ATE94404T1 - Insulinzubereitung. - Google Patents
Insulinzubereitung.Info
- Publication number
- ATE94404T1 ATE94404T1 AT89112310T AT89112310T ATE94404T1 AT E94404 T1 ATE94404 T1 AT E94404T1 AT 89112310 T AT89112310 T AT 89112310T AT 89112310 T AT89112310 T AT 89112310T AT E94404 T1 ATE94404 T1 AT E94404T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin preparation
- insulin
- bloodstream
- bioavailability
- absorption
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- -1 polyoxyethylene Polymers 0.000 abstract 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physiology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22268288A | 1988-07-21 | 1988-07-21 | |
| EP89112310A EP0351651B1 (de) | 1988-07-21 | 1989-07-06 | Insulinzubereitung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE94404T1 true ATE94404T1 (de) | 1993-10-15 |
Family
ID=22833245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89112310T ATE94404T1 (de) | 1988-07-21 | 1989-07-06 | Insulinzubereitung. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0351651B1 (de) |
| JP (1) | JPH0273021A (de) |
| AT (1) | ATE94404T1 (de) |
| DE (1) | DE68909135T2 (de) |
| ES (1) | ES2045276T3 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0414080B1 (de) * | 1989-08-21 | 1994-02-16 | F. Hoffmann-La Roche Ag | Insulinzubereitung für nicht-parenterale Verabreichung |
| IL99699A (en) * | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| EP0533938A4 (en) * | 1991-02-19 | 1993-06-16 | Tsumura & Co. | Composition for rectal administration of difficultly absorbable peptide |
| AU5095393A (en) * | 1992-10-02 | 1994-04-26 | Pfizer Inc. | Pharmaceutical compositions containing nonionic surfactants |
| GB9516268D0 (en) | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
| WO2000033866A1 (en) * | 1998-12-04 | 2000-06-15 | Provalis Uk Limited | Pharmaceutical compositions containing insulin |
| AU2003215885B2 (en) * | 2002-02-25 | 2008-07-03 | Lyfjathroun Hf | Absorption enhancing agent |
| US6855332B2 (en) | 2002-07-03 | 2005-02-15 | Lyfjathroun Hf. | Absorption promoting agent |
| NZ588603A (en) | 2008-03-26 | 2012-03-30 | Oramed Ltd | Methods and compositions for oral administration of a protein of up to 100000 Daltaons, a first protease inhibitor and a second protease inhibitor wherein said protease inhibitors inhibit trypsin |
| EP3275460A1 (de) | 2008-05-05 | 2018-01-31 | Oramed Ltd. | Verfahren und zusammensetzungen zur oralen verabreichung von exenatid |
| HUP0900482A2 (en) | 2009-08-03 | 2011-03-28 | Cera Med Kft | Pharmaceutical formulation for oral administration |
| JP6174601B2 (ja) | 2012-01-03 | 2017-08-02 | オラムド エルティーディー． | 糖尿病を処置するための方法及び組成物 |
| DK2814504T3 (da) | 2012-02-01 | 2022-05-02 | Oramed Ltd | Protease inhibitor indeholdende sammensætninger, sammensætninger omfattende samme og metoder til fremstilling og brug af samme |
| CN110151979A (zh) | 2013-01-03 | 2019-08-23 | 奥拉姆德有限公司 | 用于治疗nafld、肝性脂肪变性及其后遗症的方法和组合物 |
| LT3471702T (lt) | 2016-06-20 | 2022-03-10 | Capretto Ehf. | Stabilios antimikrobinių lipidų kompozicijos |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1554157A (en) * | 1975-06-13 | 1979-10-17 | Takeda Chemical Industries Ltd | Stable insulin preparation for intra nasal administration |
| IL77186A0 (en) * | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
-
1989
- 1989-07-06 AT AT89112310T patent/ATE94404T1/de not_active IP Right Cessation
- 1989-07-06 ES ES89112310T patent/ES2045276T3/es not_active Expired - Lifetime
- 1989-07-06 EP EP89112310A patent/EP0351651B1/de not_active Expired - Lifetime
- 1989-07-06 DE DE89112310T patent/DE68909135T2/de not_active Expired - Fee Related
- 1989-07-19 JP JP1184851A patent/JPH0273021A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE68909135D1 (de) | 1993-10-21 |
| EP0351651A2 (de) | 1990-01-24 |
| ES2045276T3 (es) | 1994-01-16 |
| EP0351651A3 (en) | 1990-10-10 |
| DE68909135T2 (de) | 1994-04-07 |
| JPH0273021A (ja) | 1990-03-13 |
| EP0351651B1 (de) | 1993-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE94404T1 (de) | Insulinzubereitung. | |
| EP0462776A3 (en) | Preparation of optically active aliphatic carboxylic acids | |
| DE60000133D1 (de) | Essentielle fettsäuren zur vorbeugung von kardiovaskulären anfällen | |
| SE8803141D0 (sv) | Neringsmedel for menniskor och djur | |
| DE3875425D1 (de) | Vasokinetisch wirkende polyungesaettigte saeuren und sie enthaltende pharmazeutische oder kosmetische zubereitungen. | |
| AU7589587A (en) | Low dosage of interferon to enhance vaccine efficiency | |
| NZ250583A (en) | Pharmaceutical, nutritional, or skin care compositions containing an ester of a cholesterol and fatty acid | |
| EP0295331A3 (en) | Use of vitamin e for normalizing the blood coagulation in the therapy with omega-3-type highly unsaturated fatty acids | |
| FR2548021B1 (fr) | Compositions pharmaceutiques dermiques a action prolongee et continue a base d'acides gras essentiels | |
| EP0302349A3 (en) | Biologically active carboxylic acid esters | |
| NO894465D0 (no) | Preparat med oekt penetrasjon gjennom huden. | |
| FR2623806B1 (fr) | Esters d'acides 3,6-dihydro-1,5(2h)-pyrimidinecarboxyliques a action therapeutique | |
| ES2026304A6 (es) | Procedimiento de fabricacion de una forma de dosificacion de nicardipina. | |
| GR3004253T3 (de) | ||
| ATE116849T1 (de) | Pharmazeutische verwendung von fettsäuren. | |
| FI881959L (fi) | Karboksyylihappoestereiden pelkistys | |
| GB2194944B (en) | Preparation of unsaturated carboxylic acid esters | |
| NO885221D0 (no) | Estere av farmakologisk aktive karboksylsyrer. | |
| HUT51105A (en) | Pesticide comprising substituted acrylic acid ester derivatives as active ingredient and process for producing the active ingredients | |
| GB8722743D0 (en) | Preparation of esters of carboxylic acids | |
| ATE62594T1 (de) | Pharmazeutische oder kosmetische zusammensetzung mit gehalt an hydrochinon und kojisaeure in liposomen. | |
| IL89902A0 (en) | Preparation of 5-chloro-3-chlorosulphonyl-2 thiophene-carboxylic acid esters | |
| AU8284387A (en) | Synthesis of 1,1,2,2-tetrahydroperfluoroalkanols and their esters | |
| FI840681A7 (fi) | Optisesti aktiivisten alfa- substituoitujen karboksyylihappoestereitten ja -happojen valmistaminen | |
| TR24025A (tr) | Suelfidik olmayan cevherlerin flatasyonunda toplayici olarak sinir yuezey aktiviteli yag asidi esterleri tuerevleri ve / veya yag asidi tuerevleri |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |