AU1054500A - N-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives, their preparation and their use as selective mglur1 antagonists - Google Patents

N-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives, their preparation and their use as selective mglur1 antagonists

Info

Publication number
AU1054500A
AU1054500A AU10545/00A AU1054500A AU1054500A AU 1054500 A AU1054500 A AU 1054500A AU 10545/00 A AU10545/00 A AU 10545/00A AU 1054500 A AU1054500 A AU 1054500A AU 1054500 A AU1054500 A AU 1054500A
Authority
AU
Australia
Prior art keywords
dihydro
substituted
preparation
oxazine derivatives
mglur1 antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU10545/00A
Inventor
Barry Peter Clark
John Richard Harris
Ann Elizabeth Kingston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co Ltd
Original Assignee
Eli Lilly and Co Ltd
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co Ltd, Eli Lilly and Co filed Critical Eli Lilly and Co Ltd
Publication of AU1054500A publication Critical patent/AU1054500A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU10545/00A 1998-11-02 1999-11-01 N-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives, their preparation and their use as selective mglur1 antagonists Abandoned AU1054500A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9823847 1998-11-02
GBGB9823847.0A GB9823847D0 (en) 1998-11-02 1998-11-02 Pharmaceutical compounds
PCT/GB1999/003586 WO2000026198A1 (en) 1998-11-02 1999-11-01 N-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives, their preparation and their use as selective mglur1 antagonists

Publications (1)

Publication Number Publication Date
AU1054500A true AU1054500A (en) 2000-05-22

Family

ID=10841621

Family Applications (1)

Application Number Title Priority Date Filing Date
AU10545/00A Abandoned AU1054500A (en) 1998-11-02 1999-11-01 N-substituted (3,6-dihydro)-2h-1,2-oxazine derivatives, their preparation and their use as selective mglur1 antagonists

Country Status (3)

Country Link
AU (1) AU1054500A (en)
GB (1) GB9823847D0 (en)
WO (1) WO2000026198A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069816A1 (en) * 1999-05-17 2000-11-23 Eli Lilly And Company Metabotropic glutamate receptor antagonists
JP4077319B2 (en) 2000-12-22 2008-04-16 エフ．ホフマン−ラ ロシュ アーゲー Tetrahydro- (benzo or thieno) -azepine-pyrazine and triazine derivatives as mGluR1 antagonists
SE0303488D0 (en) * 2003-12-19 2003-12-19 Astrazeneca Ab New use 1X
SE0303489D0 (en) * 2003-12-19 2003-12-19 Astrazeneca Ab New use VII
WO2008066750A1 (en) 2006-11-22 2008-06-05 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism
US20130058915A1 (en) 2010-03-02 2013-03-07 Children's Medica Center Corporation Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110294879A1 (en) 2010-05-28 2011-12-01 Xenoport, Inc. Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders
US20120016021A1 (en) 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
WO2012054724A1 (en) 2010-10-21 2012-04-26 Massachusetts Institute Of Technology Methods of treating seizure disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1191379B (en) * 1963-02-19 1965-04-22 Esso A G Process for the preparation of N-substituted 3, 6-dihydro-1, 2-oxazines
FR1564792A (en) * 1968-03-04 1969-04-25
JPH01221371A (en) * 1988-02-29 1989-09-04 Hokko Chem Ind Co Ltd Production of cyclic oxyamine derivative
JPH01221372A (en) * 1988-03-01 1989-09-04 Hokko Chem Ind Co Ltd Cyclic acylhydroxylamine derivative
JPH02229175A (en) * 1989-03-02 1990-09-11 Hokko Chem Ind Co Ltd Cyclic acylhydroxylamine derivative and production thereof
CN1158264C (en) * 1997-11-21 2004-07-21 Nps药物有限公司 Metabotropic glutamate receptor antagonists for treating central nervous system disease

Also Published As

Publication number Publication date
WO2000026198A1 (en) 2000-05-11
GB9823847D0 (en) 1998-12-23

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase