AU2001228647A1 - Dihydrofolate reductase inhibitors - Google Patents

Dihydrofolate reductase inhibitors

Info

Publication number
AU2001228647A1
AU2001228647A1 AU2001228647A AU2864701A AU2001228647A1 AU 2001228647 A1 AU2001228647 A1 AU 2001228647A1 AU 2001228647 A AU2001228647 A AU 2001228647A AU 2864701 A AU2864701 A AU 2864701A AU 2001228647 A1 AU2001228647 A1 AU 2001228647A1
Authority
AU
Australia
Prior art keywords
reductase inhibitors
dihydrofolate reductase
dihydrofolate
inhibitors
reductase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001228647A
Inventor
Gordon Lowe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of AU2001228647A1 publication Critical patent/AU2001228647A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AU2001228647A 2000-01-24 2001-01-24 Dihydrofolate reductase inhibitors Abandoned AU2001228647A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0001565.1A GB0001565D0 (en) 2000-01-24 2000-01-24 Dihydrofolate reductase inhibitors
GB0001565 2000-01-24
PCT/GB2001/000267 WO2001053276A1 (en) 2000-01-24 2001-01-24 Dihydrofolate reductase inhibitors

Publications (1)

Publication Number Publication Date
AU2001228647A1 true AU2001228647A1 (en) 2001-07-31

Family

ID=9884217

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001228647A Abandoned AU2001228647A1 (en) 2000-01-24 2001-01-24 Dihydrofolate reductase inhibitors

Country Status (4)

Country Link
US (1) US20030203908A1 (en)
AU (1) AU2001228647A1 (en)
GB (1) GB0001565D0 (en)
WO (1) WO2001053276A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101198597B (en) * 2005-06-14 2011-11-16 先灵公司 Preparation and use of compounds as aspartyl protease inhibitors
EP2332925A4 (en) 2008-08-25 2014-03-26 Hamari Chemicals Ltd Novel dihydrotriazine derivative
CN105622431A (en) * 2011-01-28 2016-06-01 肯塔基大学研究基金会 Stilbene analogs and methods of treating cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2900385A (en) * 1959-08-18 Dihydrotriazines and method of
US2803628A (en) * 1957-08-20 New triazinederivatives
US3074947A (en) * 1963-01-22 Certificate of correction
GB667094A (en) * 1949-01-31 1952-02-27 Muriel Ruth Curd Manufacture of biguanide derivatives
GB1007021A (en) * 1962-04-20 1965-10-13 Parke Davis & Co Salts of substituted 1,2-dihydro-s-triazines
US3215600A (en) * 1962-06-29 1965-11-02 Parke Davis & Co Antimalarial composition containing an acylated sulfonylaniline with triazine or pyrimidine salt, and method of use
WO1991008667A1 (en) * 1989-12-07 1991-06-27 Protos Corporation Inhibitors of pneumocystis carinii dihydrofolate reductase

Also Published As

Publication number Publication date
WO2001053276A1 (en) 2001-07-26
GB0001565D0 (en) 2000-03-15
US20030203908A1 (en) 2003-10-30

Similar Documents

Publication Publication Date Title
AU2001258771A1 (en) -secretase inhibitors
AU2001237041A1 (en) Kinase inhibitors
AU2002250394A1 (en) Rho-kinase inhibitors
AU2002245709A1 (en) Rho-kinase inhibitors
AUPR201600A0 (en) Quinazolinone derivative
AU2002219555A1 (en) VLA-4 Inhibitors
AU2002220241A1 (en) Parb inhibitors
AU2002215116A1 (en) Expander
AU2002212436A1 (en) Quinazoline derivatives
AU2001285750A1 (en) Urokinase inhibitors
AU4217201A (en) Tri-aryl-substituted-ethane pde4 inhibitors
AU2001292137A1 (en) Quinazoline derivatives
AU2001236052A1 (en) Urease inhibitors
AU2002211662A1 (en) Nf-kappab inhibitors
AU2002222627A1 (en) Tak1 inhibitors
AU2001244562A1 (en) Neovascularization inhibitors
AU2002224550A1 (en) Corrosion inhibitors
AU3235100A (en) Prothease inhibitors
AU2002222628A1 (en) Keratinocyte proliferation inhibitors
IL157597A0 (en) Diaminoquinazoline esters for use as dihydrofolate reductase inhibitors
AU2001283340A1 (en) Factor viia inhibitors
AU2001278997A1 (en) Thrombin inhibitors
AU2001228647A1 (en) Dihydrofolate reductase inhibitors
AU2001233965A1 (en) Novel cd23 inhibitors
AU2001268853A1 (en) Biocatalyst inhibitors