ATE972T1 - PROCESS FOR THE PRODUCTION OF A MACROPOROUS POLYMERIC SUPPORT MATERIAL FOR THE COVALENT BINDING OF PROTEINS. - Google Patents

PROCESS FOR THE PRODUCTION OF A MACROPOROUS POLYMERIC SUPPORT MATERIAL FOR THE COVALENT BINDING OF PROTEINS.

Info

Publication number
ATE972T1
ATE972T1 AT79102809T AT79102809T ATE972T1 AT E972 T1 ATE972 T1 AT E972T1 AT 79102809 T AT79102809 T AT 79102809T AT 79102809 T AT79102809 T AT 79102809T AT E972 T1 ATE972 T1 AT E972T1
Authority
AT
Austria
Prior art keywords
groups
sulfonic acid
proteins
binding
omega
Prior art date
Application number
AT79102809T
Other languages
German (de)
Inventor
Chung-Ji Dr. Dipl.-Chem. Tschang
Heinrich Dr. Dipl.-Chem. Klefenz
Axel Dr. Dipl.-Chem. Sanner
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Application granted granted Critical
Publication of ATE972T1 publication Critical patent/ATE972T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

A macroporous crosslinked styrene resin, used as a carrier for covalently binding proteins, which resin contains isocyanate, thioisocyanate or aldehyde groups as protein-binding groups and may or may not contain sulfonic acid groups-which may also be in the form of the sodium salt or of sulfonic acid amide groups-as hydrophilic groups. The carrier according to the invention is prepared from a sulfochlorinated macroporous crosslinked styrene resin by reacting the sulfonic acid chloride groups with an alpha , omega -diamino compound, with hydrazine or with an alpha , omega -diamino-diether, converting any sulfonic acid chloride groups which may still be present to free sulfonic acid groups, their sodium salt or a sulfonamide group, and then reacting the terminal amino groups with phosgene, thiophosgene or a diisocyanate in order to produce the binding groups, which in turn fix a biologically active protein by covalent bonds.
AT79102809T 1978-08-07 1979-08-04 PROCESS FOR THE PRODUCTION OF A MACROPOROUS POLYMERIC SUPPORT MATERIAL FOR THE COVALENT BINDING OF PROTEINS. ATE972T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782834539 DE2834539A1 (en) 1978-08-07 1978-08-07 MACROPOROUS POLYMERS AS CARRIER MATERIAL FOR THE COVALENT BINDING OF PROTEINS
EP79102809A EP0008100B1 (en) 1978-08-07 1979-08-04 Process for the production of macroporous polymeric support material for the covalent binding of proteins

Publications (1)

Publication Number Publication Date
ATE972T1 true ATE972T1 (en) 1982-05-15

Family

ID=6046405

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79102809T ATE972T1 (en) 1978-08-07 1979-08-04 PROCESS FOR THE PRODUCTION OF A MACROPOROUS POLYMERIC SUPPORT MATERIAL FOR THE COVALENT BINDING OF PROTEINS.

Country Status (5)

Country Link
US (2) US4235973A (en)
EP (1) EP0008100B1 (en)
JP (1) JPS5525485A (en)
AT (1) ATE972T1 (en)
DE (2) DE2834539A1 (en)

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US4425460A (en) * 1981-05-15 1984-01-10 Exxon Research And Engineering Co. Amine terminated polyalkylene oxide neutralized sulfonated thermoplastic polymers
DE3138194A1 (en) * 1981-09-25 1983-04-14 Basf Ag, 6700 Ludwigshafen WATER-INSOLUBLE POROESES PROTEIN MATERIAL, THEIR PRODUCTION AND USE
DE3223885A1 (en) * 1982-06-26 1983-12-29 Basf Ag, 6700 Ludwigshafen MACROPOROISE, HYDROPHILE CARRIER FOR ENZYME
US4714676A (en) * 1982-09-16 1987-12-22 Owens-Illinois Glass Container Inc. Protein modification to provide enzyme activity
US4525456A (en) * 1982-11-08 1985-06-25 Uop Inc. Support matrix and immobilized enzyme system
DE3248331A1 (en) * 1982-12-28 1984-06-28 Bayer Ag, 5090 Leverkusen SO (DOWN ARROW) 3 (DOWN ARROW) / IMID ADDUCTS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS SULFONING AGENT
IT1173459B (en) * 1984-03-22 1987-06-24 Sirac Spa STABLE BORONIC RESINS WITH HIGH SELECTIVE ABSORBING POWER
DE3435156A1 (en) * 1984-09-25 1986-04-03 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR PRODUCING THE STEREOISOMERS OF 1-AMINO-ALKYLPHOSPHONIC ACIDS OR 1-AMINOALKYLPHOSPHINIC ACIDS
NZ213819A (en) * 1984-10-31 1988-05-30 Kanegafuchi Chemical Ind Lipoprotein adsorbent using hydroxy-containing polymer gel
US4548955A (en) * 1985-02-25 1985-10-22 Sogo Pharmaceutical Company Limited Nylon capsule responding to pH
US4716181A (en) * 1986-07-21 1987-12-29 Hercules Incorporated Scavengers for the removal of impurities from arsine and phosphine
US4696953A (en) * 1986-07-21 1987-09-29 Hercules Incorporated Scavengers for the removal of impurities from arsine and phosphine
ATE175681T1 (en) * 1988-10-17 1999-01-15 Hemasure Inc METHOD FOR THE COVALENT SURFACE MODIFICATION OF HYDROPHOBIC POLYMERS AND PRODUCTS THEREOF
AT397723B (en) * 1989-08-21 1994-06-27 Epipharm Allergie Service METHOD FOR PRODUCING RADIO-CONJUGATED POLYMERS AND USE THEREOF
US5468622A (en) * 1990-04-03 1995-11-21 Immunomatrix, Inc. Salt stabilization of antibody-enzyme conjugates heat-dried into paper
US5403750A (en) * 1991-03-06 1995-04-04 W. R. Grace & Co.-Conn. Biocompatible, low protein adsorption affinity matrix
AT396789B (en) * 1991-07-02 1993-11-25 Hermann W D Dipl Ing Katinger THERMALLY STERILIZABLE POROUS SUPPORT BODY FOR BIOCATALYSTS
US6096530A (en) * 1992-04-22 2000-08-01 Canon Kabushiki Kaisha Pseudomonas cepacia strain isolated from termite intestines that degrades trichlorethylene and furan compounds
US5518890A (en) * 1992-11-20 1996-05-21 Mccormick & Company, Inc. Method and apparatus for the quantitation and separation of contaminants from particulate materials
EP0646642A3 (en) * 1993-09-30 1995-08-16 Canon Kk Microorganism-holding carrier and method for remediation of soil employing the carrier.
GB9716454D0 (en) * 1997-08-05 1997-10-08 Univ St Andrews Polymer
GB9717173D0 (en) 1997-08-13 1997-10-22 Akzo Nobel Nv Solid phase supports
US7462366B2 (en) * 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7053134B2 (en) * 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
CA2492339A1 (en) * 2002-06-12 2003-12-24 Boston Scientific Limited Bulking agents
US7449236B2 (en) * 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7976823B2 (en) * 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7901770B2 (en) * 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7736671B2 (en) * 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) * 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
GB0425102D0 (en) * 2004-11-15 2004-12-15 Ciba Spec Chem Water Treat Ltd Polymeric compositions and methods of employing them in papermaking processes
US8425550B2 (en) * 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7501179B2 (en) * 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US8414927B2 (en) * 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
ES2340131B1 (en) * 2008-11-27 2011-03-16 Consejo Superior De Investigaciones Cientificas (Csic) (80%) PREPARATION OF FUNCTIONALIZED SURFACES OF POLYSTYRENE SUBSTRATES.

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US3326866A (en) * 1963-06-10 1967-06-20 Mobil Oil Corp Sulfonated resin catalyst with enhanced activity
US3458976A (en) * 1967-10-30 1969-08-05 Dow Chemical Co Article of manufacture for making chromatographic separations
CH453269A4 (en) 1968-03-29 1973-01-31
AU439765B2 (en) * 1968-07-19 1973-08-23 THE CANCER INSTITUTE and GORDON ALFRED SARFATY Graft copolymers
DE2440254A1 (en) * 1973-08-27 1975-03-06 Pentapharm Ag INSOLUBLE ENZYME PREPARATION AND METHOD FOR MANUFACTURING IT
DE2621974A1 (en) 1976-05-18 1977-11-24 Max Planck Gesellschaft PROCESS FOR PRODUCING A COVALENT BOND WITH BIOLOGICALLY ACTIVE MATERIALS
US4217421A (en) * 1977-06-27 1980-08-12 Rohm And Haas Company Anion exchange resins prepared from crosslinked polystyrenesulfonylchloride

Also Published As

Publication number Publication date
DE2834539A1 (en) 1980-02-21
US4266030A (en) 1981-05-05
DE2962699D1 (en) 1982-06-24
JPS5525485A (en) 1980-02-23
US4235973A (en) 1980-11-25
EP0008100B1 (en) 1982-05-05
EP0008100A1 (en) 1980-02-20

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