ATE969T1 - AMINOGLYCOSIDES DERIVED FROM DESOXYSTREPTAMINE AND THEIR SALTS, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. - Google Patents

AMINOGLYCOSIDES DERIVED FROM DESOXYSTREPTAMINE AND THEIR SALTS, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Info

Publication number
ATE969T1
ATE969T1 AT79400541T AT79400541T ATE969T1 AT E969 T1 ATE969 T1 AT E969T1 AT 79400541 T AT79400541 T AT 79400541T AT 79400541 T AT79400541 T AT 79400541T AT E969 T1 ATE969 T1 AT E969T1
Authority
AT
Austria
Prior art keywords
preparation
salts
desoxystreptamine
processes
pharmaceutical compositions
Prior art date
Application number
AT79400541T
Other languages
German (de)
Inventor
Jean-Claude Gasc
Claude Rettien
Original Assignee
Roussel-Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel-Uclaf filed Critical Roussel-Uclaf
Application granted granted Critical
Publication of ATE969T1 publication Critical patent/ATE969T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Novel aminoglycoside derivatives of desoxystreptamines of the formula <IMAGE> I wherein R1 and R2 are selected from the group consisting of hydrogen and hydroxyl with at least one of them being hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties and their preparation.
AT79400541T 1978-09-06 1979-07-31 AMINOGLYCOSIDES DERIVED FROM DESOXYSTREPTAMINE AND THEIR SALTS, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. ATE969T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7825604A FR2435481A1 (en) 1978-09-06 1978-09-06 NOVEL AMINOGLYCOSIDES DERIVED FROM DESOXYSTREPTAMINE AND SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND APPLICATION AS MEDICAMENTS
EP79400541A EP0008965B1 (en) 1978-09-06 1979-07-31 Aminoglycosides derived from desoxystreptamin and their salts, their method of preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE969T1 true ATE969T1 (en) 1982-05-15

Family

ID=9212381

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79400541T ATE969T1 (en) 1978-09-06 1979-07-31 AMINOGLYCOSIDES DERIVED FROM DESOXYSTREPTAMINE AND THEIR SALTS, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Country Status (11)

Country Link
US (1) US4242331A (en)
EP (1) EP0008965B1 (en)
JP (1) JPS5538378A (en)
AT (1) ATE969T1 (en)
AU (1) AU524737B2 (en)
CA (1) CA1133476A (en)
DE (1) DE2962697D1 (en)
FR (1) FR2435481A1 (en)
HU (1) HU180288B (en)
IE (1) IE49299B1 (en)
ZA (1) ZA794155B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1001869A3 (en) * 1988-10-12 1990-04-03 Franz Legros METHOD OF PACKAGING liposomal AMINOGLUCOSIDIQUES ANTIBIOTICS IN PARTICULAR THE GENTAMYCIN.
US5442047A (en) * 1991-12-04 1995-08-15 Schering Corporation Process for preparing isepamicin
IT1237490B (en) * 1989-09-22 1993-06-07 Chementecno S R L Monza Milano PROCEDURE FOR THE SYNTHESIS OF 1 N (S DELTA AMINO ALFA IDROSSIBUTIRRIL) KAMANYCIN A BASED ON THE TREATMENT OF 1 N (S DELTA BENZYOXYCARBONLAMINE ALPHA HYDROXYBUTYRRIL) 3.6 'OF N BENZYLSYCARBONYLKANAMYCIN A WITH FORMIC ACID
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001208A (en) * 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
CA1046512A (en) * 1974-03-19 1979-01-16 Peter J.L. Daniels Derivatives of diaminocyclitols and method for their preparation
FR2290908A1 (en) * 1974-11-13 1976-06-11 Roussel Uclaf NEW AMINOGLYCOSIDIC DERIVATIVE AND ITS SALTS, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2318648A1 (en) * 1975-07-23 1977-02-18 Roussel Uclaf NEW DERIVATIVE OF DESOXYSTREPTAMINE AND SALTS, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2358156A1 (en) * 1976-03-31 1978-02-10 Roussel Uclaf Antibacterial 2-desoxy-streptamine derivs. - prepd. from methyl-4,6-benzylidene-3-ethoxy:carbonylamino 3-desoxy-gluco:pyranoside
US4146617A (en) * 1976-07-15 1979-03-27 Roussel Uclaf Desoxystreptamine derivatives, salts, pharmaceutical compositions and method of use

Also Published As

Publication number Publication date
AU524737B2 (en) 1982-09-30
EP0008965B1 (en) 1982-05-05
JPS5538378A (en) 1980-03-17
FR2435481B1 (en) 1981-07-24
JPS6340196B2 (en) 1988-08-10
US4242331A (en) 1980-12-30
EP0008965A3 (en) 1980-04-02
CA1133476A (en) 1982-10-12
IE791693L (en) 1980-03-06
DE2962697D1 (en) 1982-06-24
EP0008965A2 (en) 1980-03-19
ZA794155B (en) 1980-08-27
IE49299B1 (en) 1985-09-18
FR2435481A1 (en) 1980-04-04
AU5058479A (en) 1980-03-13
HU180288B (en) 1983-02-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EETV Partially withdrawn
REN Ceased due to non-payment of the annual fee