AU1857083A - New 2-nitro-1, 1-ethenediames and their use as medicaments - Google Patents

New 2-nitro-1, 1-ethenediames and their use as medicaments

Info

Publication number
AU1857083A
AU1857083A AU18570/83A AU1857083A AU1857083A AU 1857083 A AU1857083 A AU 1857083A AU 18570/83 A AU18570/83 A AU 18570/83A AU 1857083 A AU1857083 A AU 1857083A AU 1857083 A AU1857083 A AU 1857083A
Authority
AU
Australia
Prior art keywords
optionally substituted
radical
ethenediames
medicaments
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU18570/83A
Inventor
Bernward Garthoff
Andreas Knorr
Ekkehard Niemers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU1857083A publication Critical patent/AU1857083A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Ink Jet (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Color Printing (AREA)

Abstract

Compounds of the formula <IMAGE> in which R1 is an optionally substituted aryl or heteroaryl radical, R2 is an alkyl or alkenyl radical which is optionally substituted by alkoxy or cycloalkyl, or an optionally substituted aryl or heteroaryl radical, and X is an optionally aklyl-substituted methylene radical or a direct bond, but if X is a direct bond R2 is not aryl, or physiologically acceptable acid addition salts thereof, exhibit activity on the circulation system particularly as hypotensive agents.
AU18570/83A 1982-09-01 1983-08-31 New 2-nitro-1, 1-ethenediames and their use as medicaments Abandoned AU1857083A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823232462 DE3232462A1 (en) 1982-09-01 1982-09-01 2-NITRO-1,1-ETHENDIAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
DE32324626 1982-09-01

Publications (1)

Publication Number Publication Date
AU1857083A true AU1857083A (en) 1984-03-08

Family

ID=6172205

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18570/83A Abandoned AU1857083A (en) 1982-09-01 1983-08-31 New 2-nitro-1, 1-ethenediames and their use as medicaments

Country Status (14)

Country Link
US (1) US4567188A (en)
EP (1) EP0104423B1 (en)
JP (1) JPS5965047A (en)
KR (1) KR840006324A (en)
AT (1) ATE19870T1 (en)
AU (1) AU1857083A (en)
DE (2) DE3232462A1 (en)
DK (1) DK397383A (en)
ES (1) ES8404850A1 (en)
FI (1) FI833075A (en)
GR (1) GR79627B (en)
IL (1) IL69598A (en)
PT (1) PT77231B (en)
ZA (1) ZA836450B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE166051T1 (en) 1987-08-01 1998-05-15 Takeda Chemical Industries Ltd INTERMEDIATE PRODUCTS, THEIR PRODUCTION AND USE FOR THE PRODUCTION OF ALPHA UNSATURATED AMINE
US4918086A (en) * 1987-08-07 1990-04-17 Ciba-Geigy Corporation 1-nitro-2,2-diaminoethylene derivatives
JP2779403B2 (en) * 1988-11-29 1998-07-23 日本バイエルアグロケム株式会社 Insecticidal nitro compounds
DK0383091T3 (en) * 1989-02-13 1994-02-07 Bayer Agrochem Kk Insecticidal active nitro compounds
US5204359A (en) * 1989-02-13 1993-04-20 Nihon Bayer Agrochem K.K. Insecticidally active nitro compounds
IL99161A (en) * 1990-08-17 1996-11-14 Takeda Chemical Industries Ltd Guanidine derivatives process for their preparation and pesticidal compositions containing them
EP0501251A3 (en) * 1991-02-27 1993-03-10 Bayer Ag The enantiomer (+)-n-(2-ethoxyphenyl)-n',n'-(1,2,2-trimethylpropyl)-2-nitroethen-1,1-diamine, method for its preparation and its use
JPH0540417U (en) * 1991-11-01 1993-06-01 積水化学工業株式会社 Unit room wall panel connection structure
EP0561237A3 (en) * 1992-03-18 1993-11-24 Bayer Ag Enantiomer, (-)-n-(2-ethoxyphenyl)-n'-(1,2,2-trimethylpropyl)-2-nitromethene-1,1-diamine, process for its preparation and its use
US5328830A (en) * 1992-09-08 1994-07-12 Miles Inc. Potassium channel modulators
EP0622673B1 (en) * 1993-04-24 1998-02-04 Kodak Limited Photographic colour couplers and photographic materials containing them
ES2096518B1 (en) * 1994-03-28 1997-12-01 Grupo Farmaceutico Almirall S NEW RINGS.
CA2331299A1 (en) * 1998-05-11 1999-11-18 Novo Nordisk A/S Substituted guanidines and diaminonitroethenes, their preparation and use
US6147098A (en) * 1998-05-11 2000-11-14 Novo Nordisk A/S Substituted guanidines and diaminonitroethenes, their preparation and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives

Also Published As

Publication number Publication date
PT77231B (en) 1986-02-04
ZA836450B (en) 1984-05-30
FI833075A0 (en) 1983-08-30
DK397383D0 (en) 1983-08-31
GR79627B (en) 1984-10-31
JPH0253430B2 (en) 1990-11-16
IL69598A (en) 1986-10-31
ES525256A0 (en) 1984-05-16
US4567188A (en) 1986-01-28
PT77231A (en) 1983-09-01
FI833075A (en) 1984-03-02
IL69598A0 (en) 1983-11-30
EP0104423A1 (en) 1984-04-04
ES8404850A1 (en) 1984-05-16
JPS5965047A (en) 1984-04-13
DE3363593D1 (en) 1986-06-26
KR840006324A (en) 1984-11-29
ATE19870T1 (en) 1986-06-15
DK397383A (en) 1984-03-02
DE3232462A1 (en) 1984-03-01
EP0104423B1 (en) 1986-05-21

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