AU2001229494A1 (en) 2000-01-21 2001-01-16 Chimeric prostate-homing peptides with pro-apoptotic activity

Country Status (5)

Country Link
EP (1) EP1250355A1 (en)
JP (1) JP2003520808A (en)
CN (1) CN1419565A (en)
AU (1) AU2001229494A1 (en)
WO (1) WO2001053342A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
AU2002323543A1 (en) * 2001-09-07 2003-03-24 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
WO2004011595A2 (en) * 2002-07-26 2004-02-05 Institut Pasteur Vectors for transferring molecules of interest in target cells
JP4524359B2 (en) * 2003-03-24 2010-08-18 学校法人日本医科大学 Cell death-inducing fusion gene specifically acting on cancer and gene product thereof
JP2007501014A (en) * 2003-08-05 2007-01-25 ウイスコンシン アラムニ リサーチ ファンデーション Targeted carrier fusion for delivery of chemotherapeutic agents
CN101052408B (en) * 2004-09-07 2013-03-27 伯纳姆研究院 Peptides that selectively home to heart vasculature and related conjugates and methods
JP5384948B2 (en) * 2007-02-09 2014-01-08 ジェノミディア株式会社 Novel polypeptide and antibacterial agent containing it as an active ingredient
CN101157729B (en) * 2007-10-23 2011-01-12 南京大学 Tumour putrescence gene related apoptosis ligand variant and uses thereof
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
CN104974227B (en) * 2014-04-04 2019-04-23 中国科学院苏州纳米技术与纳米仿生研究所 The amphiphilic film targeting alpha-helix polypeptide of cation and its application
US9029319B1 (en) * 2014-08-04 2015-05-12 Centaur, Inc. Water buffalo derived peptide antibiotic therapies
US11090358B2 (en) 2015-09-09 2021-08-17 Fred Hutchinson Cancer Research Center Cartilage-homing peptides
JP7060216B2 (en) 2016-11-16 2022-04-26 アカデミシュ ジーケンハウス ライデン ハー．オー．デー．エン． ルムク Substances for targeting a variety of selected organs or tissues
CN106699896B (en) * 2016-12-05 2020-06-05 华中科技大学同济医学院附属协和医院 Tumor killing polypeptide capable of self-assembling into hydrogel and application thereof
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN106632688B (en) * 2016-12-23 2020-06-05 华中科技大学同济医学院附属协和医院 Polypeptide for modifying microvesicle and pharmaceutical preparation targeting GBM
JP7280193B2 (en) 2017-03-16 2023-05-23 ブレイズ バイオサイエンス， インコーポレイテッド Cartilage homing peptide conjugates and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69734887T2 (en) * 1996-09-10 2006-08-24 The Burnham Institute, La Jolla TUMOR FINDING MOLECULES, DIVIDING CONJUGATES, AND METHOD FOR USE THEREOF
WO1999013329A1 (en) * 1997-09-10 1999-03-18 The Burnham Institute Methods of identifying molecules that home to angiogenic vasculature in tumors
CA2323071C (en) * 1998-03-13 2011-06-21 The Burnham Institute Molecules that home to various selected organs or tissues
EP1150701A4 (en) * 1999-01-22 2003-03-26 Burnham Inst Homing pro-apoptotic conjugates and methods of using same

Also Published As

Publication number Publication date
JP2003520808A (en) 2003-07-08
WO2001053342A1 (en) 2001-07-26
WO2001053342A9 (en) 2002-10-31
EP1250355A1 (en) 2002-10-23
CN1419565A (en) 2003-05-21

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