ATE93518T1 - ENANTIOMERIC DERIVATIVES OF AMINO ACID, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE. - Google Patents
ENANTIOMERIC DERIVATIVES OF AMINO ACID, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE.Info
- Publication number
- ATE93518T1 ATE93518T1 AT88402944T AT88402944T ATE93518T1 AT E93518 T1 ATE93518 T1 AT E93518T1 AT 88402944 T AT88402944 T AT 88402944T AT 88402944 T AT88402944 T AT 88402944T AT E93518 T1 ATE93518 T1 AT E93518T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- preparation
- therapeutic use
- enantiomeric derivatives
- enantiomeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8716239A FR2623498B1 (en) | 1987-11-24 | 1987-11-24 | NOVEL ENANTIOMERIC COMPOUNDS DERIVED FROM AMINO ACIDS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS |
EP88402944A EP0318377B1 (en) | 1987-11-24 | 1988-11-24 | Enantiomeric derivatives of amino acids, process for their preparation and their pharmaceutical applications |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE93518T1 true ATE93518T1 (en) | 1993-09-15 |
Family
ID=9357085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88402944T ATE93518T1 (en) | 1987-11-24 | 1988-11-24 | ENANTIOMERIC DERIVATIVES OF AMINO ACID, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
Country Status (7)
Country | Link |
---|---|
US (3) | US5208255A (en) |
EP (1) | EP0318377B1 (en) |
JP (2) | JP2529172B2 (en) |
AT (1) | ATE93518T1 (en) |
DE (1) | DE3883495T2 (en) |
ES (1) | ES2059554T3 (en) |
FR (1) | FR2623498B1 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2623498B1 (en) * | 1987-11-24 | 1990-04-06 | Bioprojet Soc Civ | NOVEL ENANTIOMERIC COMPOUNDS DERIVED FROM AMINO ACIDS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS |
US5223516A (en) * | 1990-03-22 | 1993-06-29 | E. R. Squibb & Sons, Inc. | 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same |
FR2673105B1 (en) * | 1991-02-26 | 1995-01-13 | Bioprojet Soc Civ | NOVEL PHARMACEUTICAL COMPOSITIONS, ESPECIALLY FOR THE TREATMENT OF FUNCTIONAL COLOPATHIES, AND METHODS OF PREPARING COMPOSITIONS AND MEDICAMENTS, ESPECIALLY FOR THE TREATMENT OF THESE CONDITIONS. |
FI922867A (en) * | 1991-06-21 | 1992-12-22 | Tanabe Seiyaku Co | DICARBONY FOR DIFFERENTIAL FARMS FOR FRAMSTAELLNING AV DEM |
FR2684553B1 (en) * | 1991-12-10 | 1995-04-07 | Bioprojet Soc Civ | NEW MEDICINES FOR THE TREATMENT OF ARTERIAL HYPERTENSION, CHRONIC HEART FAILURE, RENAL FAILURE AND, IN GENERAL, CONDITIONS CAUSING HYDROSODED RETENTION. |
JPH06199850A (en) * | 1992-12-28 | 1994-07-19 | Tanabe Seiyaku Co Ltd | Indole-containing peptide and its production |
US5760241A (en) * | 1995-12-28 | 1998-06-02 | Zambon Group S.P.A. | Thiol derivatives with metallopeptidase inhibitory activity |
FR2744446B1 (en) * | 1996-02-05 | 1998-04-17 | Bioprojet Soc Civ | ASYMMETRICAL SYNTHESIS OF S-ACYL DERIVATIVES OF 2-MERCAPTOMETHYL 3-PHENYL PROPANOIC ACID, APPLICATION TO THE SYNTHESIS OF N- (MERCAPTOACYL) AMINO-ACID DERIVATIVES |
AU3708397A (en) | 1996-08-02 | 1998-02-25 | Kaneka Corporation | Sulfonic ester derivatives, process for preparing the same, and use thereof |
DE69906849T2 (en) | 1998-02-16 | 2004-01-22 | Ajinomoto Co., Inc. | Process for the preparation of optically active phenylpropionic acid derivative |
GB0015490D0 (en) * | 2000-06-23 | 2000-08-16 | Smithkline Beecham Lab | Novel formulations |
US6992075B2 (en) * | 2003-04-04 | 2006-01-31 | Barr Laboratories, Inc. | C(14) estrogenic compounds |
JP2011517313A (en) | 2007-12-11 | 2011-06-02 | ビアメト ファーマシューティカルズ,インク. | Metalloenzyme inhibitors that use a metal binding moiety in combination with a targeting moiety |
WO2009077386A1 (en) | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Process for synthesis of tritiated and deuterated thiorphan and acetorphan |
FR2950362B1 (en) * | 2009-09-21 | 2011-10-21 | Univ Clermont Auvergne | USE OF K2P POTASSIUM CHANNEL ACTIVATORS AS ANALGIC. |
US8993631B2 (en) * | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
CA2819153A1 (en) | 2010-12-15 | 2012-06-21 | Theravance, Inc. | Neprilysin inhibitors |
CN105061314A (en) | 2010-12-15 | 2015-11-18 | 施万生物制药研发Ip有限责任公司 | Neprilysin inhibitors |
JP5959065B2 (en) | 2011-02-17 | 2016-08-02 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | Substituted aminobutyric acid derivatives as neprilysin inhibitors |
WO2012154249A1 (en) | 2011-02-17 | 2012-11-15 | Theravance, Inc. | Substituted aminobutyric derivatives as neprilysin inhibitors |
CN103596928B (en) | 2011-05-31 | 2017-02-15 | 施万生物制药研发Ip有限责任公司 | Neprilysin inhibitors |
CN103748070B (en) | 2011-05-31 | 2015-06-24 | 施万生物制药研发Ip有限责任公司 | Neprilysin inhibitors |
EP2714660B1 (en) | 2011-05-31 | 2018-09-26 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
WO2013181332A1 (en) | 2012-05-31 | 2013-12-05 | Theravance, Inc. | Nitric oxide donor neprilysin inhibitors |
AU2013271537B2 (en) | 2012-06-08 | 2017-05-11 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
ES2710932T3 (en) | 2012-06-08 | 2019-04-29 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
US9801819B2 (en) | 2012-06-28 | 2017-10-31 | Johnson & Johnson Consumer Inc. | Racecadotril compositions |
RU2632441C2 (en) | 2012-06-28 | 2017-10-04 | МакНЕЙЛ-ППС, ИНК. | Lipid compositions of racecadotril |
RS55797B1 (en) | 2012-08-08 | 2017-08-31 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
LT2964616T (en) | 2013-03-05 | 2017-07-25 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
US9585882B2 (en) | 2014-01-30 | 2017-03-07 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
AU2015210983B2 (en) | 2014-01-30 | 2018-10-04 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
MA40859A (en) | 2014-10-29 | 2017-09-05 | Johnson & Johnson Consumer Inc | CADOTRIL PARTICLES |
SG11201706308RA (en) | 2015-02-11 | 2017-09-28 | Theravance Biopharma R&D Ip Llc | (2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor |
PL3259255T3 (en) | 2015-02-19 | 2021-07-26 | Theravance Biopharma R&D Ip, Llc | (2r,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid |
MX2018010727A (en) | 2016-03-08 | 2019-01-24 | Theravance Biopharma R&D Ip Llc | Crystalline(2s,4r)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl] -4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-m ethylpentanoic acid and uses thereof. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2480747A1 (en) * | 1980-04-17 | 1981-10-23 | Roques Bernard | AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION |
US4798904A (en) * | 1983-10-03 | 1989-01-17 | E. R. Squibb & Sons, Inc. | Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase |
FR2559770B1 (en) * | 1984-02-20 | 1986-10-24 | Roussel Uclaf | NOVEL N-ALKYL-O-MERCAPTOPROPANAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED |
US4740499A (en) * | 1986-07-28 | 1988-04-26 | Monsanto Company | Method of enhancing the bioactivity of atrial peptides |
FR2623498B1 (en) * | 1987-11-24 | 1990-04-06 | Bioprojet Soc Civ | NOVEL ENANTIOMERIC COMPOUNDS DERIVED FROM AMINO ACIDS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS |
-
1987
- 1987-11-24 FR FR8716239A patent/FR2623498B1/en not_active Expired - Lifetime
-
1988
- 1988-11-22 US US07/274,884 patent/US5208255A/en not_active Expired - Lifetime
- 1988-11-24 DE DE88402944T patent/DE3883495T2/en not_active Expired - Lifetime
- 1988-11-24 AT AT88402944T patent/ATE93518T1/en not_active IP Right Cessation
- 1988-11-24 EP EP88402944A patent/EP0318377B1/en not_active Expired - Lifetime
- 1988-11-24 JP JP63297144A patent/JP2529172B2/en not_active Expired - Lifetime
- 1988-11-24 ES ES88402944T patent/ES2059554T3/en not_active Expired - Lifetime
-
1993
- 1993-02-01 US US08/011,690 patent/US5296509A/en not_active Expired - Lifetime
- 1993-02-01 US US08/011,672 patent/US5331008A/en not_active Expired - Lifetime
-
1995
- 1995-05-15 JP JP7139872A patent/JP2537159B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FR2623498A1 (en) | 1989-05-26 |
US5331008A (en) | 1994-07-19 |
DE3883495D1 (en) | 1993-09-30 |
EP0318377A2 (en) | 1989-05-31 |
JPH0859606A (en) | 1996-03-05 |
ES2059554T3 (en) | 1994-11-16 |
EP0318377A3 (en) | 1990-03-07 |
EP0318377B1 (en) | 1993-08-25 |
DE3883495T2 (en) | 1993-12-09 |
JPH02161A (en) | 1990-01-05 |
US5296509A (en) | 1994-03-22 |
FR2623498B1 (en) | 1990-04-06 |
JP2537159B2 (en) | 1996-09-25 |
JP2529172B2 (en) | 1996-08-28 |
US5208255A (en) | 1993-05-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |