AU2000259855B2 - Bioactive calcium phosphate composite layers electrochemically deposited on implants - Google Patents
Bioactive calcium phosphate composite layers electrochemically deposited on implants Download PDFInfo
- Publication number
- AU2000259855B2 AU2000259855B2 AU2000259855A AU2000259855A AU2000259855B2 AU 2000259855 B2 AU2000259855 B2 AU 2000259855B2 AU 2000259855 A AU2000259855 A AU 2000259855A AU 2000259855 A AU2000259855 A AU 2000259855A AU 2000259855 B2 AU2000259855 B2 AU 2000259855B2
- Authority
- AU
- Australia
- Prior art keywords
- calcium phosphate
- composite layer
- electrochemically deposited
- bioactive calcium
- phosphate composite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Description
9 January 2003
DECLARATION
I, Johannes Reckzeh, being technical translator and member of Bundesverband der Dolmetscher und Ubersetzer e.V., do hereby declare that I am conversant with the German and English languages, and I certify that the following translation is to the best of my knowledge and belief a true and correct translation of the authentic text of the International Patent Application PCT/EP00/06838 titled ,,Elektrochemisch abgeschiedene, bioaktive Calciumphosphat-Kompositschichten auf Implantaten" WO 02/05862 PCT/EPOO/06838 Bioactive calcium phosphate composite layers electrochemically deposited on implants For about 10 years investigations on calcium phosphate layers electrochemically deposited on bone implants have been carrying out with the objective to improve the compound between the bone tissue and implant (Redepenning, J. et al.: Chem. Mater. 2(1990) 625-7; Redepenning, US 5 310 464, US 5 413 693; Teller, J. et al.: DE 4 431 862, EP 774 982, US 759 376; Kumar, M. et al.: J. Biomed. Mat. Res. 45(1999) 302-10). Calcium phosphates as mineral constituents of the bone tissue have bioactive properties, i.e. they assist the bone formation. The genesis of calcium phosphate layers from electrolytic bathes deposited on implants are very similiar to the processes proceeding during the bone growth. Their microporous structure encourages the immobilization of cells, leading of which new bone tissue is allowed to form and to knit together with the bone tissue surrounding the implant such as with the normal wound healing.
In the literature, besides the preparation of phase-pure calcium phosphates it is also informed on composite layers electrochemically deposited on implants. US 5 205 921 (Shirkhanzadeh, and DE 4 431 862 (Teller, J. et al.) describe the electrochemical deposition of calcium phosphate composite layers from tricalcium phosphate and hydroxylapatite therefore from two more difficult soluble calcium phosphate phases. DE 19 504 386 (Scharnweber, D. et al.) deals with an electrochemical method for the preparation of a refined adhesive-proof coating from calcium phosphate and metal oxide phases on titanium implants by a mutual cathodic and anodic polarization. Another method of the preparation of adhesiveproof hydroxylapatite/ cobalt composites leads from electrochemically deposited brushite layers which are chemically converted into hydroxylapatite and are subsequently coated with cobalt in another bath (Zhang J.M. et al.: J. Mat.
Sci. Lett. 17 (1998) 1077-9). With the difficult soluble calcium phosphate phases, in particular hydroxylapatite, which is striven for with the preparation of these composite layers it is sought to achieve a possibly great likelihood to the structure of the natural full developed bone, and healing the implant into the bone shall be encouraged with that. Then, it can always be assumed that due to its low solubility the hydroxylapatite remains on the implant, and thus a durable improvement of the interaction between the implant surface and biological system will be achieved. Also, any other attempts to completely convert brushite layers electrochemically deposited on implants into hydroxylapatite lead from the objective to artificially develop bone similiar relations on the implant, forever. Although the body thus is offered a surface known to it, such layers have the disadvantage such that due to their low solubility they only excite the bone moderately for the endogenous osteosynthesis.
From the literature it is known for several years that the grade of bioactivity of a layer is growing with its instability in a physiological ambiance. Good conditions for the reproduction and differentiation of the osteoblasts responsible for the bone formation are provided by the local increase of the concentration of calcium and phosphate ions in the healing zone of the implant. (Ducheyne, P. et al.: Biomaterials 11(1990) 531-40). Calcium phosphates with a solubility being very much higher than that of brushite and monetite in comparison with hydroxylapatite thus have a particular importance especially for the healing phase of the implant into the bone.
Hence, the invention is based on the object to deposit a layer on the bone implant which 0 o optimally assists healing the implant into the bone which then will be entirely resorbed and thus enables the immediate and complete friction-fit contact of the bone with the implant.
According to an aspect of the invention there is provided an electrochemically deposited, bioactive calcium phosphate composite layer on implants, characterized by a fully 0 absorbable composite layer having the following features: said composite layer consists of readily soluble Ca-P compounds and of more oslowly soluble Ca-P compounds, o said composite layer comprises a microporous structure.
The composite layer according to preferred embodiments of the invention especially includes the more easily soluble phases of the young bone tissue in addition to the more difficult soluble calcium phosphate phases of the more developed bone. In particular, the easily soluble phases of brushite and monetite are allowed to actively assist the endogenous osteogenesis by locally increased calcium and phosphate concentrations since the reproduction and maturation of osteoblasts required for the osteogenesis is accelerated under these conditions. After the dissolution of the more easily soluble phases has taken place the more difficult soluble phases ensure a slightly increased concentration of calcium and phosphate ions over a longer time period in the healing zone of the implant and thus encouraging the enlargement and stabilization of the new bone tissue.
Due to the high-porous structure adjustable by the parameters of the electrochemical deposition, the composite layer is not allowed to serve and shall not serve as a barrier between the implant and bone, but is hall serve such as a harmonizing factor or host with endogenous structuring the boundary layer between the implant and bone. The high bioactivity of this spongy composite is manifesting itself in excellent moistening due to the body fluid present in the wound bed of the bone and the adhesion connected therewith of the factors included in this fluid and stimulating the osteogenesis.
The composite layers can be adapted to the respective implant and the bone surrounding the implant with respect to the structure, composition and thickness.
The preparation of this composite is allowed then to take place such that the individual phases are simultaneously or subsequently deposited as well, and portions of one phase, e.g. of the more soluble calcium phosphate phase, respectively are converted into a less soluble phase by means of a chemical reaction. On that occasion, superficially it is not intended to provide a vertical solubility gradient in the composite.
The differentphases rather are to laterally develop side by side and dissolve again after implantation. Then, the porosity of the composite first will increase due to the decrease of the more easily soluble phases, and it will be made room for a new bone tissue until the entire composite is also converted into a bone tissue after dissolving the less soluble calcium phosphate phases. Assuming from first contacts of the immobilized cells with the implant via the pores of the composite from the beginning a friction-fit connection between the bone and implant is to develop by the proceeding dissolution of the individual phases.
The time history of the dissolution of the composite layer is to simply characterize by three sections. In the section I the greatest local increase of the concentration of calcium and phosphate ions available in the boundary layer between the implant and bone is substantially determined by the more easily soluble phases. In this section it must be ensured that a fibrous encapsulation of the implant does not occur, and thus enabling its immediate osteointegration. In the section II the more difficult soluble composite portion will determine the local ion budget, and in particular will assist the mineralization of the new bone tissue. In the section III the entire composite is dissolved and substituted by a new bone.
The implant is healed into the bone in a friction-fit manner.
In case of need the osteoinductive additives and/ or antimicrobial agents will also be released from the composite.
Claims (7)
1. Electrochemically deposited, bioactive calcium phosphate composite layer on Simplants, characterised by a fully absorbable composite layer having the following features: said composite layer consists of readily soluble Ca-P compounds and of more slowly soluble Ca-P compounds, n- said composite layer comprises a microporous structure. 00
2. Electrochemically deposited, bioactive calcium phosphate composite layer on Simplants according to claim 1, characerised in that said readily soluble Ca-P compounds oare monetite or brushite.
3. Electrochemically deposited, bioactive calcium phosphate composite layer on implants according to claims 1 and 2, characterised in that with regard to their phase composition and solubility, said different Ca-P compounds are adapted to said relevant implant and to the bone enclosing said implant.
4. Electrochemically deposited, bioactive calcium phosphate composite layer according to claim 1, characterised by osteoinductive additives and/or antimicrobial agents.
A method for producing an electrochemically deposited, bioactive calcium phosphate composite layer according to claim 1, characterised in that with regard to its phase composition and solubility, said composite layer is modifiable in a controlled manner during the deposition and/or by means ofaftertreatment.
6. An electrochemically deposited, bioactive calcium phosphate composite layer on implants, said layer being substantially as herein described with reference to the accompanying examiples and/or drawings.
7. A method for producing an electrochemically deposited, bioactive calcium phosphate layer, said method being substantially as herein described with reference to the accompanying examples and/or drawings. Dated this 20" day of December 2005. DOT GMBH By FRASER OLD &SOHN Patent Attorneys for the Applicant
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2000/006838 WO2002005862A1 (en) | 2000-07-17 | 2000-07-17 | Bioactive calcium phosphate composite layers electrochemically deposited on implants |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2000259855A1 AU2000259855A1 (en) | 2002-05-02 |
AU2000259855B2 true AU2000259855B2 (en) | 2006-02-02 |
Family
ID=8164028
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU5985500A Pending AU5985500A (en) | 2000-07-17 | 2000-07-17 | Bioactive calcium phosphate composite layers electrochemically deposited on implants |
AU2000259855A Ceased AU2000259855B2 (en) | 2000-07-17 | 2000-07-17 | Bioactive calcium phosphate composite layers electrochemically deposited on implants |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU5985500A Pending AU5985500A (en) | 2000-07-17 | 2000-07-17 | Bioactive calcium phosphate composite layers electrochemically deposited on implants |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1301220A1 (en) |
JP (1) | JP2004503333A (en) |
AU (2) | AU5985500A (en) |
CA (1) | CA2416201C (en) |
HK (1) | HK1060070A1 (en) |
WO (1) | WO2002005862A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080011613A1 (en) * | 2004-07-21 | 2008-01-17 | Rizhi Wang | Method of electrolytically depositing a pharmaceutical coating onto a conductive osteal implant |
US10004604B2 (en) | 2006-09-08 | 2018-06-26 | Kyocera Corporation | Bioimplant for artifical joint with evanescent coating film |
US10610614B2 (en) | 2006-09-08 | 2020-04-07 | Kyocera Corporation | Bioimplant with evanescent coating film |
US11278642B2 (en) | 2006-09-08 | 2022-03-22 | Takao Hotokebuchi | Bioimplant with evanescent coating film |
DE102012001260B4 (en) | 2012-01-23 | 2015-04-02 | Dot Gmbh | Antibacterial and osteoinductive implant coating |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0806212A1 (en) * | 1996-05-10 | 1997-11-12 | Matrix Medical B.V. | Device for incorporation and release of biologically active agents |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5205921A (en) * | 1991-02-04 | 1993-04-27 | Queen's University At Kingston | Method for depositing bioactive coatings on conductive substrates |
DE19504386C2 (en) * | 1995-02-10 | 1997-08-28 | Univ Dresden Tech | Process for the production of a graded coating from calcium phosphate phases and metal oxide phases on metallic implants |
US6045683A (en) * | 1997-12-01 | 2000-04-04 | University Of Alabama In Huntsville | Modified brushite surface coating, process therefor, and low temperature conversion to hydroxyapatite |
AU766735B2 (en) * | 1998-09-15 | 2003-10-23 | Isotis N.V. | Osteoinduction |
-
2000
- 2000-07-17 AU AU5985500A patent/AU5985500A/en active Pending
- 2000-07-17 EP EP00945927A patent/EP1301220A1/en not_active Ceased
- 2000-07-17 WO PCT/EP2000/006838 patent/WO2002005862A1/en active IP Right Grant
- 2000-07-17 CA CA002416201A patent/CA2416201C/en not_active Expired - Fee Related
- 2000-07-17 AU AU2000259855A patent/AU2000259855B2/en not_active Ceased
- 2000-07-17 JP JP2002511793A patent/JP2004503333A/en active Pending
-
2004
- 2004-04-29 HK HK04103012A patent/HK1060070A1/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0806212A1 (en) * | 1996-05-10 | 1997-11-12 | Matrix Medical B.V. | Device for incorporation and release of biologically active agents |
Also Published As
Publication number | Publication date |
---|---|
JP2004503333A (en) | 2004-02-05 |
CA2416201A1 (en) | 2003-01-15 |
EP1301220A1 (en) | 2003-04-16 |
WO2002005862A8 (en) | 2002-05-30 |
HK1060070A1 (en) | 2004-07-30 |
AU5985500A (en) | 2002-01-30 |
WO2002005862A1 (en) | 2002-01-24 |
AU2000259855A1 (en) | 2002-05-02 |
CA2416201C (en) | 2008-11-18 |
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Legal Events
Date | Code | Title | Description |
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FGA | Letters patent sealed or granted (standard patent) | ||
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |