ATE92031T1 - NEW LEUKOTRIEN-B 4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS. - Google Patents

NEW LEUKOTRIEN-B 4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.

Info

Publication number
ATE92031T1
ATE92031T1 AT90904600T AT90904600T ATE92031T1 AT E92031 T1 ATE92031 T1 AT E92031T1 AT 90904600 T AT90904600 T AT 90904600T AT 90904600 T AT90904600 T AT 90904600T AT E92031 T1 ATE92031 T1 AT E92031T1
Authority
AT
Austria
Prior art keywords
radical
atoms
group
pct
trans
Prior art date
Application number
AT90904600T
Other languages
German (de)
Inventor
Josef Heindl
Werner Skuballa
Bernd Buchmann
Wolfgang Froehlich
Roland Ekerdt
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE92031T1 publication Critical patent/ATE92031T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Abstract

PCT No. PCT/DE90/00209 Sec. 371 Date Nov. 19, 1990 Sec. 102(e) Date Nov. 19, 1990 PCT Filed Mar. 16, 1990 PCT Pub. No. WO90/11272 PCT Pub. Date Oct. 4, 1990.The invention relates to leukotriene-B4 derivatives of formula I, <IMAGE> (I) in which n=1-10, R1 means radical CH2OH, radical COOR4, radical CONHR5 or radical CONR6R7, A means a cis, trans or trans, trans-CH=CH-CH=CH group or tetramethylene group, B means an alkylene group with up to 10 C atoms, D means a direct compound, oxygen, sulfur, a -C 3BOND C group or a -CH=CR8 group, B and D together mean a direct bond, R2 means a hydrogen atom or an acid radical of an organic acid with 1-15 C atoms and R3 means a hydrogen atom, an optionally substituted alkyl radical with 1-10 C atoms, a cycloalkyl radical with 3-10 C atoms, an optionally substituted aryl radical with 6-10 C atoms or a 5-6 member heterocyclic radical and if R4 means a hydrogen atom, their salts with physiologically compatible bases and their cyclodextrin clathrates, process for their production and their pharmaceutical use.
AT90904600T 1989-03-17 1990-03-16 NEW LEUKOTRIEN-B 4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS. ATE92031T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3909326A DE3909326A1 (en) 1989-03-17 1989-03-17 NEW LEUKOTRIA B4 DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
PCT/DE1990/000209 WO1990011272A1 (en) 1989-03-17 1990-03-16 New leucotriene b4 derivatives, a method of preparing them, and their use as drugs

Publications (1)

Publication Number Publication Date
ATE92031T1 true ATE92031T1 (en) 1993-08-15

Family

ID=6376895

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90904600T ATE92031T1 (en) 1989-03-17 1990-03-16 NEW LEUKOTRIEN-B 4 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.

Country Status (8)

Country Link
US (1) US5183925A (en)
EP (1) EP0416069B1 (en)
JP (1) JPH03505220A (en)
AT (1) ATE92031T1 (en)
DE (2) DE3909326A1 (en)
DK (1) DK0416069T3 (en)
ES (1) ES2058896T3 (en)
WO (1) WO1990011272A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4120698A1 (en) * 1991-06-22 1992-12-24 Gruenenthal Gmbh New phenoxy-alkanol derivs. which are 5-lipoxygenase inhibitors - used to treat asthma, thrombosis, shock, ischaemic coronary infarction, etc.
US8729108B2 (en) * 2008-06-17 2014-05-20 Christopher J Dannaker Waterborne topical compositions for the delivery of active ingredients such as azelaic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0109225B1 (en) * 1982-11-11 1985-08-28 Beecham Group Plc Arachidonic acid analogues, processes for their preparation and their use in medicine
ES2052639T3 (en) * 1987-06-26 1994-07-16 Searle & Co ANALOGS OF FENILEN-, FURIL- AND TIENIL-LEUCOTRENE B4.

Also Published As

Publication number Publication date
EP0416069B1 (en) 1993-07-28
JPH03505220A (en) 1991-11-14
WO1990011272A1 (en) 1990-10-04
US5183925A (en) 1993-02-02
DE3909326A1 (en) 1990-09-20
DK0416069T3 (en) 1993-12-20
EP0416069A1 (en) 1991-03-13
ES2058896T3 (en) 1994-11-01
DE59002088D1 (en) 1993-09-02

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