ATE94404T1 - Insulinzubereitung. - Google Patents

Insulinzubereitung.

Info

Publication number
ATE94404T1
ATE94404T1 AT89112310T AT89112310T ATE94404T1 AT E94404 T1 ATE94404 T1 AT E94404T1 AT 89112310 T AT89112310 T AT 89112310T AT 89112310 T AT89112310 T AT 89112310T AT E94404 T1 ATE94404 T1 AT E94404T1
Authority
AT
Austria
Prior art keywords
insulin preparation
insulin
bloodstream
bioavailability
absorption
Prior art date
Application number
AT89112310T
Other languages
English (en)
Inventor
Leroy Arthur Campfield
Alberto Davidovich
Martin Howard Infeld
Navnit Shah
Francoise Jeanne Smith
Joel Unowsky
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE94404T1 publication Critical patent/ATE94404T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT89112310T 1988-07-21 1989-07-06 Insulinzubereitung. ATE94404T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22268288A 1988-07-21 1988-07-21
EP89112310A EP0351651B1 (de) 1988-07-21 1989-07-06 Insulinzubereitung

Publications (1)

Publication Number Publication Date
ATE94404T1 true ATE94404T1 (de) 1993-10-15

Family

ID=22833245

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89112310T ATE94404T1 (de) 1988-07-21 1989-07-06 Insulinzubereitung.

Country Status (5)

Country Link
EP (1) EP0351651B1 (de)
JP (1) JPH0273021A (de)
AT (1) ATE94404T1 (de)
DE (1) DE68909135T2 (de)
ES (1) ES2045276T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69006662T2 (de) * 1989-08-21 1994-05-26 Hoffmann La Roche Insulinzubereitung für nicht-parenterale Verabreichung.
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
WO1992014479A1 (fr) * 1991-02-19 1992-09-03 Tsumura & Co. Composition pour administration par voie rectale de peptides difficiles a absorber
CA2145763A1 (en) * 1992-10-02 1994-04-14 William J. Curatolo Pharmaceutical compositions containing nonionic surfactants
GB9516268D0 (en) 1995-08-08 1995-10-11 Danbiosyst Uk Compositiion for enhanced uptake of polar drugs from the colon
WO2000033866A1 (en) * 1998-12-04 2000-06-15 Provalis Uk Limited Pharmaceutical compositions containing insulin
BR0307913A (pt) * 2002-02-25 2005-01-11 Lyfjathroun Hf Uso de uma composição, composição farmacêutica para administração nasal, e, métodos para eliciar um efeito terapêutico, profilático e/ou diagnóstico em um mamìfero, para obter um inìcio rápido de um efeito terapêutico, profilático e/ou diagnóstico de uma substância ativa em um mamìfero e para melhorar a biodisponibilidade de um efeito terapêutico, profilático e/ou diagnóstico de uma substância ativa em um mamìfero
US6855332B2 (en) 2002-07-03 2005-02-15 Lyfjathroun Hf. Absorption promoting agent
NZ588603A (en) 2008-03-26 2012-03-30 Oramed Ltd Methods and compositions for oral administration of a protein of up to 100000 Daltaons, a first protease inhibitor and a second protease inhibitor wherein said protease inhibitors inhibit trypsin
CN105903005A (zh) 2008-05-05 2016-08-31 奥拉姆德有限公司 用于口服给予艾塞那肽的方法和组合物
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
US10398762B2 (en) * 2012-01-03 2019-09-03 Oramed Ltd. Methods and compositions for treating diabetes
JP6567827B2 (ja) 2012-02-01 2019-08-28 オラムド エルティーディー． プロテアーゼ阻害剤を含有する組成物、該組成物を含む組成物、および、該組成物を製造および使用する方法
CN104902921A (zh) 2013-01-03 2015-09-09 奥拉姆德有限公司 用于治疗nafld、肝性脂肪变性及其后遗症的方法和组合物
PT3471702T (pt) 2016-06-20 2022-03-17 Capretto Ehf Formulação termoestável de substâncias biologicamente ativas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1554157A (en) * 1975-06-13 1979-10-17 Takeda Chemical Industries Ltd Stable insulin preparation for intra nasal administration
IL77186A0 (en) * 1985-11-29 1986-04-29 Touitou Elka Pharmaceutical insulin composition

Also Published As

Publication number Publication date
EP0351651A2 (de) 1990-01-24
EP0351651A3 (en) 1990-10-10
DE68909135D1 (de) 1993-10-21
ES2045276T3 (es) 1994-01-16
EP0351651B1 (de) 1993-09-15
DE68909135T2 (de) 1994-04-07
JPH0273021A (ja) 1990-03-13

Similar Documents

Publication Publication Date Title
ATE94404T1 (de) Insulinzubereitung.
EP0462776A3 (en) Preparation of optically active aliphatic carboxylic acids
DE60000133D1 (de) Essentielle fettsäuren zur vorbeugung von kardiovaskulären anfällen
SE8803141D0 (sv) Neringsmedel for menniskor och djur
DE3875425D1 (de) Vasokinetisch wirkende polyungesaettigte saeuren und sie enthaltende pharmazeutische oder kosmetische zubereitungen.
AU7589587A (en) Low dosage of interferon to enhance vaccine efficiency
NZ250583A (en) Pharmaceutical, nutritional, or skin care compositions containing an ester of a cholesterol and fatty acid
EP0295331A3 (en) Use of vitamin e for normalizing the blood coagulation in the therapy with omega-3-type highly unsaturated fatty acids
FR2548021B1 (fr) Compositions pharmaceutiques dermiques a action prolongee et continue a base d'acides gras essentiels
EP0302349A3 (en) Biologically active carboxylic acid esters
NO894465D0 (no) Preparat med oekt penetrasjon gjennom huden.
IL92545A0 (en) Preparation of 2-chloropyridine-3-carboxylic acid esters
FR2623806B1 (fr) Esters d'acides 3,6-dihydro-1,5(2h)-pyrimidinecarboxyliques a action therapeutique
FI896321A7 (fi) Aktiiviainetta sisältävät mikrorakeet, jotka koostuvat pääasiassa kyllästettyjen rasvahappojen triglyseridistä, ja niiden käyttö paikallisesti sairaanhoitoalalla
ES2026304A6 (es) Procedimiento de fabricacion de una forma de dosificacion de nicardipina.
GR3004253T3 (de)
DE69015910D1 (de) Pharmazeutische Verwendung von Fettsäuren.
FI881959L (fi) Karboksyylihappoestereiden pelkistys
GB2194944B (en) Preparation of unsaturated carboxylic acid esters
HUT51105A (en) Pesticide comprising substituted acrylic acid ester derivatives as active ingredient and process for producing the active ingredients
GB8722743D0 (en) Preparation of esters of carboxylic acids
ATE62594T1 (de) Pharmazeutische oder kosmetische zusammensetzung mit gehalt an hydrochinon und kojisaeure in liposomen.
FI875685A0 (fi) Foerfarande foer framstaellning av 1,1,2,2-tetrahydroperfluoralkanoler och estrar daerav.
FI840681A7 (fi) Optisesti aktiivisten alfa- substituoitujen karboksyylihappoestereitten ja -happojen valmistaminen
TR24025A (tr) Suelfidik olmayan cevherlerin flatasyonunda toplayici olarak sinir yuezey aktiviteli yag asidi esterleri tuerevleri ve / veya yag asidi tuerevleri

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee