AU2001216030A1 - A method for generating genetically altered antigens - Google Patents

A method for generating genetically altered antigens

Info

Publication number
AU2001216030A1
AU2001216030A1 AU2001216030A AU1603001A AU2001216030A1 AU 2001216030 A1 AU2001216030 A1 AU 2001216030A1 AU 2001216030 A AU2001216030 A AU 2001216030A AU 1603001 A AU1603001 A AU 1603001A AU 2001216030 A1 AU2001216030 A1 AU 2001216030A1
Authority
AU
Australia
Prior art keywords
useful
genes
methods
cells
generating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001216030A
Inventor
Luigi Grasso
Nicholas C. Nicolaides
Philip M. Sass
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphotek Inc
Original Assignee
Morphotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphotek Inc filed Critical Morphotek Inc
Publication of AU2001216030A1 publication Critical patent/AU2001216030A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within genes encoding for therapeutic antigens to produce altered polypeptides with enhanced antigenic and immunogenic activity. Moreover, these methods are useful for generating effective vaccines.
AU2001216030A 2000-11-14 2000-11-14 A method for generating genetically altered antigens Abandoned AU2001216030A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/031135 WO2002040499A1 (en) 2000-11-14 2000-11-14 A method for generating genetically altered antigens

Publications (1)

Publication Number Publication Date
AU2001216030A1 true AU2001216030A1 (en) 2002-05-27

Family

ID=21741992

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001216030A Abandoned AU2001216030A1 (en) 2000-11-14 2000-11-14 A method for generating genetically altered antigens

Country Status (8)

Country Link
EP (1) EP1363930B1 (en)
JP (1) JP2005509399A (en)
AT (1) ATE336505T1 (en)
AU (1) AU2001216030A1 (en)
CA (1) CA2429134C (en)
DE (1) DE60030172T2 (en)
DK (1) DK1363930T3 (en)
WO (1) WO2002040499A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5917017A (en) * 1994-06-08 1999-06-29 President And Fellows Of Harvard College Diphtheria toxin vaccines bearing a mutated R domain
EP0766740A1 (en) * 1994-06-17 1997-04-09 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Nucleotide sequences of pestivirus strains, polypeptides encoded by these sequences and use thereof for diagnosis and prevention of pestivirus infections
AU3241095A (en) * 1994-07-29 1996-03-04 Chiron Corporation Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same
US5612030A (en) * 1995-01-17 1997-03-18 University Of Kentucky Research Foundation Anti-idiotype monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma
US5843757A (en) * 1995-08-24 1998-12-01 The Johns Hopkins University Human JTV1 gene overlaps PMS2 gene
EP1005363B1 (en) * 1997-07-31 2006-03-29 Hawaii Biotech, Inc. Recombinant dimeric envelope vaccine against flaviviral infection
US6146894A (en) * 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms

Also Published As

Publication number Publication date
DE60030172D1 (en) 2006-09-28
EP1363930B1 (en) 2006-08-16
ATE336505T1 (en) 2006-09-15
JP2005509399A (en) 2005-04-14
DK1363930T3 (en) 2006-09-04
EP1363930A4 (en) 2004-04-14
DE60030172T2 (en) 2007-07-05
CA2429134A1 (en) 2002-05-23
WO2002040499A1 (en) 2002-05-23
EP1363930A1 (en) 2003-11-26
CA2429134C (en) 2011-03-15

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