ATE817T1 - 2-(1-PHENYL-2,5-CYCLOHEXA DIENYL)-AETHYLAMINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE, THEIR USE AS PHARMACEUTICAL SUBSTANCES AND MEDICATIONS CONTAINING THEM. - Google Patents

2-(1-PHENYL-2,5-CYCLOHEXA DIENYL)-AETHYLAMINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE, THEIR USE AS PHARMACEUTICAL SUBSTANCES AND MEDICATIONS CONTAINING THEM.

Info

Publication number
ATE817T1
ATE817T1 AT79103906T AT79103906T ATE817T1 AT E817 T1 ATE817 T1 AT E817T1 AT 79103906 T AT79103906 T AT 79103906T AT 79103906 T AT79103906 T AT 79103906T AT E817 T1 ATE817 T1 AT E817T1
Authority
AT
Austria
Prior art keywords
aethylamine
phenyl
derivatives
manufacture
pharmaceutical substances
Prior art date
Application number
AT79103906T
Other languages
German (de)
Inventor
Peter M. Dr. Mueller
Rudolf Dr. Pfister
Rene Dr. Urban
Original Assignee
F. Hoffmann-La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann-La Roche & Co. Aktiengesellschaft
Application granted granted Critical
Publication of ATE817T1 publication Critical patent/ATE817T1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/225Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/20Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/235Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • C07C47/238Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings having unsaturation outside the aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT79103906T 1978-10-11 1979-10-11 2-(1-PHENYL-2,5-CYCLOHEXA DIENYL)-AETHYLAMINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE, THEIR USE AS PHARMACEUTICAL SUBSTANCES AND MEDICATIONS CONTAINING THEM. ATE817T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1055278 1978-10-11
EP79103906A EP0012801B1 (en) 1978-10-11 1979-10-11 2-(1-phenyl-2,5-cyclohexadienyl)-ethylamine derivatives, process for their preparation, their use as active pharmaceutical agents and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE817T1 true ATE817T1 (en) 1982-04-15

Family

ID=4364419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79103906T ATE817T1 (en) 1978-10-11 1979-10-11 2-(1-PHENYL-2,5-CYCLOHEXA DIENYL)-AETHYLAMINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE, THEIR USE AS PHARMACEUTICAL SUBSTANCES AND MEDICATIONS CONTAINING THEM.

Country Status (23)

Country Link
US (1) US4269788A (en)
EP (1) EP0012801B1 (en)
JP (1) JPS5553248A (en)
AR (1) AR224135A1 (en)
AT (1) ATE817T1 (en)
AU (1) AU5163679A (en)
BR (1) BR7906487A (en)
CA (1) CA1130318A (en)
CS (1) CS213395B2 (en)
CU (1) CU35135A (en)
DE (1) DE2962464D1 (en)
DK (1) DK428079A (en)
ES (3) ES484890A0 (en)
FI (1) FI792998A (en)
GR (1) GR72475B (en)
HU (1) HU180248B (en)
IE (1) IE48847B1 (en)
IL (1) IL58391A0 (en)
MC (1) MC1287A1 (en)
NO (1) NO147273C (en)
PH (1) PH15443A (en)
PT (1) PT70302A (en)
ZA (1) ZA795301B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH644580A5 (en) * 1980-01-29 1984-08-15 Hoffmann La Roche CYCLOHEXEN DERIVATIVES.
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
WO2008044628A1 (en) * 2006-10-06 2008-04-17 Tokai University Educational System Process for production of peptide thioester
CN106336368A (en) * 2016-08-24 2017-01-18 天津德凯化工股份有限公司 Dye intermediate and preparation method thereof
CN106349128A (en) * 2016-08-24 2017-01-25 天津德凯化工股份有限公司 Novel dye intermediate and active dye prepared from dye intermediate
US10654979B2 (en) 2017-08-18 2020-05-19 Becton, Dickinson And Company Amphiphilic graft copolymers

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1298527B (en) * 1962-06-09 1969-07-03 Knoll Ag Process for the preparation of bicyclically substituted aminoalkanes
DE1284421B (en) * 1962-06-09 1968-12-05 Knoll Ag Bicyclically substituted aminoalkanes and processes for their preparation
DE1518545A1 (en) * 1965-04-01 1970-01-15 Boehringer Mannheim Gmbh Process for the preparation of new phenylcyclohexylalkylamines and their salts
US3320283A (en) * 1965-07-06 1967-05-16 Parke Davis & Co Phenylcyclohexylmethylamine compounds
DE1518663A1 (en) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basically substituted cycloalkene derivatives and process for their preparation
GB1122050A (en) * 1966-07-14 1968-07-31 Labofina Sa Process for the resolution of alpha-arylalkylamines into their optical antipodes
FR316E (en) * 1968-01-17 1902-12-08 Progress Soc As Egg preservation process
DE1907909A1 (en) * 1969-02-17 1970-12-03 Goedecke Ag 3-amino-4-phenyl-cyclohexenes with analgesic - activity
US3928603A (en) * 1970-10-28 1975-12-23 Fuveau Sa New derivatives of alpha-methyl benzylamine in treating inflammation
US3864391A (en) * 1972-10-02 1975-02-04 Du Pont 2,5-Diphenylcycloaliphatic Alkylamines
GB1549174A (en) * 1975-05-08 1979-08-01 Lilly Industries Ltd Amine derivatives

Also Published As

Publication number Publication date
IE791930L (en) 1980-04-11
ES493544A0 (en) 1981-07-16
AU5163679A (en) 1980-04-17
DK428079A (en) 1980-04-12
FI792998A (en) 1980-04-12
IL58391A0 (en) 1980-01-31
PH15443A (en) 1983-01-18
AR224135A1 (en) 1981-10-30
NO147273B (en) 1982-11-29
NO147273C (en) 1983-03-09
CU35135A (en) 1982-08-24
ZA795301B (en) 1980-09-24
IE48847B1 (en) 1985-05-29
ES493543A0 (en) 1981-07-16
NO793267L (en) 1980-04-14
ES8200859A1 (en) 1981-11-01
EP0012801B1 (en) 1982-04-07
HU180248B (en) 1983-02-28
ES484890A0 (en) 1981-11-01
GR72475B (en) 1983-11-11
CS213395B2 (en) 1982-04-09
DE2962464D1 (en) 1982-05-19
JPS5553248A (en) 1980-04-18
ES8106129A1 (en) 1981-07-16
BR7906487A (en) 1980-07-15
EP0012801A1 (en) 1980-07-09
CA1130318A (en) 1982-08-24
US4269788A (en) 1981-05-26
PT70302A (en) 1979-11-01
ES8106128A1 (en) 1981-07-16
MC1287A1 (en) 1980-07-22

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