ATE92037T1 - CARDIOVASCULAR ACTIVE CONNECTIONS. - Google Patents

CARDIOVASCULAR ACTIVE CONNECTIONS.

Info

Publication number
ATE92037T1
ATE92037T1 AT88121441T AT88121441T ATE92037T1 AT E92037 T1 ATE92037 T1 AT E92037T1 AT 88121441 T AT88121441 T AT 88121441T AT 88121441 T AT88121441 T AT 88121441T AT E92037 T1 ATE92037 T1 AT E92037T1
Authority
AT
Austria
Prior art keywords
active connections
cardiovascular active
compounds
formula
cardiovascular
Prior art date
Application number
AT88121441T
Other languages
German (de)
Inventor
Cesare Casagrande
Gabriele Norcini
Francesco Santangelo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Application granted granted Critical
Publication of ATE92037T1 publication Critical patent/ATE92037T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Compounds of formula <CHEM> (wherein R, R1, R2 and R3 have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described. The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.
AT88121441T 1987-12-23 1988-12-21 CARDIOVASCULAR ACTIVE CONNECTIONS. ATE92037T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT23182/87A IT1224404B (en) 1987-12-23 1987-12-23 ACTIVE COMPOUNDS ON THE CARDIOVASCULAR SYSTEM
EP88121441A EP0321967B1 (en) 1987-12-23 1988-12-21 Compounds active on the cardiovascular system

Publications (1)

Publication Number Publication Date
ATE92037T1 true ATE92037T1 (en) 1993-08-15

Family

ID=11204633

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88121441T ATE92037T1 (en) 1987-12-23 1988-12-21 CARDIOVASCULAR ACTIVE CONNECTIONS.

Country Status (6)

Country Link
EP (1) EP0321967B1 (en)
JP (1) JP2772650B2 (en)
AT (1) ATE92037T1 (en)
DE (1) DE3882677T2 (en)
ES (1) ES2058227T3 (en)
IT (1) IT1224404B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4422517A1 (en) * 1994-06-28 1996-01-04 Dresden Arzneimittel New (2- (3,4-dimethoxy-phenyl) -ethyl) - (2-phenoxy-ethyl) -amines, processes for their preparation and their use as medicines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3161165D1 (en) * 1980-05-08 1983-11-17 Beecham Group Plc Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions
EP0062596B1 (en) * 1981-04-06 1985-07-03 Cortial S.A. Derivatives of 4-aminoethoxy-5-isopropyl-2-methyl phenol, process for their preparation and their use as medicines

Also Published As

Publication number Publication date
IT1224404B (en) 1990-10-04
JPH02743A (en) 1990-01-05
EP0321967A3 (en) 1990-10-24
DE3882677T2 (en) 1993-11-04
JP2772650B2 (en) 1998-07-02
DE3882677D1 (en) 1993-09-02
ES2058227T3 (en) 1994-11-01
EP0321967B1 (en) 1993-07-28
IT8723182A0 (en) 1987-12-23
EP0321967A2 (en) 1989-06-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee