AU1314192A - Imidazopyridine - Google Patents

Imidazopyridine

Info

Publication number
AU1314192A
AU1314192A AU13141/92A AU1314192A AU1314192A AU 1314192 A AU1314192 A AU 1314192A AU 13141/92 A AU13141/92 A AU 13141/92A AU 1314192 A AU1314192 A AU 1314192A AU 1314192 A AU1314192 A AU 1314192A
Authority
AU
Australia
Prior art keywords
image
imidazopyridine
aldosteronism
angiotensin
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU13141/92A
Other versions
AU655458B2 (en
Inventor
Norbert Dr. Beier
Ingeborg Dr. Lues
Werner Dr. Mederski
Klaus-Otto Dr. Minck
Pierre Dr. Schelling
Johannes Dr. Sombroek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU1314192A publication Critical patent/AU1314192A/en
Application granted granted Critical
Publication of AU655458B2 publication Critical patent/AU655458B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Novel imidazopyridine derivatives of the formula I <IMAGE> in which R denotes <IMAGE> and R<1> to R<6>, X and Y have the meanings given in Patent Claim 1, and their salts display angiotensin II-antagonistic properties and can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
AU13141/92A 1991-03-27 1992-03-23 Imidazopyridine Ceased AU655458B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4110019 1991-03-27
DE4110019A DE4110019C2 (en) 1991-03-27 1991-03-27 Imidazopyridines, processes for their production and pharmaceutical preparations containing them

Publications (2)

Publication Number Publication Date
AU1314192A true AU1314192A (en) 1992-10-01
AU655458B2 AU655458B2 (en) 1994-12-22

Family

ID=6428299

Family Applications (1)

Application Number Title Priority Date Filing Date
AU13141/92A Ceased AU655458B2 (en) 1991-03-27 1992-03-23 Imidazopyridine

Country Status (16)

Country Link
EP (1) EP0505893B1 (en)
JP (1) JP3382963B2 (en)
KR (1) KR100253772B1 (en)
AT (1) ATE194005T1 (en)
AU (1) AU655458B2 (en)
CA (1) CA2063926C (en)
CZ (1) CZ280591B6 (en)
DE (2) DE4110019C2 (en)
DK (1) DK0505893T3 (en)
ES (1) ES2148156T3 (en)
GR (1) GR3034230T3 (en)
HU (1) HU221010B1 (en)
IE (1) IE920968A1 (en)
MX (1) MX9201317A (en)
PT (1) PT505893E (en)
TW (1) TW213913B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU653281B2 (en) * 1991-12-18 1994-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Imidazopyridines

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4211474A1 (en) * 1992-04-06 1993-10-07 Merck Patent Gmbh imidazopyridines
DE4305602A1 (en) * 1992-06-17 1993-12-23 Merck Patent Gmbh imidazopyridines
DE4225835A1 (en) * 1992-08-05 1994-02-10 Merck Patent Gmbh Process for the preparation of imidazopyridines
DE4236026A1 (en) * 1992-10-24 1994-04-28 Merck Patent Gmbh imidazopyridines
DE4242459A1 (en) * 1992-12-16 1994-06-23 Merck Patent Gmbh imidazopyridines
DE4318813A1 (en) * 1993-06-07 1994-12-08 Merck Patent Gmbh imidazopyridines
DE4333697A1 (en) * 1993-10-02 1995-04-06 Merck Patent Gmbh Process for the preparation of 3-aminopyridines from 3-nitropyridines
DE4339868A1 (en) * 1993-11-23 1995-05-24 Merck Patent Gmbh imidazopyridazines
DE4341453A1 (en) * 1993-12-06 1995-06-08 Merck Patent Gmbh imidazopyridines
DE4432860A1 (en) * 1994-09-15 1996-03-21 Merck Patent Gmbh imidazopyridines
DE19845153A1 (en) 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo [4,5] pyridin-4-one derivatives
SE9903028D0 (en) 1999-08-27 1999-08-27 Astra Ab New use
KR20050122220A (en) 2003-03-25 2005-12-28 다케다 샌디에고, 인코포레이티드 Dipeptidyl peptidase inhibitors
CN1867560A (en) 2003-08-13 2006-11-22 武田药品工株式会社 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
JP2007505121A (en) 2003-09-08 2007-03-08 武田薬品工業株式会社 Dipeptidyl peptidase inhibitor
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN102134231B (en) 2004-03-15 2020-08-04 武田药品工业株式会社 Dipeptidyl peptidase inhibitors
JP2008501714A (en) 2004-06-04 2008-01-24 武田薬品工業株式会社 Dipeptidyl peptidase inhibitor
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
JP2008524331A (en) 2004-12-21 2008-07-10 武田薬品工業株式会社 Dipeptidyl peptidase inhibitor
EA015169B1 (en) 2005-09-14 2011-06-30 Такеда Фармасьютикал Компани Лимитед Use of dipeptidyl peptidase inhibitors
CA2622642C (en) 2005-09-16 2013-12-31 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101772513B (en) 2007-06-04 2013-11-13 协同医药品公司 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2009143477A1 (en) * 2008-05-22 2009-11-26 Amgen Inc. Heterocycles as protein kinase inhibitors
ES2522968T3 (en) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (en) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
JP2016514671A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists and uses thereof
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
AR108906A1 (en) 2016-06-29 2018-10-10 Bristol Myers Squibb Co BIARILMETILE HETEROCICLES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
EP0424317A3 (en) * 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
JPH04235974A (en) * 1990-06-08 1992-08-25 Roussel Uclaf New benzimidazole derivatives, process for producing same, obtained new intermediates, use thereof as medicines and pharmaceutical compositions containing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU653281B2 (en) * 1991-12-18 1994-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Imidazopyridines

Also Published As

Publication number Publication date
HU221010B1 (en) 2002-07-29
AU655458B2 (en) 1994-12-22
HU9200932D0 (en) 1992-05-28
DK0505893T3 (en) 2000-10-02
KR920018049A (en) 1992-10-21
IE920968A1 (en) 1992-11-18
ES2148156T3 (en) 2000-10-16
HUT63165A (en) 1993-07-28
TW213913B (en) 1993-10-01
GR3034230T3 (en) 2000-12-29
CZ78292A3 (en) 1993-04-14
DE4110019C2 (en) 2000-04-13
KR100253772B1 (en) 2000-09-01
CA2063926A1 (en) 1992-09-28
CA2063926C (en) 2002-10-01
EP0505893A1 (en) 1992-09-30
PT505893E (en) 2000-12-29
DE4110019A1 (en) 1992-10-01
JP3382963B2 (en) 2003-03-04
CZ280591B6 (en) 1996-02-14
MX9201317A (en) 1992-10-01
JPH05125077A (en) 1993-05-21
EP0505893B1 (en) 2000-06-21
DE59209843D1 (en) 2000-07-27
ATE194005T1 (en) 2000-07-15

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