ATE92031T1 - NEW LEUKOTRIEN-B 4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS. - Google Patents
NEW LEUKOTRIEN-B 4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.Info
- Publication number
- ATE92031T1 ATE92031T1 AT90904600T AT90904600T ATE92031T1 AT E92031 T1 ATE92031 T1 AT E92031T1 AT 90904600 T AT90904600 T AT 90904600T AT 90904600 T AT90904600 T AT 90904600T AT E92031 T1 ATE92031 T1 AT E92031T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- atoms
- group
- pct
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PCT No. PCT/DE90/00209 Sec. 371 Date Nov. 19, 1990 Sec. 102(e) Date Nov. 19, 1990 PCT Filed Mar. 16, 1990 PCT Pub. No. WO90/11272 PCT Pub. Date Oct. 4, 1990.The invention relates to leukotriene-B4 derivatives of formula I, <IMAGE> (I) in which n=1-10, R1 means radical CH2OH, radical COOR4, radical CONHR5 or radical CONR6R7, A means a cis, trans or trans, trans-CH=CH-CH=CH group or tetramethylene group, B means an alkylene group with up to 10 C atoms, D means a direct compound, oxygen, sulfur, a -C 3BOND C group or a -CH=CR8 group, B and D together mean a direct bond, R2 means a hydrogen atom or an acid radical of an organic acid with 1-15 C atoms and R3 means a hydrogen atom, an optionally substituted alkyl radical with 1-10 C atoms, a cycloalkyl radical with 3-10 C atoms, an optionally substituted aryl radical with 6-10 C atoms or a 5-6 member heterocyclic radical and if R4 means a hydrogen atom, their salts with physiologically compatible bases and their cyclodextrin clathrates, process for their production and their pharmaceutical use.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3909326A DE3909326A1 (en) | 1989-03-17 | 1989-03-17 | NEW LEUKOTRIA B4 DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
PCT/DE1990/000209 WO1990011272A1 (en) | 1989-03-17 | 1990-03-16 | New leucotriene b4 derivatives, a method of preparing them, and their use as drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE92031T1 true ATE92031T1 (en) | 1993-08-15 |
Family
ID=6376895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90904600T ATE92031T1 (en) | 1989-03-17 | 1990-03-16 | NEW LEUKOTRIEN-B 4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5183925A (en) |
EP (1) | EP0416069B1 (en) |
JP (1) | JPH03505220A (en) |
AT (1) | ATE92031T1 (en) |
DE (2) | DE3909326A1 (en) |
DK (1) | DK0416069T3 (en) |
ES (1) | ES2058896T3 (en) |
WO (1) | WO1990011272A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4120698A1 (en) * | 1991-06-22 | 1992-12-24 | Gruenenthal Gmbh | New phenoxy-alkanol derivs. which are 5-lipoxygenase inhibitors - used to treat asthma, thrombosis, shock, ischaemic coronary infarction, etc. |
US8729108B2 (en) * | 2008-06-17 | 2014-05-20 | Christopher J Dannaker | Waterborne topical compositions for the delivery of active ingredients such as azelaic acid |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0109225B1 (en) * | 1982-11-11 | 1985-08-28 | Beecham Group Plc | Arachidonic acid analogues, processes for their preparation and their use in medicine |
CA1325809C (en) * | 1987-06-26 | 1994-01-04 | Stevan Wakefield Djuric | Phenylene furyl, and thienyl leukotriene b_ analogues |
-
1989
- 1989-03-17 DE DE3909326A patent/DE3909326A1/en not_active Withdrawn
-
1990
- 1990-03-16 ES ES90904600T patent/ES2058896T3/en not_active Expired - Lifetime
- 1990-03-16 DK DK90904600.5T patent/DK0416069T3/en active
- 1990-03-16 WO PCT/DE1990/000209 patent/WO1990011272A1/en active IP Right Grant
- 1990-03-16 AT AT90904600T patent/ATE92031T1/en not_active IP Right Cessation
- 1990-03-16 EP EP90904600A patent/EP0416069B1/en not_active Expired - Lifetime
- 1990-03-16 DE DE9090904600T patent/DE59002088D1/en not_active Expired - Fee Related
- 1990-03-16 US US07/623,386 patent/US5183925A/en not_active Expired - Fee Related
- 1990-03-16 JP JP2504626A patent/JPH03505220A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DK0416069T3 (en) | 1993-12-20 |
EP0416069A1 (en) | 1991-03-13 |
ES2058896T3 (en) | 1994-11-01 |
EP0416069B1 (en) | 1993-07-28 |
US5183925A (en) | 1993-02-02 |
DE59002088D1 (en) | 1993-09-02 |
JPH03505220A (en) | 1991-11-14 |
WO1990011272A1 (en) | 1990-10-04 |
DE3909326A1 (en) | 1990-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE40368T1 (en) | XANTHINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
ATE129503T1 (en) | AMIDINOPHENYLALANINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND AGENTS CONTAINING THEM AS ANTICOAGULANTS. | |
ATE108763T1 (en) | NEW BENZOCYCLOHEPTEN DERIVATIVES, THEIR PREPARATION AND USE FOR PHARMACEUTICALS. | |
ATE17728T1 (en) | XANTHIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
DE3481985D1 (en) | 9-HALOGEN PROSTAGLAND DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS. | |
DE3774888D1 (en) | DIHYDROBENZOFURANE AND CHROMANCARBOXAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A NEUROLEPTICA. | |
ATE38831T1 (en) | NEW CARBACYCLINES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINES. | |
ATE134623T1 (en) | SALICYL(THIO)ETHER DERIVATIVES, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION | |
DE3575715D1 (en) | ADAMANTANAMINE DERIVATIVES, METHOD FOR THE PRODUCTION AND MEDICINES CONTAINING THEM. | |
ATE34575T1 (en) | NEW THEOPHYLLINE DERIVATIVES AND PROCESSES FOR THEIR PRODUCTION. | |
ATE173260T1 (en) | 1,7-ANNATED 3-(PIPERAZINO-ALKYL)INDOLE DERIVATIVES AND METHOD AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS | |
ATE93863T1 (en) | ENZYME INHIBITING AMINO ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION, COMPOSITIONS THEREOF AND THEIR USE. | |
ATE114633T1 (en) | NEW LEUKOTRIENE B4 DERIVATIVES PROCESSES FOR THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS. | |
ATE166345T1 (en) | BENZOSPIROALKENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | |
DE69116237D1 (en) | Derivatives of hexahydroazepine, process for their preparation and medicinal products containing them | |
DE3769563D1 (en) | NEW DERIVATIVES OF 4,5-DIHYDRO-OXAZOLES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE. | |
ATE107298T1 (en) | 3-AMINOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
ATE172976T1 (en) | 3-AMINOCHROMANE SPIRODERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | |
ATE94532T1 (en) | NEW LEUKOTRIEN-B4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS. | |
ATE92031T1 (en) | NEW LEUKOTRIEN-B 4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS. | |
ATE122339T1 (en) | 9-HALOGEN-11(BETA)-HYDROXY-PROSTAGLAND INDERIVATE, METHOD FOR THE PRODUCTION THEREOF AND ITS USE AS A MEDICINAL PRODUCT. | |
ATE140693T1 (en) | PHENYLALKYLAMINOALKYL COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS | |
ATE139441T1 (en) | USE OF 2-IMINOTHIAZOLIDINE-4-ONE DERIVATIVES AS NOVEL DRUG INGREDIENTS | |
DE3866292D1 (en) | PIPERAZINYLALKYLPIPERAZINDION DERIVATIVES, THEIR METHOD FOR THE PRODUCTION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
DE3676378D1 (en) | ISOXAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |